An aqueous extract of the popular Chinese nutraceutical Kwei Ling Ko (Tortoise shell-Rhizome Jelly) activates the PPARγ pathway and down-regulates the NFκB activity

Phytomedicine

Volumn 12, Issue 10, 2005, Pages 748-759

  Yip, E C H ^a   Liu, A M F ^a   Wong, J T Y ^a   Wong, Y H ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

Adipocyte differentiation; NF B; PPAR; Reporter gene assay

Indexed keywords

CHINESE DRUG; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KWEI LING KO; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; UNCLASSIFIED DRUG;

ADIPOCYTE; AQUEOUS SOLUTION; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; FIBROBLAST; FLOW CYTOMETRY; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOMODULATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

3T3 CELLS; ADIPOGENESIS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; DOWN-REGULATION; DRUGS, CHINESE HERBAL; GENES, REPORTER; HUMANS; MICE; NF-KAPPA B; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; RHIZOME; SMILAX; TUMOR NECROSIS FACTOR-ALPHA; TURTLES; UP-REGULATION;

EID: 27144486598     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2004.11.002     Document Type: Article

References (45)

1. N. Auphan, J.A. DiDonato, C. Rosette, A. Helmberg, and M. Karin Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκB synthesis Science 270 1995 286 290
2. P.A. Baeuerle, and D. Baltimore IκB: a specific inhibitor of the NF-κB transcription factor Science 242 1988 540 546
3. P.J. Barnes Anti-inflammatory actions of glucocorticoids: molecular mechanisms Clin. Sci. (Lond.) 94 1998 557 572
4. A.A. Beg, and A.S. Baldwin Jr. The IκB proteins: multifunctional regulators of Rel/NF-kappa B transcription factors Genes Dev. 7 1993 2064 2070 Review
5. Bensky, D., Gamble, A., 1993. Chinese herbal medicine: In: Bensky, D., Gamble, A. (Eds.), Materia Medica, Revised Edition. Eastland Press, Inc.
6. C. Brostjan, J. Anrather, V. Csizmadia, D. Stroka, M. Soares, F.H. Bach, and H. Winkler Glucocorticoid-mediated repression of NFκB activity in endothelial cells does not involve induction of IκBα synthesis J. Biol. Chem. 271 1996 19612 19616
7. Y. Cai, T. Chen, and Q. Xu Astilbin suppresses collagen-induced arthritis via the dysfunction of lymphocytes Inflamm. Res. 52 2003 334 340
8. T. Chen, J. Li, J. Cao, Q. Xu, K. Komatsu, and T. Namba A new flavanone isolated from Rhizome Smilacis glabrae and the structural requirements of its derivatives for preventing immunological hepatocyte damage Planta Med. 65 1999 56 59
9. Chen, P., Zheng, G., 1998. Chinese herbs and compatibility. In: Chen, P., Zheng, G. (Eds.), Advanced TCM Series, vol. 4. Science Press, Beijing; IOS Press, Amsterdam; Ohmsha, Tokyo.
10. J. Choi, K.T. Lee, H. Jung, H.S. Park, and H.J. Park Anti-rheumatoid arthritis effect of the Kochia fruits and activity comparison of momordin Ic, its prosapogenin and sapogenin Arch. Pharm. Res. 25 2002 336 342
11. R.M. Cowherd, R.E. Lyle, and R.E. McGehee Jr. Molecular regulation of adipocyte differentiation Cell Dev. Biol. 10 1999 3 10
12. P. Delerive, K. De Bosscher, S. Besnard, W. Vanden Berghe, J.M. Peters, F.J. Gonzalez, J.C. Fruchart, A. Tedgui, G. Haegeman, and B. Staels Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-κB and AP-1 J. Biol. Chem. 274 1999 32048 32054
13. T.S. Finco, A.A. Beg, and A.S. Baldwin Jr. Inducible phosphorylation of IκBα is not sufficient for its dissociation from NF-κB and is inhibited by protease inhibitors Proc. Natl. Acad. Sci. USA 91 1994 11884 11888
14. A.M. Gaben-Cogneville, B. Breant, A.M. Coudray, D.H. Hoa, and J. Mester Differentiation of newborn rat preadipocytes in culture: effects of insulin and dexamethasone Exp. Cell Res. 191 1991 133 140
15. M. Gottlicher, E. Widmark, Q. Li, and J.A. Gustafsson Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor Proc. Natl. Acad. Sci. USA 89 1992 4653 4657
16. P. Greenspan, D. Czerucka, M. Rassoulzadegan, F. Cuzin, and G. Ailhaud Nile red: a selective fluorescent stain for intracellular lipid droplets J. Cell Biol. 100 1985 965 973
17. S. Guller, R.E. Corin, D.C. Mynarcik, B.M. London, and M. Sonenberg Role of insulin in growth hormone-stimulated 3T3 cell adipogenesis Endocrinology 122 1988 2084 2089
18. E. Harlow, and D.P. Lane Antibodies Laboratory Manual 1988 Cold Spring Harbor Laboratory Press Cold Spring Harbor
19. S. Heck, K. Bender, M. Kullmann, M. Gottlicher, P. Herrlich, and A.C. Cato IκBα-independent downregulation of NF-κB activity by glucocorticoid receptor EMBO J. 16 1997 4698 4707
20. K.I. Jeon, J.Y. Jeong, and D.M. Jue Thiol-reactive metal compounds inhibit NF-κB activation by blocking IκB kinase J. Immunol. 164 2000 5981 5989
21. J. Jiang, F. Wu, J. Lu, Z. Lu, and Q. Xu Anti-inflammatory activity of the aqueous extract from Rhizome Smilacis glabrae Pharmacol. Res. 36 1997 309 314
22. C. Jobin, C.A. Bradham, M.P. Russo, B. Juma, A.S. Narula, D.A. Brenner, and R.B. Sartor Curcumin blocks cytokine-mediated NF-κB activation and proinflammatory gene expression by inhibiting inhibitory factor IκB kinase activity J. Immunol. 163 1999 3474 3483
23. P. Kapahi, T. Takahashi, G. Natoli, S.R. Adams, Y. Chen, R.Y. Tsien, and M. Karin Inhibition of NF-κB activation by arsenite through reaction with a critical cysteine in the activation loop of IκB kinase J. Biol. Chem. 275 2000 36062 36066
24. H. Keller, A. Mahfoudi, C. Dreyer, A.K. Hihi, J. Medin, K. Ozato, and W. Wahli Peroxisome proliferator-activated receptors and lipid metabolism Proc. Natl. Acad. Sci. USA 684 1993 157 173
25. S.A. Kliewer, J.M. Lehmann, M.V. Milburn, and T.M. Willson The PPARs and PXRs: nuclear xenobiotic receptors that define novel hormone signaling pathways Recent Prog. Horm. Res. 54 1999 345 368
26. J.M. Lehmann, L.B. Moore, T.A. Smith-Oliver, W.O. Wilkison, T.M. Willson, and S.A. Kliewer An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma J. Biol. Chem. 270 1995 12953 12956
27. M.J. May, and S. Ghosh Signal transduction through NF-κB Immunol. Today 19 1998 80 88
28. D.M. Miller-Martini, R.Y.K. Chan, N.Y. Ip, S.J. Sheu, and Y.H. Wong A reporter gene assay for the detection of phytoestrogens in traditional Chinese medicine Phytother. Res. 15 2001 487 492
29. D.C. New, D.M. Miller-Martini, and Y.H. Wong Reporter gene assays and their applications to bioassays of natural products Phytother. Res. 17 2003 439 448
30. Z. Qiu, Y. Wei, N. Chen, M. Jiang, J. Wu, and K. Liao DNA synthesis and mitotic clonal expansion is not a required step for 3T3-L1 preadipocyte differentiation into adipocytes J. Biol. Chem. 276 2001 11988 11995
31. M. Ricote, A.C. Li, T.M. Willson, C.J. Kelly, and C.K. Glass The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation Nature 391 1998 79 82
32. A. Rossi, P. Kapahi, G. Natoli, T. Takahashi, Y. Chen, M. Karin, and M.G. Santoro Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase Nature 403 2000 103 108
33. R.I. Scheinman, P.C. Cogswell, A.K. Lofquist, and A.S. Baldwin Jr. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids Science 270 1995 283 286
34. U. Siebenlist, G. Franzoso, and K. Brown Structure, regulation and function of NF-κB Annu. Rev. Cell Biol. 10 1994 405 455
35. P.J. Smith, L.S. Wise, R. B̈erkowitz, C. Wan, and C.S. Rubin Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes J. Biol Chem. 263 1988 9402 9408
36. M.J. Smyth, R.L. Sparks, and W. Wharton Preadipocyte cell lines: models of cellular proliferation and differentiation J. Cell Sci. 106 1993 1 9
37. N. Sueoka, M. Suganuma, E. Sueoka, S. Okabe, S. Matsuyama, K. Imai, K. Nakachi, and H. Fujiki A new function of green tea: prevention of lifestyle-related diseases Ann. New York Acad. Sci. 928 2001 274 280
38. P. Tontonoz, E. Hu, R.A. Graves, A.I. Budavari, and B.M. Spiegelman mPPAR γ2: tissue-specific regulator of an adipocyte enhancer Genes Dev. 8 1994 1224 1234
39. P. Tontonoz, E. Hu, and B.M. Spiegelman Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor Cell 79 1994 1147 1156
40. C.B. Wright, T. Mikami, S. Hauser, K. Yanagi, R. Hiramatsu, C.N. Serhan, and B.M. Spiegelman A synthetic antagonist for the peroxisome proliferator-activated receptor γ inhibits adipocyte differentiation J. Biol. Chem. 275 2000 1873 1877
41. Z. Wu, N.L. Bucher, and S.R. Farmer Induction of peroxisome proliferator-activated receptor γ during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPβ, C/EBPδ, and glucocorticoids Mol. Cell Biol. 16 1996 4128 4136
42. T. Yanase, T. Yashiro, K. Takitani, S. Kato, S. Taniguchi, R. Takayanagi, and S. Nawata Differential expression of PPARγ1 and γ2 isoforms in human adipose tissue Biochem. Biophys. Res. Commun. 233 1997 320 324
43. M.J. Yin, Y. Yamamoto, and R.B. Gaynor The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β Nature 396 1998 77 80
44. J.C. Yu, Z.D. Min, and N.Y. Ip Melia toosendan regulates PC12 cell differentiation via the activation of protein kinase A and extracellular signal-regulated kinases Neurosignals 13 2004 248 257
45. Y. Zhu, C. Qi, J.R. Korenberg, X.N. Chen, D. Noya, M.S. Rao, and J.K. Reddy Structural organization of mouse peroxisome proliferator-activated receptor γ (mPPAR γ) gene: alternative promoter use and different splicing yield two mPPAR γ isoforms Proc. Natl. Acad. Sci. USA 92 1995 7921 7925