Anti-rheumatoid arthritis effect of the Kochia scoparia fruits and activity comparison of momordin Ic, its prosapogenin and sapogenin

Archives of Pharmacal Research

Volumn 25, Issue 3, 2002, Pages 336-342

  Choi, Jongwon ^a   Lee, Kyung Tae ^b   Jung, Hyun Ju ^c   Park, Hee Sun ^c   Park, Hee Juhn ^c  

^a Kyungsung University   (South Korea)

^b Kyung Hee University   (South Korea)

^c Sangji University   (South Korea)

Author keywords

Antinociceptive; Chenopodiaceae; Edema; Kochia scoparia; Momordin Ic; Oleanolic acid; Rheumatoid arthritis

Indexed keywords

ACETIC ACID; CARRAGEENAN; DIAGNOSTIC AGENT; DRUG DERIVATIVE; MOMORDIN I (OLEANOLIC ACID); OLEANOLIC ACID; PLANT EXTRACT; SAPOGENIN;

ANIMAL; ARTHRITIS; ARTICLE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECT; EDEMA; FRUIT; GOOSEFOOT; HYDROLYSIS; INSTITUTE FOR CANCER RESEARCH MOUSE; ISOLATION AND PURIFICATION; MALE; MOUSE; PAIN ASSESSMENT; RAT; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION;

ACETIC ACID; ANIMALS; ARTHRITIS, EXPERIMENTAL; CARRAGEENAN; CHENOPODIACEAE; EDEMA; FRUIT; HYDROLYSIS; MALE; MICE; MICE, INBRED ICR; OLEANOLIC ACID; PAIN MEASUREMENT; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; SAPOGENINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036594042     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF02976636     Document Type: Article

References (16)

1. Choi, J. W., Huh, K., Kim, S. H., Lee, K. T., Park, H. J., and Han, Y. N., Antinociceptive and antirheumatoidal effects of Kalopanax pictus extract and its saponin components in experimental animals. Journal of Ethnopharmacology, 199-204 (2002a).
2. Choi, J. W., Huh, K., Kim, S. H., Lee, K. T., Lee, H. K., and Park, H. J., Kalopanaxsaponin A from Kalopanax pictus, a potent antioxidant in the rheumatoidal rat treated with Freund's complete adjuvant reagent. Journal of Ethnopharmacology, 113-118 (2002b).
3. Giner-Larza E. M., Manez, S., Recio, M. C., and Giner, R. M., Oleanonic acid, a 3-oxotriterpene from Pistacia inhibits leukotriene synthesis and has antiinflammatory activity. European Journal of Pharmacology, 428, 137-143 (2001).
4. Kawamura, N., Watanabe, H., and Oshio, H., Saponins from the roots of Momordica cochinchinensis. Phyto-chemistry, 11, 3585-3591 (1988).
5. Kim, D. H., Yu, K. W., Bae, E. A., Park, H. J., and Choi, J. W., Metabolism of Kalopanaxsaponin B and H by human intestinal bacteria and antidiabetic activity of their metabolites. Biological and Pharmaceutical Bulletin, 21, 360-365 (1998).
6. Matsuda, H., Dai, Y., Ido, Y., Ko, S., Yoshikawa, M., and Kubo, M., Studies on Kochiae Fructus III. Antinociceptive and antiinflammatory effects of 70% ethanol extract and its component, momordin Ic from dried fruits of Kochia scoparia L. Biological and Pharmaceutical Bulletin, 20, 1086-1091 (1997a).
7. Matsuda, H., Dai, Y., Ido, Y., Yoshikawa, M., and Kubo, M., Studies on Kochiae Fructus IV. Anti-allergic effects of 70% ethanol extract and its component, momordin Ic from dried fruits of Kochia scoparia L. Biological and Pharmaceutical Bulletin, 20, 1165-1170 (1997b).
8. Matsuda, H., Li, Y., Murakami, T., Yamahara, J., and Yoshikawa, M., Structure-related inhibitory activity of oleanolic acid glycosides on gastric emptying in mice. Bioorg. Med. Chem., 7, 323-327 (1999a).
9. Matsuda, H., Li, Y., and Yoshikawa, M., Roles of capsaicin-sensitive sensory nerves, endogenous nitric oxide, sulfhydryls, and prostaglandins in gastroprotection by momordin Ic, an oleanolic acid oligoglycoside, on ethanol-induced mucosal lesions in rats. Life Science, 65, PL27-32 (1999b).
10. Shao, C. -J., Kasai, R., Xu, J. -D., and Tanaka, O., Saponins from roots of Kalopanax septemlobus (Thunb.) Koidz., Ciqiu: Structures of Kalopanaxsaponins C, D, E and F. Chemical and Pharmaceutical Bulletin, 37, 311-314 (1989).
11. Wen Y., Chen, Y., Cui, Z., Li, J., and Wang, Z., Triterpenoid glycosides from the fruits of Kochia scoparia. Planta Medica, 61, 450-452 (1995).
12. Whittle, B.A., The use of change in capillary permeability to distinguish between narcotic and anagesic. British Journal of Pharmacology. 22, 246-460 (1949).
13. Yoshikawa, M., Dai, Y., Shimada, H., Morikawa, T., Matsumura, N., Yoshizumi, H., Matsuda, H., and Kubo, M., Studies on Kochiae Fructus. II. On the saponin constituets from the fruit of Chinese Kocia scoparia (Chenopodiaceae): Chemical structures of Kochianosides I, II, III, and IV. Chemical and Pharmaceutical Bulletin, 45, 1052-1055 (1997).
14. Yoshikawa, M., Shimada, H., Morikawa, T., Yoshizumi, S., Matsumura, N., Murakami, T., Matsuda, H., Hori, K., and Yamahara, J., Medicinal foodstuffs. VII. On the saponin constituents with glucose and alcohol adsorption-inhibitory activity from a food garnish "tonburi", the fruit of Japanese Kochia scoparia (L.) Schrad.: Structures of scoparianosides A, B and C. Chem. Pharm. Bull., 45, 1300-1305 (1997).
15. Winter, C. A., Risley, E. A., and Nuss, G. W., Carrageenin induced edema in hind paw of the rat as an assay for antiinflammatory drugs. Pro. Soc. Exp. Biol. Med. 111: 544-548 (1962).
16. Yim, T. K., Wu, W. K., Pak, W. F., Ko, K. M., Hepatoprotective action of oleanolic acid-enriched extract of Ligustrum lucidum fruits is mediated through an enhancement on hepatic glutathione regeneration capacity in mice. Phytotherapy Research, 15, 589-592 (2001).