Solving the primary biliary cirrhosis puzzle: The emerging image of immunopathology in primary biliary cirrhosis

Clinical and Applied Immunology Reviews

Volumn 5, Issue 4, 2005, Pages 271-284

  Lan, Ruth Y ^a   Leung, Patrick ^a   Ansari, Aftab A ^b   Coppel, Ross L ^c   Gershwin, M Eric ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MONASH UNIVERSITY   (Australia)

Author keywords

Autoantigen; Autoimmunity; Eosinophils; Epitope; Granulomas; Macrophages; Molecular mimicry; PDC E2; Primary biliary cirrhosis

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; CELL ADHESION MOLECULE; CHEMOATTRACTANT; IMMUNOGLOBULIN M; MITOCHONDRION ANTIBODY;

ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; EOSINOPHIL; GRANULOMA; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOLOGY; INNATE IMMUNITY; LIVER CIRRHOSIS; LYMPHOCYTE ACTIVATION; LYMPHOCYTIC INFILTRATION; MACROPHAGE FUNCTION; PATHOGENICITY; PATHOPHYSIOLOGY; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

EID: 26944465732     PISSN: 15291049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cair.2005.07.001     Document Type: Article

References (61)

1. M.M. Kaplan Primary biliary cirrhosis N Engl J Med 335 21 1996 1570-1580
2. C. Selmi P. Invernizzi M. Miozzo M. Podda M.E. Gershwin Primary biliary cirrhosis: Does X mark the spot? Autoimmun Rev 3 7-8 2004 493-499
3. Y. Ichiki S. Shimoda H. Ishibashi M.E. Gershwin Is primary biliary cirrhosis a model autoimmune disease? Autoimmun Rev 3 4 2004 331-336
4. C.T. Wu J.P. Eiserich A.A. Ansari R.L. Coppel S. Balasubramanian C.L. Bowlus et al. Myeloperoxidase-positive inflammatory cells participate in bile duct damage in primary biliary cirrhosis through nitric oxide-mediated reactions Hepatology 38 4 2003 1018-1025
5. S.P. Fussey J.R. Guest O.F. James M.F. Bassendine S.J. Yeaman Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis Proc Natl Acad Sci U S A 85 22 1988 8654-8658
6. P.S. Leung R.L. Coppel A. Ansari S. Munoz M.E. Gershwin Antimitochondrial antibodies in primary biliary cirrhosis Semin Liver Dis 17 1 1997 61-69
7. D.E. Jones F.E. Watt J.V. Metcalf M.F. Bassendine O.F. James Familial primary biliary cirrhosis reassessed: A geographically-based population study J Hepatol 30 3 1999 402-407
8. M.M. Kaplan Novosphingobium aromaticivorans: A potential initiator of primary biliary cirrhosis Am J Gastroenterol 99 11 2004 2147-2149
9. S.A. Long J. Van de Water M.E. Gershwin Antimitochondrial antibodies in primary biliary cirrhosis: The role of xenobiotics Autoimmun Rev 1 1-2 2002 37-42
10. H. Ishibashi M. Nakamura S. Shimoda M.E. Gershwin T cell immunity and primary biliary cirrhosis Autoimmun Rev 2 1 2003 19-24
11. K. Harada S. Ozaki Y. Sudo K. Tsuneyama H. Ohta Y. Nakanuma Osteopontin is involved in the formation of epithelioid granuloma and bile duct injury in primary biliary cirrhosis Pathol Int 53 1 2003 8-17
12. A. Bjorkland L. Loof I. Mendel-Hartvig T.H. Totterman Primary biliary cirrhosis. High proportions of B cells in blood and liver tissue produce anti-mitochondrial antibodies of several Ig classes J Immunol 153 6 1994 2750-2757
13. K. Kikuchi Z.X. Lian G.X. Yang A.A. Ansari S. Ikehara M. Kaplan et al. Bacterial CpG induces hyper-IgM production in CD27(+) memory B cells in primary biliary cirrhosis Gastroenterology 128 2 2005 304-312
14. J. Neuberger Antibodies and primary biliary cirrhosis - piecing together the jigsaw J Hepatol 36 1 2002 126-129
15. G.D. Benson K. Kikuchi H. Miyakawa A. Tanaka M.R. Watnik M.E. Gershwin Serial analysis of antimitochondrial antibody in patients with primary biliary cirrhosis Clin Dev Immunol 11 2 2004 129-133
16. L. Dubel A. Tanaka P.S. Leung J. Van de Water R. Coppel T. Roche et al. Autoepitope mapping and reactivity of autoantibodies to the dihydrolipoamide dehydrogenase-binding protein (E3BP) and the glycine cleavage proteins in primary biliary cirrhosis Hepatology 29 4 1999 1013-1018
17. T. Mori K. Ono M. Hakozaki H. Kochi Epitope mapping on E1 alpha subunit of pyruvate dehydrogenase complex with autoantibodies of patients with primary biliary cirrhosis Liver Int 23 5 2003 355-362
18. C.D. Surh R. Coppel M.E. Gershwin Structural requirement for autoreactivity on human pyruvate dehydrogenase-E2, the major autoantigen of primary biliary cirrhosis. Implication for a conformational autoepitope J Immunol 144 9 1990 3367-3374
19. S. Shimoda M. Nakamura H. Ishibashi K. Hayashida Y. Niho HLA DRB40101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: Evidence of molecular mimicry in human autoimmune diseases J Exp Med 181 5 1995 1835-1845
20. H. Kita Z.X. Lian J. Van de Water X.S. He S. Matsumura M. Kaplan et al. Identification of HLA-A2-restricted CD8(+) cytotoxic T cell responses in primary biliary cirrhosis: T cell activation is augmented by immune complexes cross-presented by dendritic cells J Exp Med 195 1 2002 113-123
21. A. Nishio J. Van de Water P.S. Leung R. Joplin J.M. Neuberger J. Lake et al. Comparative studies of antimitochondrial autoantibodies in sera and bile in primary biliary cirrhosis Hepatology 25 5 1997 1085-1089
22. S. Reynoso-Paz P.S. Leung J. Van De Water A. Tanaka S. Munoz N. Bass et al. Evidence for a locally driven mucosal response and the presence of mitochondrial antigens in saliva in primary biliary cirrhosis Hepatology 31 1 2000 24-29
23. A. Tanaka G. Nalbandian P.S. Leung G.D. Benson S. Munoz J.A. Findor et al. Mucosal immunity and primary biliary cirrhosis: Presence of antimitochondrial antibodies in urine Hepatology 32 5 2000 910-915
24. N. Ikuno I.R. Mackay J. Jois K. Omagari M.J. Rowley Antimitochondrial autoantibodies in saliva and sera from patients with primary biliary cirrhosis J Gastroenterol Hepatol 16 12 2001 1390-1394
25. P.L. Tuma A.L. Hubbard Transcytosis: Crossing cellular barriers Physiol Rev 83 3 2003 871-932
26. A.C. Malmborg D.B. Shultz F. Luton K.E. Mostov E. Richly P.S. Leung et al. Penetration and co-localization in MDCK cell mitochondria of IgA derived from patients with primary biliary cirrhosis J Autoimmun 11 5 1998 573-580
27. S. Matsumura J. Van De Water P. Leung J.A. Odin K. Yamamoto G.J. Gores et al. Caspase induction by IgA antimitochondrial antibody: IgA-mediated biliary injury in primary biliary cirrhosis Hepatology 39 5 2004 1415-1422
28. J. Van de Water J. Turchany P.S. Leung J. Lake S. Munoz C.D. Surh et al. Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2 J Clin Invest 91 6 1993 2653-2664
29. T.K. Mato P.A. Davis J.A. Odin R.L. Coppel M.E. Gershwin Sidechain biology and the immunogenicity of PDC-E2, the major autoantigen of primary biliary cirrhosis Hepatology 40 6 2004 1241-1248
30. H. Kita M. Imawari M.E. Gershwin Cellular immune response in primary biliary cirrhosis Hepatol Res 28 1 2004 12-17
31. J. Medina P. Sanz-Cameno L. Garcia-Buey S. Martin-Vilchez M. Lopez-Cabrera R. Moreno-Otero Evidence of angiogenesis in primary biliary cirrhosis: An immunohistochemical descriptive study J Hepatol 42 1 2005 124-131
32. S. Shimoda J. Van de Water A. Ansari M. Nakamura H. Ishibashi R.L. Coppel et al. Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis J Clin Invest 102 10 1998 1831-1840
33. H. Tanimoto S. Shimoda M. Nakamura H. Ishibashi A. Kawano T. Kamihira et al. Promiscuous T cells selected by Escherichia coli: OGDC-E2 in primary biliary cirrhosis J Autoimmun 20 3 2003 255-263
34. M. Yasoshima Y. Nakanuma K. Tsuneyama J. Van de Water M.E. Gershwin Immunohistochemical analysis of adhesion molecules in the micro-environment of portal tracts in relation to aberrant expression of PDC-E2 and HLA-DR on the bile ducts in primary biliary cirrhosis J Pathol 175 3 1995 319-325
35. K. Isse K. Harada Y. Zen T. Kamihira S. Shimoda M. Harada et al. Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts Hepatology 41 3 2005 506-516
36. K. Harada K. Tsuneyama M. Yasoshima Y. Kanemori H. Ohta S. Masuda et al. Type1 and type2 memory T cells imbalance shown by expression of intrahepatic chemokine receptors relates to pathogenesis of primary biliary cirrhosis Hepatol Res 24 3 2002 290
37. K. Harada J. Van de Water P.S. Leung R.L. Coppel A. Ansari Y. Nakanuma et al. In situ nucleic acid hybridization of cytokines in primary biliary cirrhosis: Predominance of the Th1 subset Hepatology 25 4 1997 791-796
38. T. Yamano T. Higashi K. Nouso H. Nakatsukasa K. Kariyama E. Yumoto et al. Serum interferon-gamma-inducing factor/IL-18 levels in primary biliary cirrhosis Clin Exp Immunol 122 2 2000 227-231
39. T. Nagano K. Yamamoto S. Matsumoto R. Okamoto M. Tagashira N. Ibuki et al. Cytokine profile in the liver of primary biliary cirrhosis J Clin Immunol 19 6 1999 422-427
40. S.M. Krams S. Cao M. Hayashi J.C. Villanueva O.M. Martinez Elevations in IFN-gamma, IL-5, and IL-10 in patients with the autoimmune disease primary biliary cirrhosis: Association with autoantibodies and soluble CD30 Clin Immunol Immunopathol 80 3 Pt 1 1996 311-320
41. D.R. Gaya D. Thorburn K.A. Oien A.J. Morris A.J. Stanley Hepatic granulomas: A 10 year single centre experience J Clin Pathol 56 11 2003 850-853
42. K. Tsuneyama K. Harada M. Yasoshima K. Hiramatsu C.R. Mackay I.R. Mackay et al. Monocyte chemotacticprotein-1, -2, and -3 are distinctively expressed in portal tracts and granulomata in primary biliary cirrhosis: implications for pathogenesis J Pathol 193 1 2001 102-109
43. K. Zachou E. Rigopoulou C. Liaskos K. Patsiaoura E. Makri N. Stathakis et al. Primary biliary cirrhosis presented as peripheral eosinophilia in asymptomatic women with or without elevated alkaline phosphatase Eur J Gastroenterol Hepatol 16 4 2004 425-428
44. N.S. Goldstein A. Soman S.C. Gordon Portal tract eosinophils and hepatocyte cytokeratin 7 immunoreactivity helps distinguish early-stage, mildly active primary biliary cirrhosis and autoimmune hepatitis Am J Clin Pathol 116 6 2001 846-853
45. K. Yamazaki I. Nakadate K. Suzuki S. Sato T. Masuda Eosinophilia in primary biliary cirrhosis Am J Gastroenterol 91 3 1996 516-522
46. N. Terada K. Maesako N. Hamano G. Houki T. Ikeda M. Sai et al. Eosinophil adhesion regulates RANTES production in nasal epithelial cells J Immunol 158 11 1997 5464-5470
47. J.M. Palmer J.A. Kirby D.E. Jones The immunology of primary biliary cirrhosis: The end of the beginning? Clin Exp Immunol 129 2 2002 191-197
48. T. Adachi R. Alam The mechanism of IL-5 signal transduction Am J Physiol 275 3 Pt 1 1998 C623-C633
49. R.G. Lee O. Epstein H. Jauregui S. Sherlock P.J. Scheuer Granulomas in primary biliary cirrhosis: A prognostic feature Gastroenterology 81 6 1981 983-986
50. Y. Takii M. Nakamura M. Ito T. Yokoyama A. Komori Y. Shimizu-Yoshida et al. Enhanced expression of type I interferon and toll-like receptor-3 in primary biliary cirrhosis Lab Invest 2005
51. S. Lindgren S. Eriksson IgM in primary biliary cirrhosis. Physicochemical and complement activating properties J Lab Clin Med 99 5 1982 636-645
52. A. Nishio E.B. Keeffe M.E. Gershwin Immunopathogenesis of primary biliary cirrhosis Semin Liver Dis 22 3 2002 291-302
53. T. Kamihira S. Shimoda M. Nakamura T. Yokoyama Y. Takii A. Kawano et al. Biliary epithelial cells regulate autoreactive T cells: Implications for biliary-specific diseases Hepatology 41 1 2005 151-159
54. K. Tsuneyama J. Van De Water D. Van Thiel R. Coppel B. Ruebner Y. Nakanuma et al. Abnormal expression of PDC-E2 on the apical surface of biliary epithelial cells in patients with antimitochondrial antibody-negative primary biliary cirrhosis Hepatology 22 5 1995 1440-1446
55. K. Harada Y. Sudo N. Kono S. Ozaki K. Tsuneyama M.E. Gershwin et al. In situ nucleic acid detection of PDC-E2, BCOADC-E2, OGDC-E2, PDC-E1alpha, BCOADC-E1alpha, OGDC-E1, and the E3 binding protein (protein X) in primary biliary cirrhosis Hepatology 30 1 1999 36-45
56. A.K. Burroughs I.J. Rosenstein O. Epstein J.M. Hamilton-Miller W. Brumfitt S. Sherlock Bacteriuria and primary biliary cirrhosis Gut 25 2 1984 133-137
57. S.P. Fussey S.T. Ali J.R. Guest O.F. James M.F. Bassendine S.J. Yeaman Reactivity of primary biliary cirrhosis sera with Escherichia coli dihydrolipoamide acetyltransferase (E2p): Characterization of the main immunogenic region Proc Natl Acad Sci U S A 87 10 1990 3987-3991
58. C. Selmi D.L. Balkwill P. Invernizzi A.A. Ansari R.L. Coppel M. Podda et al. Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium Hepatology 38 5 2003 1250-1257
59. S.A. Long C. Quan J. Van de Water M.H. Nantz M.J. Kurth D. Barsky et al. Immunoreactivity of organic mimeotopes of the E2 component of pyruvate dehydrogenase: Connecting xenobiotics with primary biliary cirrhosis J Immunol 167 5 2001 2956-2963
60. P.S. Leung C. Quan O. Park J. Van de Water M.J. Kurth M.H. Nantz et al. Immunization with a xenobiotic 6-bromohexanoate bovine serum albumin conjugate induces antimitochondrial antibodies J Immunol 170 10 2003 5326-5332
61. K. Amano P.S. Leung R. Rieger C. Quan X. Wang J. Marik et al. Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid J Immunol 174 9 2005 5874-5883