Elevations in IFN-γ, IL-5, and IL-10 in patients with the autoimmune disease primary biliary cirrhosis: Association with autoantibodies and soluble CD30

Clinical Immunology and Immunopathology

Volumn 80, Issue 3 II, 1996, Pages 311-320

  Krams, Sheri M ^a   Cao, Sean ^a   Hayashi, Michihiro ^a   Villanueva, Janeth C ^a   Martinez, Olivia M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD30 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 5;

ARTICLE; AUTOIMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; ETIOLOGY; HUMAN; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL;

ANTIGENS, CD30; AUTOANTIBODIES; AUTOIMMUNE DISEASES; B-LYMPHOCYTES; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-5; LIVER CIRRHOSIS, BILIARY; LIVER TRANSPLANTATION; SOLUBILITY; T-LYMPHOCYTES;

EID: 0029795784     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1996.0129     Document Type: Article

References (45)

1. Gershwin, M. E., and Mackay, I. R., Primary biliary cirrhosis: Paradigm or paradox for autoimmunity. Gastroenterology 100, 822-833, 1991.
2. Van de Water, J., Gershwin, M. E., Leung, P., Ansari, A., and Coppel, R. L., The autoepitope of the 74 kD mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase. J. Exp. Med. 167, 1791-1799, 1988.
3. Fussey, S. P. M., Guest, J., James, O. F. W., Bassendine, M. F., and Yeaman, S. J., Identification and analysis of the major M2 mitochondrial autoantigen of primary biliary cirrhosis. Proc. Natl. Acad. Sci. USA 85, 8654-8658, 1988.
4. Bjorkland, A., Loof, L., Mendel-Hartvig, I., and Totterman, T. H., Primary biliary cirrhosis: High proportions of B cells in blood and liver tissue produce anti-mitochondrial antibodies of several Ig classes. J. Immunol. 153, 2750-2757, 1994.
5. Krams, S. M., Van de Water, J., Coppel, R. L., Esquivel, C., Roberts, J., Ansari, A., and Gershwin, M. E., Analysis of hepatic T lymphocyte and immunoglobulin deposits in patients with primary biliary cirrhosis. Hepatology 12, 306-313, 1990.
6. Joplin, R., Lindsay, J., Hubscher, S. G., Johnson, G. D., Shaw, J. C., Strain, A. J., and Neuberger, J. M., Distribution of dihydrolipoamide acetyltransferase (E2) in the liver and portal lymph nodes of patients with primary biliary cirrhosis: An immunohistochemical study. Hepatology 14, 442-447, 1991.
7. Van de Water, J., Turchany, J., Leung, P. S. C., Lake, J., Munoz, S., Surh, C. D., Coppel, R., Ansari, A., Nakanuma, Y., and Gershwin, M. E., Molecular mimicry in primary biliary cirrhosis: Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2. J. Clin. Invest. 91, 2653-2664, 1993.
8. Bjorkland, A., Festin, R., Mendel-Hartvig, I., Nyberg, A., Loof, L., and Totterman, T. H., Blood and liver-infiltrating lymphocytes in primary biliary cirrhosis: Increase in activated T and natural killer cells and recruitement of primed memory cells. Hepatology 13, 1106-1111, 1991.
9. Jones, D. E. J., Palmer, J., James, O. F. W., Yeaman, S. J., Bassendine, M. F., and Diamond, A. G., T cell responses to the components of pyruvate dehydrogenase complex in primary biliary cirrhosis. Hepatology 21, 995-1002, 1995.
10. Van de Water, J., Ansari, A., Surh, C. D., Coppel, R., Roche, T., Bonkovsky, H., Kaplan, M., and Gershwin, M. E., Evidence for the targeting by 2-oxo-dehydrogenase enzymes in the T cell response of primary biliary cirrhosis. J. Immunol. 146, 89-94, 1991.
11. Van de Water, J., Ansari, A., Prindiville, T., Coppel, R. L., Ricalton, N., Kotzin, B. L., Liu, S., Roche, T. E., Krams, S. M., Munoz, S., and Gershwin, M. E., Heterogeneity of autoreactive T cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis. J. Exp. Med. 181, 723-733, 1995.
12. Martinez, O. M., Villanueva, J. C., Gershwin, M. E., and Krams, S. M., Cytokine patterns and cytotoxic mediators in primary biliary cirrhosis. Hepatology 21, 113-119, 1995.
13. Adams, D. H., Hubscher, S., Shaw, J., Johnson, G. D., Babbs, L., Rothlein, R., and Neuberger, J., Increased expression of ICAM-1 on bile ducts in primary biliary cirrhosis and primary sclerosing cholangitis. Hepatology 14, 426-431, 1991.
14. Ballardini, G., Miriakian, R., Bianchi, F. B., Pisis, E., Doniach, D., and Bottazzo, G. F., Aberrant expression of HLA-DR antigens on the bile duct epithelium in primary biliary cirrhosis: Relevance to pathogenesis. Lancet iii, 1009-1013, 1984.
15. Saidman, S. L., Duquesnoy, R., Zeevi, A., Fung, J. J., Starzl, T. E., and Demetris, A. J., Recognition of MHC antigens on cultured biliary epithelial cells by alloreactive lymphocytes. Hepatology 14, 426-431, 1991.
16. Andreesen, R., Osterholz, J., Lohr, G. W., and Bross, K. J., A Hodgkin cell-specific antigen is expressed on a subset of auto-and alloactivated T (helper) lymphoblasts. Blood 63, 1299-1305, 1984.
17. Durkop, H., Latza, U., Hummel, M., Eitelbach, F., Seed, B., and Stein, H., Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic of Hodgkin's disease. Cell 68, 421-427, 1992.
18. Alzona, M., Jack, H-M., Fisher, R. I., and Ellis, T. M., CD30 defines a subset of activated human T cells that produce IFN-γ and IL-5 and exhibit enhanced B cell helper activity. J. Immunol. 153, 2861-2867, 1994.
19. Martinez, O. M., Villanueva, J. C., Lawrence-Miyasaki, L., Quinn, M. B., Cox, K., and Krams, S. M., Viral and immunologic aspects of Epstein-Barr virus infection in pediatric liver transplant recipients. Transplantation 59, 519-524, 1995.
20. Surh, C. D., Cooper, A., Coppel, R. L., Leung, P., Ahmed, A., Dickson, R., and Gershwin, M. E., The predominance of IgG3 and IgM isotype antimitochondrial auto antibodies against recombinant fused mitochondrial polypeptide in patients with primary biliary cirrhosis. Hepatology 8, 290-295, 1988.
21. Martinez, O. M., Villanueva, J., Lake, J., Roberts, J. P., Ascher, N. L., and Krams, S. M., IL-2 and IL-5 gene expression in response to alloantigen in liver allograft recipients and in vitro. Transplantation 55, 1159-1166, 1993.
22. Neuberger, J., Wallace, L., Joplin, R., and Hubscher, S., Hepatic distribution of E2 component of pyruvate dehydrogenase complex after transplantation. Hepatology 22, 798-801, 1995.
23. Beck, O. E., Distribution of virus antibody activity among human IgG subclasses. Clin. Exp. Immunol. 43, 626-632, 1981.
24. Punnonen, J., and de Vries, J., IL-13 induces proliferation, Ig isotype switching, and Ig synthesis by immature fetal B cells. J. Immunol. 152, 1094-1102, 1994.
25. +) B cells to secrete IgG1 and IgG3. J. Exp. Med. 179, 757-762, 1994.
26. Llorente, L., Zou, W., Levy, Y., Richaud-Patin, Y., Wijdenes, J., Alcocer-Varela, J., Morel-Fourrier, B., Brouet, J-C., Alarcon-Segovia, D., Galanaud, P., and Emilie, D., Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus. J. Exp. Med. 181, 839-844, 1995.
27. + T cell subsets defined by isoforms of CD45 in primary biliary cirrhosis. Clin. Exp. Immunol. 99, 233-239, 1995.
28. + T cells. J. Immunol. 151, 2380-2389, 1993.
29. Sugita, K., Torimoto, Y., Nojima, Y., Daley, J. F., Schlossman, S. F., and Morimoto, The 1A4 molecule (CD27) is involved in T cell activation. J. Immunol. 147, 1477-1482, 1991.
30. Watanabe-Fukanuga, R., Brannan, C., Itoh, N., Yonehara, S., Copeland, N., Jenkins, N., and Nagata, S., The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. J. Immunol. 148, 1274-1279, 1992.
31. + T cell clones in human immunodeficiency virus infection. J. Exp. Med. 180, 2407-2411, 1994.
32. Del Prete, G., Maggi, E., Pizzolo, G., and Romagnani, S., CD30, Th2 cytokines and HIV infection: A complex and fascinating link. Immunol. Today 16, 76-80, 1995.
33. Napoli, J., Bishop, G. A., and McCaughan, G. W., Increased intrahepatic messenger RNA expression of interleukins 2, 6, and 8 in human cirrhosis. Gastroenterology 107, 789-798, 1994.
34. Morikawa, K., Oseko, F., Morikawa, S., Imai, K., and Sawada, M., Recombinant human IL-5 augments immunoglobulin generation by human B lymphocytes in the presence of IL-2. Cell. Immunol. 149, 390-401, 1993.
35. Fujisawa, T., Abu-Ghazaleh, R., Kita, H., Sanderson, C. J., and Gleich, G. J., Regulatory effects of cytokines on eosinophil degranulation. J. Immunol. 144, 642-646, 1990.
36. Lopez, A. F., Sanderson, C. J., Gamble, J. R., Campbell, H. D., Young, I. G., and Vadas, M. A., Recombinant human interleukin 5 is a selective activator of human eosinophil function. J. Exp. Med. 167, 219-223, 1988.
37. Yokota, T., Coffman, R., Hagiwara, H., Rennick, D. M., Takebe, Y., Yokota, K., Spits, H., de Vries, J., Banchereau, J., Lee, F. D., Arai, N., and Arai, K., Isolation and characterization of lymphokine cDNA clones encoding mouse and human IgA enhancing factor and eosinophil colony stimulating factor activities: Relation to IL-5. Proc. Natl. Acad. Sci. USA 84, 7388-7392, 1987.
38. Bertolini, J. N., Sanderson, C., and Benson, E. M., Human interleukin-5 induces Staphylococcal A Cowan 1 strain-activated human B cells to secrete IgM. Eur. J. Immunol. 23, 398-402, 1993.
39. Terasaki, S., Nakanuma, Y., Yamazaki, M., and Unoura, M., Eosinophilic infiltration of the liver in primary biliary cirrhosis: A morphological study. Hepatology 17, 206-212, 1993.
40. Piccinni, M-P., Giudizi, M-G., Biagiotti, R., Beloni, L., Giannarini, L., Sampognaro, S., Parronchi, P., Manetti, R., Annuziato, F., Livi, C., Romagnani, S., and Maggi, E., Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones. J. Immunol. 155, 128-133, 1995.
41. McDonald, P. P., Cassatella, M. A., Bald, A., Maggi, E., Romagnani, S., Gruss, H-J., and Pizzolo, G., CD30 ligation induces nuclear factor-κB activation in human T cell lines. Eur. J. Immunol. 25, 2870-2876, 1995.
42. Amakawa, R., Hakem, A., Kundig, T. M., Matsuyama, T., Simard, J. J. L., Timms, E., Wakeham, A., Mittrueker, H-W., Griesser, H., Takimoto, H., Schmits, R., Shahinian, A., Ohashi, P. S., Penninger, J. M., and Mak, T. W., Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice. Cell 84, 551-562, 1996.
43. + T cell lines/clones derived from autoimmune thyroiditis lesions: They recognize self-thyroid antigens directly on TEC to exhibit T cell cell 1-type lymphokine production and cytotoxicity against TEC. J. Immunol. 155, 1619-1628, 1995.
44. Rabinovitch, A., Suarez-Pinzon, W., Sorensen, O., Bleackley, R. C., and Power, R. F., IFN-gamma gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice. J. Immunol. 154, 4874-4882, 1995.
45. Yung, R. L., Quddus, J., Chrisp, C. E., Johnson, K. J., and Richardson, B. C., Mechanisms of drug-induced lupus. 1. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo. J. Immunol. 154, 3025 -3035, 1995.