A Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replication

BMC Molecular Biology

Volumn 5, Issue , 2004, Pages

  Jares, Pedro ^a,b   Luciani, M Gloria ^a   Blow, J Julian ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN CDC7; PROTEIN DBF4; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; CDC7 PROTEIN, HUMAN; CDC7 PROTEIN, MOUSE; CDC7 PROTEIN, XENOPUS; CELL CYCLE PROTEIN; DBF4 PROTEIN, HUMAN; DNA BINDING PROTEIN; RECOMBINANT PROTEIN; XENOPUS PROTEIN;

ARTICLE; CELL CYCLE; CELL FREE SYSTEM; CHROMATIN; CONTROLLED STUDY; DNA REPLICATION; FROGS AND TOADS; HUMAN; INTERPHASE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; SEQUENCE HOMOLOGY; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; COMPARATIVE STUDY; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; PHYSIOLOGY; XENOPUS;

AMINO ACID SEQUENCE; ANIMALS; CELL CYCLE PROTEINS; CELL LINE; CHROMATIN; CLONING, MOLECULAR; DNA REPLICATION; DNA-BINDING PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; XENOPUS; XENOPUS PROTEINS;

EID: 26444602092     PISSN: 14712199     EISSN: 14712199     Source Type: Journal    
DOI: 10.1186/1471-2199-5-5     Document Type: Article

References (52)

1. Blow JJ, Hodgson B: Replication licensing - defining the proliferative state? Trends in Cell Biology 2002, 12:72-78.
2. Nishitani H, Lygerou Z: Control of DNA replication licensing in a cell cycle. Genes to Cells 2002, 7:523-534.
3. Jares P, Donaldson A, Blow JJ: The Cdc7/Dbf4 protein kinase: target of the S phase checkpoint? EMBO Rep 2000, 1:319-322.
4. Johnston LH, Masai H, Sugino A: A Cdc7p-Dbf4p protein kinase activity is conserved from yeast to humans. Prog Cell Cycle Res 2000, 4:61-69.
5. Masai H, Arai K: Cdc7 kinase complex: a key regulator in the initiation of DNA replication. J Cell Physiol 2002, 190:287-296.
6. Sclafani RA: Cdc7p-Dbf4p becomes famous in the cell cycle - Commentary. J Cell Sci 2000, 113:2111-2117.
7. Jackson AL, Pahl PM, Harrison K, Rosamond J, Sclafani RA: Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein. Molecular and Cellular Biology 1993, 13:2899-2908.
8. Yoon HJ, Loo S, Campbell JL: Regulation of Saccharomyces cerevisiae CDC7 function during the cell cycle. Molecular Biology of the Cell 1993, 4:195-208.
9. Brown GW, Kelly TJ: Cell cycle regulation of Dfp1, an activator of the Hsk1 protein kinase. Proceedings of the National Academy of Sciences of the USA 1999, 96:8443-8448.
10. Oshiro G, Owens JC, Shellman Y, Sclafani RA, Li JJ: Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability. Molecular and Cellular Biology 1999, 19:4888-4896.
11. Takeda T, Ogino K, Matsui E, Cho MK, Kumagai H, Miyake T, Arai K, Masai H: A fission yeast gene, him1(+)/dfp1(+), encoding a regulatory subunit for Hsk1 kinase, plays essential roles in Sphase initiation as well as in S-phase checkpoint control and recovery from DNA damage. Molecular and Cellular Biology 1999, 19:5535-5547.
12. Cheng L, Collyer T, Hardy CF: Cell cycle regulation of DNA replication initiator factor Dbf4p. Molecular and Cellular Biology 1999, 19:4270-4278.
13. Weinreich M, Stillman B: Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway. EMBO Journal 1999, 18:5334-5346.
14. Ferreira MF, Santocanale C, Drury LS, Diffley JF: Dbf4p, an essential S phase-promoting factor, is targeted for degradation by the anaphase-promoting complex. Molecular and Cellular Biology 2000, 20:242-248.
15. Johnston LH, Masai H, Sugino A: First the CDKs, now the DDKs. Trends in Cell Biology 1999, 9:249-252.
16. Masai H, Arai K: Dbf4 motifs: conserved motifs in activation subunits for Cdc7 kinases essential for S-phase. Biochem Biophys Res Commun 2000, 275:228-232.
17. Ogino K, Takeda T, Matsui E, Iiyama H, Taniyama C, Arai K, Masai H: Bipartite binding of a kinase activator activates Cdc7-related kinase essential for S phase. J Biol Chem 2001, 276:31376-31387.
18. Sato N, Sato M, Nakayama M, Saitoh R, Arai K, Masai H: Cell cycle regulation of chromatin binding and nuclear localization of human Cdc7-ASK kinase complex. Genes Cells 2003, 8:451-463.
19. Bousset K, Diffley JF: The Cdc7 protein kinase is required for origin firing during S phase. Genes and Development 1998, 12:480-490.
20. Donaldson AD, Fangman WL, Brewer BJ: Cdc7 is required throughout the yeast S phase to activate replication origins. Genes and Development 1998, 12:491-501.
21. Pasero P, Duncker BP, Schwob E, Gasser SM: A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation-competent origins of replication. Genes and Development 1999, 13:2159-2176.
22. Jares P, Blow JJ: Xenopus Cdc7 function is dependent on licensing but not on XORC, XCdc6 or CDK activity and is required for XCdc45 loading. Genes and Development 2000, 14:1528-1540.
23. Dowell SJ, Romanowski P, Diffley JF: Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo. Science 1994, 265:1243-1246.
24. Furukohri A, Sato N, Masai H, Arai K, Sugino A, Waga S: Identification and characterization of a Xenopus homolog of Dbf4, a regulatory subunit of the Cdc7 protein kinase required for the initiation of DNA replication. J Biochem (Tokyo) 2003, 134:447-457.
25. Montagnoli A, Bosotti R, Villa F, Rialland M, Brotherton D, Mercurio C, Berthelsen J, Santocanale C: Drf1, a novel regulatory subunit for human Cdc7 kinase. Embo J 2002, 21:3171-3181.
26. Yanow SK, Gold DA, Yoo HY, Dunphy WG: Xenopus Drf1, a regulator of Cdc7, displays checkpoint-dependent accumulation on chromatin during an S-phase arrest. J Biol Chem 2003, 278:41083-41092.
27. Blow JJ: Control of chromosomal DNA replication in the early Xenopus embryo. EMBO J 2001, 20:3293-3297.
28. Stillman B: Cell cycle control of DNA replication. Science 1996, 274:1659-1664.
29. Donaldson AD, Blow JJ: The regulation of replication origin activation. Current Opinion in Genetics and Development 1999, 9:62-68.
30. Walter JC: Evidence for sequential action of cdc7 and cdk2 protein kinases during initiation of DNA replication in Xenopus egg extracts. J Biol Chem 2000, 275:39773-39778.
31. Duncker BP, Shimada K, Tsai-Pflugfelder M, Pasero P, Gasser SM: An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing. Proc Natl Acad Sci U S A 2002, 99:16087-16092.
32. Walter J, Newport J: Initiation of eukaryotic DNA replication: Origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha. Mol Cell 2000, 5:617-627.
33. McGarry TJ, Kirschner MW: Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 1998, 93:1043-1053.
34. Tada S, Li A, Maiorano D, Mechali M, Blow JJ: Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin. Nat Cell Biol 2001, 3:107-113.
35. Wohlschlegel JA, Dwyer BT, Dhar SK, Cvetic C, Walter JC, Dutta A: Inhibition of eukaryotic replication by geminin binding to Cdt1. Science 2000, 290:2309-2312.
36. Rowles A, Chong JP, Brown L, Howell M, Evan GI, Blow JJ: Interaction between the origin recognition complex and the replication licensing system in Xenopus. Cell 1996, 87:287-296.
37. Kubota Y, Mimura S, Nishimoto S, Masuda T, Nojima H, Takisawa H: Licensing of DNA replication by a multi-protein complex of MCM/P1 proteins in Xenopus eggs. European Molecular Biology Organization Journal 1997, 16:3320-3331.
38. Thömmes P, Kubota Y, Takisawa H, Blow JJ: The RLF-M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptides. European Molecular Biology Organization Journal 1997, 16:3312-3319.
39. Prokhorova TA, Blow JJ: Sequential MCM/P1 subcomplex assembly is required to form a hetero-hexamer with replication licensing activity. Journal of Biological Chemistry 2000, 275:2491-2504.
40. Oehlmann M, Score AJ, Blow JJ: The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation. J Cell Biol 2004, 165:181-190.
41. Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J: An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol Cell 2003, 11:203-213.
42. Guo Z, Kumagai A, Wang SX, Dunphy WG: Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes Dev 2000, 14:2745-2756.
43. Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, Donehower LA, Elledge SJ: Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev 2000, 14:1448-1459.
44. Jiang W, McDonald D, Hope TJ, Hunter T: Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication. EMBO J 1999, 18:5703-5713.
45. Kumagai H, Sato N, Yamada M, Mahony D, Seghezzi W, Lees E, Arai K, Masai H: A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells. Molecular and Cellular Biology 1999, 19:5083-5095.
46. Shreeram S, Sparks A, Lane DP, Blow JJ: Cell type-specific responses of human cells to inhibition of replication licensing. Oncogene 2002, 21:6624-6632.
47. Fung AD, Ou J, Bueler S, Brown GW: A conserved domain of Schizosaccharomyces pombe dfp1(+) is uniquely required for chromosome stability following alkylation damage during S phase. Mol Cell Biol 2002, 22:4477-4490.
48. Frangioni JV, Neel BG: Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins. Anal Biochem 1993, 210:179-187.
49. Strausfeld UP, Howell M, Rempel R, Maller JL, Hunt T, Blow JJ: Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases. Current Biology 1994, 4:876-883.
50. Chong JP, Thömmes P, Rowles A, Mahbubani HM, Blow JJ: Characterization of the Xenopus replication licensing system. Methods in Enzymology 1997, 283:549-564.
51. Tada S, Chong JPJ, Mahbubani HM, Blow JJ: The RLF-B component of the replication licensing system is distinct from Cdc6 and functions after Cdc6 binds to chromatin. Current Biology 1999, 9:211-214.
52. Kumagai A, Guo Z, Emami KH, Wang SX, Dunphy WG: The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts. J Cell Biol 1998, 142:1559-1569.