Human polyomaviruses and brain tumors

Brain Research Reviews

Volumn 50, Issue 1, 2005, Pages 69-85

  White, Martyn K ^a   Gordon, Jennifer ^a   Reiss, Krzysztof ^a   Del Valle, Luis ^a   Croul, Sidney ^a   Giordano, Antonio ^a   Darbinyan, Armine ^a   Khalili, Kamel ^a  

^a Temple University   (United States)

Author keywords

Brain tumor; Polyomavirus; T antigen

Indexed keywords

POLIOMYELITIS VACCINE; VIRUS PROTEIN; VIRUS T ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ALLOGRAFT; BK VIRUS; BRAIN TUMOR; CARCINOGENESIS; CELL CYCLE; CELL FUNCTION; DNA DAMAGE; DNA REPAIR; DNA SEQUENCE; HOST CELL; HUMAN; JC VIRUS; MOLECULE; NONHUMAN; POLYOMA VIRUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; REVIEW; RHESUS MONKEY; SIMIAN VIRUS 40; VIRUS TRANSMISSION;

ANIMALS; ANTIGENS, VIRAL, TUMOR; BK VIRUS; BRAIN NEOPLASMS; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; JC VIRUS; POLYOMAVIRUS; POLYOMAVIRUS INFECTIONS; SIMIAN VIRUS 40;

EID: 26444530763     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresrev.2005.04.007     Document Type: Review

References (226)

1. S. Ahmed, M. Chowdhury, and K. Khalili Regulation of a human neurotropic virus promoter, JCV(E): identification of a novel activator domain located upstream from the 98 bp enhancer promoter region Nucleic Acids Res. 18 1990 7417 7423
2. S. Ahmed, J. Rappaport, H. Tada, D. Kerr, and K. Khalili A nuclear protein derived from brain cells stimulates transcription of the human neurotropic virus promoter JCVE, in vitro J. Biol. Chem. 265 1990 13899 13905
3. A.S. Arrington, and J.S. Butel SV40 and human tumors K. Khalili G.L. Stoner Human Polyomaviruses: Molecular and Clinical Perspective 2001 Wiley-Liss Inc. New York 461 489
4. A.S. Arrington, M.S. Moore, and J.S. Butel SV40-positive brain tumor in scientist with risk of laboratory exposure to the virus Oncogene 23 2004 2231 2235
5. R.R. Arthur, S.A. Grossman, B.M. Ronnett, S.H. Bigner, B. Vogelstein, and K.V. Shah Lack of association of human polyomaviruses with human brain tumors J. Neuro-Oncol. 20 1994 55 58
6. J.R. Berger Progressive multifocal leukoencephalopathy in acquired immuno-deficiency syndrome: explaining the high incidence and disproportionate frequency of the illness relative to other immunosuppressive conditions J. NeuroVirol. 9 Suppl. 1 2003 38 41
7. J.R. Berger, and M. Concha Progressive multifocal leukoencephalopathy: the evolution of a disease once considered rare J. NeuroVirol. 1 1995 5 18
8. J.R. Berger, B. Kaszovitz, M.J. Post, and G. Dickinson Progressive multifocal leukoencephalopathy associated with human immunodeficiency virus infection. A review of the literature with a report of sixteen cases Ann. Intern. Med. 107 1987 78 87
9. J.R. Berger, A. Chauhan, D. Galey, and A. Nath Epidemiological evidence and molecular basis of interactions between HIV and JC virus J. NeuroVirol. 7 2001 329 338
10. D.J. Bergsagel, M.J. Finegold, J.S. Butel, W.J. Kupsky, and R.L. Garcea DNA sequences similar to those of simian virus 40 in ependymomas and choroid plexus tumors of childhood N. Engl. J. Med. 326 1992 988 993
11. M. Bocchetta, I. Di Resta, A. Powers, R. Fresco, A. Tosolini, J.R. Testa, H.I. Pass, P. Rizzo, and M. Carbone Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity Proc. Natl. Acad. Sci. U. S. A. 97 2000 10214 10219
12. S. Bofill-Mas, and R. Girones Excretion and transmission of JCV in human populations J. NeuroVirol. 7 2001 345 349
13. S. Bofill-Mas, M. Formiga-Cruz, P. Clemente-Casares, F. Calafell, and R. Girones Potential transmission of human polyomaviruses through the gastrointestinal tract after exposure to virions or viral DNA J. Virol. 75 2001 10290 10299
14. S. Bofill-Mas, P. Clemente-Casares, E.O. Major, B. Curfman, and R. Girones Analysis of the excreted JC virus strains and their potential oral transmission J. NeuroVirol. 9 2003 498 507
15. R. Boldorini, R. Caldarelli-Stefano, G. Monga, M. Zocchi, M. Mediati, A. Tosoni, and P. Ferrante PCR detection of JC virus DNA in the brain tissue of a 9-year-old child with pleomorphic xanthoastrocytoma J. NeuroVirol. 4 1998 242 245
16. B. Bollag, W.F. Chuke, and R.J. Frisque Hybrid genomes of the polyomaviruses JC virus, BK virus, and simian virus 40: identification of sequences important for efficient transformation J. Virol. 63 1989 863 872
17. B. Bollag, C. Prins, E.L. Snyder, and R.J. Frisque Purified JC virus T and T′ proteins differentially interact with the retinoblastoma family of tumor suppressor proteins Virology 274 2000 165 178
18. A. Bretscher, K. Edwards, and R.G. Fehon ERM proteins and merlin: integrators at the cell cortex Nat. Rev., Mol. Cell Biol. 3 2002 586 599
19. R.L. Brinster, H.Y. Chen, A. Messing, T. van Dyke, A.J. Levine, and R.D. Palmiter Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors Cell 37 1984 367 379
20. T.M. Bryan, and R.R. Reddel SV40-induced immortalization of human cells Crit. Rev. Oncog. 5 1994 331 357
21. R. Caldarelli-Stefano, R. Boldorini, G. Monga, E. Meraviglia, E.O. Zorini, and P. Ferrante JC virus in human glial-derived tumors Hum. Pathol. 31 2000 394 395
22. M. Carbone, C. Burck, M. Rdzanek, J. Rudzinski, R. Cutrone, and M. Bocchetta Different susceptibility of human mesothelial cells to polyomavirus infection and malignant transformation Cancer Res. 63 2003 6125 6129
23. M. Carbone, J. Rudzinski, and M. Bocchetta High throughput testing of the SV40 Large T antigen binding to cellular p53 identifies putative drugs for the treatment of SV40-related cancers Virology 315 2003 409 414
24. P. Castaigne, P. Rondot, R. Escourolle, J.L. Ribadeau Dumas, F. Cathala, and J.J. Hauw Progressive multifocal leukoencephalopathy and multiple gliomas Rev. Neurol. 130 1974 379 392
25. L.S. Chang, M.M. Pater, N.I. Hutchinson, and G. di Mayorca Transformation by purified early genes of simian virus 40 Virology 133 1984 341 353
26. T.H. Chang, F.A. Ray, D.A. Thompson, and R. Schlegel Disregulation of mitotic checkpoints and regulatory proteins following acute expression of SV40 large T antigen in diploid human cells Oncogene 14 1997 2383 2393
27. M. Chatterjee, T.B. Weyandt, and R.J. Frisque Identification of archetype and rearranged forms of BK virus in leukocytes from healthy individuals J. Med. Virol. 60 2000 353 362
28. P.M. Chesters, J. Heritage, and D.J. McCance Persistence of DNA sequences of BK virus and JC virus in normal human tissues and in diseased tissues J. Infect. Dis. 147 1983 676 684
29. G. Christofori, P. Naik, and D. Hanahan A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis Nature 369 1994 414 418
30. C. Cicala, M.L. Avantaggiati, A. Graessmann, K. Rundell, A.S. Levine, and M. Carbone Simian virus 40 small-t antigen stimulates viral DNA replication in permissive monkey cells J. Virol. 68 1984 3138 3144
31. C. Cicala, F. Pompetti, and M. Carbone SV40 induces mesotheliomas in hamsters Am. J. Pathol. 142 1993 1524 1533
32. P.T. Cohen Novel protein serine/threonine phosphatases: variety is the spice of life Trends Biochem. Sci. 22 1997 245 251
33. C.N. Cole Polyomavirinae: the viruses and their replication B.N. Fields D.M. Knipe P.M. Howley Fundamental Virology Third edition 1996 Lippincott, Williams and Wilkins Philadelphia 917 946
34. A. Corallini, M. Pagnani, P. Viadana, E. Silini, M. Mottes, G. Milanesi, G. Gerna, R. Vettor, G. Trapella, V. Silvani, G. Gaist, and G. Barbanti-Brodano Association of BK virus with human brain tumors and tumors of pancreatic islets Int. J. Cancer 39 1987 60 67
35. A. Corallini, M. Tognon, M. Negrini, and G. Barbanti-Brodano Evidence for BK virus as a human tumor virus K. Khalili G.L. Stoner Human Polyomaviruses: Molecular and Clinical Perspective 2001 Wiley-Liss Inc. New York 431 460
36. M. Cotsiki, R.L. Lock, Y. Cheng, G.L. Williams, J. Zhao, D. Perera, R. Freire, A. Entwistle, E.A. Golemis, T.M. Roberts, P.S. Jats, and O.V. Gjoerup Simian virus 40 large T-antigen targets the spindle assembly checkpoint protein Bub1 Proc. Natl. Acad. Sci. U. S. A. 101 2004 947 952
37. J. Coyle-Rink, L. Del Valle, T. Sweet, K. Khalili, and S. Amini Developmental expression of Wnt signaling factors in mouse brain Cancer Biol. Ther. 1 2002 640 645
38. W.D. Cress, and J.R. Nevins Use of the E2F transcription factor by DNA tumor virus regulatory proteins Curr. Top Microbiol. Immunol. 208 1996 63 78
39. S. Croul, J. Otte, and K. Khalili Brain tumors and polyomaviruses J. NeuroVirol. 9 2003 173 182
40. S.A. Dalrymple, and K.L. Beemon BK virus T antigens induce kidney carcinomas and thymoproliferative disorders in transgenic mice J. Virol. 64 1990 1182 1191
41. T. Dang-Tan, S.M. Mahmud, R. Puntoni, and E.L. Franco Polio vaccines, Simian Virus 40, and human cancer: the epidemiologic evidence for a causal association Oncogene 23 2004 6535 6540
42. A. Darbinyan, N. Darbinian, M. Safak, S. Radhakrishnan, A. Giordano, and K. Khalili Evidence for dysregulation of cell cycle by human polyomavirus, JCV, late auxiliary protein Oncogene 21 2002 5574 5581
43. A. Darbinyan, K.M. Siddiqui, D. Slonina, N. Darbinian, S. Amini, M.K. White, and K. Khalili Role of JCV agnoprotein in DNA repair J. Virol. 78 2004 8593 8600
44. D. Das, R.B. Shah, and M.J. Imperiale Detection and expression of human BK virus sequences in neoplastic prostate tissues Oncogene 23 2004 7031 7046
45. J.A. Davies, J.T. Hughes, and D.R. Oppenheimer Richardson's disease (progressive multifocal leukoencephalopathy). A study of four cases Q. J. Med. 42 1973 481 501
46. J.A. DeCaprio, J.W. Ludlow, J. Figge, J.Y. Shew, C.M. Huang, W.H. Lee, E. Marsilio, E. Paucha, and D.M. Livingston SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene Cell 54 1988 275 283
47. L. Del Valle, S.A. Azizi, B. Krynska, S. Enam, S.E. Croul, and K. Khalili Reactivation of human neurotropic JC virus expressing oncogenic protein in a recurrent glioblastoma multiforme Ann. Neurol. 48 2000 932 936
48. L. Del Valle, J. Gordon, P. Ferrante, and K. Khalili JC virus in experimental and clinical brain tumorigenesis K. Khalili G.L. Stoner Human Polyomaviruses: Molecular and Clinical Perspective 2001 Wiley-Liss Inc. New York 409 430
49. L. Del Valle, J. Gordon, M. Assimakopolou, S. Enam, J.F. Geddes, J. Varakis, C. Katsesos, S.E. Croul, and K. Khalili Detection of JC virus DNA sequences and expression of the viral regulatory protein, T-antigen, in tumors of the central nervous system Cancer Res. 61 2001 4287 4293
50. L. Del Valle, J. Baehring, C. Lorenzana, A. Giordano, K. Khalili, and S. Croul Expression of a human polyomavirus oncoprotein and tumour suppressor proteins in medulloblastomas Mol. Pathol. 54 2001 331 337
51. L. Del Valle, J. Gordon, S. Enam, S. Delbue, S. Croul, S. Abraham, S. Radhakrishnan, M. Assimakopoulou, C.D. Katsetos, and K. Khalili Expression of human neurotropic polyomavirus JCV late gene product agnoprotein in human medulloblastoma J. Natl. Cancer Inst. 94 2002 267 273
52. L. Del Valle, S. Delbue, J. Gordon, S. Enam, S. Croul, P. Ferrante, and K. Khalili Expression of JC Virus T-antigen in a patient with multiple sclerosis and glioblastoma multiforme Neurology 58 2002 895 900
53. L. Del Valle, S. Enam, C. Lara, C. Ortiz-Hidalgo, C.D. Katsetos, and K. Khalili Detection of JC polyomavirus DNA sequences and cellular localization of T-antigen and agnoprotein in oligodendrogliomas Clin. Cancer Res. 8 2002 3332 3340
54. L. Del Valle, S. Enam, C. Lara, J. Miklossy, K. Khalili K, and J. Gordon Primary central nervous system lymphoma expressing the human neurotropic polyomavirus, JC virus, genome J. Virol. 78 2004 3462 3469
55. L. Del Valle, M.K. White, S. Enam, S. Piña-Oviedo, M.Q. Bromer, R.M. Thomas, H.P. Parkman, and K. Khalili Detection of JC virus DNA sequences and expression of viral T-antigen and agnoprotein in esophageal cancer Cancer 103 2004 516 527
56. G.T. Diamandopoulos Leukemia, lymphoma, and osteosarcoma induced in the Syrian golden hamster by simian virus 40 Science 176 1972 173 175
57. M. Digweed, I. Demuth, S. Rothe, R. Scholz, A. Jordan, C. Grotzinger, D. Schindler, M. Grompe, and K. Sperling SV40 large T-antigen disturbs the formation of nuclear DNA-repair foci containing MRE11 Oncogene 21 2002 4873 4878
58. K. Dorries, G. Loeber, and J. Meixensberger Association of polyomaviruses JC, SV40, and BK with human brain tumors Virology 160 1987 268 270
59. N. Dyson, R. Bernards, S.H. Friend, L.R. Gooding, J.A. Hassell, E.O. Major, J.M. Pipas, T. Vandyke, and E. Harlow Large antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein J. Virol. 64 1990 1353 1356
60. B.E. Eddy, G.S. Borman, G.E. Grubbs, and R.D. Young Identification of the oncogenic substance in rhesus monkey kidney cell culture as simian virus 40 Virology 17 1962 65 75
61. S. Efrat, and D. Hanahan Evidence for threshold effects in transformation of pancreatic beta cells by SV40 T antigen in transgenic mice Curr. Top Microbiol. Immunol. 144 1989 89 95
62. J.D. Egan, B.L. Ring, M.J. Reding, I.C. Wells, and R.M. Shuman Reticulum cell sarcoma and progressive multifocal leukoencephalopathy following renal transplantation Transplantation 29 1980 84 86
63. M. Ellman, I. Bikel, J. Figge, T. Roberts, R. Schlossman, and D.M. Livingston Localization of the simian virus 40 small t antigen in the nucleus and cytoplasm of monkey and mouse cells J. Virol. 50 1984 623 628
64. G.F. Elphick, W. Querbes, J.A. Jordan, G.V. Gee, S. Eash, K. Manley, A. Dugan, M. Stanifer, A. Bhatnagar, W.K. Kroeze, B.L. Roth, and W.J. Atwood The human polyomavirus, JCV, uses serotonin receptors to infect cells Science 306 2004 1380 1383
65. S. Emri, T. Kocagoz, A. Olut, Y. Gungen, L. Mutti, and Y.I. Baris Simian virus 40 is not a cofactor in the pathogenesis of environmentally induced malignant pleural mesothelioma in Turkey Anticancer Res. 20 2000 891 894
66. S. Enam, L. Del Valle, C. Lara, D.D. Gan, C. Ortiz-Hidalgo, J.P. Palazzo, and K. Khalili Association of human polyomavirus JCV with colon cancer: evidence for interaction of viral T-antigen and beta-catenin Cancer Res. 2 2002 793 7101
67. S. Endo, Y. Okada, Y. Orba, H. Nishihara, S. Tanaka, K. Nagashima, and H. Sawa JC virus agnoprotein colocalizes with tubulin J. NeuroVirol. 9 Suppl. 1 2003 10 14
68. E.A. Engels, W.M. Switzer, W. Heneine, and R.P. Viscidi Serologic evidence for exposure to simian virus 40 in North American zoo workers J. Infect. Dis. 190 2004 2065 2069
69. Z.L. Fei, C. D'Ambrosio, S. Li, E. Surmacz, and R. Baserga Association of insulin receptor substrate 1 with simian virus 40 large T antigen Mol. Cell. Biol. 15 1995 4232 4239
70. L. Feigenbaum, S.H. Hinrichs, and G. Jay JC virus and SV40 enhancers and transforming proteins: role in determining tissue specificity and pathogenicity in transgenic mice J. Virol. 66 1992 1176 1182
71. T. Flaegstad, P.A. Andresen, J.I. Johnsen, S.K. Asomani, G.E. Jorgensen, S. Vignarajan, A. Kjuul, P. Kogner, and T. Traavik A possible contributory role of BK virus infection in neuroblastoma development Cancer Res. 59 1999 1160 1163
72. R.R. Franks, A. Rencic, J. Gordon, P.W. Zoltick, M. Curtis, R.L. Knobler, and K. Khalili Formation of undifferentiated mesenteric tumors in transgenic mice expressing human neurotropic polyomavirus early protein T-antigen Oncogene 12 1996 2573 2578
73. R.J. Frisque Structure and function of JC virus T′ proteins J. NeuroVirol. 7 2001 293 297
74. R.J. Frisque, and F.A. White The molecular biology of JC virus, causative agent of progressive multifocal leukoencephalopathy R.P. Roos Molecular Neurovirology 1992 Humana Press Inc. Totowa, NJ 25 158
75. R.J. Frisque, B. Bollag, S.K. Tyagarajan, and L.H. Kilpatrick T′ proteins influence JC virus biology J. NeuroVirol. 9 Suppl. 1 2003 15 20
76. G.L. Gallia, J. Gordon, and K. Khalili Tumor pathogenesis of human neurotropic JC virus in the CNS J. NeuroVirol. 4 1998 175 181
77. D.D. Gan, and K. Khalili Interaction between JCV large T-antigen and beta-catenin Oncogene 23 2004 483 490
78. D.D. Gan, K. Reiss, T. Carrill, L. Del Valle, S. Croul, A. Giordano, P. Fishman, and K. Khalili Involvement of Wnt signaling pathway in murine medulloblastoma induced by human neurotropic JC virus Oncogene 20 2001 4864 4870
79. R.L. Garcea, and M.J. Imperiale Simian virus 40 infection of humans J. Virol. 77 2003 5039 5045
80. S.D. Gardner Prevalence in England of antibody to human polyomavirus (B.K.) Br. Med. J. 1 1973 77 78
81. S.D. Gardner, A.M. Field, D.V. Coleman, and B. Hulme New human papovavirus (B.K.) isolated from urine after renal transplantation Lancet 1 1971 1253 1257
82. D. Geetha, B.C. Tong, L. Racusen, J.S. Markowitz, and W.H. Westra Bladder carcinoma in a transplant recipient: evidence to implicate the BK human polyomavirus as a causal transforming agent Transplantation 73 2002 1933 1936
83. M.H. GiaRusso, and A.H. Koeppen Atypical progressive multifocal leukoencephalopathy and primary cerebral malignant lymphoma J. Neurol. Sci. 35 1978 391 398
84. J. Gordon, and K. Khalili The human polyomavirus, JCV, and neurological diseases (review) Int. J. Mol. Med. 1 1998 647 655
85. J. Gordon, L. Del Valle, J. Otte, and K. Khalili Pituitary neoplasia induced by expression of human neurotropic polyomavirus, JCV, early genome in transgenic mice Oncogene 19 2000 4840 4846
86. F. Gullotta, T. Masini, G. Scarlato, and K. Kuchelmeister Progressive multifocal leukoencephalopathy and gliomas in a HIV-negative patient Pathol. Res. Pract. 188 1992 964 972
87. J. Goudsmit, M.L. Baak, K.W. Slaterus, and J. van der Noordaa Human papovavirus isolated from urine of a child with acute tonsillitis Br. Med. J. 283 1981 1363 1364
88. W.C. Hahn, C.M. Counter, A.S. Lundberg, R.L. Beijersbergen, M.W. Brooks, and RA. Weinberg Creation of human tumour cells with defined genetic elements Nature 400 1999 464 468
89. K.F. Harris, J.B. Christensen, and M.J. Imperiale BK virus large T antigen: interactions with the retinoblastoma family of tumor suppressor proteins and effects on cellular growth control J. Virol. 70 1996 2378 2386
90. K.F. Harris, J.B. Christensen, E.H. Radany, and M.J. Imperiale Novel mechanisms of E2F induction by BK virus large-T antigen: requirement of both the pRb-binding and the J domains Mol. Cell. Biol. 18 1998 1746 1756
91. Y. Hashida, P.C. Gaffney, and E.J. Yunis Acute haemorrhagic cystitis of childhood and papovavirus-like particles J. Pediatr. 89 1976 85 87
92. A.M. Helt, and D.A. Galloway Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins Carcinogenesis 24 2003 159 169
93. J.W. Henson, B.L. Schnitker, T.-S. Lee, and J. McAllister Cell-specific activation of the glial-specific JC virus early promoter by large T antigen J. Biol. Chem. 270 1995 13240 13245
94. H.H. Hirsch, and J. Steiger Polyomavirus BK Lancet Infect. Dis. 3 2003 611 623
95. A. Hirvonen, K. Mattson, A. Karjalainen, T. Ollikainen, L. Tammilehto, T. Hovi, H. Vainio, H.I. Pass, I. Di Resta, M. Carbone, and K. Linnainmaa Simian virus 40 (SV40)-like DNA sequences not detectable in Finnish mesothelioma patients not exposed to SV40-contaminated polio vaccines Mol. Carcinog. 26 1999 93 99
96. K. Ho, J.C. Garancis, R.D. Paegle, M.A. Gerber, and W.J. Borkowski Progressive multifocal leukoencephalopathy and malignant lymphoma of the brain in a patient with immunosuppressive therapy Acta Neuropathol. (Berl.) 52 1980 81 83
97. C.J. Horvath, M.A. Simon, D.J. Bergsagel, D.R. Pauley, N.W. King, R.L. Garcea, and D.J. Ringler Simian virus 40-induced disease in rhesus monkeys with simian acquired immunodeficiency syndrome Am. J. Pathol. 140 1992 1431 1440
98. H. Huang, R. Reis, Y. Yonekawa, J.M. Lopes, P. Kleihues, and H. Ohgaki Identification in human brain tumors of DNA sequences specific for SV40 large T antigen Brain Pathol. 9 1999 33 42
99. M.J. Imperiale The human polyoma viruses: an overview K. Khalili G.L. Stoner Human Polyomaviruses: Molecular and Clinical Perspective 2001 Wiley-Liss Inc. New York 53 71
100. V. Jackson, and R. Chalkley Use of whole-cell fixation to visualize replicating and maturing simian virus 40: identification of new viral gene product Proc. Natl. Acad. Sci. U. S. A. 78 1981 6081 6085
101. G. Jay, S. Nomura, C.W. Anderson, and G. Khoury Identification of the SV40 agnogene product: a DNA binding protein Nature 291 1981 346 349
102. W.L. Kelley, and C. Georgopoulos The T/t common exon of simian virus 40, JC, and BK polyomavirus T antigens can functionally replace the J-domain of the Escherichia coli DnaJ molecular chaperone Proc. Natl. Acad. Sci. U. S. A. 94 1997 3679 3684
103. S. Kenny, V. Natarajan, D. Strike, G. Khoury, and N.P. Salzman JC virus enhancer-promoter activity in human brain cells Science 226 1984 1337 1339
104. K. Khalili, B. Krynska, L. Del Valle, C.D. Katsetos, and S. Croul Medulloblastomas and the human neurotropic polyomavirus JC virus Lancet 353 1999 1152 1153
105. K. Khalili, L. Del Valle, J. Otte, M. Weaver, and J. Gordon Human neurotropic polyomavirus, JCV, and its role in carcinogenesis Oncogene 22 2003 5181 5191
106. K. Khalili, L. Del Valle, J.Y. Wang, N. Darbinian, A. Lassak, M. Safak, and K. Reiss T-antigen of human polyomavirus JC cooperates with the IGF-IR signaling system in cerebellar tumors of the childhood-medulloblastomas AntiCancer Res. 23 2003 2035 2041
107. K. Khalili, M.K. White, H. Sawa, K. Nagashima, and M. Safak The agnoprotein of polyomaviruses: a multifunctional auxiliary protein J. Cell. Physiol. 204 2004 1 7
108. K. Khalili, J. Gordon, and M.K. White The polyomavirus, JCV, and its involvement in human disease N. Ahsan Polyomaviruses and Human Diseases 2005 Landes Bioscience Georgetown, TX
109. H.S. Kim, J.W. Henson, and R.J. Frisque Transcription and replication in the human polyomaviruses K. Khalili G.L. Stoner Human Polyomaviruses: Molecular and Clinical Perspective 2001 Wiley-Liss Inc. New York 73 126
110. H. Kim, N.J. Kwak, J.Y. Lee, B.H. Choi, Y. Lim, Y.J. Ko, Y.H. Kim, P.W. Huh, K.H. Lee, H.K. Rha, and Y.P. Wang Merlin neutralizes the inhibitory effect of Mdm2 on p53 J. Biol. Chem. 279 2004 7812 7818
111. R.L. Kirschstein, and P. Gerber Ependymomas produced after intracerebral inoculation of SV40 into new-born hamsters Nature 195 1962 299 300
112. W.A. Knowles, P. Pipkin, N. Andrews, A. Vyse, P. Minor, D.W. Brown, and E. Mille Population-based study of antibody to the human polyomaviruses BKV and JCV and the simian polyomavirus SV40 J. Med. Virol. 71 2003 115 123
113. R. Komagome, H. Sawa, T. Suzuki, Y. Suzuki, S. Tanaka, W.J. Atwood, and K. Nagashima Oligosaccharides as receptors for JC virus J. Virol. 76 2002 12992 13000
114. P. Krieg, E. Amtmann, D. Jonas, H. Fischer, K. Zang, and G. Sauer Episomal simian virus 40 genomes in human brain tumors Proc. Natl. Acad. Sci. U. S. A. 78 1981 6446 6450
115. B. Krynska, J. Gordon, J. Otte, R. Franks, R. Knobler, A. DeLuca, A. Giordano, and K. Khalili Role of cell cycle regulators in tumor formation in transgenic mice expressing the human neurotropic virus, JCV, early protein J. Cell. Biochem. 67 1997 223 230
116. B. Krynska, L. Del Valle, S. Croul, J. Gordon, C.D. Katsetos, M. Carbone, A. Giordano, and K. Khalili Detection of human neurotropic JC virus DNA sequence and expression of the viral oncogenic protein in pediatric medulloblastomas Proc. Natl. Acad. Sci. U. S. A. 96 1999 11519 11524
117. B. Krynska, J. Otte, R. Franks, K. Khalili, and S. Croul Human ubiquitous JCV(CY) T-antigen gene induces brain tumors in experimental animals Oncogene 18 1999 39 46
118. L. Laghi, A.E. Randolph, D.P. Chauhan, G. Marra, E.O. Major, J.V. Neel, and C.R. Boland JC virus DNA is present in the mucosa of the human colon and in colorectal cancers Proc. Natl. Acad. Sci. U. S. A. 96 1999 7484 7489
119. A. Lassak, L. Del Valle, F. Peruzzi, J.Y. Wang, S. Enam, S. Croul, K. Khalili, and K. Reiss Insulin receptor substrate 1 translocation to the nucleus by the human JC virus T-antigen J. Biol. Chem. 277 2002 17231 17238
120. J.R. Lazutka, J.V. Neel, E.O. Major, V. Dedonyte, J. Mierauskine, G. Slapsyte, and A. Kesminiene High titres of antibodies to two human polyomaviruses, JCV and BKV, correlate with increased frequency of chromosomal damage in human lymphocytes Cancer Lett. 109 1996 177 183
121. J.A. Lednicky, R.L. Garcea, D.J. Bergsagel, and D.J. Butel Natural simian virus 40 strains are present in human choroid plexus and ependymoma tumors Virology 212 1995 710 717
122. A.J. Levine p53, the cellular gatekeeper for growth and division Cell 88 1997 323 331
123. P.P. Liberski, J. Alwasiak, and Z. Wegrzyn Atypical progressive multifocal leucoencephalopathy and primary cerebral lymphoma Neuropatol. Pol. 20 1982 413 419
124. C.K. Liu, G. Wei, and W.J. Atwood Infection of glial cells by the human polyomavirus JC is mediated by an N-linked glycoprotein containing terminal alpha(2-6)-linked sialic acids J. Virol. 72 1998 4643 4649
125. W.T. London, S.A. Houff, D.L. Madden, D.A. Fuccillo, M. Gravell, W.C. Wallen, A.E. Palmer, J.L. Sever, B.L. Padgett, D.L. Walker, G.M. ZuRhein, and T. Ohashi Brain tumors in owl monkeys inoculated with a human polyomavirus (JC virus) Science 201 1978 1246 1249
126. W.T. London, S.A. Houff, P.E. McKeever, W.C. Wallen, J.L. Sever, B.L. Padgett, and D.L. Walker Viral-induced astrocytomas in squirrel monkeys J.L. Sever D.L. Madden Polyomaviruses and Human Neurological Diseases 1983 Alan R. Liss Inc. New York 227 237
127. J.W. Ludlow Interactions between SV40 large-tumor antigen and the growth suppressor proteins pRb and p53 FASEB J. 7 1993 866 871
128. L. Macera-Bloch, J. Houghton, M. Lenahan, K.K. Jha, and H.L. Ozer Termination of lifespan of SV40-transformed human fibroblasts in crisis is due to apoptosis J. Cell. Physiol. 190 2002 332 344
129. E.O. Major, and D.A. Vacante Human fetal astrocytes in culture support the growth of the neurotropic human polyomavirus, JCV J. Neuropathol. Exp. Neurol. 48 1989 425 436
130. E.O. Major, K. Amemiya, C.S. Tornatore, S.A. Houff, and J.R. Berger Pathogenesis and molecular biology of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain Clin. Microbiol. Rev. 5 1992 49 73
131. D. Malkin, S. Chilton-MacNeill, L.A. Meister, E. Sexsmith, L. Diller, and R.L. Garcea Tissue-specific expression of SV40 in tumors associated with the Li-Fraumeni syndrome Oncogene 20 2001 4441 4449
132. C. Mandl, D.L. Walker, and R.J. Frisque Derivation and characterization of POJ cells, transformed human fetal glial cells that retain their permissivity for JC virus J. Virol. 61 1987 755 763
133. R.G. Martin, V.P. Setlow, C.A. Edwards, and D. Vembu The roles of the simian virus 40 tumor antigens in transformation of Chinese hamster lung cells Cell 17 1979 635 643
134. D.J. McCance Persistence of animal and human papovavirus in renal and nervous tissue Prog. Clin. Biol. Res. 105 1983 343 357
135. S.M. Mendoza, T. Konishi, and C.W. Miller Integration of SV40 in human osteosarcoma DNA Oncogene 17 1998 2457 2462
136. A. Messing, H.Y. Chen, R.D. Palmiter, and R.L. Brinster Peripheral neuropathies, hepatocellular carcinomas and islet cell adenomas in transgenic mice Nature 316 1985 461 463
137. N.R. Miller, P.E. McKeever, W. London, B.L. Padgett, D.L. Walker, and W.C. Wallen Brain tumors of owl monkeys inoculated with JC virus contain the JC virus genome J. Virol. 49 1984 848 856
138. M.C. Monaco, P.N. Jensen, J. Hou, L.C. Durham, and E.O. Major Detection of JC virus DNA in human tonsil tissue: evidence for site of initial viral infection J. Virol. 72 1998 9918 9923
139. J.V. Neel, E.O. Major, A.A. Awa, T. Glover, A. Burgess, R. Traub, B. Curfman, and C. Satoh Hypothesis: "Rogue cell"-type chromosomal damage in lymphocytes is associated with infection with the JC human polyoma virus and has implications for oncogenesis Proc. Natl. Acad. Sci. U. S. A. 93 1996 2690 2695
140. Y. Niv, A. Goel, and C.R. Boland JC virus and colorectal cancer: a possible trigger in the chromosomal instability pathways Curr. Opin. Gastroenterol. 21 2005 85 99
141. L.C. Norkin Simian virus 40 infection via MHC class I molecules and caveolae Immunol. Rev. 168 1999 13 22
142. S. Ohsumi, I. Ikehara, M. Motoi, K. Ogawa, K. Nagashima, and K. Yasui Induction of undifferentiated brain tumors in rats by a human polyomavirus (JC virus) Jpn. J. Cancer Res. 76 1985 429 431
143. Y. Okada, S. Endo, H. Takahashi, H. Sawa, T. Umemura, and K. Nagashima Distribution and function of JCV agnoprotein J. NeuroVirol. 7 2001 302 306
144. D.M. Ornitz, R.E. Hammer, A. Messing, R.D. Palmiter, and R.L. Brinster Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice Science 238 1987 188 193
145. B.L. Padgett, D.L. Walker, G.M. ZuRhein, and R.J. Eckroade Cultivation of papova-like virus from human brain with progressive mutifocal leucoencephalopathy Lancet 1 1971 1257 1260
146. B.L. Padgett, D.L. Walker, M.M. Desquitado, and D.U. Kim BK virus and non-haemorrhagic cystitis in a child Lancet 1 1983 770
147. M. Pagnani, A. Corallini, A. Caputo, G. Altavilla, R. Selvatici, L. Catozzi, L. Possati, and G. Barbanti-Brodano Co-operation in cell transformation between BK virus and the human c-Harvey-ras oncogene Int. J. Cancer 42 1988 405 413
148. D.C. Pallas, L.K. Shahrik, B.L. Martin, S. Jaspers, T.B. Miller, D.L. Brautigan, and T.M. Roberts Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A Cell 12 1990 167 176
149. H.I. Pass, M. Bocchetta, and M. Carbone Evidence of an important role for SV40 in mesothelioma Thorac. Surg. Clin. 14 2004 489 495
150. J.M. Pipas Common and unique features of T antigens encoded by the polyomavirus group J. Virol. 66 1992 3979 3985
151. J.M. Pipas, and A.J. Levine Role of T antigen interactions with p53 in tumorigenesis Semin. Cancer Biol. 11 2001 23 30
152. J. Ponten Spontaneous and virus induced transformation in cell culture Virol. Monogr. 8 1971 1 253
153. M. Portolani, A. Marzocchi, G. Brabanti-Brodano, and M. La Placa Prevalence in Italy of antibodies to a new human papovavirus (BK virus) J. Med. Microbiol. 7 1974 543 546
154. C. Prins, and R.J. Frisque JC virus T′ proteins encoded by alternatively spliced early mRNAs enhance T antigen-mediated viral DNA replication in human cells J. NeuroVirol. 7 2001 250 264
155. M. Prisco, F. Santini, R. Baffa, M. Liu, R. Drakas, A. Wu, and R. Baserga Nuclear translocation of insulin receptor substrate-1 by the simian virus 40 T antigen and the activated type 1 insulin-like growth factor receptor J. Biol. Chem. 277 2002 32078 32085
156. A.S. Rabson, G.T. O'Conor, R.L. Kirschstein, and W.J. Branigan Papillary ependymomas produced in Rattus (Mastomys) natalensis inoculated with vacuolating virus (SV40) J. Natl. Cancer Inst. 29 1962 765 787
157. S. Radhakrishnan, J. Otte, S. Enam, L. Del Valle, K. Khalili, and J. Gordon JC virus-induced changes in cellular gene expression in primary human astrocytes J. Virol. 77 2003 10638 10644
158. S. Radhakrishnan, J. Gordon, L. Del Valle, J. Cui, and K. Khalili Intracellular approach for blocking JCV gene expression using RNA interference during viral infection J. Virol. 78 2004 7264 7269
159. G.V. Raj, and K. Khalili Transcriptional regulation: lessons from the human neurotropic polyomavirus, JCV Virology 213 1995 283 291
160. F.A. Ray, D.S. Peabody, J.L. Cooper, L.S. Cram, and P.M. Kraemer SV40 T antigen alone drives karyotype instability that precedes neoplastic transformation of human diploid fibroblasts J. Cell. Biochem. 42 1990 13 31
161. F.A. Ray, J. Meyne, and P.M. Kraemer SV40 T antigen induced chromosomal changes reflect a process that is both clastogenic and aneuploidogenic and is ongoing throughout neoplastic progression of human fibroblasts Mutat. Res. 284 1992 265 273
162. A. Rencic, J. Gordon, J. Otte, M. Curtis, A. Kovatich, P. Zoltick, K. Khalili, and D. Andrews Detection of JC virus DNA sequence and expression of the viral oncoprotein, tumor antigen, in brain of immunocompetent patient with oligoastrocytoma Proc. Natl. Acad. Sci. U. S. A. 93 1996 7352 7357
163. M.D. Reploeg, G.A. Storch, and D.B. Clifford BK virus: a clinical review Clin. Infect. Dis. 33 2001 191 202
164. L. Ricciardiello, L. Laghi, P. Ramamirtham, C.L. Chang, D.K. Chang, A.E. Randolph, and C.R. Boland JC virus DNA sequences are frequently present in the human upper and lower gastrointestinal tract Gastroenterology 119 2000 1228 1235
165. L. Ricciardiello, D.K. Chang, L. Laghi, A. Goel, C.L. Chang, and C.R. Boland Mad-1 is the exclusive JC virus strain present in the human colon, and its transcriptional control region has a deleted 98-base pair sequence in colon cancer tissues J. Virol. 75 2001 1996 2001
166. L. Ricciardiello, M. Baglioni, C. Giovannini, M. Pariali, G. Cenacchi, A. Ripalti, M.P. Landini, H. Sawa, K. Nagashima, R.J. Frisque, A. Goel, C.R. Boland, M. Tognon, E. Roda, and F. Bazzoli Induction of chromosomal instability in colonic cells by the human polyomavirus JC virus Cancer Res. 63 2003 7256 7262
167. E.P. Richardson Progressive multifocal leukoencephalopathy N. Engl. J. Med. 265 1961 815 823
168. C.H. Rinaldo, T. Traavik, and A. Hey The agnogene of the human polyomavirus BK is expressed J. Virol. 72 1998 6233 6236
169. M.T. Saenz-Robles, C.S. Sullivan, and J.M. Pipas Transforming functions of Simian virus 40 Oncogene 20 2001 7899 7907
170. M. Safak, and K. Khalili An overview: human polyomavirus JC virus and its
171. M. Safak, B. Sadowska, R. Barrucco, and K. Khalili Functional interaction between JC virus late regulatory agnoprotein and cellular Y-box binding transcription factor, YB-1 J. Virol. 76 2002 3828 3838
172. S. Schrump, and I. Waheed Strategies to circumvent SV40 oncoprotein expression in malignant pleural mesotheliomas Semin. Cancer Biol. 11 2001 73 80
173. K.V. Shah Causality of mesothelioma: SV40 question Thorac. Surg. Clin. 14 2004 497 504
174. K.V. Shah, R.W. Daniel, and R.M. Warszawski High prevalence of antibodies to BK virus, an SV40-related papovavirus, in residents of Maryland J. Infect. Dis. 128 1973 784 787
175. H.M. Shein, and J.F. Enders Transformation induced by simian virus 40 in human renal cell cultures: I. Morphology and growth characteristics Proc. Natl. Acad. Sci. U. S. A. 48 1962 1164 1172
176. T.E. Shenk, J. Carbon, and P. Berg Construction and analysis of viable deletion mutants of simian virus 40 J. Virol. 18 1976 664 671
177. N. Shivapurkar, T. Wiethege, I.I. Wistuba, E. Salomon, S. Milchgrub, K.M. Muller, A. Churg, H. Pass, and A.F. Gazdar Presence of simian virus 40 sequences in malignant mesotheliomas and mesothelial cell proliferations J. Cell. Biochem. 76 1999 181 188
178. N. Shivapurkar, K. Harada, J. Reddy, R.H. Scheuermann, Y. Xu, R.W. McKenna, S. Milchgrub, S.H. Kroft, Z. Feng, and A.F. Gazdar Presence of simian virus 40 DNA sequences in human lymphomas Lancet 359 2002 851 852
179. D. Shollar, L. Del Valle, K. Khalili, J. Otte, and J. Gordon JCV T-antigen interacts with the neurofibromatosis type 2 gene product in a transgenic mouse model of malignant peripheral nerve sheath tumors Oncogene 23 2004 5459 5467
180. A.A. Sima, S.D. Finkelstein, and D.R. McLachlan Multiple malignant astrocytomas in a patient with spontaneous progressive multifocal leukoencephalopathy Ann. Neurol. 14 1983 183 188
181. M.J. Sleigh, W.C. Topp, R. Hanich, and J.F. Sambrook Mutants of SV40 with an altered small t protein are reduced in their ability to transform cells Cell 14 1978 79 88
182. J.A. Small, G. Khoury, G. Jay, P.M. Howley, and G.A. Scangos Early regions of JC virus and BK virus induce distinct and tissue-specific tumors in transgenic mice Proc. Natl. Acad. Sci. U. S. A. 83 1986 8288 8292
183. J.A. Small, G.A. Scangos, L. Cork, G. Jay, and G. Khoury The early region of human papovavirus JC induces dysmyelination in transgenic mice Cell 46 1986 13 18
184. E. Sontag Protein phosphatase 2A: the Trojan Horse of cellular signaling Cell Signalling 13 2001 7 16
185. E. Sontag, S. Fedorov, C. Kamibayashi, D. Robbins, M. Cobb, and M. Mumby The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation Cell 75 1993 887 897
186. E. Sontag, J.M. Sontag, and A. Garcia Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 small t to promote cell growth and NF-kappaB activation EMBO J. 16 1997 5662 5671
187. F. Soriano, C.E. Shelburne, and M. Gokcen Simian virus 40 in a human cancer Nature 249 1974 421 424
188. A. Srinivasan, A.J. McClellan, J. Vartikar, I. Marks, P. Cantalupo, Y. Li, P. Whyte, K. Rundell, J.L. Brodsky, and J.M. Pipas The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain Mol. Cell. Biol. 17 1997 4761 4773
189. N. Stewart, and S. Bacchetti Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells Virology 180 1991 49 57
190. S.E. Stewart, B.E. Eddy, and N.G. Borgese Neoplasms in mice inoculated with a tumor agent carried in tissue culture J. Natl. Cancer Inst. 20 1958 1223 1243
191. A.R. Stewart, J.A. Lednicky, U.S. Benzick, M.J. Tevethia, and J.S. Butel Identification of a variable region at the carboxy terminus of SV40 large T-antigen Virology 221 1996 355 361
192. A.R. Stewart, J.A. Lednicky, and J.S. Butel Sequence analyses of human tumor-associated SV40 DNAs and SV40 viral isolates from monkeys and humans J. NeuroVirol. 4 1998 182 193
193. H.D. Strickler International SV40 Working Group, A multicenter evaluation of assays for detection of SV40 DNA and results in masked mesothelioma specimens Cancer Epidemiol., Biomarkers Prev. 10 2001 523 532
194. C.S. Sullivan, and J.M. Pipas T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis Microbiol. Mol. Biol. Rev. 66 2002 179 202
195. S. Suzuki, H. Sawa, R. Komagome, Y. Orba, M. Yamada, Y. Okada, Y. Ishida, H. Nishihara, S. Tanaka, and K. Nagashima Broad distribution of the JC virus receptor contrasts with a marked cellular restriction of virus replication Virology 286 2001 100 112
196. B.H. Sweet, and M.R. Hilleman The vacuolating virus, SV40 Proc. Soc. Exp. Biol. Med. 105 1960 420 427
197. K. Tabuchi, W.M. Kirsch, M. Low, D. Gaskin, J. Van Buskirk, and S. Maa Screening of human brain tumors for SV40-related T antigen Int. J. Cancer 21 1978 12 17
198. J.E. Tavis, P.W. Trowbridge, and R.J. Frisque Converting the JCV T antigen Rb binding domain to that of SV40 does not alter JCV's limited transforming activity but does eliminate viral viability Virology 199 1994 384 392
199. J.R. Testa, M. Carbone, A. Hirvonen, K. Khalili, B. Krynska, K. Linnainmaa, F.D. Pooley, P. Rizzo, V. Rusch, and G.H. Xiao A multi-institutional study confirms the presence and expression of simian virus 40 in human malignant mesotheliomas Cancer Res. 58 1998 4505 4509
200. M. Theile, and G. Grabowski Mutagenic activity of BKV and JCV in human and other mammalian cells Arch. Virol. 113 1990 221 233
201. M. Tognon, A. Corallini, F. Martini, M. Negrini, and G. Barbanti-Brodano Oncogenic transformation by BK virus and association with human tumors Oncogene 22 2003 5192 5200
202. C. Trabanelli, A. Corallini, R. Gruppioni, A. Sensi, A. Bonfatti, D. Campioni, M. Merlin, N. Calza, L. Possati, and G. Barbanti-Brodano Chromosomal aberrations induced by BK virus T antigen in human fibroblasts Virology 243 1998 492 496
203. B.D. Trapp, J.A. Small, M. Pulley, G. Khoury, and G.A. Scangos Dysmyelination in transgenic mice containing JC virus early region Ann. Neurol. 23 1988 38 48
204. J. Trofe, J. Gordon, P. Roy-Chaudhury, I.J. Koralnik, W.J. Atwood, R.R. Alloway, K. Khalili, and E.S. Woodle Polyomavirus nephropathy in kidney transplantation Prog. Transplant. 14 2004 130 140
205. J. Trojanek, T. Ho, L. Del Valle, M. Nowicki, J.Y. Wang, A. Lassak, F. Peruzzi, K. Khalili, T. Skorski, and K. Reiss Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination Mol. Cell. Biol. 23 2003 7510 7524
206. J. Trojanek, T. Ho, L. Del Valle, J.Y. Wang, A. Darbinyan, M. Nowicki, S. Croul, T. Skorski, K. Khalili, K. Reiss, T-antigen from human polyomavirus JC attenuates faithful DNA repair by forcing nuclear interaction between IRS-1 and Rad51. Mol. Cell (in press).
207. P.W. Trowbridge, and R.J. Frisque Identification of three new JC virus proteins generated by alternative splicing of the early viral mRNA J. NeuroVirol. 1 1995 195 206
208. S. Uppal, and A.P. Coatesworth Neurofibromatosis type 2 Int. J. Clin. Pract. 57 2003 698 703
209. R.A. Vilchez, C.R. Madden, C.A. Kozinetz, S.J. Halvorson, Z.S. White, J.L. Jorgensen, C.J. Finch, and J.S. Butel Association between simian virus 40 and non-Hodgkin lymphoma Lancet 359 2002 817 823
210. B. Vogelstein, and K.W. Kinzler Cancer genes and the pathways they control Nat. Med. 10 2004 789 799
211. B. Vogelstein, D. Lane, and A.J. Levine Surfing the p53 network Nature 408 2000 307 310
212. I. Waheed, Z.S. Guo, G.A. Chen, T.S. Weiser, D.M. Nguyen, and D.S. Schrump Antisense to SV40 early gene region induces growth arrest and apoptosis in T-antigen-positive human pleural mesothelioma cells Cancer Res. 59 1999 6068 6073
213. D.L. Walker, B.L. Padgett, G.M. ZuRhein, A.E. Albert AE, and R.F. Marsh Human papovavirus (JC): induction of brain tumors in hamsters Science 181 1973 674 676
214. G. Watanabe, A. Howe, R.J. Lee, C. Albanese, I.W. Shu, A.N. Karnezis, L. Zon, J. Kyriakis, K. Rundell, and R.G. Pestell Induction of cyclin D1 by simian virus 40 small tumor antigen Proc. Natl. Acad. Sci. U. S. A. 93 1996 12861 12866
215. F. Weber, C. Goldmann, M. Kramer, F.J. Kaup, M. Pickhardt, P. Young, H. Petry, T. Weber, and W. Luke Cellular and humoral immune response in progressive multifocal leukoencephalopathy Ann. Neurol. 49 2001 636 642
216. R.A. Weinberg The retinoblastoma protein and cell cycle control Cell 81 1995 323 330
217. R.A. Weinberg E2F and cell proliferation: a world turned upside down Cell 85 1996 457 459
218. M.K. White, and K. Khalili Polyomaviruses and human cancer: molecular mechanisms underlying patterns of tumorigenesis (mini-review) Virology 324 2004 1 16
219. M.K. White, and K. Khalili Signaling pathways and polyomavirus oncoproteins: importance in malignant transformation Gene Ther. Mol. Biol. 8 2004 19 30
220. P.J. Williamson, N.C. Allan, and M.A. McIntyre Cerebral Hodgkin's disease and progressive multifocal leucoencephalopathy Clin. Lab. Haematol. 11 1989 281 285
221. C. Woods, C. LeFeuvre, N. Stewart, and S. Bacchetti Induction of genomic instability in SV40 transformed human cells: sufficiency of the N-terminal 147 amino acids of large T antigen and role of pRb and p53 Oncogene 9 1994 2943 2950
222. X. Wu, D. Avni, T. Chiba, F. Yan, Q. Zhao, Y. Lin, H. Heng, and D. Livingston SV40 T antigen interacts with Nbs1 to disrupt DNA replication control Genes Dev. 18 2004 1305 1316
223. S.I. Yang, R.L. Lickteig, R. Estes, K. Rundell, G. Walter, and M.C. Mumby Control of protein phosphatase 2A by simian virus 40 small-t antigen Mol. Cell. Biol. 11 1991 1988 1995
224. J. Zerrahn, U. Knippschild, T. Winkler, and W. Deppert Independent expression of the transforming amino-terminal domain of SV40 large T antigen from an alternatively spliced third SV40 early mRNA EMBO J. 12 1993 4739 4746
225. J. Zhu, H. Wang, J.M. Bishop, and E.H. Blackburn Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening Proc. Natl. Acad. Sci. U. S. A. 96 1999 3723 3728
226. G.M. Zu Rhein Studies of JCV-induced nervous system tumors in the Syrian hamster: a review Polyomaviruses and Human Neurological Diseases 1983 Alan R. Liss, Inc. New York 205 221