Role of cell cycle regulators in tumor formation in transgenic mice expressing the human neurotropic virus, JCV, early protein

Journal of Cellular Biochemistry

Volumn 67, Issue 2, 1997, Pages 223-230

  Krynska, Barbara ^a   Gordon, Jennifer ^a   Otte, Jessica ^a   Franks, Roberta ^b   Knobler, Robert ^c   DeLuca, Antonio ^c   Giordano, Antonio ^c   Khalili, Kamel ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Human JC virus; p53; T antigen; Transgenic mice; Tumor cells

Indexed keywords

VIRUS LARGE T ANTIGEN;

ANIMAL TISSUE; ARTICLE; CANCER; CARCINOGENESIS; CELL CYCLE; MOUSE; NEURAL CREST; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE; VIRUS CARCINOGENESIS;

ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; CDC2-CDC28 KINASES; CYCLIN A; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; GENE EXPRESSION; HUMANS; JC VIRUS; MICE; MICE, TRANSGENIC; NEOPLASMS, NERVE TISSUE; PHOSPHORYLATION; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; JC VIRUS; MUS MUSCULUS;

EID: 0030931636     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19971101)67:2<223::AID-JCB7>3.0.CO;2-Z     Document Type: Article

References (31)

1. Bergsagel DJ, Finegold MJ, Butel JS, Kupky WJ, Garcea RL (1992): DNA sequences similar to those of simian virus 40 in ependymomas and choroid plexux tumors of childhood. N Engl J Med 326:988-993.
2. Cox LS, Lane DP (1995): Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage. BioEssays 17:501-508.
3. Franks R, Rencic A, Gordon J, Zoltick PW, Curtis M, Knobler RL, Khalili K (1996): Formation of undifferentiated mesenteric tumors in transgenic mice expressing human neurotropic polyomavirus early protein. Oncogene 12: 2573-2578.
4. Frisque RJ, White FA (1992): The molecular biology of JC virus, causative agent of progressive multifocal leukoencephalopthy. In Roos RP (ed): "Molecular Neurovirology." Towana, NJ: Humana Press, pp 25-258.
5. Frisque RJ, Bream GL, Cannella MT (1984): Human polyomavirus JC virus genome. J Virol 51:458-469.
6. GiaRusso MH, Koeppen AH (1978): Atypical progressive multifocal leukoencephalopathy and primary cerebral malignant lymphoma. J Neurol Sci 35:391-398.
7. Gordon JW, Ruddle FH (1983): Gene transfer into mouse embryos: Production of transgenic mice by pronuclear injection. Methods Enzymol 101:411-433.
8. Hartwell LH, Kastan MB (1994): Cell cycles control and cancer. Science 266:1821-1828.
9. Kim TA, Ravitz M, Wenner C (1994): Transforming growth factor-beta regulation of retinoblastoma gene product and E2F transcription factor during cell cycle progression in mouse fibroblasts. J Cell Physiol 160:1-9.
10. Lang FF, Miller DC, Koslow M, Newcomb EW (1994): Pathways leading to glioblastoma multiforme: A molecular analysis of genetic alterations in 65 astrocytic tumors. J Neurosurg 81:427-436.
11. Lednicky JA, Garcea RL, Bergsagel DJ, Butel JS (1995): Natural simian virus 40 strains are present in human choroid plexus and ependymoma tumors. Virology 212: 710-717.
12. London W, Houff SA, Madden DL, Fuccillo DA, Gravell M, Wallen WC, Palmer AE, Sever JL, Padgett BL, Walker DL, ZuRhein GM, Ohashi T (1978): Brain tumors in owl monkeys inoculated with a human polyomavirus (JC virus). Science 201:1246-1249.
13. Major EO, Traub R (1986): JC virus T protein during productive infection in human fetal brain and kidney cells. Virology 148:221-225.
14. Major EO, Mourrain P, Cummins C (1984): JC virus-induced owl monkey glioblastoma cells in culture: Biological properties associated with the viral early gene product. Virology 136:359-367.
15. Major EO, Vacante DA, Traub RG, London WT, Sever JL (1987): Owl monkey astrocytoma cells in culture spontaneously produce infectious JC virus which demonstrates altered biological properties. J Virol 61:1435-1441.
16. Manfredi JJ, Prives C (1994): The transforming activity of simian virus 40 large tumor antigen. The transforming activity of simian virus 40 large tumor antigen. Biochim Biophys Acta 1198:65-83.
17. Miller N, McKeever P, London W, Padgett BL, Walker DL, Wallen W (1984): Brain tumors of owl monkeys inoculated with JC virus contain the JC virus genome. J Virol 49:848-856.
18. Nagashima K, Yasui K, Kimura J, Washizu K, Yamaguchi K, Mori W (1984): Induction of brain tumors by a newly isolated JC virus (Tokyo-1 strain). Am J Pathol 116:455-463.
19. Padgett BL, ZuRhein GM, Walker D, Echoroade R, Dessel B (1971): Cultivation of papova-like virus from human brain with progressive multifocal leukoencephalopathy. Lancet 1:1257-1260.
20. Raj GV, Khalili K (1995): Transcriptional regulation: Lessons from the human neurotropic polyomavirus, JCV. Virology 213:283-291.
21. Rencic A, Gordon J, Otte J, Curtis M, Kovatich A, Zoltick PW, Khalili K, Andrews D (1996): Detection of JC virus DNA sequence and expression of the viral oncoprotein, tumor antigen, in brain of immunocompetent patient with oligoastrocytoma. Proc Natl Acad Sci USA 93:7352-7357.
22. Scherr C (1996): Cancer cell cycles. Science 274:672-1677.
23. Schlegel U (1993): Mechanisms of molecular development of human glioma. (Review.) Nervenarzt 64:485-493.
24. Sima AF, Finkelstein SD, McLachlan DR (1983): Multiple malignant astrocytomas in a patient with spontaneous progressive multifocal leukoencephalopathy. Ann Neurol 14:183-188.
25. Small J, Khoury G, Jay G, Howley P, Scangos G (1986): Early regions of JC virus and BK virus induce distinct and tissue-specific tumors in transgenic mice. Proc Natl Acad Sci USA 83:8288-8292.
26. Varakis J, ZuRhein GM, Padgett BL, Walker DL (1976): Induction of peripheral neuroblastomas in Syrian hamsters after injection as neonates with JC virus, a human polyoma virus. Cancer Res 38:1718-1722.
27. Walker DL, Padgett BL, ZuRhein GM, Albert A, Marsh RF (1973): Human papovavirus (JC): Induction of brain tumors in hamsters. Science 181:674-676.
28. Wong A, Zoltick P, Moscatello D (1994): The molecular biology and molecular genetics of astrocytic neoplasms. Semin Oncol 21:139-148.
29. ZuRhein GM, Chou SM (1965): Particles resembling papovaviruses in human cerebral demyelinating disease. Science 148:1477-1479.
30. ZuRhein GM, Varakis J (1975): Morphology of brain tumors induced in Syrian hamsters after inoculation with JC virus, a new human papovavirus. In Kornyey S, Tariska S, Gosztonyi G (eds): "Proceedings of the Seventh International Congress of Neuropathology." Vol. 1. Budapest: Akademia Kiado, pp 479-481.
31. ZuRhein GM, Varakis J (1979): Perinatal induction of medulloblastomas in Syrian Golden hamsters by a human polyomavirus (JC). In Rice JM (ed): "Perinatal Carcinogenesis." National Cancer Institute Monograph 51. Bethesda: National Cancer Institute, pp 205-208.