Structure and function of JC virus T' proteins

Journal of NeuroVirology

Volumn 7, Issue 4, 2001, Pages 293-297

  Frisque, R J ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CELL PROTEIN; COMPLEMENTARY DNA; MESSENGER RNA; PROTEIN P130; VIRUS PROTEIN; VIRUS RNA;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; BK VIRUS; CONTROLLED STUDY; GENE FUNCTION; GENETIC CODE; GLIA CELL; HUMAN; HUMAN CELL; JC VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RAT; RNA PROCESSING; RNA TRANSCRIPTION; TRANSACTIVATION; VIRUS INFECTION; VIRUS REPLICATION; VIRUS TRANSFORMATION;

ANTIGENS, POLYOMAVIRUS TRANSFORMING; GENE EXPRESSION REGULATION, VIRAL; JC VIRUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034831094     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.1080/13550280152537120     Document Type: Article

References (19)

1. Hybrid genomes of the polyomaviruses JC virus, BK virus, and simian virus 40: Identification of sequences important for efficient transformation
2. Purified JC virus T antigen derived from insect cells preferentially interacts with binding site II of the viral core origin under replication conditions
3. Purified JC virus T and T′ proteins differentially interact with the retinoblastoma family of tumor suppressor proteins
4. Polyomavirus T antigens: Molecular chaperones for multiprotein complexes
5. Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein
6. The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus
7. Human polyomavirus JC virus genome
8. JC virus-simian virus 40 genomes containing heterologous regulatory signals and chimeric early regions: Identification of regions restricting transformation by JC virus
9. Retinoblastoma-related protein pRb2/p130 and suppression of tumor growth in vivo
10. Inhibition of SV40 large T antigen induced apoptosis by small T antigen
11. JC virus T′ proteins encoded by alternatively spliced early mRNAs enhance T antigen-mediated viral DNA replication in human cells
12. The DnaJ domain of polyomavirus large T is required to regulate to regulate RB family tumor suppressor function
13. Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen
14. The molecular chaperone activity of simian virus 40 large T antigen is required to disrupt Rb-E2F family complexes by an ATP-dependent mechanism
15. ATP-dependent simian virus 40 T-antigen-Hsc70 complex formation
16. Species-specific elements in the large T-antigen J domain are required for cellular transformation and DNA replication by simian virus 40
17. Converting the JCV T antigen Rb binding domain to that of SV40 does not alter JCV's limited transforming activity but does eliminate viral viability
18. Analysis of G418-selected Rat2 cells containing prototype, variant, mutant, and chimeric JC-virus and SV40 genomes
19. Identification of three new JC virus proteins generated by alternative splicing of the early viral mRNA