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Volumn 16, Issue 18, 1997, Pages 5662-5671

Protein phosphatase 2A is a critical regulator of protein kinase C ζ signaling targeted by SV40 small t to promote cell growth and NF-κB activation

Author keywords

NF B; PI 3 kinase; PKC ; PP2A; SV40 small t

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE C; TUMOR NECROSIS FACTOR ALPHA; VIRUS SMALL T ANTIGEN; WORTMANNIN;

EID: 0030769625     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.18.5662     Document Type: Article
Times cited : (179)

References (52)
  • 1
    • 0030022346 scopus 로고    scopus 로고
    • EGF or PDGF receptors activate PKCl through phosphatidylinositol 3-kinase
    • Akimoto, K. et al. (1996) EGF or PDGF receptors activate PKCl through phosphatidylinositol 3-kinase. EMBO J., 15, 788-798.
    • (1996) EMBO J. , vol.15 , pp. 788-798
    • Akimoto, K.1
  • 2
    • 0025872515 scopus 로고
    • HIV enhancer activity perpetuated by NF-κB induction on infection of monocytes
    • Bachelerie, F., Alcami, J., Arenzana-Seisdedos, F. and Virelizier, J.L. (1991) HIV enhancer activity perpetuated by NF-κB induction on infection of monocytes. Nature, 350, 709-712.
    • (1991) Nature , vol.350 , pp. 709-712
    • Bachelerie, F.1    Alcami, J.2    Arenzana-Seisdedos, F.3    Virelizier, J.L.4
  • 3
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB and IκB proteins: New discoveries and insights
    • Baldwin, A.S. (1996) The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14, 649-681.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 649-681
    • Baldwin, A.S.1
  • 5
    • 0030271387 scopus 로고    scopus 로고
    • NF-κB: Ten years later
    • Bauerle, P.A. and Baltimore, D. (1996) NF-κB: ten years later. Cell, 87, 13-20.
    • (1996) Cell , vol.87 , pp. 13-20
    • Bauerle, P.A.1    Baltimore, D.2
  • 6
    • 0031060452 scopus 로고    scopus 로고
    • Altered susceptibility to tumor necrosis factor α-induced apoptosis of mouse cells expressing polyomavirus middle and small T antigens
    • Bergqvist, A., Soderbarg, K. and Magnusson, G. (1997) Altered susceptibility to tumor necrosis factor α-induced apoptosis of mouse cells expressing polyomavirus middle and small T antigens. J. Virol., 71, 276-283.
    • (1997) J. Virol. , vol.71 , pp. 276-283
    • Bergqvist, A.1    Soderbarg, K.2    Magnusson, G.3
  • 9
    • 0029097310 scopus 로고
    • Evidence for a bifurcation of the mitogenic signaling pathway activated by ras and phosphatidylcholine-hydrolysing phospholipase C
    • Bjorkoy, G., Overvatn, A., Diaz-Meco, M.T., Moscat, J. and Johansen, T. (1995) Evidence for a bifurcation of the mitogenic signaling pathway activated by ras and phosphatidylcholine-hydrolysing phospholipase C. J. Biol. Chem., 270, 21299-21306.
    • (1995) J. Biol. Chem. , vol.270 , pp. 21299-21306
    • Bjorkoy, G.1    Overvatn, A.2    Diaz-Meco, M.T.3    Moscat, J.4    Johansen, T.5
  • 10
    • 0028986075 scopus 로고
    • Control of I-κB-α proteolysis by site-specific, signal-induced phosphorylation
    • Brown, K., Gerstberger, S., Carlson, L., Franzoso, G. and Siebenlist, U. (1995) Control of I-κB-α proteolysis by site-specific, signal-induced phosphorylation. Science, 267, 1485-1488.
    • (1995) Science , vol.267 , pp. 1485-1488
    • Brown, K.1    Gerstberger, S.2    Carlson, L.3    Franzoso, G.4    Siebenlist, U.5
  • 11
    • 0031038588 scopus 로고    scopus 로고
    • Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase
    • Cai, H., Smola, U., Wixler, V., Eisenmann-Tappe, I., Diaz-Meco, M., Moscat, J., Rapp, U. and Cooper, G.M. (1997) Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase. Mol. Cell. Biol. 17, 732-741.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 732-741
    • Cai, H.1    Smola, U.2    Wixler, V.3    Eisenmann-Tappe, I.4    Diaz-Meco, M.5    Moscat, J.6    Rapp, U.7    Cooper, G.M.8
  • 13
    • 0028303006 scopus 로고
    • Simian virus 40 small-t antigen stimulates viral DNA replication in permissive monkey cells
    • Cicala, C., Avantaggiati, M.L., Graessmann, A., Rundell, K., Levine, A.S. and Carbone, M. (1994) Simian virus 40 small-t antigen stimulates viral DNA replication in permissive monkey cells. J. Virol., 68, 3138-3144.
    • (1994) J. Virol. , vol.68 , pp. 3138-3144
    • Cicala, C.1    Avantaggiati, M.L.2    Graessmann, A.3    Rundell, K.4    Levine, A.S.5    Carbone, M.6
  • 14
    • 0029098523 scopus 로고
    • Overexpression of mammalian protein kinase C-zeta does not affect the growth characteristics of NIH 3T3 cells
    • Crespo, P., Mischak, H. and Gutkind, J.S. (1995) Overexpression of mammalian protein kinase C-zeta does not affect the growth characteristics of NIH 3T3 cells. Biochem. Biophys. Res. Commun., 213, 266-272.
    • (1995) Biochem. Biophys. Res. Commun. , vol.213 , pp. 266-272
    • Crespo, P.1    Mischak, H.2    Gutkind, J.S.3
  • 15
    • 0027295420 scopus 로고
    • A dominant negative protein kinase C ζ subspecies blocks NF-κB activation
    • Diaz-Meco, M.T. et al. (1993) A dominant negative protein kinase C ζ subspecies blocks NF-κB activation. Mol. Cell. Biol., 13, 4770-4775.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4770-4775
    • Diaz-Meco, M.T.1
  • 17
    • 0030572696 scopus 로고    scopus 로고
    • The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C
    • Diaz-Meco, M.T., Municio, M.M., Frutos, S., Snachez, P., Lozano, J., Sanz, L. and Moscat, J. (1996) The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C. Cell, 86, 777-786.
    • (1996) Cell , vol.86 , pp. 777-786
    • Diaz-Meco, M.T.1    Municio, M.M.2    Frutos, S.3    Snachez, P.4    Lozano, J.5    Sanz, L.6    Moscat, J.7
  • 18
    • 0027395852 scopus 로고
    • Inhibition of protein kinase C ζ subspecies blocks the activation of an NF-κB-like activity in Xenopus laevis oocytes
    • Dominguez, I., Sanz, L., Arenzana-Seisdedos, F., Diaz-Meco, M.T., Virelizier, J.-L. and Moscat, J. (1993) Inhibition of protein kinase C ζ subspecies blocks the activation of an NF-κB-like activity in Xenopus laevis oocytes. Mol. Cell. Biol. 13, 1290-1295.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 1290-1295
    • Dominguez, I.1    Sanz, L.2    Arenzana-Seisdedos, F.3    Diaz-Meco, M.T.4    Virelizier, J.-L.5    Moscat, J.6
  • 20
    • 0027936410 scopus 로고
    • Simian virus 40 small t antigen cooperates with mitogen activated kinases to stimulate AP-1 activity
    • Frost, J.A., Alberts, A.S., Sontag, E., Guan, K., Mumby, M.C. and Feramisco, J.R. (1994) Simian virus 40 small t antigen cooperates with mitogen activated kinases to stimulate AP-1 activity. Mol Biol. Cell., 14, 6244-6252.
    • (1994) Mol Biol. Cell. , vol.14 , pp. 6244-6252
    • Frost, J.A.1    Alberts, A.S.2    Sontag, E.3    Guan, K.4    Mumby, M.C.5    Feramisco, J.R.6
  • 21
    • 0026573663 scopus 로고
    • Cellular transcription factors involved in the regulation of HIV-1 gene expression
    • Gaynor, R. (1992) Cellular transcription factors involved in the regulation of HIV-1 gene expression. AIDS, 6, 347-363.
    • (1992) AIDS , vol.6 , pp. 347-363
    • Gaynor, R.1
  • 22
    • 0029062127 scopus 로고
    • The ζ isoform of protein kinase C controls interleukin-2-mediated proliferation in a murine T cell line: Evidence for an additional role of protein kinase C ζ
    • Gomez, J., Pitton, C., Garcia, A., Martinez de Aragon, A., Silva, A. and Rebollo A. (1995) The ζ isoform of protein kinase C controls interleukin-2-mediated proliferation in a murine T cell line: evidence for an additional role of protein kinase C ζ. Exp. Cell Res., 218, 105-113.
    • (1995) Exp. Cell Res. , vol.218 , pp. 105-113
    • Gomez, J.1    Pitton, C.2    Garcia, A.3    Martinez De Aragon, A.4    Silva, A.5    Rebollo, A.6
  • 23
    • 85047692201 scopus 로고
    • Activation of protein kinases and the inactivation of protein phosphatase 2A in tumour necrosis factor and interleukin-1 signal-transduction pathways
    • Guy, G.R., Philp, R. and Tan, Y.H. (1995) Activation of protein kinases and the inactivation of protein phosphatase 2A in tumour necrosis factor and interleukin-1 signal-transduction pathways. Eur. J. Biochem., 229, 503-511.
    • (1995) Eur. J. Biochem. , vol.229 , pp. 503-511
    • Guy, G.R.1    Philp, R.2    Tan, Y.H.3
  • 24
    • 0030448021 scopus 로고    scopus 로고
    • Functions of ceramide in coordinating cellular responses to stress
    • Hannun, Y.A. (1996) Functions of ceramide in coordinating cellular responses to stress. Science. 274, 1855-1859.
    • (1996) Science. , vol.274 , pp. 1855-1859
    • Hannun, Y.A.1
  • 25
    • 0027981333 scopus 로고
    • 1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells
    • Hara, K. et al. (1994) 1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells. Proc. Natl Acad. Sci. USA, 91, 7415-7419.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 7415-7419
    • Hara, K.1
  • 26
    • 0029039957 scopus 로고
    • Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway
    • Karnitz, L.M., Burns, L.A., Sutor, S.L., Blenis, J. and Abraham, R.T. (1995) Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway. Mol. Cell. Biol., 15, 3049-3057.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3049-3057
    • Karnitz, L.M.1    Burns, L.A.2    Sutor, S.L.3    Blenis, J.4    Abraham, R.T.5
  • 27
    • 0029615509 scopus 로고
    • Protein kinase C is regulated in vivo by three functionally distinct phosphorylations
    • Keranen, L.M., Dutil, E.M. and Newton, A.C. (1995) Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. Curr. Biol., 5, 1394-1403.
    • (1995) Curr. Biol. , vol.5 , pp. 1394-1403
    • Keranen, L.M.1    Dutil, E.M.2    Newton, A.C.3
  • 28
    • 9344226760 scopus 로고    scopus 로고
    • Protein kinase C ζ reverts v-raf transformation of NIH-3T3 cells
    • Kieser, A. et al. (1996) Protein kinase C ζ reverts v-raf transformation of NIH-3T3 cells. Genes Dev., 10, 1455-1466.
    • (1996) Genes Dev. , vol.10 , pp. 1455-1466
    • Kieser, A.1
  • 29
    • 0028567280 scopus 로고
    • Phosphatidic acid activation of protein kinase C ζ overexpressed in COS cells: Comparison with other protein kinase C isotypes and other acidic lipids
    • Limatola, C., Schaap, D., Moolenaar, W.H. and van Blitterswijk, W.J. (1994) Phosphatidic acid activation of protein kinase C ζ overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids. Biochem. J., 304, 1001-1008.
    • (1994) Biochem. J. , vol.304 , pp. 1001-1008
    • Limatola, C.1    Schaap, D.2    Moolenaar, W.H.3    Van Blitterswijk, W.J.4
  • 30
    • 0027965006 scopus 로고
    • Protein kinase C ζ isoform is critical for κB-dependent promoter activation by sphingomyelinase
    • Lozano, J., Berra, E., Municio, M.M., Diaz-Meco, M.T., Dominguez, I., Sanz, L. and Moscat, J. (1994) Protein kinase C ζ isoform is critical for κB-dependent promoter activation by sphingomyelinase. J. Biol. Chem., 269, 19200-19202.
    • (1994) J. Biol. Chem. , vol.269 , pp. 19200-19202
    • Lozano, J.1    Berra, E.2    Municio, M.M.3    Diaz-Meco, M.T.4    Dominguez, I.5    Sanz, L.6    Moscat, J.7
  • 31
    • 0028825531 scopus 로고
    • Ras target proteins in eukaryotic cells
    • Marshall, M.S. (1995) Ras target proteins in eukaryotic cells. FASEB J., 9, 1311-1318.
    • (1995) FASEB J. , vol.9 , pp. 1311-1318
    • Marshall, M.S.1
  • 32
    • 0018608683 scopus 로고
    • The roles of the simian virus 40 tumor antigens in transformation of Chinese hamster lung cells
    • Martin, R.G., Setlow, V.P. Edwards, C.A.F. and Vembu, D. (1979) The roles of the simian virus 40 tumor antigens in transformation of Chinese hamster lung cells. Cell, 17, 635-643.
    • (1979) Cell , vol.17 , pp. 635-643
    • Martin, R.G.1    Setlow, V.P.2    Edwards, C.A.F.3    Vembu, D.4
  • 33
    • 0028988988 scopus 로고
    • Overexpression of PKC ζ in NIH3T3 cells does not induce cell transformation nor tumorigenicity and does not alter NF-κB activity
    • Montaner, S., Ramos, A., Perona, R., Esteve, P., Carnero, A. and Lacal, J.C. (1995) Overexpression of PKC ζ in NIH3T3 cells does not induce cell transformation nor tumorigenicity and does not alter NF-κB activity. Oncogene, 10, 2213-2220.
    • (1995) Oncogene , vol.10 , pp. 2213-2220
    • Montaner, S.1    Ramos, A.2    Perona, R.3    Esteve, P.4    Carnero, A.5    Lacal, J.C.6
  • 34
    • 9044253707 scopus 로고    scopus 로고
    • Platelet-derived growth factor activates protein kinase C ε through redundant and independent signaling pathways involving phospholipase Cγ or phosphatidylinositol 3-kinase
    • Moriya, S. et al. (1996) Platelet-derived growth factor activates protein kinase C ε through redundant and independent signaling pathways involving phospholipase Cγ or phosphatidylinositol 3-kinase. Proc. Natl Acad. Sci. USA, 93, 151-155.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 151-155
    • Moriya, S.1
  • 35
    • 0029003788 scopus 로고
    • PKC ζ is a molecular switch in signal transduction of TNF-α. bifunctionally regulated by ceramide and arachidonic acid
    • Müller, G., Ayoub, M., Storz, P., Rennecke, J., Fabbro, P. and Pfizenmaier, K. (1995) PKC ζ is a molecular switch in signal transduction of TNF-α. bifunctionally regulated by ceramide and arachidonic acid. EMBO J., 14, 1961-1969.
    • (1995) EMBO J. , vol.14 , pp. 1961-1969
    • Müller, G.1    Ayoub, M.2    Storz, P.3    Rennecke, J.4    Fabbro, P.5    Pfizenmaier, K.6
  • 36
    • 0027143725 scopus 로고
    • Protein serine/threonine phosphatases: Structure, regulation, and functions in cell growth
    • Mumby, M.C. and Walter, G. (1993) Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth. Phvsiol. Rev., 73, 673-700.
    • (1993) Phvsiol. Rev. , vol.73 , pp. 673-700
    • Mumby, M.C.1    Walter, G.2
  • 37
    • 0027535742 scopus 로고
    • Activation of the ζ isozyme of protein kinase C by phosphatidylinositol 3,4,5-triphosphate
    • Nakanishi, H., Brewer, K.A. and Exton, J.H. (1993) Activation of the ζ isozyme of protein kinase C by phosphatidylinositol 3,4,5-triphosphate. J. Biol. Chem., 268, 13-16.
    • (1993) J. Biol. Chem. , vol.268 , pp. 13-16
    • Nakanishi, H.1    Brewer, K.A.2    Exton, J.H.3
  • 38
    • 0030987070 scopus 로고    scopus 로고
    • Regulation of protein kinase C
    • Newton, A. (1997) Regulation of protein kinase C. Curr. Opin. Cell Biol., 9, 161-167.
    • (1997) Curr. Opin. Cell Biol. , vol.9 , pp. 161-167
    • Newton, A.1
  • 39
    • 0029832292 scopus 로고    scopus 로고
    • Overexpression of protein kinase C-ζ inhibits invasive and metastatic abilities of Dunning R-3327 MAT-LyLu rat prostate cancer cells
    • Powell, C.T., Gschwend, J.E., Fair, W.R., Brittis, N.J., Stec, D. and Huryk, R. (1996) Overexpression of protein kinase C-ζ inhibits invasive and metastatic abilities of Dunning R-3327 MAT-LyLu rat prostate cancer cells. Cancer Res., 56, 4137-4141.
    • (1996) Cancer Res. , vol.56 , pp. 4137-4141
    • Powell, C.T.1    Gschwend, J.E.2    Fair, W.R.3    Brittis, N.J.4    Stec, D.5    Huryk, R.6
  • 40
    • 0028584245 scopus 로고
    • The phosphatidyl-inositol 3-kinase α is required for DNA synthesis induced by some but not all, growth factors
    • Roche, S., Koegl, M. and Courtneidge, S.A. (1994) The phosphatidyl-inositol 3-kinase α is required for DNA synthesis induced by some but not all, growth factors. Proc. Natl Acad. Sci. USA, 91, 9185-9189.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 9185-9189
    • Roche, S.1    Koegl, M.2    Courtneidge, S.A.3
  • 41
    • 0023094011 scopus 로고
    • Complete interaction of cellular 56,000- and 32,000-Mr proteins with simian virus 40 small-t antigen in productively infected cells
    • Rundell, K. (1987) Complete interaction of cellular 56,000- and 32,000-Mr proteins with simian virus 40 small-t antigen in productively infected cells. J. Virol., 61, 1240-1243.
    • (1987) J. Virol. , vol.61 , pp. 1240-1243
    • Rundell, K.1
  • 42
    • 0027772552 scopus 로고
    • The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the MAP kinase pathway and induces cell proliferation
    • Sontag, E., Fedorov, S., Kamibayashi, C. Robbins, D., Cobb, M.H. and Mumby, M. (1993) The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the MAP kinase pathway and induces cell proliferation. Cell, 75, 887-897.
    • (1993) Cell , vol.75 , pp. 887-897
    • Sontag, E.1    Fedorov, S.2    Kamibayashi, C.3    Robbins, D.4    Cobb, M.H.5    Mumby, M.6
  • 43
    • 0028978217 scopus 로고
    • Activation of NF-κB by phosphatase inhibitors involves the phosphorylation of IκBα at phosphatase 2A-sensitive sites
    • Sun, S.-C. Maggirwar, S.B. and Harhaj, E. (1995) Activation of NF-κB by phosphatase inhibitors involves the phosphorylation of IκBα at phosphatase 2A-sensitive sites. J. Biol. Chem., 270, 18347-18351.
    • (1995) J. Biol. Chem. , vol.270 , pp. 18347-18351
    • Sun, S.-C.1    Maggirwar, S.B.2    Harhaj, E.3
  • 44
    • 0025013726 scopus 로고
    • Induction of nuclear factor-κB and the human immunodeficiency virus long terminal repeat by okadaic acid, a specific inhibitor of phosphatases 1 and 2A
    • Thévenin, C., Kim, S.J., Rieckmann, P., Fujiki, H., Norcross, M.A., Sporn, M.B., Fauci, A.S. and Kehrl, J.H. (1990) Induction of nuclear factor-κB and the human immunodeficiency virus long terminal repeat by okadaic acid, a specific inhibitor of phosphatases 1 and 2A. New Biol., 2, 793-800.
    • (1990) New Biol. , vol.2 , pp. 793-800
    • Thévenin, C.1    Kim, S.J.2    Rieckmann, P.3    Fujiki, H.4    Norcross, M.A.5    Sporn, M.B.6    Fauci, A.S.7    Kehrl, J.H.8
  • 45
    • 0028978032 scopus 로고
    • Phosphorylation of human IκB-α proteolysis and NF-κB activation in response to diverse stimuli
    • Traenckner, E.B.-M., Pahl, H.L., Henkel, T., Schmidt, K.N., Wilk, S. and Bauerle, P.A. (1995) Phosphorylation of human IκB-α proteolysis and NF-κB activation in response to diverse stimuli. EMBO J., 14, 2876-2883.
    • (1995) EMBO J. , vol.14 , pp. 2876-2883
    • Traenckner, E.B.-M.1    Pahl, H.L.2    Henkel, T.3    Schmidt, K.N.4    Wilk, S.5    Bauerle, P.A.6
  • 47
    • 0028170210 scopus 로고
    • A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1benzopyran-4-one (LY294002)
    • Vlahos, C.J., Matter, W.F., Hui, K.Y. and Brown, R.F. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1benzopyran-4-one (LY294002). J. Biol. Chem., 269, 5241-5248.
    • (1994) J. Biol. Chem. , vol.269 , pp. 5241-5248
    • Vlahos, C.J.1    Matter, W.F.2    Hui, K.Y.3    Brown, R.F.4
  • 48
    • 0028040416 scopus 로고
    • Simian virus 40 small tumor antigen inhibits dephosphorylation of protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation
    • Wheat, W.H., Roesler, W.J. and Klemm, D.J. (1994) Simian virus 40 small tumor antigen inhibits dephosphorylation of protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation. Mol. Cell. Biol., 14, 5881-5890.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 5881-5890
    • Wheat, W.H.1    Roesler, W.J.2    Klemm, D.J.3
  • 49
    • 0029670843 scopus 로고    scopus 로고
    • Constitutive activation of NF-κB is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type 1 Tax protein
    • Yamaoka, S., Inoue, H., Sakurai, M., Sugiyama, T., Hazama, M., Yamada, T. and Hatanaka, M. (1996) Constitutive activation of NF-κB is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type 1 Tax protein. EMBO J., 15, 873-887.
    • (1996) EMBO J. , vol.15 , pp. 873-887
    • Yamaoka, S.1    Inoue, H.2    Sakurai, M.3    Sugiyama, T.4    Hazama, M.5    Yamada, T.6    Hatanaka, M.7
  • 51
    • 0027374488 scopus 로고
    • Inhibition of histamine secretion by wortmannin through the blockade of phosphatadylinositol 3-kinase in RBL-2H3 cells
    • Yano, H., Nakanishi, S., Kimura, K., Hanni, N., Saitoh, Y., Fukui, Y., Nonomura, Y. and Matsuola, Y. (1993) Inhibition of histamine secretion by wortmannin through the blockade of phosphatadylinositol 3-kinase in RBL-2H3 cells. J. Biol. Chem., 268, 25846-25856.
    • (1993) J. Biol. Chem. , vol.268 , pp. 25846-25856
    • Yano, H.1    Nakanishi, S.2    Kimura, K.3    Hanni, N.4    Saitoh, Y.5    Fukui, Y.6    Nonomura, Y.7    Matsuola, Y.8


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