A non-active site mutation in human hypoxanthine guanine phosphoribosyltransferase expands substrate specificity

Archives of Biochemistry and Biophysics

Volumn 427, Issue 1, 2004, Pages 116-122

  Raman, Jayalakshmi ^a   Sumathy, K ^a,b   Anand, Ranjith P ^a   Balaram, Hemalatha ^a  

^a JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

^b Monsanto Enterprises Ltd   (India)

Author keywords

Hypoxanthine guanine phosphoribosyltransferase; Non active site mutant; Random mutagenesis; Substrate specificity

Indexed keywords

HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; PURINE; XANTHINE;

ARTICLE; CONTROLLED STUDY; ENZYME SPECIFICITY; ENZYME STRUCTURE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTOZOON; SITE DIRECTED MUTAGENESIS;

ANIMALS; BASE SEQUENCE; BINDING SITES; DNA PRIMERS; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PLASMODIUM FALCIPARUM; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

FELIS CATUS; PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 2642563574     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.abb.2004.04.014     Document Type: Article

References (42)

1. Sloan D.L., Ali L.Z., Picou D., Joseph A. Adv. Exp. Med. Biol. 165:1984;45-50
2. Allen T.E., Ullman B. Mol. Biochem. Parasitol. 65:1994;233-245
3. Allen T.E., Hwang H.Y., Jardim A., Olafson R., Ullman B. Mol. Biochem. Parasitol. 73:1995;133-143
4. Dovey H.F., McKerrow J.H., Aldritt S.M., Wang C.C. J. Biol. Chem. 261:1986;944-948
5. Beck J.T., Wang C.C. Mol. Biochem. Parasitol. 60:1993;187-194
6. Naguib F.N., Iltzsch M.H., el Kouni M.M., Panzica R.P., el Kouni M.H. Biochem. Pharmacol. 50:1995;1685-1693
7. Queen S.A., Vander Jagt D., Reyes P. Mol. Biochem. Parasitol. 30:1988;123-133
8. Sommer J.M., Ma H., Wang C.C. Mol. Biochem. Parasitol. 78:1996;185-193
9. Vos S., de Jersey J., Martin J.L. Biochemistry. 36:1997;4125-41234
10. Craig S.P. 3rd, Eakin A.E. J. Biol. Chem. 275:2000;20231-20234
11. Shi W., Li C.M., Tyler P.C., Furneaux R.H., Grubmeyer C., Schramm V.L., Almo S.C. Nat. Struct. Biol. 6:1999;588-593
12. Heroux A., White E.L., Ross L.J., Davis R.L., Borhani D.W. Biochemistry. 38:1999;14495-14506
13. Shi W., Li C.M., Tyler P.C., Furneaux R.H., Cahill S.M., Girvin M.E., Grubmeyer C., Schramm V.L., Almo S.C. Biochemistry. 38:1999;9872-9880
14. Somoza J.R., Chin M.S., Focia P.J., Wang C.C., Fletterick R.J. Biochemistry. 35:1996;7032-7040
15. Focia P.J., Craig S.P. 3rd, Nieves-Alicea R., Fletterick R.J., Eakin A.E. Biochemistry. 37:1998;15066-15075
16. Eads J.C., Scapin G., Xu Y., Grubmeyer C., Sacchettini J.C. Cell. 78:1994;325-334
17. Shi W., Munagala N.R., Wang C.C., Li C.M., Tyler P.C., Furneaux R.H., Grubmeyer C., Schramm V.L., Almo S.C. Biochemistry. 39:2000;6781-6790
18. Schumacher M.A., Carter D., Ross D.S., Ullman B., Brennan R.G. Nat. Struct. Biol. 3:1996;881-887
19. Sujay Subbayya I.N., Sukumaran S., Shivashankar K., Balaram H. Biochem. Biophys. Res. Commun. 272:2000;596-602
20. Heroux A., White E.L., Ross L.J., Borhani D.W. Biochemistry. 38:1999;14485-14494
21. Munagala N.R., Wang C.C. Biochemistry. 37:1998;16612-16619
22. Shao Z., Arnold F.H. Curr. Opin. Struct. Biol. 6:1996;513-518
23. Lesch M., Nyhan W.L. Am. J. Med. 36:1964;561-570
24. Jinnah H.A., De Gregorio L., Harris J.C., Nyhan W.L., O'Neill J.P. Mutat. Res. 463:2000;309-326
25. Jochimsen B., Nygaard P., Vestergaard T. Mol. Gen. Genet. 143:1975;85-91
26. Eakin A.E., Nieves-Alicea R., Tosado-Acevedo R., Chin M.S., Wang C.C., Craig S.P. 3rd Antimicrob. Agents Chemother. 39:1995;620-625
27. Shivashankar K., Sujay Subbayya I.N., Balaram H. J. Mol. Microbiol. Biotechnol. 3:2001;557-562
28. Fromant M., Blanquet S., Plateau P. Anal. Biochem. 224:1995;347-353
29. Sarkar G., Sommer S.S. Biotechniques. 8:1990;404-407
30. Sujay Subbayya I.N., Balaram H. FEBS Lett. 521:2002;72-76
31. Bradford M.M. Anal. Biochem. 72:1976;248-254
32. Giacomello A., Salerno C. Anal. Biochem. 79:1977;263-267
33. Sujay Subbayya I.N., Balaram H. Biochem. Biophys. Res. Commun. 279:2000;433-437
34. Keough D.T., Ng L., Winzor D.J., Emmerson B.T., de Jersey J. Mol. Biochem. Parasitol. 98:1999;29-41
35. Xu Y., Eads J., Sacchettini J.C., Grubmeyer C. Biochemistry. 36:1997;3700-3712
36. Xu Y., Grubmeyer C. Biochemistry. 37:1998;4114-4124
37. Yaun L., Wu C.S., Craig S.P. 3rd, Liu A.F., Wang C.C. Biochim. Biophys. Acta. 1162:1993;10-16
38. Kessler A.I., Gots J.S. J. Bacteriol. 164:1985;1288-1293
39. Mager J., Magasnik B. J. Biol. Chem. 235:1960;1474-1477
40. Pitera J.W., Munagala N.R., Wang C.C., Kollman P.A. Biochemistry. 38:1999;10298-10306
41. Kraulis P.J. J. Appl. Cryst. 24:1991;946-950
42. Merritt E.A., Bacon D.J. Methods Enzymol. 277:1997;505-524