Negative factor from SIV binds to the catalytic subunit of the V-ATPase to internalize CD4 and to increase viral infectivity

Molecular Biology of the Cell

Volumn 12, Issue 2, 2001, Pages 463-473

  Mandic, R ^a   Fackler, O T ^a   Geyer, M ^a   Linnemann, T ^a   Zheng, Y H ^a   Peterlin, B M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CD4 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NEF PROTEIN;

ARTICLE; DOWN REGULATION; ENDOCYTOSIS; INTERNALIZATION; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN INTERACTION; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS INFECTIVITY;

EID: 0035157781     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.2.463     Document Type: Article

References (54)

1. Functional domain mapping of the clathrin-associated adaptor medium chains μ1 and μ2
2. Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
3. HIV-1 Nef leads to inhibition or activation of T-cells depending on its intracellular localization
4. Down-regulation of cell-surface CD4 expression by simian immunodeficiency virus prevents viral super infection
5. A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 down-regulation and binds the AP-1 clathrin adaptor
6. Cutting edge: SIV Nef protein utilizes both leucine- and tyrosine-based protein sorting pathways for down-regulation of CD4
7. Characterization of a CD4-expressing macaque cell-line that can detect virus after a single replication cycle and can be infected by diverse simian immunodeficiency virus isolates
8. Endocytosis of β2 integrins by stimulated human neutrophils analyzed by flow cytometry
9. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
10. Selective ablation of human T-cell lymphotropic virus type 1 p12(I) reduces viral infectivity in vivo
11. Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity
12. Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene
13. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients
14. AP-4, a novel protein complex related to clathrin adaptors
15. AP-3: An adaptor-like protein complex with ubiquitous expression
16. p21-activated kinase 1 plays a critical role in cellular activation by Nef
17. Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions
18. Endocytic entry of HIV-1
19. Infectious mutants of HTLV-III with changes in the 3′ region and markedly reduced cytopathic effects
20. Nef-mediated clathrin-coated pit formation
21. The human T-cell lymphotrophic virus type-I P12(I) protein cooperates with the E5 oncoprotein of bovine papillomavirus in cell transformation and binds the 16-kilodalton subunit of the vacuolar H+-A.T.Pase
22. Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein
23. A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for down-regulation of CD4
24. The SH3 domain-binding and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes
25. Shared antigenic epitopes of the major core protein of human and simian immunodeficiency virus isolates
26. Characterization of a fourth adaptor-related protein complex
27. Regulation of V-ATPases by reversible disassembly
28. Importance of the nef gene for maintenance of high virus loads and for development of AIDS
29. Selection of the R17Y substitution in SIV-mac239 Nef coincided with a dramatic increase in plasma viremia and rapid progression to death
30. Absence of intact Nef sequences in a long-term survivor with nonprogressive HIV-1 infection
31. Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner
32. Nef interacts with the μ subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC class I molecules
33. Activity and in vitro reassembly of the coated vesicle (H+)-ATPase requires the 50-kDa subunit of the clathrin assembly complex AP-2
34. Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of C.D4 endocytosis
35. Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4
36. Activation of the T-cell receptor signaling pathway by Nef from an aggressive strain of simian immunodeficiency virus
37. SIV/HIV nef recombinant virus (SHIVnef) produces simian AIDS in rhesus macaques
38. Characterization of an alternatively spliced isoform of rat vesicle associated membrane protein-2 (VAMP-2)
39. The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane
40. Acidification of the endocytic and exocytic pathways
41. The coated vesicle vacuolar (H+)-ATPase associates with and is phosphorylated by the 50-kDa polypeptide of the clathrin assembly protein (AP-2)
42. Interaction of tyrosine-based sorting signals with clathrin associated proteins
43. A structural explanation for the recognition of tyrosine-based endocytotic signals
44. Clathrin adapters, and sorting
45. Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes
46. Nef-induced C.D4 degradation: A diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes
47. Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site
48. Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein
49. Human-immunodeficiency-virus type-1 nef associates with a cellular serine kinase in T-lymphocytes
50. Activation of PAK by HIV and SIV Nef: Importance for AIDS in rhesus macaques
51. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein
52. Amantadine selection of a mutant influenza-virus containing an acid-stable hemagglutinin glycoprotein - Evidence for virus-specific regulation of the pH of glycoprotein transport vesicles
53. +)-ATPase
54. Human-immunodeficiency-virus type-1 vpu protein regulates the formation of intracellular gp 160-CD4