Mutagen sensitivity of human lymphoblastoid cells with a BRCA1 mutation in comparison to ataxia telangiectasia heterozygote cells

Cytogenetics and Cell Genetics

Volumn 91, Issue 1-4, 2000, Pages 261-266

  Speit, Günter ^a   Trenz, K ^a   Schutz P ^a   Bendix, R ^b   Dork T ^b  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; CAFFEINE; HYDROGEN PEROXIDE;

ARTICLE; ATAXIA TELANGIECTASIA; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; FEMALE; GAMMA IRRADIATION; GENE MUTATION; HETEROZYGOTE; HUMAN; HUMAN CELL; HYPERSENSITIVITY; LYMPHOBLASTOID CELL LINE; MICRONUCLEUS; MUTAGEN TESTING; PRIORITY JOURNAL;

EID: 0034486523     PISSN: 03010171     EISSN: None     Source Type: Journal    
DOI: 10.1159/000056855     Document Type: Article

References (25)

1. Caffeine does not potentiate γ-radiation induced DNA damage in ataxia telangiectasia lymphoblastoid cells
2. Induction of p 53 protein by gamma radiation in lymphocyte lines from breast cancer and ataxia telangiectasia patients
3. ATM-heterozygous germline mutations contribute to breast cancer susceptibility
4. Multiple ATM-dependent pathways: An explanation for pleiotropy
5. Requirement of ATM-dependent phosphorylation of BRCA1 in the DNA damage response to double-strand breaks
6. Distinct Chk2 activation pathways are triggered by genisteine and DNA-damaging agents in human melanoma cells
7. Identification of ataxia-telangiectasia heterozygotes, a cancer prone population, using the single cell gel electrophoresis (comet) assay
8. Frequent splicing mutation of the ATM gene in breast cancer
9. Gamma-rays-induced death of human cells carrying mutations of BRCA 1 or BRCA2
10. Confirmation of BRCA 1 by analysis of germline mutations linked to breast and ovarian cancer in ten families
11. Role for ATM in DNA damage-induced phosphorylation of BRCA 1
12. Effect of caffeine in G2on x-ray-induced chromosomal aberrations and mitotic inhibition in ataxia telangiectasia fibroblast and lymphoblastoid cells
13. DNA effects in repair deficient V79 Chinese hamster cells studied by comet assay
14. Identification of a potentially radiosensitive subgroup among patients with breast cancer
15. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
16. Override of the radiation-induced mitotic block in human tumour cells by methylxanthines and its relationship to the potentiation of cytotoxicity
17. A routine method for the establishment of permanent growing lymphoblastoid cell lines
18. Induced micronu-cleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families
19. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent caffeine
20. Ataxia-telangiectasia and Nijmegen breakage syndrome: Related disorders but genes apart
21. Response of fibroblast cultures from ataxia-telangiectasia patients to reactive oxygen species generated during inflammatory reactions
22. Insights into the functions of BRCA1 and BRCA2
23. The effect of caffeine on X-ray-induced mitotic delay in normal human and ataxia-telangiectasia fibroblasts
24. 2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase