Bleomycin-induced DNA damage and its removal in lymphocytes of breast cancer patients studied by comet assay

Mutation Research - DNA Repair

Volumn 385, Issue 3, 1997, Pages 223-233

  Jałoszyński, Paweł ^a   Kujawski, Maciej ^a   Czub Świerczek, Maria ^b   Janina Markowska, ^b   Szyfter, Krzysztof ^a  

^a INSTITUTE OF HUMAN GENETICS   (Poland)

^b POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Bleomycin; Breast cancer; Comet assay; DNA break; DNA repair

Indexed keywords

BLEOMYCIN;

ADULT; AGED; ARTICLE; BREAST CANCER; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; FEMALE; GENOTOXICITY; HUMAN; HUMAN CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL;

ADULT; AGED; ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; BREAST NEOPLASMS; DNA; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; LYMPHOCYTES; MIDDLE AGED;

EID: 0344624874     PISSN: 09218777     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0921-8777(97)00046-3     Document Type: Article

References (33)

1. Denekamp J., Rojas A. Cell kinetics and radiation pathology. Experientia. 45:1989;33-41.
2. Powell S., McMillan T.J. DNA damage and repair following treatment with ionising radiation. Radiother. Oncol. 19:1990;95-108.
3. 6-methylguanine-DNA methyltransferases in DNA repair. Mutation Res. 254:1991;37-44.
4. 6-Methylguanine-DNA methyltransferase activity in breast and brain tumors. Int. J. Cancer. 61(3):1995;321-326.
5. Musarrat J., Wilson J.A., Abou-Issa H., Wani A.A. O(6)-alkylguanine DNA alkyltransferase activity levels in normal, benign and malignant human female breast. Biochem. Biophys. Res. Commun. 208(2):1995;688-696.
6. Bohr V.A., Evans M.K., Fornace A.J. Jr. Biology of disease. DNA repair and its pathogenetic implications. Lab. Invest. 50:1989;945-950.
7. Hanawalt P., Sarasin A. Cancer-prone hereditary diseases with DNA processing abnormalities. Trends Genet. 2(5):1986;124-129.
8. Lehmann A.R., Norris P.G. DNA repair and cancer: Speculations based on studies with xeroderma pigmentosum, Cockayne's syndrome and trichothiodystrophy. Carcinogenesis. 10(8):1989;1353-1356.
9. Schwartz J.L., Vaughan A.T.M. Association among DNA/chromosome break rejoining rates, chromatin structure alterations, and radiation sensitivity in human tumor cell lines. Cancer Res. 49:1989;5054-5057.
10. Lefterov I.M., Koldamova R.P. Schedule dependent variation in human lymphocyte sensitivity to bleomycin and repair of chromosomal aberrations in G2. Mutation Res. 284:1992;195-204.
11. Povirk L.F., Austin M.J.F. Genotoxicity of bleomycin. Mutation Res. 257:1991;127-143.
12. Östling O., Johanson K.J. Bleomycin, in contrast to γ irradiation, induces extreme variation of DNA strand breakage from cell to cell. Int. J. Radiat. Biol. 52(5):1987;683-691.
13. Markowska J., Czub M., Głuszak B. Retrospective appraisal of intensity of skin postradiation reactions in breast cancer patients treated with telegammatherapy. Eur. J. Gynaecol. Oncol. 15(5):1994;372-374.
14. R.B. Painter, Radiobiology of ataxia-telangiectasia, in: R.A. Gatti, R.B. Painter (Eds.), Ataxia-telangiectasia, Springer, 1992, pp. 257-268.
15. Taylor A.M., Metcalf J.A., McConville C. Increased radiosensitivity and the basic defect in ataxia telangiectasia. Int. J. Radiat. Biol. 56:1989;677-684.
16. Swift M., Sholman L., Perry M., Chase C.L. Malignant neoplasms in the families of patients with ataxia-telangiectasia. Cancer Res. 36:1976;209-215.
17. Swift M., Reitnauer P.J., Morrel D., Chase C.L. Breast and other cancers in families with ataxia-telangiectasia. N. Engl. J. Med. 316:1987;1289-1294.
18. Pippard E.C., Hall A.J., Barker J.P., Bridges B.A. Cancer in homozygotes and heterozygotes of ataxia-telangiectasia and xeroderma pigmentosum in Britain. Cancer Res. 48:1988;2929-2932.
19. Borresen A.-L., Andersen T.I., Treti S., Heiberg A., Moller P. Breast cancer and other cancers in Norwegian families with ataxia-telangiectasia. Genes Chrom. Cancer. 2:1990;339-340.
20. Szyfter K., Wiktorowicz K., Wielgosz M.S., Zajaczek S., Kujawski M., Jałoszyński P., Czub M., Markowska J. Relationship between DNA replication and DNA repair in human lymphocytes proliferating in vitro in presence and in absence of mutagen. J. Appl. Genet. 36(4):1995;379-388.
21. Singh N.P., McKoy M.T., Tice R., Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual calls. Exp. Cell Res. 175:1988;184-191.
22. Collins A.R., Ai-guo M., Duthie S.J. The kinetics of repair of oxidative DNA damage (strand breaks and oxidised pyrimidines) in human cells. Mutation Res. 336:1995;69-77.
23. Steighner R.J., Povirk L.F. Bleomycin-induced DNA lesions at mutational hot spots: Implications for the mechanism of double-strand cleavage. Proc. Natl. Acad. Sci. USA. 87:1990;8350-8354.
24. Seki S., Oda T. An exonuclease possibly involved in the initiation of repair of bleomycin-damaged DNA in mouse ascites sarcoma cells. Carcinogenesis. 9(12):1988;2239-2244.
25. Sen P., Hittelman W.N. Kinetics and repair of bleomycin-induced chromosome damage in quiescent normal human fibroblasts and human mononuclear blood cells. Cancer Res. 44:1984;591-596.
26. L.E. Knudsen, Evaluation of UDS in human lymphocytes as an indicator of genetic exposure, Ph.D. Thesis, Univ. Copenhagen, 1992.
27. Pandita T.K., Hittelman W.N. Increased initial levels of chromosome damage and heterogeneous chromosome repair in ataxia telangiectasia heterozygote cells. Mutation Res. 310:1994;1-13.
28. Swift M., Chase C.L., Morrel D. Cancer predisposition of ataxia-telangiectasia heterozygotes. Cancer Genet. Cytogenet. 46:1990;21-27.
29. Helzlsouer K.J., Harris E.L., Parshad R., Fogel S., Bigbee W.L., Sanford K.K. Familial clustering of breast cancer: Possible interaction between DNA repair proficiency and radiation exposure in the development of breast cancer. Int. J. Cancer. 64(1):1995;14-17.
30. Helzlsouer K.J., Harris E.L., Parshad R., Perry H.R., Price F.M., Sanford K.K. DNA repair proficiency: Potential susceptibility factor for breast cancer. J. Natl. Cancer Inst. 88(11):1996;754-755.
31. Knudson A.G. Jr. Hereditary cancers: from discovery to intervention. J. Natl. Cancer Inst. Monogr. 17:1995;5-7.
32. Fairbairn D.W., Olive P.L., O'Neill K.L. The comet assay: a comprehensive review. Mutation Res. 339:1995;37-59.
33. Núñez M.I., Villalobos M., Olea N., Valenzuela M.T., Pedraza V., McMillan T.J., Ruiz de Almodovar J.M. Br. J. Cancer. 71(2):1995;311-316.