Thymic Cortical Epithelium Is Sufficient for the Development of Mature T Cells in relB-Deficient Mice

Journal of Immunology

Volumn 158, Issue 6, 1997, Pages 2558-2566

  DeKoning, Jenefer ^a   DiMolfetto, Lisa ^a   Reilly, Christina ^a   Wei, Qun ^a   Havran, Wendy L ^a   Lo, David ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR; ONCOPROTEIN; RELB PROTEIN, MOUSE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RELB;

ANIMAL; ARTICLE; B LYMPHOCYTE; C57BL MOUSE; CELL DIFFERENTIATION; EPITHELIUM; GENETICS; IMMUNOLOGY; IMMUNOPHENOTYPING; METABOLISM; MOUSE; MOUSE MUTANT; PATHOLOGY; T LYMPHOCYTE; THYMUS;

ANIMALS; B-LYMPHOCYTES; CELL DIFFERENTIATION; EPITHELIUM; IMMUNOPHENOTYPING; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; PROTO-ONCOGENE PROTEINS; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES; THYMUS GLAND; TRANSCRIPTION FACTOR RELB; TRANSCRIPTION FACTORS;

EID: 0031569124     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Anderson, G., N. C. Moore, J. J. T. Owen, and E. J. Jenkinson. 1996. Cellular interactions in thymocyte development. Annu. Rev. Immunol. 14:73.
2. van Ewijk, W. 1991. T-cell differentiation is influenced by thymic microenvironments. Annu. Rev. Immunol. 9:591.
3. Lo, D., Y. Ron, and J. Sprent. 1986. Induction of MHC-restricted specificity and tolerance in the thymus. Immunol. Res. 5:221.
4. Benoist, C., and D. Mathis. 1989. Positive selection of the T cell repertoire: where and when does it occur? Cell 58:1027.
5. Robey, E., and B. J. Fowlkes. 1994. Selective events in T cell development. Annu. Rev. Immnuol. 12:675.
6. Shimonkevitz, R. P., and M. J. Bevan. 1988. Split tolerance induced by the intrathymic adoptive transfer of thymocyte stem cells. J. Exp. Med. 168:143.
7. + T cells by transgenic I-E restricted to thymic medullary epithelium. J. Immunol. 151:3954.
8. + thymocytes. J. Immunol. 152:3254.
9. Hoffman, M. W., J. Allison, and J. F. A. P. Miller. 1992. Tolerance induction by thymic medullary epithelium. Proc. Natl. Acad. Sci. USA 89:2526.
10. Spain, L. M., and L. J. Berg. 1994. Quantitative analysis of the efficiency of clonal deletion in the thymus. Dev. Immunol. 4:43.
11. Berg, L. J., B. Fazekas de St. Groth, A. M. Pullen, and M. M. Davis. 1989. Phenotypic differences between alpha beta versus beta T-cell receptor transgenic mice undergoing negative selection. Nature 340:559.
12. lo thymocytes in vivo. Science 250: 1720.
13. Laufer, T. M., J. DeKoning, J. S. Markowitz, D. Lo, and L. H. Glimcher. 1996. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature. 382:81.
14. Allison, J. P., and W. L. Havran. 1991. The immunobiology of T cells with invariant γδ antigen receptors. Annu. Rev. Immunol. 9:679.
15. Farr, A., S. Hosier, A. Nelson, S. Itohara, and S. Tonegawa. 1990. Distribution of thymocytes expressing γδ receptors in the murine thymus during development. J. Immunol. 144:492.
16. Boismenu, R., M. Rhein, W. H. Fischer, and W. L. Havran. 1996. A role for CD81 in early T cell development. Science 271:198.
17. Lo, D., H. Quill, L. Burkly, B. Scott, R. D. Palmiter, and R. L. Brinster. 1992. A recessive defect in lymphocyte and/or granulocyte function caused by an integrated transgene. Am. J. Pathol. 141:1237.
18. Weih, F., D. Carrasco, S. K. Durham, D. S. Barton, C. A. Rizzo, R.-P. Ryseck, S. A. Lira, and R. Bravo. 1995. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of relB, a member of the NF-κB/Rel family. Cell 80:331.
19. Burkly, L., C. Hession, L. Ogata, C. Reilly, L. A. Marconi, D. Olson, R. Tizard, R. Cate, and D. Lo. 1995. Expression of relB is required for the development of thymic medulla and dendritic cells. Nature 373:531.
20. + single positive cells with a class II major histocompatibility complex-restricted receptor. J. Exp. Med. 180: 25.
21. + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 341:746.
22. Kraal, G., M. Breel, M. Janse, and G. Bruin. 1986. Langerhans cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody. J. Exp. Med. 163:981.
23. Adkins, B., G. F. Tidmarsh, and I. L. Weissman. 1988. Normal thymic cortical epithelial cells developmentally regulate the expression of a B-lineage transformation-associated antigen. Immunogenetics 27:180.
24. + dendritic epidermal cells revealed by Vγ3-specific monoclonal antibody. Proc. Natl. Acad. Sci. USA 86: 4185.
25. Ferrick, D. A., M. D. Schrenzel, T. Mulvania, H. Hsieh, W. G. Ferlin, and H. Lepper. 1995. Differential production of interferon-gamma and interleukin-4 in response to Th1- and Th2-stimulating pathogens by gamma delta T cells in vivo. Nature 373:255.
26. Farr, A. G., and S. K. Anderson. 1985. Epithelial heterogeneity in the murine thymus: fucose-specific lectins bind medullary epithelial cells. J. Immunol. 134: 2971.
27. Weih, F., S. K. Durham, D. S. Barton, W. C. Sha, D. Baltimore, and R. Bravo. 1996. Both multiorgan inflammation and myeloid hyperplasia in relB-deficient mice are T cell dependent. J. Immunol. 157:3974.
28. Michie, S. A., E. A. Kirkpatrick, and R. V. Rouse. 1988. Rare peripheral T cells migrate to and persist in normal mouse thymus. J. Exp. Med. 168:1929.
29. Agus, D. B., C. D. Surh, and J. Sprent. 1991. Reentry of T cells to the adult thymus is restricted to activated T cells. J. Exp. Med. 173:1039.
30. Surh, C. D., J. Sprent, and S. R. Webb. 1993. Exclusion of circulating T cells from the thymus does not apply in the neonatal period. J. Exp. Med. 177:379.