-
1
-
-
0028117163
-
Cytokine signal transduction
-
Kishimoto T, Taga T, Akira S. Cytokine signal transduction. Cell 1994;76:253-262.
-
(1994)
Cell
, vol.76
, pp. 253-262
-
-
Kishimoto, T.1
Taga, T.2
Akira, S.3
-
2
-
-
2442590862
-
New drugs for rheumatoid arthritis
-
Olsen NJ, Stein CM. New drugs for rheumatoid arthritis. N Engl J Med 2004;350:2167-2179.
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 2167-2179
-
-
Olsen, N.J.1
Stein, C.M.2
-
5
-
-
0023685762
-
Cloning and expression of the human interleukin-6 (BSF-2/INF β2) receptor
-
Yamasaki K, Taga T, Hirata Y, Yawata H, Kawanishi Y, Seed B, Taniguchi T, Hirano T, Kishimoto T. Cloning and expression of the human interleukin-6 (BSF-2/INF β2) receptor. Science 1988;241:825-828.
-
(1988)
Science
, vol.241
, pp. 825-828
-
-
Yamasaki, K.1
Taga, T.2
Hirata, Y.3
Yawata, H.4
Kawanishi, Y.5
Seed, B.6
Taniguchi, T.7
Hirano, T.8
Kishimoto, T.9
-
6
-
-
0024393839
-
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
-
Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, Hirano T, Kishimoto T. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 1989;58:573-581.
-
(1989)
Cell
, vol.58
, pp. 573-581
-
-
Taga, T.1
Hibi, M.2
Hirata, Y.3
Yamasaki, K.4
Yasukawa, K.5
Matsuda, T.6
Hirano, T.7
Kishimoto, T.8
-
7
-
-
0025630163
-
Molecular cloning and expression of an IL-6 signal transducer, gp130
-
Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 1990;63:1149-1157.
-
(1990)
Cell
, vol.63
, pp. 1149-1157
-
-
Hibi, M.1
Murakami, M.2
Saito, M.3
Hirano, T.4
Taga, T.5
Kishimoto, T.6
-
8
-
-
0027502201
-
Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth
-
Sato K, Tsuchiya M, Saldanha J, Koishihara Y, Ohsugi Y, Kishimoto T, Bendig MM. Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth. Cancer Res 1993;53:851-856.
-
(1993)
Cancer Res.
, vol.53
, pp. 851-856
-
-
Sato, K.1
Tsuchiya, M.2
Saldanha, J.3
Koishihara, Y.4
Ohsugi, Y.5
Kishimoto, T.6
Bendig, M.M.7
-
9
-
-
0025304539
-
Rheumatoid arthritis: Pathophysiology and implications for therapy
-
Harris Jr, ED. Rheumatoid arthritis: Pathophysiology and implications for therapy. N Engl J Med 1990;322:1277-1289.
-
(1990)
N. Engl. J. Med.
, vol.322
, pp. 1277-1289
-
-
Harris Jr., E.D.1
-
10
-
-
0023811772
-
Phenotypic analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheumatoid arthritis
-
Cush JJ, Lipsky PE. Phenotypic analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheumatoid arthritis. Arthritis Rheum 1988;31:1230-1238.
-
(1988)
Arthritis Rheum.
, vol.31
, pp. 1230-1238
-
-
Cush, J.J.1
Lipsky, P.E.2
-
11
-
-
0024269961
-
Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis
-
Hirano T, Matsuda T, Turner M, Miyasaka N, Buchan G, Tang B, Sato K, Shimizu M, Maini R, Feldmann M, et al. Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur J Immunol 1988;18:1797-1801.
-
(1988)
Eur. J. Immunol.
, vol.18
, pp. 1797-1801
-
-
Hirano, T.1
Matsuda, T.2
Turner, M.3
Miyasaka, N.4
Buchan, G.5
Tang, B.6
Sato, K.7
Shimizu, M.8
Maini, R.9
Feldmann, M.10
-
12
-
-
0024371576
-
Constitutive production of interleukin 6/B cell stimulatory factor-2 from inflammatory synovium
-
Miyasaka N, Sato K, Hashimoto J, Kohsaka H, Yamamoto K, Goto M, Inoue K, Matsuda T, Hirano T, Kishimoto T, et al. Constitutive production of interleukin 6/B cell stimulatory factor-2 from inflammatory synovium. Clin Immunol Immunopathol 1989;52:238-247.
-
(1989)
Clin. Immunol. Immunopathol.
, vol.52
, pp. 238-247
-
-
Miyasaka, N.1
Sato, K.2
Hashimoto, J.3
Kohsaka, H.4
Yamamoto, K.5
Goto, M.6
Inoue, K.7
Matsuda, T.8
Hirano, T.9
Kishimoto, T.10
-
13
-
-
0026376796
-
Interleukin 1 and tumor necrosis factor-alpha synergistically increase the production of interleukin 6 in human synovial fibroblast
-
Harigai M, Hara M, Kitani A, Norioka K, Hirose T, Hirose W, Suzuki K, Kawakami M, Masuda K, Shinmei M, et al. Interleukin 1 and tumor necrosis factor-alpha synergistically increase the production of interleukin 6 in human synovial fibroblast. J Clin Lab Immunol 1991;34:107-113.
-
(1991)
J. Clin. Lab. Immunol.
, vol.34
, pp. 107-113
-
-
Harigai, M.1
Hara, M.2
Kitani, A.3
Norioka, K.4
Hirose, T.5
Hirose, W.6
Suzuki, K.7
Kawakami, M.8
Masuda, K.9
Shinmei, M.10
-
14
-
-
0022499547
-
Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
-
Hirano T, Yasukawa K, Harada H, Taga T, Watanabe Y, Matsuda T, Kashiwamura S, Nakajima K, Koyama K, Iwamatsu A, et al. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 1986;324:73-76.
-
(1986)
Nature
, vol.324
, pp. 73-76
-
-
Hirano, T.1
Yasukawa, K.2
Harada, H.3
Taga, T.4
Watanabe, Y.5
Matsuda, T.6
Kashiwamura, S.7
Nakajima, K.8
Koyama, K.9
Iwamatsu, A.10
-
15
-
-
0023176706
-
Enhancement of the interleukin-2 receptor expression on T cells by multiple B-lymphotropic lymphokines
-
Noma T, Mizuta T, Rosen A, Hirano T, Kishimoto T, Honjo T. Enhancement of the interleukin-2 receptor expression on T cells by multiple B-lymphotropic lymphokines. Immunol Lett 1987;15:249-253.
-
(1987)
Immunol Lett.
, vol.15
, pp. 249-253
-
-
Noma, T.1
Mizuta, T.2
Rosen, A.3
Hirano, T.4
Kishimoto, T.5
Honjo, T.6
-
16
-
-
0023803252
-
IL-6/BSF-2 functions as killer helper factor in the in vitro induction of cytotoxic T cells
-
Okada M, Kitahara M, Kishimoto S, Matsuda T, Hirano T, Kishimoto T. IL-6/BSF-2 functions as killer helper factor in the in vitro induction of cytotoxic T cells. J Immunol 1988;141:1543-1549.
-
(1988)
J. Immunol.
, vol.141
, pp. 1543-1549
-
-
Okada, M.1
Kitahara, M.2
Kishimoto, S.3
Matsuda, T.4
Hirano, T.5
Kishimoto, T.6
-
17
-
-
0034193039
-
IL-6 is required for the development of Th1 cell-mediated murine colitis
-
Yamamoto M, Yoshizaki K, Kishimoto T, Ito H. IL-6 is required for the development of Th1 cell-mediated murine colitis. J Immunol 2000;164:4878-4882.
-
(2000)
J. Immunol.
, vol.164
, pp. 4878-4882
-
-
Yamamoto, M.1
Yoshizaki, K.2
Kishimoto, T.3
Ito, H.4
-
18
-
-
0024565275
-
Elevation of serum interleukin 6 prior to acute phase proteins on the inflammation by surgical operation
-
Nishimoto N, Yoshizaki K, Tagoh H, Monden M, Kishimoto S, Hirano T, Kishimoto T. Elevation of serum interleukin 6 prior to acute phase proteins on the inflammation by surgical operation. Clin Immunol Immunopathol 1989;50:399-401.
-
(1989)
Clin. Immunol. Immunopathol.
, vol.50
, pp. 399-401
-
-
Nishimoto, N.1
Yoshizaki, K.2
Tagoh, H.3
Monden, M.4
Kishimoto, S.5
Hirano, T.6
Kishimoto, T.7
-
19
-
-
0025967588
-
Reciprocal expression of NF-IL6 and C/EBP in hepatocytes: Possible involvement of NF-IL6 in acute phase protein gene expression
-
Isshiki H, Akira S, Sugita T, Nishio Y, Hashimoto S, Pawlowski T, Suematsu S, Kishimoto T. Reciprocal expression of NF-IL6 and C/EBP in hepatocytes: Possible involvement of NF-IL6 in acute phase protein gene expression. N Biol 1991;3:63-70.
-
(1991)
N. Biol.
, vol.3
, pp. 63-70
-
-
Isshiki, H.1
Akira, S.2
Sugita, T.3
Nishio, Y.4
Hashimoto, S.5
Pawlowski, T.6
Suematsu, S.7
Kishimoto, T.8
-
20
-
-
0001288334
-
Human interleukin 6 is a direct promoter of maturation of megakaryocytes in vitro
-
Ishibashi T, Kimura H, Uchida T, Kariyone S, Friese P, Burstein SA. Human interleukin 6 is a direct promoter of maturation of megakaryocytes in vitro. Proc Natl Acad Sci USA 1989;86:5953-5957.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 5953-5957
-
-
Ishibashi, T.1
Kimura, H.2
Uchida, T.3
Kariyone, S.4
Friese, P.5
Burstein, S.A.6
-
21
-
-
0024446495
-
Interleukin-6 is a potent thrombopoietic factor in vivo in mice
-
Ishibashi T, Kimura H, Shikama Y, Uchida T, Kariyone S, Hirano T, Kishimoto T, Takatsuki F, Akiyama Y. Interleukin-6 is a potent thrombopoietic factor in vivo in mice. Blood 1989;74:1241-1244.
-
(1989)
Blood
, vol.74
, pp. 1241-1244
-
-
Ishibashi, T.1
Kimura, H.2
Shikama, Y.3
Uchida, T.4
Kariyone, S.5
Hirano, T.6
Kishimoto, T.7
Takatsuki, F.8
Akiyama, Y.9
-
22
-
-
0038798085
-
Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis
-
Nakahara H, Song J, Sugimoto M, Hagihara K, Kishimoto T, Yoshizaki K, Nishimoto N. Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis. Arthritis Rheum 2003;48:1521-1529.
-
(2003)
Arthritis Rheum.
, vol.48
, pp. 1521-1529
-
-
Nakahara, H.1
Song, J.2
Sugimoto, M.3
Hagihara, K.4
Kishimoto, T.5
Yoshizaki, K.6
Nishimoto, N.7
-
23
-
-
0027136189
-
Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6
-
Tamura T, Udagawa N, Takahashi N, Miyaura C, Tanaka S, Yamada Y, Koishihara Y, Ohsugi Y, Kumaki K, Taga T, et al. Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. Proc Natl Acad Sci USA 1993;90: 11924-11928.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 11924-11928
-
-
Tamura, T.1
Udagawa, N.2
Takahashi, N.3
Miyaura, C.4
Tanaka, S.5
Yamada, Y.6
Koishihara, Y.7
Ohsugi, Y.8
Kumaki, K.9
Taga, T.10
-
24
-
-
0024405580
-
Enhanced production of interleukin-6 in mice with type II collagen-induced arthritis
-
Takai Y, Seki N, Senoh H, Yokota T, Lee F, Hamaoka T, Fujiwara H. Enhanced production of interleukin-6 in mice with type II collagen-induced arthritis. Arthritis Rheum 1989;32:594-600.
-
(1989)
Arthritis Rheum.
, vol.32
, pp. 594-600
-
-
Takai, Y.1
Seki, N.2
Senoh, H.3
Yokota, T.4
Lee, F.5
Hamaoka, T.6
Fujiwara, H.7
-
25
-
-
0027241253
-
Enhanced expression of interleukin 6 in rat and murine arthritis models
-
Sugita T, Furukawa O, Ueno M, Murakami T, Takata I, Tosa T. Enhanced expression of interleukin 6 in rat and murine arthritis models. Int J Immunopharmacol 1993;15:469-476.
-
(1993)
Int. J. Immunopharmacol.
, vol.15
, pp. 469-476
-
-
Sugita, T.1
Furukawa, O.2
Ueno, M.3
Murakami, T.4
Takata, I.5
Tosa, T.6
-
26
-
-
0032429668
-
Blockage of Interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis
-
Takagi N, Mihara M, Moriya Y, Nishimoto N, Yoshizaki K, Kishimoto T, Takeda Y, Ohsugi Y. Blockage of Interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis. Arthritis Rheum 1998;41:2117-2121.
-
(1998)
Arthritis Rheum.
, vol.41
, pp. 2117-2121
-
-
Takagi, N.1
Mihara, M.2
Moriya, Y.3
Nishimoto, N.4
Yoshizaki, K.5
Kishimoto, T.6
Takeda, Y.7
Ohsugi, Y.8
-
27
-
-
0033503152
-
Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient mice
-
Sasai M, Saeki Y, Ohshima S, Nishioka K, Mima T, Tanaka T, Katada Y, Yoshizaki K, Suemura M, Kishimoto T. Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient mice. Arthritis Rheum 1999;42: 1635-1643.
-
(1999)
Arthritis Rheum.
, vol.42
, pp. 1635-1643
-
-
Sasai, M.1
Saeki, Y.2
Ohshima, S.3
Nishioka, K.4
Mima, T.5
Tanaka, T.6
Katada, Y.7
Yoshizaki, K.8
Suemura, M.9
Kishimoto, T.10
-
28
-
-
0026644298
-
Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis
-
Williams RO, Feldmann M, Maini RN. Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc Natl Acad Sci USA 1992;89: 9784-9788.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 9784-9788
-
-
Williams, R.O.1
Feldmann, M.2
Maini, R.N.3
-
30
-
-
13144259627
-
Interleukin 6 plays a key role in the development of antigen-induced arthritis
-
Ohshima S, Saeki Y, Mima T, Sasai M, Nishioka K, Nomura S, Kopf M, Katada Y, Tanaka T, Suemura M, Kishimoto T. Interleukin 6 plays a key role in the development of antigen-induced arthritis. Proc Natl Acad Sci USA 1998;95: 8222-8226.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 8222-8226
-
-
Ohshima, S.1
Saeki, Y.2
Mima, T.3
Sasai, M.4
Nishioka, K.5
Nomura, S.6
Kopf, M.7
Katada, Y.8
Tanaka, T.9
Suemura, M.10
Kishimoto, T.11
-
31
-
-
0025836012
-
Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-I
-
Iwakura Y, Tosu M, Yoshida E, Takiguchi M, Sato K, Kitajima I, Nishioka K, Yamamoto K, Takeda T, Hatanaka M, et al. Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-I. Science 1991;253: 1026-1028.
-
(1991)
Science
, vol.253
, pp. 1026-1028
-
-
Iwakura, Y.1
Tosu, M.2
Yoshida, E.3
Takiguchi, M.4
Sato, K.5
Kitajima, I.6
Nishioka, K.7
Yamamoto, K.8
Takeda, T.9
Hatanaka, M.10
-
32
-
-
0029148912
-
Autoimmunity induction by HTLV-1 in transgenic mice that develop chronic inflammatory arthropathy resembling rheumatoid arthritis in humans
-
Iwakura Y, Saijo S, Kioka Y, Nakayama-Yamada J, Itagaki K, Tosu M, Asano M, Kanai Y, Kakimoto K. Autoimmunity induction by HTLV-1 in transgenic mice that develop chronic inflammatory arthropathy resembling rheumatoid arthritis in humans. J Immunol 1995;155:1588-1598.
-
(1995)
J. Immunol.
, vol.155
, pp. 1588-1598
-
-
Iwakura, Y.1
Saijo, S.2
Kioka, Y.3
Nakayama-Yamada, J.4
Itagaki, K.5
Tosu, M.6
Asano, M.7
Kanai, Y.8
Kakimoto, K.9
-
33
-
-
0036166344
-
Suppression of autoimmune arthritis in interleukin-1-deficient mice in which T cell activation is impaired due to low levels of CD40 ligand and OX40 expression on T cells
-
Saijo S, Asano M, Horai R, Yamamoto H, Iwakura Y. Suppression of autoimmune arthritis in interleukin-1-deficient mice in which T cell activation is impaired due to low levels of CD40 ligand and OX40 expression on T cells. Arthritis Rheum 2002;46:533-544.
-
(2002)
Arthritis Rheum.
, vol.46
, pp. 533-544
-
-
Saijo, S.1
Asano, M.2
Horai, R.3
Yamamoto, H.4
Iwakura, Y.5
-
34
-
-
0034677123
-
Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice
-
Horai R, Saijo S, Tanioka H, Nakae S, Sudo K, Okahara A, Ikuse T, Asano M, Iwakura Y. Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice. J Exp Med 2000;191:313-320.
-
(2000)
J. Exp. Med.
, vol.191
, pp. 313-320
-
-
Horai, R.1
Saijo, S.2
Tanioka, H.3
Nakae, S.4
Sudo, K.5
Okahara, A.6
Ikuse, T.7
Asano, M.8
Iwakura, Y.9
-
35
-
-
0038623916
-
IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist
-
Nakae S, Saijo S, Horai R, Sudo K, Mori S, Iwakura Y. IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc Natl Acad Sci USA 2003;100:5986-5990.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 5986-5990
-
-
Nakae, S.1
Saijo, S.2
Horai, R.3
Sudo, K.4
Mori, S.5
Iwakura, Y.6
-
36
-
-
0037037586
-
A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis
-
Atsumi T, Ishihara K, Kamimura D, Ikushima H, Ohtani T, Hirota S, Kobayashi H, Park SJ, Saeki Y, Kitamura Y, Hirano T. A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis. J Exp Med 2002;196:979-990.
-
(2002)
J. Exp. Med.
, vol.196
, pp. 979-990
-
-
Atsumi, T.1
Ishihara, K.2
Kamimura, D.3
Ikushima, H.4
Ohtani, T.5
Hirota, S.6
Kobayashi, H.7
Park, S.J.8
Saeki, Y.9
Kitamura, Y.10
Hirano, T.11
-
37
-
-
0033506335
-
Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappa B decoy oligodeoxynucleotides as a gene therapy
-
Tomita T, Takeuchi E, Tomita N, Morishita R, Kaneko M, Yamamoto K, Nakase T, Seki H, Kato K, Kaneda Y, Ochi T. Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappa B decoy oligodeoxynucleotides as a gene therapy. Arthritis Rheum 1999;42: 2532-2542.
-
(1999)
Arthritis Rheum.
, vol.42
, pp. 2532-2542
-
-
Tomita, T.1
Takeuchi, E.2
Tomita, N.3
Morishita, R.4
Kaneko, M.5
Yamamoto, K.6
Nakase, T.7
Seki, H.8
Kato, K.9
Kaneda, Y.10
Ochi, T.11
-
38
-
-
0033928439
-
Transcription factor decoy for NF kappa B inhibits cytokine and adhesion molecule expressions in synovial cells derived from rheumatoid arthritis
-
Tomita T, Takano H, Tomita N, Morishita R, Kaneko M, Shi K, Takahi K, Nakase T, Kaneda Y, Yoshikawa H, Ochi T. Transcription factor decoy for NF kappa B inhibits cytokine and adhesion molecule expressions in synovial cells derived from rheumatoid arthritis. Rheumatology 2000;39:749-757.
-
(2000)
Rheumatology
, vol.39
, pp. 749-757
-
-
Tomita, T.1
Takano, H.2
Tomita, N.3
Morishita, R.4
Kaneko, M.5
Shi, K.6
Takahi, K.7
Nakase, T.8
Kaneda, Y.9
Yoshikawa, H.10
Ochi, T.11
-
39
-
-
10744223505
-
Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity
-
Hanada T, Yoshida H, Kato S, Tanaka K, Masutani K, Tsukada J, Nomura Y, Mimata H, Kubo M, Yoshimura A. Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Immunity 2003;19:437-450.
-
(2003)
Immunity
, vol.19
, pp. 437-450
-
-
Hanada, T.1
Yoshida, H.2
Kato, S.3
Tanaka, K.4
Masutani, K.5
Tsukada, J.6
Nomura, Y.7
Mimata, H.8
Kubo, M.9
Yoshimura, A.10
-
40
-
-
10744227089
-
Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases
-
Fujimoto M, Tsutsui H, Xinshou O, Tokumoto M, Watanabe D, Shima Y, Yoshimoto T, Hirakata H, Kawase I, Nakanishi K, Kishimoto T, Naka T. Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases. Int Immunol 2004;16:303-314.
-
(2004)
Int. Immunol.
, vol.16
, pp. 303-314
-
-
Fujimoto, M.1
Tsutsui, H.2
Xinshou, O.3
Tokumoto, M.4
Watanabe, D.5
Shima, Y.6
Yoshimoto, T.7
Hirakata, H.8
Kawase, I.9
Nakanishi, K.10
Kishimoto, T.11
Naka, T.12
-
41
-
-
0035667907
-
Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis
-
Shouda T, Yoshida T, Hanada T, Wakioka T, Oishi M, Miyoshi K, Komiya S, Kosai K, Hanakawa Y, Hashimoto K, Nagata K, Yoshimura A. Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis. J Clin Investig 2001;108:1781-1788.
-
(2001)
J. Clin. Investig.
, vol.108
, pp. 1781-1788
-
-
Shouda, T.1
Yoshida, T.2
Hanada, T.3
Wakioka, T.4
Oishi, M.5
Miyoshi, K.6
Komiya, S.7
Kosai, K.8
Hanakawa, Y.9
Hashimoto, K.10
Nagata, K.11
Yoshimura, A.12
-
42
-
-
0035090840
-
Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys
-
Mihara M, Kotoh M, Nishimoto N, Oda Y, Kumagai E, Takagi N, Tsunemi K, Ohsugi Y, Kishimoto T, Yoshizaki K, Takeda Y. Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys. Clin Immunol 2001;98:319-326.
-
(2001)
Clin. Immunol.
, vol.98
, pp. 319-326
-
-
Mihara, M.1
Kotoh, M.2
Nishimoto, N.3
Oda, Y.4
Kumagai, E.5
Takagi, N.6
Tsunemi, K.7
Ohsugi, Y.8
Kishimoto, T.9
Yoshizaki, K.10
Takeda, Y.11
-
43
-
-
0031734477
-
Treatment of rheumatoid synovitis with anti-reshaping human interleukin-6 receptor monoclonal antibody
-
Matsuno H, Sawai T, Nezuka T, Uzuki M, Tsuji H, Nishimoto N, Yoshizaki K. Treatment of rheumatoid synovitis with anti-reshaping human interleukin-6 receptor monoclonal antibody. Arthritis Rheum 1998;41:2014-2021.
-
(1998)
Arthritis Rheum
, vol.41
, pp. 2014-2021
-
-
Matsuno, H.1
Sawai, T.2
Nezuka, T.3
Uzuki, M.4
Tsuji, H.5
Nishimoto, N.6
Yoshizaki, K.7
-
45
-
-
0036899812
-
Therapeutic benefit after blocking interleukin-6 activity in rheumatoid arthritis with an anti-interleukin-6 receptor monoclonal antibody
-
Choy EH, Isenberg DA, Garrood T, Farrow S, Ioannou Y, Bird H, Cheung N, Williams B, Hazleman B, Price R, et al. Therapeutic benefit after blocking interleukin-6 activity in rheumatoid arthritis with an anti-interleukin-6 receptor monoclonal antibody. Arthritis Rheum 2002;46:3143-3150.
-
(2002)
Arthritis Rheum.
, vol.46
, pp. 3143-3150
-
-
Choy, E.H.1
Isenberg, D.A.2
Garrood, T.3
Farrow, S.4
Ioannou, Y.5
Bird, H.6
Cheung, N.7
Williams, B.8
Hazleman, B.9
Price, R.10
-
46
-
-
0038166958
-
Toxicity, pharmacokinetics, and dose finding study of repetitive treatment with humanized anti-interleukin 6 receptor antibody, MRA, in rheumatoid arthritis -Phase I/II clinical study
-
Nishimoto N, Yoshizaki K, Maeda K, Kuritani T, Deguchi H, Sato B, Imai N, Suemura M, Kakehi T, Takagi N, et al. Toxicity, pharmacokinetics, and dose finding study of repetitive treatment with humanized anti-interleukin 6 receptor antibody, MRA, in rheumatoid arthritis -Phase I/II clinical study. J Rheumatol 2003;30:1426-1435.
-
(2003)
J. Rheumatol.
, vol.30
, pp. 1426-1435
-
-
Nishimoto, N.1
Yoshizaki, K.2
Maeda, K.3
Kuritani, T.4
Deguchi, H.5
Sato, B.6
Imai, N.7
Suemura, M.8
Kakehi, T.9
Takagi, N.10
-
47
-
-
2642558925
-
Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: A multicenter, double-blind, placebo-controlled trial
-
Nishimoto N, Yoshizaki K, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Hashimoto J, Azuma J, Kishimoto T. Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: A multicenter, double-blind, placebo-controlled trial. Arthritis Rheum 2004;50:1761-1769.
-
(2004)
Arthritis Rheum.
, vol.50
, pp. 1761-1769
-
-
Nishimoto, N.1
Yoshizaki, K.2
Miyasaka, N.3
Yamamoto, K.4
Kawai, S.5
Takeuchi, T.6
Hashimoto, J.7
Azuma, J.8
Kishimoto, T.9
-
48
-
-
0030954732
-
A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease
-
Crohn's disease cA2 study group
-
Targan SR, Hanauer SB, van Deventer SJ, Mayer L, Present DH, Braakman T, DeWoody KL, Schaible TF, Rutgeerts PJ. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's disease cA2 study group. N Engl J Med 1997;337:1029-1035.
-
(1997)
N. Engl. J. Med.
, vol.337
, pp. 1029-1035
-
-
Targan, S.R.1
Hanauer, S.B.2
van Deventer, S.J.3
Mayer, L.4
Present, D.H.5
Braakman, T.6
DeWoody, K.L.7
Schaible, T.F.8
Rutgeerts, P.J.9
-
49
-
-
0026336617
-
Colonic mucosal interleukin-6 in inflammatory bowel disease
-
Mitsuyama K, Sasaki E, Toyonaga A, Ikeda H, Tsuruta O, Irie A, Arima N, Oriishi T, Harada K, Fujisaki K, et al. Colonic mucosal interleukin-6 in inflammatory bowel disease. Digestion 1991;50:104-111.
-
(1991)
Digestion
, vol.50
, pp. 104-111
-
-
Mitsuyama, K.1
Sasaki, E.2
Toyonaga, A.3
Ikeda, H.4
Tsuruta, O.5
Irie, A.6
Arima, N.7
Oriishi, T.8
Harada, K.9
Fujisaki, K.10
-
50
-
-
0028796711
-
Soluble interleukin-6 receptors in inflammatory bowel disease: Relation to circulating interleukin-6
-
Mitsuyama K, Toyonaga A, Sasaki E, Ishida O, Ikeda H, Tsuruta O, Harada K, Tateishi H, Nishiyama T, Tanikawa K. Soluble interleukin-6 receptors in inflammatory bowel disease: Relation to circulating interleukin-6. Gut 1995;36:45-49.
-
(1995)
Gut
, vol.36
, pp. 45-49
-
-
Mitsuyama, K.1
Toyonaga, A.2
Sasaki, E.3
Ishida, O.4
Ikeda, H.5
Tsuruta, O.6
Harada, K.7
Tateishi, H.8
Nishiyama, T.9
Tanikawa, K.10
-
51
-
-
0031718221
-
Mucosal expression of interleukin-6 and interleukin-8 messenger RNA in ulcerative colitis and in Crohn's disease
-
Arai F, Takahashi T, Furukawa K, Matsushima K, Asakura H. Mucosal expression of interleukin-6 and interleukin-8 messenger RNA in ulcerative colitis and in Crohn's disease. Dig Dis Sci 1998;43:2071-2079.
-
(1998)
Dig. Dis. Sci.
, vol.43
, pp. 2071-2079
-
-
Arai, F.1
Takahashi, T.2
Furukawa, K.3
Matsushima, K.4
Asakura, H.5
-
52
-
-
0031972742
-
Spectrum of cytokine gene expression in intestinal mucosal lesions of Crohn's disease and ulcerative colitis
-
Funakoshi K, Sugimura K, Anezaki K, Bannai H, Ishizuka K, Asakura H. Spectrum of cytokine gene expression in intestinal mucosal lesions of Crohn's disease and ulcerative colitis. Digestion 1998;59:73-78.
-
(1998)
Digestion
, vol.59
, pp. 73-78
-
-
Funakoshi, K.1
Sugimura, K.2
Anezaki, K.3
Bannai, H.4
Ishizuka, K.5
Asakura, H.6
-
53
-
-
0026101722
-
Significance of interleukin-6 in patients with inflammatory bowel disease
-
Mitsuyama K, Sata M, Tanikawa K. Significance of interleukin-6 in patients with inflammatory bowel disease. Gastroenterol Jpn 1991;26:20-28.
-
(1991)
Gastroenterol. Jpn.
, vol.26
, pp. 20-28
-
-
Mitsuyama, K.1
Sata, M.2
Tanikawa, K.3
-
54
-
-
0029017776
-
Elevation of interleukin-6 in inflammatory bowel disease is macrophage- and epithelial cell-dependent
-
Kusugami K, Fukatsu A, Tanimoto M, Shinoda M, Haruta J, Kuroiwa A, Ina K, Kanayama K, Ando T, Matsuura T, et al. Elevation of interleukin-6 in inflammatory bowel disease is macrophage- and epithelial cell-dependent. Dig Dis Sci 1995;40:949-959.
-
(1995)
Dig. Dis. Sci.
, vol.40
, pp. 949-959
-
-
Kusugami, K.1
Fukatsu, A.2
Tanimoto, M.3
Shinoda, M.4
Haruta, J.5
Kuroiwa, A.6
Ina, K.7
Kanayama, K.8
Ando, T.9
Matsuura, T.10
-
55
-
-
6544233336
-
Interleukin-6 and soluble interleukin-6 receptor in the colonic mucosa of inflammatory bowel disease
-
Hosokawa T, Kusugami K, Ina K, Ando T, Shinoda M, Imada A, Ohsuga M, Sakai T, Matsuura T, Ito K, Kaneshiro K. Interleukin-6 and soluble interleukin-6 receptor in the colonic mucosa of inflammatory bowel disease. J Gastroenterol Hepatol 1999;14:987-996.
-
(1999)
J. Gastroenterol. Hepatol.
, vol.14
, pp. 987-996
-
-
Hosokawa, T.1
Kusugami, K.2
Ina, K.3
Ando, T.4
Shinoda, M.5
Imada, A.6
Ohsuga, M.7
Sakai, T.8
Matsuura, T.9
Ito, K.10
Kaneshiro, K.11
-
56
-
-
18344410191
-
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo
-
Atreya R, Mudter J, Finotto S, Mullberg J, Jostock T, Wirtz S, Schutz M, Bartsch B, Holtmann M, Becker C, et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo. Nat Med 2000;6:583-588.
-
(2000)
Nat. Med.
, vol.6
, pp. 583-588
-
-
Atreya, R.1
Mudter, J.2
Finotto, S.3
Mullberg, J.4
Jostock, T.5
Wirtz, S.6
Schutz, M.7
Bartsch, B.8
Holtmann, M.9
Becker, C.10
-
57
-
-
0036855607
-
Anti-IL-6 receptor monoclonal antibody inhibits leukocyte recruitment and promotes T-cell apoptosis in a murine model of Crohn's disease
-
Ito H, Hirotani T, Yamamoto M, Ogawa H, Kishimoto T. Anti-IL-6 receptor monoclonal antibody inhibits leukocyte recruitment and promotes T-cell apoptosis in a murine model of Crohn's disease. J Gastroenterol 2002;37(Suppl 14):56-61.
-
(2002)
J. Gastroenterol.
, vol.37
, Issue.SUPPL. 14
, pp. 56-61
-
-
Ito, H.1
Hirotani, T.2
Yamamoto, M.3
Ogawa, H.4
Kishimoto, T.5
-
58
-
-
0035910753
-
CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation
-
Suzuki A, Hanada T, Mitsuyama K, Yoshida T, Kamizono S, Hoshino T, Kubo M, Yamashita A, Okabe M, Takeda K, Akira S, Matsumoto S, Toyonaga A, Sata M, Yoshimura A. CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med 2001;193:471-481.
-
(2001)
J. Exp. Med.
, vol.193
, pp. 471-481
-
-
Suzuki, A.1
Hanada, T.2
Mitsuyama, K.3
Yoshida, T.4
Kamizono, S.5
Hoshino, T.6
Kubo, M.7
Yamashita, A.8
Okabe, M.9
Takeda, K.10
Akira, S.11
Matsumoto, S.12
Toyonaga, A.13
Sata, M.14
Yoshimura, A.15
-
59
-
-
0035137669
-
Interleukin-18 and Crohn's disease
-
Kanai T, Watanabe M, Okazawa A, Sato T, Hibi T. Interleukin-18 and Crohn's disease. Digestion 2001;63 (Suppl. 1):37-42.
-
(2001)
Digestion
, vol.63
, Issue.SUPPL. 1
, pp. 37-42
-
-
Kanai, T.1
Watanabe, M.2
Okazawa, A.3
Sato, T.4
Hibi, T.5
-
60
-
-
0034800289
-
Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease
-
Kanai T, Watanabe M, Okazawa A, Sato T, Yamazaki M, Okamoto S, Ishii H, Totsuka T, Iiyama R, Okamoto R, Ikeda M, Kurimoto M, Takeda K, Akira S, Hibi T. Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease. Gastroenterology 2001;121:875-888.
-
(2001)
Gastroenterology
, vol.121
, pp. 875-888
-
-
Kanai, T.1
Watanabe, M.2
Okazawa, A.3
Sato, T.4
Yamazaki, M.5
Okamoto, S.6
Ishii, H.7
Totsuka, T.8
Iiyama, R.9
Okamoto, R.10
Ikeda, M.11
Kurimoto, M.12
Takeda, K.13
Akira, S.14
Hibi, T.15
-
61
-
-
11144358366
-
A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease
-
Ito H, Takazoe M, Fukuda Y, Hibi T, Kusugami K, Andoh A, Matsumoto T, Yamamura T, Azuma J, Nishimoto N, Yoshizaki K, Shimoyama T, Kishimoto T. A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology 2004;126:989-996.
-
(2004)
Gastroenterology
, vol.126
, pp. 989-996
-
-
Ito, H.1
Takazoe, M.2
Fukuda, Y.3
Hibi, T.4
Kusugami, K.5
Andoh, A.6
Matsumoto, T.7
Yamamura, T.8
Azuma, J.9
Nishimoto, N.10
Yoshizaki, K.11
Shimoyama, T.12
Kishimoto, T.13
-
62
-
-
0031720762
-
Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban, 1997
-
Petty RE, Southwood TR, Baum J, Bhettay E, Glass DN, Manners P, Maldonado-Cocco J, Suarez-Almazor M, Orozco-Alcala J, Prieur AM. Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban, 1997. J Rheumatol 1998;25:1991-1994.
-
(1998)
J. Rheumatol.
, vol.25
, pp. 1991-1994
-
-
Petty, R.E.1
Southwood, T.R.2
Baum, J.3
Bhettay, E.4
Glass, D.N.5
Manners, P.6
Maldonado-Cocco, J.7
Suarez-Almazor, M.8
Orozco-Alcala, J.9
Prieur, A.M.10
-
63
-
-
0035511981
-
Macrophage activation syndrome: A potentially fatal complication of rheumatic disorders
-
Sawhney S, Woo P, Murray KJ. Macrophage activation syndrome: A potentially fatal complication of rheumatic disorders. Arch Dis Child 2001;85:421-426.
-
(2001)
Arch. Dis. Child
, vol.85
, pp. 421-426
-
-
Sawhney, S.1
Woo, P.2
Murray, K.J.3
-
64
-
-
0031993121
-
Is systemic juvenile rheumatoid arthritis an interleukin 6 mediated disease?
-
De Benedetti F, Martini A. Is systemic juvenile rheumatoid arthritis an interleukin 6 mediated disease? J Rheumatol 1998;25:203-207.
-
(1998)
J. Rheumatol.
, vol.25
, pp. 203-207
-
-
De Benedetti, F.1
Martini, A.2
-
65
-
-
0041328139
-
Interleukin 6 as a therapeutic target in systemic-onset juvenile idiopathic arthritis
-
Yokota S. Interleukin 6 as a therapeutic target in systemic-onset juvenile idiopathic arthritis. Curr Opin Rheumatol 2003;15:581-586.
-
(2003)
Curr. Opin. Rheumatol.
, vol.15
, pp. 581-586
-
-
Yokota, S.1
-
66
-
-
20144362101
-
Therapeutic efficacy of humanized recombinant anti-interleukin-6 receptor antibody in children with systemic-onset juvenile idiopathic arthritis
-
Yokota S, Miyamae T, Imagawa T, Iwata N, Katakura S, Mori M, Woo P, Nishimoto N, Yoshizaki K, Kishimoto T. Therapeutic efficacy of humanized recombinant anti-interleukin-6 receptor antibody in children with systemic-onset juvenile idiopathic arthritis. Arthritis Rheum 2005;52:818-825.
-
(2005)
Arthritis Rheum.
, vol.52
, pp. 818-825
-
-
Yokota, S.1
Miyamae, T.2
Imagawa, T.3
Iwata, N.4
Katakura, S.5
Mori, M.6
Woo, P.7
Nishimoto, N.8
Yoshizaki, K.9
Kishimoto, T.10
-
67
-
-
0036898472
-
Humanized monoclonal anti-interleukin-6 receptor antibody for treatment of intractable adult-onset Still's disease
-
Iwamoto M, Nara H, Hirata D, Minota S, Nishimoto N, Yoshizaki K. Humanized monoclonal anti-interleukin-6 receptor antibody for treatment of intractable adult-onset Still's disease. Arthritis Rheum 2002;46:3388-3389.
-
(2002)
Arthritis Rheum.
, vol.46
, pp. 3388-3389
-
-
Iwamoto, M.1
Nara, H.2
Hirata, D.3
Minota, S.4
Nishimoto, N.5
Yoshizaki, K.6
|