Transcription factor decoy for NFκB inhibits cytokine and adhesion molecule expressions in synovial cells derived from rheumatoid arthritis

Rheumatology

Volumn 39, Issue 7, 2000, Pages 749-757

  Tomita, T ^a   Takano, H ^a   Tomita, N ^a   Morishita, R ^a   Kaneko, M ^a   Shi, K ^a   Takahi, K ^a   Nakase, T ^a   Kaneda, Y ^a   Yoshikawa, H ^a   Ochi, T ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Gene therapy; HVJ liposome; Rheumatoid arthritis; Synovial cells; Transcription factor decoy

Indexed keywords

CELL ADHESION MOLECULE; COLLAGENASE; CYTOKINE; DOUBLE STRANDED DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 6; LIPOSOME; MATRIX METALLOPROTEINASE; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL COUNT; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA BINDING; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE CONTROL; GENE THERAPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERPLASIA; NORTHERN BLOTTING; PARAINFLUENZA VIRUS 1; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; SYNOVITIS; SYNOVIUM;

EID: 0033928439     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/39.7.749     Document Type: Article

References (41)

1. Rheumatoid arthritis. Pathophysiology and implications for therapy
2. Pathogenesis of rheumatoid arthritis
3. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor α in rheumatoid arthritis
4. Rheumatoid arthritis. Pathophysiology and implications for therapy
5. Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis
6. Detection of cytokines at the cartilage/pannus junction in patients with rheumatoid arthritis: Implications for the role of cytokines in cartilage destruction and repair
7. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor
8. Evolution of collagen-induced arthritis in mice is arrested by treatment with anti-tumor necrosis factor (TNF) antibody or a recombinant soluble TNF receptor
9. Anti-tumor necrosis factor ameliorates joint disease in murine collagen- induced arthritis
10. Influence of a recombinant human soluble tumor necrosis factor receptor FC fusion protein on type II collagen-induced arthritis in mice
11. Phase I study of recombinant human interleukin-1 receptor (RHU IL-1R) administered intra-articularly in active rheumatoid arthritis
12. Treatment with recombinant human interleukin-1 receptor antagonist (rhIL- 1ra) in rheumatoid arthritis (RA)
13. Treatment of severe rheumatoid arthritis by anti-interleukin-6 monoclonal antibody
14. Regulation of tumor necrosis factor alpha transcription in macrophages: Involvement of four κB-like motifs and of constitutive and inducible form of NF-κB
15. κB-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor α gene in primary macrophages
16. Activation of interleukin-6 gene expression through the NF-κB transcription factor
17. NF-κB as inducible transcriptional activation of the granulocyte- macrophage colony-stimulating factor gene
18. Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5'-regulatory region: induction by cytokines and phorbol ester
19. Activation of transcription factor NFκB in human synovial cells in response to tumor necrosis factor α
20. Nuclear factor-κB in rheumatoid synovium. Localization of p50 and p65
21. Activation of the transcription factor nuclear factor-κB in human inflamed synovial tissue
22. Nuclear factor κB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1β-stimulated synovial fibroblasts
23. Hypertensive rats produced in vivo introduction of the human renin gene
24. Transient decrease in high blood pressure by in vivo transfer of antisense oligodeoxynucleotides against rat angiotensinogen
25. A novel molecular strategy using cis element 'decoy' of E2F binding site inhibits smooth muscle proliferation in vivo
26. In vivo transfection of cis element 'decoy' against NFκB binding site prevented myocardial infarction as gene therapy
27. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
28. An oligonucleotide decoy for transcription factor E2F inhibits mesangial cell proliferation in vitro
29. Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis
30. The adhesion molecules of inflammation
31. Cellular biology of cartilage degradation
32. Tumor necrosis factor stimulates resorption and inhibits synthesis of proteoglycan in cartilage
33. Interleukin-1 induces leukocyte infiltration and cartilage proteoglycan degradation in the synovial joint
34. Arthritogenic actions of recombinant IL-1 and tumor necrosis factor alpha in the rabbit: Evidence for synergistic interactions between cytokines in vivo
35. In vivo direct gene transfer into articular cartilage by intraarticular injection mediated by HVJ (Sendai virus) and liposomes
36. Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor κB decoy oligodeoxynucleotides as a gene therapy
37. Antitumor promotion and antiinflammation: Down-modulation of AP-1 (fos/jun) activity by glucocorticoid hormone
38. Transcriptional interference between c-jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction
39. Phorbol ester-inducible genes contain a common cis element recognized by TPA-modulated trans-acting factor
40. Novel phorbol ester response region in the collagenase promoter binds Fos and Jun
41. Two activating protein-1 elements in the matrix metalloproteinase-1 promoter have different effects on transcription and bind JunD, c-Fos, and Fra-2