Camptothecins inhibit the utilization of hydrogen peroxide in the ligation step of topoisomerase I catalysis

Biochemistry

Volumn 37, Issue 30, 1998, Pages 10815-10827

  Lisby, Michael ^a   Krogh, Berit Olsen ^a,c   Boege, Fritz ^b   Westergaard, Ole ^a   Knudsen, Birgitta Ruth ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; CELL DNA; DNA TOPOISOMERASE; HYDROGEN PEROXIDE; IRINOTECAN; TOPOTECAN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CATALYSIS; DNA CLEAVAGE; DNA CONFORMATION; ENZYME ACTIVE SITE; ENZYME INHIBITOR INTERACTION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING;

CAMPTOTHECIN; CATALYSIS; DNA; DNA TOPOISOMERASES, TYPE I; HUMANS; HYDROGEN PEROXIDE; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; MODELS, CHEMICAL; PHENOLS; SUBSTRATE SPECIFICITY; SUPEROXIDES;

EID: 0032575299     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi980757r     Document Type: Article

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