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Volumn 379, Issue 3, 2004, Pages 749-756

Transforming growth factor (TGF) β, fibroblast growth factor (FGF) and retinoid signalling pathways promote pancreatic exocrine gene expression in mouse embryonic stem cells

Author keywords

Acinar pancreas; Differentiation pathway; Embryonic stem (ES) cell; Endocrine; Transcription factor

Indexed keywords

BIOCHEMISTRY; CELLS; GROWTH KINETICS; PLANTS (BOTANY); REACTION KINETICS;

EID: 2542570175     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20031784     Document Type: Article
Times cited : (42)

References (56)
  • 1
    • 0025615950 scopus 로고
    • Embryonic stem cells: Proliferation and differentiation
    • Bradley, A. (1990) Embryonic stem cells: proliferation and differentiation. Curr. Opin. Cell Biol. 2, 1013-1017
    • (1990) Curr. Opin. Cell Biol. , vol.2 , pp. 1013-1017
    • Bradley, A.1
  • 2
    • 0034614379 scopus 로고    scopus 로고
    • Stem cells: A new lease on life
    • Fuchs, E. and Segre, J. A. (2000) Stem cells: a new lease on life. Cell 100, 143-155
    • (2000) Cell , vol.100 , pp. 143-155
    • Fuchs, E.1    Segre, J.A.2
  • 3
    • 0035479915 scopus 로고    scopus 로고
    • Mouse ES cells: Experimental exploitation of pluripotent differentiation potential
    • Rathjen, R. and Rathjen, P. D. (2001) Mouse ES cells: experimental exploitation of pluripotent differentiation potential. Curr. Opin. Genet. Dev. 11, 587-594
    • (2001) Curr. Opin. Genet. Dev. , vol.11 , pp. 587-594
    • Rathjen, R.1    Rathjen, P.D.2
  • 4
    • 0037010158 scopus 로고    scopus 로고
    • A molecular view on pluripotent stem cells
    • Eiges, R. and Benvenisty, N. (2002) A molecular view on pluripotent stem cells. FEBS Lett. 529, 135-141
    • (2002) FEBS Lett. , vol.529 , pp. 135-141
    • Eiges, R.1    Benvenisty, N.2
  • 5
    • 0033979603 scopus 로고    scopus 로고
    • Insulin-secreting cells derived from embryonic stem cells normalize glycaemia in streptozotocin-induced diabetic mice
    • Soria, B., Roche, E., Berna, G., Leon-Quinto, T., Reig, J. A. and Martin, F. (2000) Insulin-secreting cells derived from embryonic stem cells normalize glycaemia in streptozotocin-induced diabetic mice. Diabetes 49, 157-162
    • (2000) Diabetes , vol.49 , pp. 157-162
    • Soria, B.1    Roche, E.2    Berna, G.3    Leon-Quinto, T.4    Reig, J.A.5    Martin, F.6
  • 6
    • 0035057914 scopus 로고    scopus 로고
    • From stem cells to β cells: New strategies in cell therapy of diabetes mellitus
    • Soria, B., Skoudy, A. and Martin, F. (2001) From stem cells to β cells: new strategies in cell therapy of diabetes mellitus. Diabetologia 44, 407-415
    • (2001) Diabetologia , vol.44 , pp. 407-415
    • Soria, B.1    Skoudy, A.2    Martin, F.3
  • 7
    • 0035906902 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets
    • Washington, D.C.
    • Lumelsky, N., Blondel, O., Laeng, P., Velasco, I., Ravin, R. and McKay, R. (2001) Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science (Washington, D.C.) 292, 1389-1394
    • (2001) Science , vol.292 , pp. 1389-1394
    • Lumelsky, N.1    Blondel, O.2    Laeng, P.3    Velasco, I.4    Ravin, R.5    McKay, R.6
  • 8
    • 0037417958 scopus 로고    scopus 로고
    • Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells
    • Blyszczuk, P., Czyz, J., Kania, G., Wagner, M., Roll, U., St-Onge, L. and Wobus, A. M. (2003) Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells. Proc. Natl. Acad. Sci. U.S.A. 100, 998-1003
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 998-1003
    • Blyszczuk, P.1    Czyz, J.2    Kania, G.3    Wagner, M.4    Roll, U.5    St-Onge, L.6    Wobus, A.M.7
  • 9
    • 0037449573 scopus 로고    scopus 로고
    • Insulin staining of ES cell progeny from insulin uptake
    • Washington, D.C.
    • Rajagopal, J., Anderson, W. J., Kume, S., Martinez, O. I. and Melton, D. A. (2003) Insulin staining of ES cell progeny from insulin uptake. Science (Washington, D.C.) 299, 363
    • (2003) Science , vol.299 , pp. 363
    • Rajagopal, J.1    Anderson, W.J.2    Kume, S.3    Martinez, O.I.4    Melton, D.A.5
  • 10
    • 0037058934 scopus 로고    scopus 로고
    • Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells
    • Hori, Y., Rulifson, I. C., Tsai, B. C., Heit, J. J., Cahoy, J. D. and Kim, S. K. (2002) Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 99, 16105-16110
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 16105-16110
    • Hori, Y.1    Rulifson, I.C.2    Tsai, B.C.3    Heit, J.J.4    Cahoy, J.D.5    Kim, S.K.6
  • 11
    • 0042453495 scopus 로고    scopus 로고
    • Analysis of insulin-producing cells during in vitro differentiation from feeder-free embryonic stem cells
    • Moritoh, Y., Yamato, E., Yasui, Y., Miyazaki, S. and Miyazaki, J. I. (2003) Analysis of insulin-producing cells during in vitro differentiation from feeder-free embryonic stem cells. Diabetes 52, 1163-1168
    • (2003) Diabetes , vol.52 , pp. 1163-1168
    • Moritoh, Y.1    Yamato, E.2    Yasui, Y.3    Miyazaki, S.4    Miyazaki, J.I.5
  • 12
    • 0035863135 scopus 로고    scopus 로고
    • Intercellular signals regulating pancreas development and function
    • Kim, S. K. and Henrok, M. (2001) Intercellular signals regulating pancreas development and function. Genes Dev. 15, 111-127
    • (2001) Genes Dev. , vol.15 , pp. 111-127
    • Kim, S.K.1    Henrok, M.2
  • 13
    • 0042847336 scopus 로고    scopus 로고
    • Pancreas specification: A budding question
    • Kumar, M. and Melton, D. (2003) Pancreas specification: a budding question. Curr. Opin. Genet. Dev. 13, 401-407
    • (2003) Curr. Opin. Genet. Dev. , vol.13 , pp. 401-407
    • Kumar, M.1    Melton, D.2
  • 14
    • 0036777339 scopus 로고    scopus 로고
    • Signaling and transcriptional control of pancreatic organogenesis
    • Kim, S. K. and MacDonald, R. J. (2002) Signaling and transcriptional control of pancreatic organogenesis. Curr. Opin. Genet. Dev. 12, 540-547
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 540-547
    • Kim, S.K.1    MacDonald, R.J.2
  • 15
    • 0036301577 scopus 로고    scopus 로고
    • Pancreatic organogenesis - Developmental mechanisms and implications for therapy
    • Edlund, H. (2002) Pancreatic organogenesis - developmental mechanisms and implications for therapy. Nature Rev. 3, 524-532
    • (2002) Nature Rev. , vol.3 , pp. 524-532
    • Edlund, H.1
  • 16
    • 0029027780 scopus 로고
    • Developmental biology of the pancreas
    • Slack, J. M. W. (1995) Developmental biology of the pancreas. Development 121, 1569-1580
    • (1995) Development , vol.121 , pp. 1569-1580
    • Slack, J.M.W.1
  • 17
    • 0033602021 scopus 로고    scopus 로고
    • Analysis of pancreatic development using a cell lineage label
    • Percival, A. C. and Slack, J. M. (1999) Analysis of pancreatic development using a cell lineage label. Exp. Cell Res. 247, 123-132
    • (1999) Exp. Cell Res. , vol.247 , pp. 123-132
    • Percival, A.C.1    Slack, J.M.2
  • 18
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreas development in mice
    • Jonsson, J., Carlsson, L., Edlund, T. and Edlund, H. (1994) Insulin-promoter-factor 1 is required for pancreas development in mice. Nature (London) 371, 606-609
    • (1994) Nature (London) , vol.371 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 20
    • 0037458120 scopus 로고    scopus 로고
    • Experimental conversion of liver to pancreas
    • Horb, M. E., Shen, C. H., Tosh, D. and Slack, N. M. (2003) Experimental conversion of liver to pancreas. Curr. Biol. 13, 105-115
    • (2003) Curr. Biol. , vol.13 , pp. 105-115
    • Horb, M.E.1    Shen, C.H.2    Tosh, D.3    Slack, N.M.4
  • 21
    • 2642589990 scopus 로고    scopus 로고
    • Notochord repression of endodermal Sonic hedgehog permits pancreas development
    • Hebrok, M., Kim, S. K. and Melton, D. A. (1998) Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev. 12, 1705-1713
    • (1998) Genes Dev. , vol.12 , pp. 1705-1713
    • Hebrok, M.1    Kim, S.K.2    Melton, D.A.3
  • 22
    • 0036665171 scopus 로고    scopus 로고
    • Development and diseases of the pancreas
    • Johansson, K. A. and Grapin-Botton, A. (2002) Development and diseases of the pancreas. Clin. Genet. 62, 14-23
    • (2002) Clin. Genet. , vol.62 , pp. 14-23
    • Johansson, K.A.1    Grapin-Botton, A.2
  • 23
    • 0033081046 scopus 로고    scopus 로고
    • Different functions for the thyroid hormone receptors TRα and TRβ in the control of thyroid hormone production and post-natal development
    • Gauthier, K., Chassande, O., Plateroti, M., Roux, J. P., Legrand, C., Pain, B., Rousset, B., Weiss, R., Trouiilas, J. and Samarut, J. (1999) Different functions for the thyroid hormone receptors TRα and TRβ in the control of thyroid hormone production and post-natal development. EMBO J. 18, 623-631
    • (1999) EMBO J. , vol.18 , pp. 623-631
    • Gauthier, K.1    Chassande, O.2    Plateroti, M.3    Roux, J.P.4    Legrand, C.5    Pain, B.6    Rousset, B.7    Weiss, R.8    Trouiilas, J.9    Samarut, J.10
  • 24
    • 0001884951 scopus 로고
    • Culture and differentiation of embryonic stem cells
    • Smith, A. G. (1991) Culture and differentiation of embryonic stem cells. J. Tiss. Cult. Meth. 13, 89-94
    • (1991) J. Tiss. Cult. Meth. , vol.13 , pp. 89-94
    • Smith, A.G.1
  • 25
    • 0342369386 scopus 로고    scopus 로고
    • Role of the basic helix-loop-helix transcription factor p48 in the differentiation phenotype of exocrine pancreas cancer cells
    • Adell, T., Gomez-Cuadrado, A., Skoudy, A., Pettengill, O. S., Longnecker, D. S and Real, F. X. (2000) Role of the basic helix-loop-helix transcription factor p48 in the differentiation phenotype of exocrine pancreas cancer cells. Cell Growth Differ. 11, 137-147
    • (2000) Cell Growth Differ. , vol.11 , pp. 137-147
    • Adell, T.1    Gomez-Cuadrado, A.2    Skoudy, A.3    Pettengill, O.S.4    Longnecker, D.S.5    Real, F.X.6
  • 26
    • 0023277545 scopus 로고
    • Single-step method for RNA isolation using guanidium thiocyanate-phenol- chloroform extraction
    • Chomczynski, P. and Sacchi, N. (1987) Single-step method for RNA isolation using guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 28
    • 0032417268 scopus 로고    scopus 로고
    • The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas
    • Krapp, A., Knofler, M., Ledermann, B., Burki, K., Berney, C., Zoerkler, N., Hagenbuchle, O. and Wellauer, P. K. (1998) The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev. 12, 3752-3763
    • (1998) Genes Dev. , vol.12 , pp. 3752-3763
    • Krapp, A.1    Knofler, M.2    Ledermann, B.3    Burki, K.4    Berney, C.5    Zoerkler, N.6    Hagenbuchle, O.7    Wellauer, P.K.8
  • 29
    • 0031011659 scopus 로고    scopus 로고
    • Involvement of hepatocyte nuclear factor 3 in endoderm differentiation of embryonic stem cells
    • Levinson-Dushnik, M. and Benvenisty, N. (1997) Involvement of hepatocyte nuclear factor 3 in endoderm differentiation of embryonic stem cells. Mol. Cell. Biol. 17, 3817-3822
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 3817-3822
    • Levinson-Dushnik, M.1    Benvenisty, N.2
  • 30
    • 0033996527 scopus 로고    scopus 로고
    • Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3
    • Huang, H. P., Liu, M., El-Hodiri, H. M., Chu, K., Jamrich, M. and Tsai, M. J. (2000) Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3. Mol. Cell. Biol. 20, 3292-3330
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 3292-3330
    • Huang, H.P.1    Liu, M.2    El-Hodiri, H.M.3    Chu, K.4    Jamrich, M.5    Tsai, M.J.6
  • 31
    • 0036340074 scopus 로고    scopus 로고
    • Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
    • Gu, G., Dubauskaite, J. and Melton, D. A. (2002) Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129, 2447-2457
    • (2002) Development , vol.129 , pp. 2447-2457
    • Gu, G.1    Dubauskaite, J.2    Melton, D.A.3
  • 33
    • 0036730427 scopus 로고    scopus 로고
    • The role of the transcriptional regulator PTF1-p48 in converting intestinal to pancreatic progenitors
    • Kawaguchi, Y., Cooper, B., Gannon, M., Ray, M. and MacDonald, R. J. (2002) The role of the transcriptional regulator PTF1-p48 in converting intestinal to pancreatic progenitors. Nat. Genet. 32, 128-134
    • (2002) Nat. Genet. , vol.32 , pp. 128-134
    • Kawaguchi, Y.1    Cooper, B.2    Gannon, M.3    Ray, M.4    MacDonald, R.J.5
  • 34
    • 84924133024 scopus 로고    scopus 로고
    • The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity
    • Pin, C. L., Rukstalis, J. M., Johnson, C. and Konieczny, S. F. (2001) The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity. J. Cell Biol. 155, 519-530
    • (2001) J. Cell Biol. , vol.155 , pp. 519-530
    • Pin, C.L.1    Rukstalis, J.M.2    Johnson, C.3    Konieczny, S.F.4
  • 35
    • 0034652287 scopus 로고    scopus 로고
    • Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    • Gradwohl, G., Dierich, A., LeMeur, M. and Guillemot, F. (2000) Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc. Natl. Acad. Sci. U.S.A. 97, 1607-1611
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 1607-1611
    • Gradwohl, G.1    Dierich, A.2    LeMeur, M.3    Guillemot, F.4
  • 36
    • 0033499662 scopus 로고    scopus 로고
    • Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development
    • Smith, S. B., Ee, H. C., Conners, J. R. and German, M. S. (1999) Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development. Mol. Cell. Biol. 19, 8272-8280
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 8272-8280
    • Smith, S.B.1    Ee, H.C.2    Conners, J.R.3    German, M.S.4
  • 39
    • 0032952973 scopus 로고    scopus 로고
    • Impaired differentiation of endocrine and exocrine cells of the pancreas in transgenic mouse expressing the truncated type II activin receptor
    • Shiozaki, S., Tajima, T., Zhang, Y. Q., Furukawa, M., Nakazato, Y. and Kojima, I. (1999) Impaired differentiation of endocrine and exocrine cells of the pancreas in transgenic mouse expressing the truncated type II activin receptor. Biochim. Biophys. Acta 1450, 1-11
    • (1999) Biochim. Biophys. Acta , vol.1450 , pp. 1-11
    • Shiozaki, S.1    Tajima, T.2    Zhang, Y.Q.3    Furukawa, M.4    Nakazato, Y.5    Kojima, I.6
  • 43
    • 0028147867 scopus 로고
    • Normal human pancreas cultures display functional ductal characteristics
    • Vila, M. R., Lloreta, J. and Real, F. X. (1994) Normal human pancreas cultures display functional ductal characteristics. Lab. Invest. 71, 423-431
    • (1994) Lab. Invest. , vol.71 , pp. 423-431
    • Vila, M.R.1    Lloreta, J.2    Real, F.X.3
  • 46
    • 0002923914 scopus 로고
    • Development of the embryonic endocrine pancreas
    • D. Steinerand, ed. William, Wildins, Baltimore
    • Pictet, R. and Rutter, W. J. (1972) Development of the embryonic endocrine pancreas. In Handbook of Physiology. Volume 1 (D. Steinerand, ed.) pp 25-66. William, Wildins, Baltimore
    • (1972) Handbook of Physiology , vol.1 , pp. 25-66
    • Pictet, R.1    Rutter, W.J.2
  • 47
    • 0026518591 scopus 로고
    • Onset of cell-specific gene expression in the developing mouse pancreas
    • Gittes, G. K. and Rutter, W. J. (1992) Onset of cell-specific gene expression in the developing mouse pancreas. Proc. Natl. Acad. Sci. U.S.A. 89, 1128-1132
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 1128-1132
    • Gittes, G.K.1    Rutter, W.J.2
  • 48
    • 0034212388 scopus 로고    scopus 로고
    • Indian hedgehog signaling in extraembryonic endoderm and ectoderm differentiation in ES embryoid bodies
    • Maye, P., Becker, S., Kasameyer, E., Byrd, N. and Grabel, L. (2000) Indian hedgehog signaling in extraembryonic endoderm and ectoderm differentiation in ES embryoid bodies. Mech. Dev. 94, 117-132
    • (2000) Mech. Dev. , vol.94 , pp. 117-132
    • Maye, P.1    Becker, S.2    Kasameyer, E.3    Byrd, N.4    Grabel, L.5
  • 49
    • 0032573227 scopus 로고    scopus 로고
    • Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor
    • Kim, S. K. and Melton, D. A. (1998) Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor. Proc. Natl. Acad. Sci. U.S.A. 95, 13036-13041
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 13036-13041
    • Kim, S.K.1    Melton, D.A.2
  • 51
    • 0142243097 scopus 로고    scopus 로고
    • Combined activities of hedgehog signaling inhibitors regulate pancreas development
    • Kawahira, H., Ma, N. H., Tzanakakis, E. S., McMahon, A. P., Chuang, P. T. and Hebrok, M. (2003) Combined activities of hedgehog signaling inhibitors regulate pancreas development. Development 130, 4871-4879
    • (2003) Development , vol.130 , pp. 4871-4879
    • Kawahira, H.1    Ma, N.H.2    Tzanakakis, E.S.3    McMahon, A.P.4    Chuang, P.T.5    Hebrok, M.6
  • 52
    • 0033602043 scopus 로고    scopus 로고
    • Embryonic stem cell development in a chemically defined medium
    • Wiles, M. V. and Johansson, B. M. (1999) Embryonic stem cell development in a chemically defined medium. Exp. Cell Res. 247, 241-248
    • (1999) Exp. Cell Res. , vol.247 , pp. 241-248
    • Wiles, M.V.1    Johansson, B.M.2
  • 53
    • 0031916664 scopus 로고    scopus 로고
    • Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development
    • Miralles, F., Czernichow, P. and Scharfmann, R. (1998) Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development. Development 125, 1017-1024
    • (1998) Development , vol.125 , pp. 1017-1024
    • Miralles, F.1    Czernichow, P.2    Scharfmann, R.3
  • 54
    • 0037706944 scopus 로고    scopus 로고
    • Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate
    • Kumar, M., Jordan, N., Melton, D. and Grapin-Botton, A. (2003) Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate. Dev. Biol. 259, 109-122
    • (2003) Dev. Biol. , vol.259 , pp. 109-122
    • Kumar, M.1    Jordan, N.2    Melton, D.3    Grapin-Botton, A.4
  • 55
    • 0032991511 scopus 로고    scopus 로고
    • Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas
    • Miralles, F., Czernichow, P., Ozaki, K., Itoh, N. and Scharfmann, R. (1999) Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas. Proc. Natl. Acad. Sci. U.S.A. 96, 6267-6272
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 6267-6272
    • Miralles, F.1    Czernichow, P.2    Ozaki, K.3    Itoh, N.4    Scharfmann, R.5
  • 56
    • 0037133681 scopus 로고    scopus 로고
    • Role for FGFR2IIIb-mediated signals in controlling pancreatic endocrine progenitor cell proliferation
    • Elghazi, L., Cras-Meneur, C., Czernichow, P. and Scharfmann, R. (2002) Role for FGFR2IIIb-mediated signals in controlling pancreatic endocrine progenitor cell proliferation. Proc. Natl. Acad. Sci. U.S.A. 99, 3884-3889
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 3884-3889
    • Elghazi, L.1    Cras-Meneur, C.2    Czernichow, P.3    Scharfmann, R.4


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