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Volumn 10, Issue 10, 2004, Pages 3438-3443

Genetic and epigenetic changes in p21 and p21B do not correlate with resistance to doxorubicin or mitomycin and 5-fluorouracil in locally advanced breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; DNA; DOXORUBICIN; FLUOROURACIL; MITOMYCIN; PROTEIN P21; PROTEIN P21B; PROTEIN P53; UNCLASSIFIED DRUG;

EID: 2542465850     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-03-0796     Document Type: Article
Times cited : (22)

References (57)
  • 2
    • 0026756737 scopus 로고
    • Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase
    • Lin D, Shields MT, Ullrich SJ, Appella E, Mercer WE. Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase. Proc Natl Acad Sci USA 1992;89:9210-4.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 9210-9214
    • Lin, D.1    Shields, M.T.2    Ullrich, S.J.3    Appella, E.4    Mercer, W.E.5
  • 4
    • 0037013154 scopus 로고    scopus 로고
    • A senescence program controlled by p53 and p16(INK4a) contributes to the outcome of cancer therapy
    • Schmitt CA, Fridman JS, Yang M, et al. A senescence program controlled by p53 and p16(INK4a) contributes to the outcome of cancer therapy. Cell 2002;109:335-46.
    • (2002) Cell , vol.109 , pp. 335-346
    • Schmitt, C.A.1    Fridman, J.S.2    Yang, M.3
  • 6
    • 0032962588 scopus 로고    scopus 로고
    • Apoptosis and therapy
    • Schmitt CA, Lowe SW. Apoptosis and therapy. J Pathol 1999;187:127-37.
    • (1999) J Pathol , vol.187 , pp. 127-137
    • Schmitt, C.A.1    Lowe, S.W.2
  • 7
    • 0027944206 scopus 로고
    • P53 status and the efficacy of cancer-therapy in-vivo
    • Lowe SW, Bodis S, Mcclatchey A, et al. P53 status and the efficacy of cancer-therapy in-vivo. Science (Wash DC) 1994;266:807-10.
    • (1994) Science (Wash DC) , vol.266 , pp. 807-810
    • Lowe, S.W.1    Bodis, S.2    Mcclatchey, A.3
  • 8
    • 0029956081 scopus 로고    scopus 로고
    • Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients
    • Aas T, Borresen AL, Geisler S, et al. Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients. Nat Med 1996;2:811-4.
    • (1996) Nat Med , vol.2 , pp. 811-814
    • Aas, T.1    Borresen, A.L.2    Geisler, S.3
  • 9
    • 0033971806 scopus 로고    scopus 로고
    • TP53 mutation and p53 overexpression for prediction of response to neoadjuvant treatment in breast cancer patients
    • Kandioler-Eckersberger D, Ludwig C, Rudas M, et al. TP53 mutation and p53 overexpression for prediction of response to neoadjuvant treatment in breast cancer patients. Clin Cancer Res 2000;6:50-6.
    • (2000) Clin Cancer Res , vol.6 , pp. 50-56
    • Kandioler-Eckersberger, D.1    Ludwig, C.2    Rudas, M.3
  • 10
    • 0344198117 scopus 로고    scopus 로고
    • TP53 gene mutations predict the response to neoadjuvant treatment with 5-fluorouracil and mitomycin in locally advanced breast cancer
    • Geisler S, Børresen-Dale AL, Johnsen H, et al. TP53 gene mutations predict the response to neoadjuvant treatment with 5-fluorouracil and mitomycin in locally advanced breast cancer. Clin Cancer Res 2003;9:5582-4.
    • (2003) Clin Cancer Res , vol.9 , pp. 5582-5584
    • Geisler, S.1    Børresen-Dale, A.L.2    Johnsen, H.3
  • 11
    • 0035866772 scopus 로고    scopus 로고
    • Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced breast cancer
    • Geisler S, Lonning PE, Aas T, et al. Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced breast cancer. Cancer Res 2001;61:2505-12.
    • (2001) Cancer Res , vol.61 , pp. 2505-2512
    • Geisler, S.1    Lonning, P.E.2    Aas, T.3
  • 12
    • 0037338906 scopus 로고    scopus 로고
    • Study of suboptimum treatment response: Lessons from breast cancer
    • Lønning P. Study of suboptimum treatment response: lessons from breast cancer. Lancet Oncol 2003;4:177-85.
    • (2003) Lancet Oncol , vol.4 , pp. 177-185
    • Lønning, P.1
  • 13
    • 12244252332 scopus 로고    scopus 로고
    • Predictive value of tumour cell proliferation in locally advanced breast cancer treated with neoadjuvant chemotherapy
    • Aas T, Geisler S, Eide GE, et al. Predictive value of tumour cell proliferation in locally advanced breast cancer treated with neoadjuvant chemotherapy. Eur J Cancer 2003;39:438-46.
    • (2003) Eur J Cancer , vol.39 , pp. 438-446
    • Aas, T.1    Geisler, S.2    Eide, G.E.3
  • 14
    • 0032984992 scopus 로고    scopus 로고
    • Mechanisms of p53-mediated apoptosis
    • Bates S, Vousden KH. Mechanisms of p53-mediated apoptosis. Cell Mol Life Sci 1999;55:28-37.
    • (1999) Cell Mol Life Sci , vol.55 , pp. 28-37
    • Bates, S.1    Vousden, K.H.2
  • 15
    • 0029063745 scopus 로고
    • Cell-cycle inhibition by independent Cdk and PCNA binding domains in P21(Cip1)
    • Luo Y, Hurwitz J, Massague J. Cell-cycle inhibition by independent Cdk and PCNA binding domains in P21(Cip1). Nature (Lond) 1995;375:159-61.
    • (1995) Nature (Lond) , vol.375 , pp. 159-161
    • Luo, Y.1    Hurwitz, J.2    Massague, J.3
  • 16
    • 0028978183 scopus 로고
    • Mice lacking P21(C/P1/Waf1) undergo normal development, but are defective in G1 checkpoint control
    • Deng CX, Zhang PM, Harper JW, Elledge SJ, Leder P. Mice lacking P21(C/P1/Waf1) undergo normal development, but are defective in G1 checkpoint control. Cell 1995;82:675-84.
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.X.1    Zhang, P.M.2    Harper, J.W.3    Elledge, S.J.4    Leder, P.5
  • 18
    • 0028220204 scopus 로고
    • P53-dependent inhibition of cyclin-dependent kinase-activities in human fibroblasts during radiation-induced G1 arrest
    • Dulic V, Kaufmann WK, Wilson SJ, et al. P53-dependent inhibition of cyclin-dependent kinase-activities in human fibroblasts during radiation-induced G1 arrest. Cell 1994;76:1013-23.
    • (1994) Cell , vol.76 , pp. 1013-1023
    • Dulic, V.1    Kaufmann, W.K.2    Wilson, S.J.3
  • 19
    • 0033559264 scopus 로고    scopus 로고
    • The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
    • Cheng MG, Olivier P, Diehl JA, et al. The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J 1999;18:1571-83.
    • (1999) EMBO J , vol.18 , pp. 1571-1583
    • Cheng, M.G.1    Olivier, P.2    Diehl, J.A.3
  • 20
    • 0027731971 scopus 로고
    • Inhibition of Cdk2 activity in-vivo by an associated 20k regulatory subunit
    • Gu Y, Turck CW, Morgan DO. Inhibition of Cdk2 activity in-vivo by an associated 20k regulatory subunit. Nature (Lond) 1993;366:707-10.
    • (1993) Nature (Lond) , vol.366 , pp. 707-710
    • Gu, Y.1    Turck, C.W.2    Morgan, D.O.3
  • 21
    • 0027496935 scopus 로고
    • The P21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The P21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993;75:805-16.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 22
    • 0028988585 scopus 로고
    • Inhibitors of mammalian G(1) cyclin-dependent kinases
    • Sherr CJ, Roberts JM. Inhibitors of mammalian G(1) cyclin-dependent kinases. Genes Dev 1995;9:1149-63.
    • (1995) Genes Dev , vol.9 , pp. 1149-1163
    • Sherr, C.J.1    Roberts, J.M.2
  • 23
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G(1)-phase progression
    • Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G(1)-phase progression. Genes Dev 1999;13:1501-12.
    • (1999) Genes Dev , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 25
    • 0031594705 scopus 로고    scopus 로고
    • Nuclear accumulation of p21(Cip1) the onset of mitosis: A role at the G(2)/M-phase transition
    • Dulic V, Stein GH, Far DF, Reed SI. Nuclear accumulation of p21(Cip1) the onset of mitosis: a role at the G(2)/M-phase transition. Mol Cell Biol 1998;18:546-57.
    • (1998) Mol Cell Biol , vol.18 , pp. 546-557
    • Dulic, V.1    Stein, G.H.2    Far, D.F.3    Reed, S.I.4
  • 26
    • 0032576632 scopus 로고    scopus 로고
    • p21(waf1) can block cells at two points in the cell cycle, but does not interfere with processive DNA-replication or stress-activated kinases
    • Medema RH, Klompmaker R, Smits VAJ, Rijksen G. p21(waf1) can block cells at two points in the cell cycle, but does not interfere with processive DNA-replication or stress-activated kinases. Oncogene 1998;16:431-41.
    • (1998) Oncogene , vol.16 , pp. 431-441
    • Medema, R.H.1    Klompmaker, R.2    Smits, V.A.J.3    Rijksen, G.4
  • 27
    • 0031961995 scopus 로고    scopus 로고
    • Effects of p21(Cip1/Waf1) at both the G(1)/S and the G(2)/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication
    • Niculescu AB, Chen XB, Smeets M, Hengst L, Prives C, Reed SI. Effects of p21(Cip1/Waf1) at both the G(1)/S and the G(2)/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol 1998;18:629-43.
    • (1998) Mol Cell Biol , vol.18 , pp. 629-643
    • Niculescu, A.B.1    Chen, X.B.2    Smeets, M.3    Hengst, L.4    Prives, C.5    Reed, S.I.6
  • 28
    • 0037075228 scopus 로고    scopus 로고
    • p21B, a variant of p21(Waf1/Cip1), is induced by the p53 family
    • Nozell S, Chen X. p21B, a variant of p21(Waf1/Cip1), is induced by the p53 family. Oncogene 2002;21:1285-94.
    • (2002) Oncogene , vol.21 , pp. 1285-1294
    • Nozell, S.1    Chen, X.2
  • 29
    • 0034046395 scopus 로고    scopus 로고
    • Inhibition of the interferon-gamma/signal transducers and activators of transcription (STAT) pathway by hypermethylation at a STAT-binding site in the p21(WAF1) promoter region
    • Chen B, He L, Savell VH, Jenkins JJ, Parham DM. Inhibition of the interferon-gamma/signal transducers and activators of transcription (STAT) pathway by hypermethylation at a STAT-binding site in the p21(WAF1) promoter region. Cancer Res 2000;60:3290-8.
    • (2000) Cancer Res , vol.60 , pp. 3290-3298
    • Chen, B.1    He, L.2    Savell, V.H.3    Jenkins, J.J.4    Parham, D.M.5
  • 30
    • 0030814105 scopus 로고    scopus 로고
    • Absence of p21 expression is associated with abnormal p53 in human breast carcinomas
    • Ellis PA, Lonning PE, Borresen-Dale A, et al. Absence of p21 expression is associated with abnormal p53 in human breast carcinomas. Br J Cancer 1997;76:480-5.
    • (1997) Br J Cancer , vol.76 , pp. 480-485
    • Ellis, P.A.1    Lonning, P.E.2    Borresen-Dale, A.3
  • 31
    • 0029745148 scopus 로고    scopus 로고
    • Mutational analysis of the p21/WAF1/CIP1/SDI1 coding region in human tumor cell lines
    • Terry LA, Boyd J, Alcorta D, et al. Mutational analysis of the p21/WAF1/CIP1/SDI1 coding region in human tumor cell lines. Mol Carcinog 1996;16:221-8.
    • (1996) Mol Carcinog , vol.16 , pp. 221-228
    • Terry, L.A.1    Boyd, J.2    Alcorta, D.3
  • 32
    • 0028852067 scopus 로고
    • Multiple polymorphisms, but no mutations, in the Waf1/Cip1 gene in human brain-tumors
    • Koopmann J, Maintz D, Schild S, et al. Multiple polymorphisms, but no mutations, in the Waf1/Cip1 gene in human brain-tumors. Br J Cancer 1995;72:1230-3.
    • (1995) Br J Cancer , vol.72 , pp. 1230-1233
    • Koopmann, J.1    Maintz, D.2    Schild, S.3
  • 33
    • 0028881595 scopus 로고
    • Polymorphisms and probable lack of mutation in the Waf1-Cip1 gene in colorectal-cancer
    • Li YJ, Laurentpuig P, Salmon RJ, Thomas G, Hamelin R. Polymorphisms and probable lack of mutation in the Waf1-Cip1 gene in colorectal-cancer. Oncogene 1995;10:599-601.
    • (1995) Oncogene , vol.10 , pp. 599-601
    • Li, Y.J.1    Laurentpuig, P.2    Salmon, R.J.3    Thomas, G.4    Hamelin, R.5
  • 34
    • 0033750793 scopus 로고    scopus 로고
    • Polymorphisms of p21 cyclin-dependent kinase inhibitor and malignant skin tumors
    • Konishi R, Sakatani S, Kiyokane K, Suzuki K. Polymorphisms of p21 cyclin-dependent kinase inhibitor and malignant skin tumors. J Dermatol Sci 2000;24:177-83.
    • (2000) J Dermatol Sci , vol.24 , pp. 177-183
    • Konishi, R.1    Sakatani, S.2    Kiyokane, K.3    Suzuki, K.4
  • 35
    • 6544264448 scopus 로고    scopus 로고
    • Analysis of the p21 gene in gliomas
    • Li YJ, Khe HX, Zhou XP, et al. Analysis of the p21 gene in gliomas. J Neurooncol 1998;40:107-11.
    • (1998) J Neurooncol , vol.40 , pp. 107-111
    • Li, Y.J.1    Khe, H.X.2    Zhou, X.P.3
  • 36
    • 0034662959 scopus 로고    scopus 로고
    • A role for transcriptional repression of p21(CIP1) by c-Myc in overcoming transforming growth factor beta-induced cell-cycle arrest
    • Claassen GF, Hann SR. A role for transcriptional repression of p21(CIP1) by c-Myc in overcoming transforming growth factor beta-induced cell-cycle arrest. Proc Natl Acad Sci USA 2000;97:9498-503.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 9498-9503
    • Claassen, G.F.1    Hann, S.R.2
  • 37
    • 0037461931 scopus 로고    scopus 로고
    • Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter
    • Wu SQ, Cetinkaya C, Munoz-Alonso MJ, et al. Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter. Oncogene 2003;22:351-60.
    • (2003) Oncogene , vol.22 , pp. 351-360
    • Wu, S.Q.1    Cetinkaya, C.2    Munoz-Alonso, M.J.3
  • 38
    • 0035011486 scopus 로고    scopus 로고
    • Integrating Myc and TGF-beta signalling in cell-cycle control
    • Amati B. Integrating Myc and TGF-beta signalling in cell-cycle control. Nat Cell Biol 2001;3:E112-3.
    • (2001) Nat Cell Biol , vol.3
    • Amati, B.1
  • 39
    • 0029923780 scopus 로고    scopus 로고
    • Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21(WAF1/CIP1) mediated by STAT1
    • Chin YE, Kitagawa M, Su WCS, You ZH, Iwamoto Y, Fu XY. Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21(WAF1/CIP1) mediated by STAT1. Science (Wash DC) 1996;272:719-22.
    • (1996) Science (Wash DC) , vol.272 , pp. 719-722
    • Chin, Y.E.1    Kitagawa, M.2    Su, W.C.S.3    You, Z.H.4    Iwamoto, Y.5    Fu, X.Y.6
  • 40
    • 0032704902 scopus 로고    scopus 로고
    • The protein SET regulates the inhibitory effect of p21(Cip1) cyclin E-cyclin-dependent kinase 2 activity
    • Estanyol JM, Jaumot M, Casanovas O, et al. The protein SET regulates the inhibitory effect of p21(Cip1) cyclin E-cyclin-dependent kinase 2 activity. J Biol Chem 1999;274:33161-5.
    • (1999) J Biol Chem , vol.274 , pp. 33161-33165
    • Estanyol, J.M.1    Jaumot, M.2    Casanovas, O.3
  • 41
    • 0034745353 scopus 로고    scopus 로고
    • Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
    • Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol 2001;3:245-52.
    • (2001) Nat Cell Biol , vol.3 , pp. 245-252
    • Zhou, B.P.1    Liao, Y.2    Xia, W.3    Spohn, B.4    Lee, M.H.5    Hung, M.C.6
  • 42
    • 0037079027 scopus 로고    scopus 로고
    • Cyclin E and survival in patients with breast cancer
    • Keyomarsi K, Tucker SL, Buchholz TA, et al. Cyclin E and survival in patients with breast cancer. N Engl J Med 2002;347:1566-75.
    • (2002) N Engl J Med , vol.347 , pp. 1566-1575
    • Keyomarsi, K.1    Tucker, S.L.2    Buchholz, T.A.3
  • 43
    • 0037063165 scopus 로고    scopus 로고
    • The cyclin D1 high and cyclin E high subgroups of breast cancer: Separate pathways in tumorogenesis based on pattern of genetic aberrations and inactivation of the pRb node
    • Loden M, Sfighall M, Nielsen NH, et al. The cyclin D1 high and cyclin E high subgroups of breast cancer: separate pathways in tumorogenesis based on pattern of genetic aberrations and inactivation of the pRb node. Oncogene 2002;21:4680-90.
    • (2002) Oncogene , vol.21 , pp. 4680-4690
    • Loden, M.1    Sfighall, M.2    Nielsen, N.H.3
  • 44
    • 1442348266 scopus 로고    scopus 로고
    • Genes causing inherited cancer as beacons to identify the mechanisms of chemoresistance
    • Lonning PE. Genes causing inherited cancer as beacons to identify the mechanisms of chemoresistance. Trends Mol Med 2004;10:113-8.
    • (2004) Trends Mol Med , vol.10 , pp. 113-118
    • Lonning, P.E.1
  • 45
    • 0029666272 scopus 로고    scopus 로고
    • Functional analysis of a p21(WAF1,CIP1,SDI1) mutant (Arg(94)→Trp) identified in a human breast carcinoma-evidence that the mutation impairs the ability of p21 to inhibit cyclin-dependent kinases
    • Balbin M, Hannon GJ, Pendas AM, et al. Functional analysis of a p21(WAF1,CIP1,SDI1) mutant (Arg(94)→Trp) identified in a human breast carcinoma-evidence that the mutation impairs the ability of p21 to inhibit cyclin-dependent kinases. J Biol Chem 1996;271:15782-6.
    • (1996) J Biol Chem , vol.271 , pp. 15782-15786
    • Balbin, M.1    Hannon, G.J.2    Pendas, A.M.3
  • 46
    • 0030861086 scopus 로고    scopus 로고
    • Altered WAF1 genes do not play a role in abnormal cell cycle regulation in breast cancers lacking p53 mutations
    • McKenzie KE, Siva A, Maier S, Runnebaum IB, Seshadri R, Sukumar S. Altered WAF1 genes do not play a role in abnormal cell cycle regulation in breast cancers lacking p53 mutations. Clin Cancer Res 1997;3:1669-73.
    • (1997) Clin Cancer Res , vol.3 , pp. 1669-1673
    • McKenzie, K.E.1    Siva, A.2    Maier, S.3    Runnebaum, I.B.4    Seshadri, R.5    Sukumar, S.6
  • 47
    • 0030986630 scopus 로고    scopus 로고
    • Association between human cancer and two polymorphisms occurring together in the p21(Waf1/Cip1) cyclin-dependent kinase inhibitor gene
    • Facher EA, Becich MJ, Deka A, Law JC. Association between human cancer and two polymorphisms occurring together in the p21(Waf1/Cip1) cyclin-dependent kinase inhibitor gene. Cancer (Phila) 1997;79:2424-9.
    • (1997) Cancer (Phila) , vol.79 , pp. 2424-2429
    • Facher, E.A.1    Becich, M.J.2    Deka, A.3    Law, J.C.4
  • 48
    • 0031025745 scopus 로고    scopus 로고
    • Decreased expression and rare somatic mutation of the CIP1/WAF1 gene in human hepatocellular carcinoma
    • Furutani M, Arii S, Tanaka H, et al. Decreased expression and rare somatic mutation of the CIP1/WAF1 gene in human hepatocellular carcinoma. Cancer Lett 1997;111:191-7.
    • (1997) Cancer Lett , vol.111 , pp. 191-197
    • Furutani, M.1    Arii, S.2    Tanaka, H.3
  • 49
    • 0028845577 scopus 로고
    • Somatic mutations of the Waf1/Cip1 gene in primary prostate-cancer
    • Gao X, Chen YQ, Wu N, et al. Somatic mutations of the Waf1/Cip1 gene in primary prostate-cancer. Oncogene 1995;11:1395-8.
    • (1995) Oncogene , vol.11 , pp. 1395-1398
    • Gao, X.1    Chen, Y.Q.2    Wu, N.3
  • 50
    • 0036330134 scopus 로고    scopus 로고
    • Mutations of the cell cycle arrest gene p21 (WAF1), but not the metastasis-inducing gene S100A4, are frequent in oral squamous cell carcinomas from Sudanese toombak dippers and non-snuff-dippers from the Sudan, Scandinavia, USA and UK
    • Ibrahim SO, Lillehaug JR, Dolphine O, Johnson NW, Wamakulasuriya KA, Vasstrand EN. Mutations of the cell cycle arrest gene p21 (WAF1), but not the metastasis-inducing gene S100A4, are frequent in oral squamous cell carcinomas from Sudanese toombak dippers and non-snuff-dippers from the Sudan, Scandinavia, USA and UK. Anticancer Res 2002;22:1445-51.
    • (2002) Anticancer Res , vol.22 , pp. 1445-1451
    • Ibrahim, S.O.1    Lillehaug, J.R.2    Dolphine, O.3    Johnson, N.W.4    Wamakulasuriya, K.A.5    Vasstrand, E.N.6
  • 51
    • 0031052558 scopus 로고    scopus 로고
    • A somatic mutation of the p21 ((Waf1/Cip1)) gene in a human adrenocortical adenoma
    • Iida S, Fujii H, Mofiwaki K. A somatic mutation of the p21 ((Waf1/Cip1)) gene in a human adrenocortical adenoma. Anticancer Res 1997;17:633-6.
    • (1997) Anticancer Res , vol.17 , pp. 633-636
    • Iida, S.1    Fujii, H.2    Mofiwaki, K.3
  • 52
    • 0030320521 scopus 로고    scopus 로고
    • Analysis of p21(WAF1/CIP1) in primary bladder tumors
    • Lacombe L, Orlow I, Silver D, et al. Analysis of p21(WAF1/CIP1) in primary bladder tumors. Oncol Res 1996;8:409-14.
    • (1996) Oncol Res , vol.8 , pp. 409-414
    • Lacombe, L.1    Orlow, I.2    Silver, D.3
  • 54
    • 0035290797 scopus 로고    scopus 로고
    • Polymorphism of the WAF1 gene is related to susceptibility to cervical cancer in Japanese women
    • Harima Y, Sawada S, Nagata K, Sougawa M, Ostapenko V, Ohnishi T. Polymorphism of the WAF1 gene is related to susceptibility to cervical cancer in Japanese women. Int J Mol Medi 2001;7:261-4.
    • (2001) Int J Mol Medi , vol.7 , pp. 261-264
    • Harima, Y.1    Sawada, S.2    Nagata, K.3    Sougawa, M.4    Ostapenko, V.5    Ohnishi, T.6
  • 55
    • 0034054802 scopus 로고    scopus 로고
    • Lack of evidence of association of p21(WAF1/CIP1) polymorphism with lung cancer susceptibility and prognosis in Taiwan
    • Shih CM, Lin PT, Wang HC, Huang WC, Wang YC. Lack of evidence of association of p21(WAF1/CIP1) polymorphism with lung cancer susceptibility and prognosis in Taiwan. Jpn J Cancer Res 2000;91:9-15.
    • (2000) Jpn J Cancer Res , vol.91 , pp. 9-15
    • Shih, C.M.1    Lin, P.T.2    Wang, H.C.3    Huang, W.C.4    Wang, Y.C.5
  • 56
    • 0036244990 scopus 로고    scopus 로고
    • Correlation of p21 gene codon 31 polymorphism and TNF-alpha gene polymorphism with nasopharyngeal carcinoma
    • Tsai MH, Chen WC, Tsai FJ. Correlation of p21 gene codon 31 polymorphism and TNF-alpha gene polymorphism with nasopharyngeal carcinoma. J Clin Lab Anal 2002;16:146-50.
    • (2002) J Clin Lab Anal , vol.16 , pp. 146-150
    • Tsai, M.H.1    Chen, W.C.2    Tsai, F.J.3
  • 57
    • 0034945274 scopus 로고    scopus 로고
    • p21 gene codon 31 arginine/serine polymorphism: Non-association with endometriosis
    • Hsieh YY, Tsai FJ, Chang CC, et al. p21 gene codon 31 arginine/serine polymorphism: non-association with endometriosis. J Clin Lab Anal 2001;15:184-7.
    • (2001) J Clin Lab Anal , vol.15 , pp. 184-187
    • Hsieh, Y.Y.1    Tsai, F.J.2    Chang, C.C.3


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