Functional analysis of a p21(WAF1,CIP1,SDI1) mutant (Arg94 → Trp) identified in a human breast carcinoma. Evidence that the mutation impairs the ability of p21 to inhibit cyclin-dependent kinases

Journal of Biological Chemistry

Volumn 271, Issue 26, 1996, Pages 15782-15786

  Balbín, Milagros ^a   Hannon, Gregory J ^b   Pendás, Alberto M ^a   Ferrando, Adolfo A ^a   Vizoso, Francisco ^c   Fueyo, Antonio ^a   López Otín, Carlos ^a  

^a UNIVERSIDAD DE OVIEDO   (Spain)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c HOSPITAL DE JOVE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLINE; PROTEIN P21; ARGININE; CDKN1A PROTEIN, HUMAN; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1A; ONCOPROTEIN; PRIMER DNA; TRYPTOPHAN;

AMINO ACID SEQUENCE; ARTICLE; BREAST CARCINOMA; CELL CYCLE; CELL PROLIFERATION; ENZYME INHIBITION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; BREAST TUMOR; CHEMISTRY; DRUG ANTAGONISM; FEMALE; GENETICS; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PAGET NIPPLE DISEASE; POINT MUTATION; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION;

EUKARYOTA; PROKARYOTA;

ARGININE; BASE SEQUENCE; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CELL CYCLE; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA PRIMERS; FEMALE; HUMANS; MOLECULAR SEQUENCE DATA; ONCOGENE PROTEINS; POINT MUTATION; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN;

EID: 0029666272     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.26.15782     Document Type: Article

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