Design, synthesis, and biological evaluation of novel 7-azaindolyl- heteroaryl-maleimides as potent and selective glycogen synthase kinase-3β (GSK-3β) inhibitors

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 12, 2004, Pages 3167-3185

  O'Neill, David J ^a   Shen, Lan ^a   Prouty, Catherine ^a   Conway, Bruce R ^a   Westover, Lori ^a   Xu, Jun Z ^a   Zhang, Han Cheng ^b   Maryanoff, Bruce E ^b   Murray, William V ^a   Demarest, Keith T ^a   Kuo, Gee Hong ^a  

^a Drug Discovery Raritan   (United States)

^b Drug Discovery   (United States)

Author keywords

Azaindolemaleimide; Cross coupling; Highly selective inhibitor; Kinase

Indexed keywords

3 (1 BENZYL 1H PYRROLO[2,3 B]PYRIDIN 3 YL) 4 (2,4 DIMETHOXYPYRIMIDIN 5 YL)PYRROLE 2,5 DIONE; 3 (2,4 DIMETHOXYPYRIMIDIN 5 YL) 4 (1 PHENETHYL 1H PYRROLO[2,3 B]PYRIDIN 3 YL]PYRROLE 2,5 DIONE; 3 (2,4 DIMETHOXYPYRIMIDIN 5 YL) 4 [1 (3 HYDROXYPROPYL) 1H PYRROLO[2,3 B]PYRIDIN 3 YL]PYRROLE 2,5 DIONE; 3 (2,4 DIMETHOXYPYRIMIDIN 5 YL) 4 [1 (3 PHENYLOXYPROPYL) 1H PYRROLO[2,3 B]PYRIDIN 3 YL]PYRROLE 2,5 DIONE; 3 (2,4 DIMETHOXYPYRIMIDIN 5 YL) 4 [1 (3 PHENYLPROPYL) 1H PYRROLO[2,3 B]PYRIDIN 3 YL]PYRROLE 2,5 DIONE; 3 (3,5 DIMETHYLISOXAZOL 4 YL) 4 [1 (3 HYDROXYPROPYL) 1H PYRROLO[2,3 B]PYRIDIN 3 YL]PYRROLE 2,5 DIONE; 3 [1 (2 HYDROXYETHYL) 1H IMIDAZOL 4 YL] 4 [1 (3 HYDROXYPROPYL) 1H PYRROLO[2,3 B]PYRIDIN] 1H PYRROLE 2,5 DIONE; 3 [1 (3 HYDROXYPROPYL) 1H IMIDAZOL 4 YL] 4 [1 (3 HYDROXYPROPYL) 1H PYRROLO[2,3 B]PYRIDIN 3 YL] 1H PYRROLE 2,5 DIONE; 3 [1 (3 HYDROXYPROPYL) 1H PYRROLO[2,3 B]PYRIDIN 3 YL] 4 (1 METHYL 1H PYRAZOL 3 YL) 1H PYRROLE 2,5 DIONE; 3 [1 (3 HYDROXYPROPYL) 1H PYRROLO[2,3 B]PYRIDIN 3 YL] 4 (1 METHYL 1H PYRAZOL 4 YL)PYRROLE 2,5 DIONE; 3 [1 (3 HYDROXYPROPYL) 1H PYRROLO[2,3 B]PYRIDIN 3 YL] 4 (2 METHYL 2H PYRAZOL 3 YL)PYRROLE 2,5 DIONE; 3 [1 (3 HYDROXYPROPYL) 1H PYRROLO[2,3 B]PYRIDIN 3 YL] 4 PYRAZIN 2 YLPYRROLE 2,5 DIONE; 3 [1 (3 HYDROXYPROPYL) 1H PYRROLO[2,3 B]PYRIDIN 3 YL] 4 PYRIMIDIN 2 YLPYRROLE 2,5 DIONE; 3 [1 (3 HYDROXYPROPYL) 1H PYRROLO[2,3 B]PYRIDIN 3 YL] 4 PYRIMIDIN 5 YLPYRROLE 2,5 DIONE; 3 [1 (3 HYDROXYPROPYL) 1H PYRROLO[2,3 B]PYRIDIN 3 YL] 4 THIAZOL 2 YLPYRROLE 2,5 DIONE; 3 [1 (3 HYDROXYPROPYL) 1H PYRROLO[2,3]PYRIDIN 3 YL] 4 (1H IMIDAZOL 2 YL) 1H PYRROLE 2,5 DIONE; 3 [1 (3 PHENYLPROPYL) 1H PYRROLO[2,3 B]PYRIDIN 3 YL] 4 PYRIMIDIN 5 YLPYRROLE 2,5 DIONE; 3 FURAN 2 YL 4 [1 (3 HYDROXYPROPYL) 1H PYRROLO[2,3 B]PYRIDIN 3 YL]PYRROLE 2,5 DIONE; 3 FURAN 3 YL 4 [1 (3 HYDROXYPROPYL) 1H PYRROLO[2,3 B]PYRIDIN 3 YL]PYRROLE 2,5 DIONE; 4 [1 (3 HYDROXYPROPYL) 1H PYRROLO[2,3 B]PYRIDIN 3 YL] 1' METHYL 1'H [3,3']BIPYRROLYL 2,5 DIONE; 4 [1 (3 HYDROXYPROPYL) 1H PYRROLO[2,3 B]PYRIDIN 3 YL][3,3' BI 1H PYRROLE] 2,5 DIONE; 4 [3 (2,5 DIOXO 4 PYRAZIN 2 YL 2,5 DIHYDRO 1H PYRROL 3 YL)PYRROLO[2,3 B]PYRIDIN 1 YL]BUTYRONITRILE; 4 [3 [4 (1 METHYL 1H PYRAZOL 3 YL) 2,5 DIOXO 2,5 DIHYDRO 1H PYRROL 3 YL]PYRROLO[2,3 B]PYRIDIN 1YL]BUTYRONITRILE; 4 [3 [4 (2,4 DIMETHOXYPYRIMIDIN 5 YL) 2,5 DIOXO 2,5 DIHYDRO 1H PYRROL 3 YL]PYRROLO[2,3 B]PYRIDIN 1 YL]BUTYRONITRILE; GLYCOGEN SYNTHASE KINASE 3BETA; GLYCOGEN SYNTHASE KINASE 3BETA INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CELL LINE; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ASSAY; HUMAN; HUMAN CELL; LIVER MICROSOME; POLYMERIZATION; STILLE REACTION; SUZUKI REACTION;

ANIMALS; AZA COMPOUNDS; CELL LINE; DRUG DESIGN; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MALEIMIDES; MICROSOMES, LIVER; MOLECULAR STRUCTURE; RABBITS; SUBSTRATE SPECIFICITY;

LATEOLABRAX JAPONICUS;

EID: 2542434120     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.04.010     Document Type: Article

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