Synthesis and biological evaluation of novel macrocyclic bis-7-azaindolylmaleimides as potent and highly selective glycogen synthase kinase-3β (GSK-3β) inhibitors

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 5, 2004, Pages 1239-1255

  Shen, Lan ^a   Prouty, Catherine ^a   Conway, Bruce R ^a   Westover, Lori ^a   Xu, Jun Z ^a   Look, Richard A ^a   Chen, Xin ^a   Beavers, Mary Pat ^a   Roberts, Jerry ^a   Murray, William V ^a   Demarest, Keith T ^a   Kuo, Gee Hong ^a  

^a Drug Discovery Raritan   (United States)

Author keywords

Azaindolemaleimide; Coupling; Cross x11dummy; Kinase; Specific inhibitor

Indexed keywords

6,7,8,13,14,15 HEXAHYDRO 9,12 EPITHIO 5,25:16,21 DIMETHENODIPYRIDO[2,3 B:3',2' H]PYRROLO[3,4 E][1,10]DIAZACYCLOTRICOSINE 22,24(23H) DIONE; 7 AZAINDOLYLMALEIMIDE DERIVATIVE; 7,8,9,10,11,12,13,14 OCTAHYDRO 10 HYDROXY 6H,21H 5,24:15,20 DIMETHENODIPYRIDO[2,3 B:3',2' H]PYRROLO[3,4 E][1,10]DIAZACYCLONONADECINE 21,23(22H) DIONE; 7,8,9,11,12,13,14 HEPTAHYDRO 6H,21H 5,24:15,20 DIMETHENODIPYRIDO[2,3 B:3',2' H]PYRROLO[3,4 E][1,10]DIAZACYCLONONADECINE 10,21,23(22H) TRIONE; AZAINDOLYLMALEIMIDE DERIVATIVE; CROWN ETHER DERIVATIVE; CYCLIN DEPENDENT KINASE 2; ENZYME INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA INHIBITOR; MACROCYCLIC COMPOUND; MALEIMIDE DERIVATIVE; NITROGEN; OXYGEN; PALLADIUM; PROTEIN KINASE; PROTEIN KINASE C BETA; THIOPHENE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CROSS COUPLING REACTION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; SIGNAL TRANSDUCTION;

EID: 10744228214     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.09.047     Document Type: Article

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