Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in mouse liver lowers blood glucose by suppressing hepatic glucose production

Journal of Clinical Investigation

Volumn 107, Issue 1, 2001, Pages 91-98

  Wu, Chaodong ^a   Okar, David A ^a   Newgard, Christopher B ^b   Lange, Alex J ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 PHOSPHOFRUCTO 2 KINASE; FRUCTOSE 2,6 BISPHOSPHATASE;

ANIMAL TISSUE; ARTICLE; DIABETES MELLITUS; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0035160650     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI11103     Document Type: Article

References (48)

1. Fructose 2,6-bisphosphate. A new activator of phosphofructokinase
2. The structure of "activation factor" for phosphofructokinase
3. Fructose 2,6-bisphosphate, the probable structure of the glucose and glucagon-sensitive stimulator of phosphofructokinase
4. Hormonal regulation of hepatic gluconeogenesis and glycolysis
5. Differential effects of proteolysis and protein modification on the activities of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
6. Fructose-2,6-bisphosphate and control of carbohydrate metabolism in eukaryotes
7. Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-bisphosphate
8. Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-biphosphate
9. Rat hepatic 6-phosphofructo 2-kinase/fructose 2,6bisphosphatase: A unique bifunctional enzyme
10. Phosphofructokinase-2: The enzyme that forms fructose-2,6-bisphosphate from fructose-6-phosphate and ATP
11. 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: A metabolic signaling enzyme
12. Glucose-stimulated synthesis of fructose 2,6-bisphosphate in rat liver: Dephosphorylation of fructose 6-phosphate, 2-kinase:fructose 2,6-bisphospharase and activation by a sugar phosphate
13. Regulation by glucagon of hepatic pyruvate kinase, 6-phosphofrucro 1-kinase, and fructose-1,6-bisphospharase
14. Hormonal modulation of key hepatic regulatory enzymes in the gluconeogenic/glycolytic pathway
15. Rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphospharase. Properties of phospho- and dephospho- forms and of two mutants in which Ser32 has been changed by site-directed mutagenesis
16. Hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Use of site-directed mutagenesis to evaluate the roles of His-258 and His-392 in catalysis
17. 2 levels
18. Regulation of glucose production by the liver
19. Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo
20. Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes
21. Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus
22. 3H] glucose. Differences in the apparent pattern of insulin resistance depending on the isotope used
23. Lilly lecture 1987. The triumvirate: Beta-cell, muscle, liver. A collusion responsible for NIDDM
24. The 6-phospho-2-kinase/fructose-2,6-bisphosphatase system: Regulation by insulin and an insulinomimetic approach to lowering blood glucose levels
25. Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice
26. Metabolic impact of glucokinase overexpression in liver: Lowering of blood glucose in fed rats is accompanied by hyperlipidemia
27. Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats
28. Isolation of a cDNA for the catalytic subunit of rat liver glucose-6-phosphatase: Regulation of gene expression in FAO hepatoma cells by insulin, dexamethasone and cAMP
29. CS-045, a new oral antidiabetic agent, stimulates fructose-2,6-bisphosphate production in rat hepatocytes
30. A kinetic study of pyrophosphate: Fructose-6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose-2,6-bisphosphate
31. Methods for animal tissues and micro-organisms
32. Glycogen determination with amyloglucosidase
33. Use of recombinant adenovirus for metabolic engineering of mammalian cells
34. Metabolic engineering with recombinant adenoviruses
35. Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen
36. Induction of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase mRNA by refeeding and insulin
37. 13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus
38. Effect of diabetes, insulin, starvation, and refeeding on the level of rat hepatic fructose 2,6-bisphosphate
39. Insulin-like effects of vanadate on glucokinase activity, and fructose 2,6-bisphosphate levels in the liver of diabetic rats
40. Insulin-like effects of vanadate on rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase mRNA and protein inductions in diabetic rats
41. Oral administration of vanadate to diabetic rats restores liver 6-phosphofructo-2-kinase content and mRNA
42. Insulinlike effects of vanadate on hepatic glycogen metabolism in nondiabetic and streptozocin-induced diabetic rats
43. Insulin-like actions of tungstate in diabetic rats. Normalization of hepatic glucose metabolism
44. In vivo effects of vanadate on hepatic glycogen metabolizing and lipogenic enzymes in insulin-dependent and insulin-resistant diabetic animals
45. Adenovirus-mediated transfer of a modified human proinsulin gene reverses hyperglycemia in diabetic mice
46. Correction of diabetic alterations by glucokinase
47. Evidence for a role of glucose-induced translocation of glucokinase in the control of hepatic glycogen synthesis
48. Glucose-6-phosphatase overexpression lowers glucose 6-phosphate and inhibits glycogen synthesis and glycolysis in hepatocytes without affecting glucokinase translocation. Evidence against feedback inhibition of glucokinase