Unraveling the chromosomal aberrations of head and neck squamous cell carcinoma: A review

Annals of Surgical Oncology

Volumn 12, Issue 10, 2005, Pages 831-842

  Patmore, Harriet S ^a   Cawkwell, Lynn ^a   Stafford, Nicholas D ^a   Greenman, John ^a  

^a UNIVERSITY OF HULL   (United Kingdom)

Author keywords

Chromosomal aberrations; Comparative genomic hybridization; Genetic analysis; Head and neck cancer

Indexed keywords

CANCER EPIDEMIOLOGY; CARCINOGENESIS; CHROMOSOME 11; CHROMOSOME 3; CHROMOSOME 3P; CHROMOSOME 3Q; CHROMOSOME 5; CHROMOSOME 5P; CHROMOSOME 5Q; CHROMOSOME 7; CHROMOSOME 7P; CHROMOSOME 7Q; CHROMOSOME 8; CHROMOSOME 8P; CHROMOSOME 8Q; CHROMOSOME 9; CHROMOSOME ABERRATION; CHROMOSOME DELETION; COMPARATIVE GENOMIC HYBRIDIZATION; DATA ANALYSIS; DNA MICROARRAY; GENETIC ANALYSIS; GENOMICS; HEAD AND NECK CANCER; HEAD AND NECK CARCINOMA; HUMAN; MEDLINE; METASTASIS; MOUTH CARCINOMA; PROTEOMICS; REVIEW; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; CHROMOSOME ABERRATIONS; GENETIC PREDISPOSITION TO DISEASE; HEAD AND NECK NEOPLASMS; HUMANS; NUCLEIC ACID HYBRIDIZATION;

EID: 25144458940     PISSN: 10689265     EISSN: None     Source Type: Journal    
DOI: 10.1245/ASO.2005.09.017     Document Type: Review

References (84)

1. Parkin DM, Pisani P, Ferlay J. Global cancer statistics. CA Cancer J Clin 1999;49:33-64.
2. Field JK. Oncogenes and tumour-suppressor genes in squamous cell carcinoma of the head and neck. Eur J Cancer B Oral Oncol 1992;28B:67-76.
3. Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988;319:525-32.
4. Califano J, van der Riet P, Westra W, et al. Genetic progression model for head and neck cancer: implications for field cancerization. Cancer Res 1996;56:2488-92.
5. Speicher MR, van der Howe C, Crotty P, et al. Comparative genomic hybridization detects novel deletions and amplifications in head and neck squamous cell carcinomas. Cancer Res 1995;55:1010-3.
6. Bosch FX, Ritter D, Enders C, et al. Head and neck tumor sites differ in prevalence and spectrum of p53 alterations but these have limited prognostic value. Int J Cancer 2004;111:530-8.
7. Dahlgren L, Mellin H, Wangsa D, et al. Comparative genomic hybridization analysis of tonsillar cancer reveals a different pattern of genomic imbalances in human papillomavirus-positive and -negative tumors. Int J Cancer 2003;107:244-9.
8. Chin D, Boyle GM, Theile DR, et al. Molecular introduction to head and neck cancer (HNSCC) carcinogenesis. Br J Plast Surg 2004;57:595-602.
9. Kim MM, Califano JA. Molecular pathology of head-and-neck cancer. Int J Cancer 2004;112:545-53.
10. Gebhart E, Liehr T. Patterns of genomic imbalances in human solid tumors (review). Int J Oncol 2000;16:383-99.
11. Weber RG, Scheer M, Born IA, et al. Recurrent chromosomal imbalances detected in biopsy material from oral premalignant and malignant lesions by combined tissue microdissection, universal DNA amplification, and comparative genomic hybridization. Am J Pathol 1998;153:295-303.
12. Okafuji M, Ita M, Oga A, et al. The relationship of genetic aberrations detected by comparative genomic hybridization to DNA ploidy and tumor size in human oral squamous cell carcinomas. J Oral Pathol Med 2000;29:226-31.
13. Kujawski M, Sarlomo-Rikala M, Gabriel A, et al. Recurrent DNA copy number losses associated with metastasis of larynx carcinoma. Genes Chromosomes Cancer 1999;26:253-7.
14. Bockmühl U, Petersen S, Schmidt S, et al. Patterns of chromosomal alterations in metastasizing and nonmetastasizing primary head and neck carcinomas. Cancer Res 1997;57:5213-6.
15. Qin LX. Chromosomal aberrations related to metastasis of human solid tumors. World J Gastroenterol 2002;8:769-76.
16. Kok K, Naylor SL, Buys CH. Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes. Adv Cancer Res 1997;71:27-92.
17. Stafford ND, Ashman JN, MacDonald AW, et al. Genetic analysis of head and neck squamous cell carcinoma and surrounding mucosa. Arch Otolaryngol Head Neck Surg 1999;125:1341-8.
18. Smith DI, Huang H, Wang L. Common fragile sites and cancer (review). Int J Oncol 1998;12:187-96.
19. Brenner C, Bieganowski P, Pace HC, Huebner K. The histidine triad superfamily of nucleotide-binding proteins. J Cell Physiol 1999;181:179-87.
20. Virgilio L, Shuster M, Gollin SM, et al. FHIT gene alterations in head and neck squamous cell carcinomas. Proc Natl Acad Sci U S A 1996;93:9770-5.
21. Heerden WF, Swart TJ, Robson B, et al. FHIT RNA and protein expression in oral squamous cell carcinomas. Anticancer Res 2001;21:2425-8.
22. Pavelic K, Krizanac S, Cacev T, et al. Aberration of FHIT gene is associated with increased tumor proliferation and decreased apoptosis-clinical evidence in lung and head and neck carcinomas. Mol Med 2001;7:442-53.
23. Chang KW, Kao SY, Tzeng RJ, et al. Multiple molecular alterations of FHIT in betel-associated oral carcinoma. J Pathol 2002;196:300-6.
24. Mineta H, Miura K, Takebayashi S, et al. Low expression of fragile histidine triad gene correlates with high proliferation in head and neck squamous cell carcinoma. Oral Oncol 2003;39:56-63.
25. Lin SC, Chen YJ, Kao SY, et al. Chromosomal changes in betel-associated oral squamous cell carcinomas and their relationship to clinical parameters. Oral Oncol 2002;38:266-73.
26. Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 2003;9:677-84.
27. Ohh M, Yauch RL, Lonergan KM, et al. The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Mol Cell 1998;1:959-68.
28. Waber PG, Lee NK, Nisen PD. Frequent allelic loss at chromosome arm 3p is distinct from genetic alterations of the Von-Hippel Lindau tumor suppressor gene in head and neck cancer. Oncogene 1996;12:365-9.
29. Singh B, Gogineni S, Goberdhan A, et al. Spectral karyotyping analysis of head and neck squamous cell carcinoma. Laryngoscope 2001;111:1545-50.
30. Hashimoto Y, Oga A, Kawauchi S, et al. Amplification of 3q26 approximately qter correlates with tumor progression in head and neck squamous cell carcinomas. Cancer Genet Cytogenet 2001;129:52-6.
31. Riazimand SH, Welkoborsky HJ, Bernauer HS, et al. Investigations for fine mapping of amplifications in chromosome 3q26.3-28 frequently occurring in squamous cell carcinomas of the head and neck. Oncology 2002;63:385-92.
32. Squire JA, Bayani J, Luk C, et al. Molecular cytogenetic analysis of head and neck squamous cell carcinoma: by comparative genomic hybridization, spectral karyotyping, and expression array analysis. Head Neck 2002;24:874-87.
33. Okafuji M, Ita M, Hayatsu Y, et al. Identification of genetic aberrations in cell lines from oral squamous cell carcinomas by comparative genomic hybridization. J Oral Pathol Med 1999;28:241-5.
34. Bockmühl U, Schluns K, Schmidt S, et al. Chromosomal alterations during metastasis formation of head and neck squamous cell carcinoma. Genes Chromosomes Cancer 2002;33:29-35.
35. Hibi K, Trink B, Patturajan M, et al. AIS is an oncogene amplified in squamous cell carcinoma. Proc Natl Acad Sci U S A 2000;97:5462-7.
36. Redon R, Muller D, Caulee K, et al. A simple specific pattern of chromosomal aberrations at early stages of head and neck squamous cell carcinomas: PIK3CA but not p63 gene as a likely target of 3q26-qter gains. Cancer Res 2001;61:4122-9.
37. Zhang L, Yang N, Katsaros D, et al. The oncogene phosphatidylinositol 3′-kinase catalytic subunit alpha promotes angiogenesis via vascular endothelial growth factor in ovarian carcinoma. Cancer Res 2003;63:4225-31.
38. Woenckhaus J, Steger K, Werner E, et al. Genomic gain of PIK3CA and increased expression of p110alpha are associated with progression of dysplasia into invasive squamous cell carcinoma. J Pathol 2002;198:335-42.
39. Wolff E, Girod S, Liehr T, et al. Oral squamous cell carcinomas are characterized by a rather uniform pattern of genomic imbalances detected by comparative genomic hybridisation. Oral Oncol 1998;34:186-90.
40. Huang Q, Yu GP, McCormick SA, et al. Genetic differences detected by comparative genomic hybridization in head and neck squamous cell carcinomas from different tumor sites: construction of oncogenetic trees for tumor progression. Genes Chromosomes Cancer 2002;34:224-33.
41. Bockmühl U, Schwendel A, Dietel M, Petersen I. Distinct patterns of chromosomal alterations in high- and low-grade head and neck squamous cell carcinomas. Cancer Res 1996;56:5325-9.
42. Welkoborsky HJ, Bernauer HS, Riazimand HS, et al. Patterns of chromosomal aberrations in metastasizing and nonmetastasizing squamous cell carcinomas of the oropharynx and hypopharynx. Ann Otol Rhinol Laryngol 2000;109:401-10.
43. Bockmühl U, Wolf G, Schmidt S, et al. Genomic alterations associated with malignancy in head and neck cancer. Head Neck 1998;20:145-51.
44. Kinzler KW, Nilbert MC, Vogelstein B, et al. Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science 1991;251:1366-70.
45. Mao EJ, Schwartz SM, Daling JR, Beckmann AM. Loss of heterozygosity at 5q21-22 (adenomatous polyposis coli gene region) in oral squamous cell carcinoma is common and correlated with advanced disease. J Oral Pathol Med 1998;27:297-302.
46. Kannan S, Yokozaki H, Jayasree K, et al. Infrequent loss of heterozygosity of the major tumour suppressor genes in Indian oral cancers. Int J Oral Maxillofac Surg 2002;31:414-8.
47. Sikdar N, Paul RR, Panda CK, et al. Loss of heterozygosity at APC and MCC genes of oral cancer and leukoplakia tissues from Indian tobacco chewers. J Oral Pathol Med 2003;32:450-4.
48. Rizos E, Sourvinos G, Arvanitis DA, et al. Low incidence of H-, K- and N-ras oncogene mutations in cytological specimens of laryngeal tumours. Oral Oncol 1999;35:561-3.
49. Das N, Majumder J, DasGupta UB. Ras gene mutations in oral cancer in eastern India. Oral Oncol 2000;36:76-80.
50. Spandidos DA, Sourvinos G, Tsatsanis C, Zafiropoulos A. Normal ras genes: their onco-suppressor and pro-apoptotic functions (review). Int J Oncol 2002;21:237-41.
51. Hermsen MA, Joenje H, Arwert F, et al. Assessment of chromosomal gains and losses in oral squamous cell carcinoma by comparative genomic hybridisation. Oral Oncol 1997;33:414-8.
52. Bergamo NA, Rogatto SR, Poli-Frederico RC, et al. Comparative genomic hybridization analysis detects frequent overrepresentation of DNA sequences at 3q, 7p, and 8q in head and neck carcinomas. Cancer Genet Cytogenet 2000;119:48-55.
53. Gebhart E, Ries J, Wiltfang J, et al. Genomic gain of the epidermal growth factor receptor harboring band 7p12 is part of a complex pattern of genomic imbalances in oral squamous cell carcinomas. Arch Med Res 2004;35:385-94.
54. Ashman JN, Patmore HS, Condon LT, et al. Prognostic value of genomic alterations in head and neck squamous cell carcinoma detected by comparative genomic hybridisation. Br J Cancer 2003;89:864-9.
55. O-Charoenrat P, Rhys-Evans PH, Modjtahedi H, Eccles SA. The role of c-erbB receptors and ligands in head and neck squamous cell carcinoma. Oral Oncol 2002;38:627-40.
56. Saranath D, Panchal RG, Nair R, et al. Amplification and overexpression of epidermal growth factor receptor gene in human oropharyngeal cancer. Eur J Cancer B Oral Oncol 1992;28B:139-43.
57. Eisbruch A, Blick M, Lee JS, et al. Analysis of the epidermal growth factor receptor gene in fresh human head and neck tumors. Cancer Res 1987;47:3603-5.
58. Nguyen DC, Parsa B, Close A, et al. Overexpression of cell cycle regulatory proteins correlates with advanced tumor stage in head and neck squamous cell carcinomas. Int J Oncol 2003;22:1285-90.
59. Weichselbaum RR, Dunphy EJ, Beckett MA, et al. Epidermal growth factor receptor gene amplification and expression in head and neck cancer cell lines. Head Neck 1989;11:437-42.
60. Tremmel SC, Gotte K, Popp S, et al. Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization. Cancer Genet Cytogenet 2003;144:165-74.
61. Cromer A, Carles A, Millon R, et al. Identification of genes associated with tumorigenesis and metastatic potential of hypopharyngeal cancer by microarray analysis. Oncogene 2004;23:2484-98.
62. Brzoska PM, Levin NA, Fu KK, et al. Frequent novel DNA copy number increase in squamous cell head and neck tumors. Cancer Res 1995;55:3055-9.
63. Rodrigo JP, Lazo PS, Ramos S, et al. MYC amplification in squamous cell carcinomas of the head and neck. Arch Otolaryngol Head Neck Surg 1996;122:504-7.
64. Nilsson JA, Cleveland JL. Myc pathways provoking cell suicide and cancer. Oncogene 2003;22:9007-21.
65. Gollin SM. Chromosomal alterations in squamous cell carcinomas of the head and neck: window to the biology of disease. Head Neck 2001;23:238-53.
66. Knobbe CB, Reifenberger G. Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3′-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas. Brain Pathol 2003;13:507-18.
67. Okamoto H, Yasui K, Zhao C, et al. PTK2 and EIF3S3 genes may be amplification targets at 8q23-q24 and are associated with large hepatocellular carcinomas. Hepatology 2003;38:1242-9.
68. van der Agochiya M, Brunton VG, Owens DW, et al. Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells. Oncogene 1999;18:5646-53.
69. van der Riet P, Nawroz H, Hruban RH, et al. Frequent loss of chromosome 9p21-22 early in head and neck cancer progression. Cancer Res 1994;54:1156-8.
70. Miracca EC, Kowalski LP, Nagai MA. High prevalence of p16 genetic alterations in head and neck tumours. Br J Cancer 1999;81:677-83.
71. Sherr CJ. Principles of tumor suppression. Cell 2004;116:235-46.
72. Brieger J, Jacob R, Riazimand HS, et al. Chromosomal aberrations in premalignant and malignant squamous epithelium. Cancer Genet Cytogenet 2003;144:148-55.
73. Wakulich C, Jackson-Boeters L, Daley TD, Wysocki GP. Immunohistochemical localization of growth factors fibroblast growth factor-1 and fibroblast growth factor-2 and receptors fibroblast growth factor receptor-2 and fibroblast growth factor receptor-3 in normal oral epithelium, epithelial dysplasias, and squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;93:573-9.
74. Mondal G, Tripathi A, Bhattacharya N, et al. Allelic imbalance at chromosome 11 in head and neck squamous cell carcinoma in an Indian patient population. J Clin Pathol 2003;56:512-8.
75. Lazar AD, Winter MR, Nogueira CP, et al. Loss of heterozygosity at 11q23 in squamous cell carcinoma of the head and neck is associated with recurrent disease. Clin Cancer Res 1998;4:2787-93.
76. Singh B, Wreesmann VB, Pfister D, et al. Chromosomal aberrations in patients with head and neck squamous cell carcinoma do not vary based on severity of tobacco/alcohol exposure. BMC Genet 2002;3:22.
77. Oga A, Kong G, Tae K, et al. Comparative genomic hybridization analysis reveals 3q gain resulting in genetic alteration in 3q in advanced oral squamous cell carcinoma. Cancer Genet Cytogenet 2001;127:24-9.
78. Wreesmann VB, Wang D, Goberdhan A, et al. Genetic abnormalities associated with nodal metastasis in head and neck cancer. Head Neck 2004;26:10-5.
79. Kujawski M, Rydzanicz M, Sarlomo-Rikala M, et al. Chromosome alterations reflect clonal evolution in squamous cell carcinoma of the larynx. Med Sci Monit 2002;8:BR279-82.
80. Patmore HS, Ashman JN, Cawkwell L, et al. Can a genetic signature for metastatic head and neck squamous cell carcinoma be characterised by comparative genomic hybridisation?. Br J Cancer 2004;90:1976-82.
81. Gotte K, Tremmel SC, Popp S, et al. Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization. Adv Otorhinolaryngol 2005;62:38-48.
82. Gebhart E, Liehr T, Wolff E, et al. Pattern of genomic imbalances in oral squamous cell carcinomas with and without an increased copy number of 11q13. Int J Oncol 1998;12:1151-5.
83. Bockmühl U, Schluns K, Kuchler I, et al. Genetic imbalances with impact on survival in head and neck cancer patients. Am J Pathol 2000;157:369-75.
84. Hermsen MA, Weiss MM, Meijer GA, Baak JP. Detection of chromosomal abnormalities by comparative genomic hybridization. Methods Mol Biol 2001;175:47-55.