Multiple molecular alterations of FHIT in betel-associated oral carcinoma

Journal of Pathology

Volumn 196, Issue 3, 2002, Pages 300-306

  Lin, Shu Chun ^a   Wong, Yong Kie ^a   Tzeng, Reuo Jar ^a   Kao, Shou Yen ^a   Chang, Kuo Wei ^a   Liu, Chung Ji ^b   Cheng, Ann Joy ^c   Yang, Shun Chun ^d  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b MACKAY MEMORIAL HOSPITAL   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

^d CHI MEI MEDICAL CENTER   (Taiwan)

Author keywords

Betel; FHIT; Mouth; Pre invasive lesion; Squamous cell carcinoma

Indexed keywords

FRAGILE HISTIDINE TRIAD PROTEIN; MESSENGER RNA;

ADULT; AGED; ARTICLE; BETEL NUT; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; EXON; FEMALE; GENE MUTATION; GENETIC CODE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MOUTH CARCINOMA; PRECANCER; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN METHYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION; SQUAMOUS CELL CARCINOMA; STATISTICAL ANALYSIS; TOBACCO;

ACID ANHYDRIDE HYDROLASES; ADULT; AGED; AGED, 80 AND OVER; ARECA; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; DNA; FEMALE; GENE DELETION; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; METHYLATION; MIDDLE AGED; MOUTH NEOPLASMS; NEOPLASM PROTEINS; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PRECANCEROUS CONDITIONS; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0036187771     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1047     Document Type: Article

References (17)

1. Alterations of p16/MTS1 gene in oral squamous cell carcinomas from Taiwanese
2. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers
3. Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit
4. Replacement of Fhit in cancer cells suppresses tumorigenicity
5. The tumor-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control
6. FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations
7. Association between cigarette smoking and FHIT gene alterations in lung cancer
8. Loss of Fhit is frequent in stage I non-small cell lung cancer and in the lungs of chronic smokers
9. The FHIT gene at 3p14.2 is abnormal in breast carcinomas
10. Methylation of the 5′ CpG island of the FHIT gene is closely associated with transcriptional inactivation in esophageal squamous cell carcinomas
11. Frequent abnormalities of FHIT, a candidate tumor suppressor gene, in head and neck cancer cell lines
12. FHIT gene alterations in head and neck squamous cell carcinomas
13. Analysis of the FHIT gene and its product in squamous cell carcinomas of the head and neck
14. Chromosome 3p loss of heterozygosity and mutation analysis of the FHIT and beta-cat genes in squamous cell carcinoma of the head and neck
15. Immunohistochemical evaluation of Fhit protein expression in oral squamous cell carcinomas
16. Abnormalities of the FHIT gene in human oral carcinogenesis
17. The FHIT gene in oral squamous cell carcinoma: Allelic imbalance is frequent but cDNA aberrations are uncommon