Comparative genomic hybridization analysis of tonsillar cancer reveals a different pattern of genomic imbalances in human papillomavirus-positive and -negative tumors

International Journal of Cancer

Volumn 107, Issue 2, 2003, Pages 244-249

  Dahlgren, Liselotte ^a   Mellin, Hanna ^a   Wangsa, Danny ^b   Heselmeyer Haddad, Kerstin ^b   Björnestal, Linda ^a   Lindholm, Johan ^a   Munck Wikland, Eva ^a   Auer, Gert ^a   Ried, Thomas ^b   Dalianis, Tina ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Chromosome 3q; Comparative genomic hybridization; Human papillomavirus; Tonsillar cancer

Indexed keywords

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CHROMOSOME 11Q; CHROMOSOME 13; CHROMOSOME 3Q; CHROMOSOME 7Q; CHROMOSOME 8Q; CHROMOSOME LOSS; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; FEMALE; GENE MAPPING; HUMAN; HUMAN TISSUE; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; SQUAMOUS CELL CARCINOMA; STATISTICAL SIGNIFICANCE; TONSIL CARCINOMA; WART VIRUS;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN; DISEASE-FREE SURVIVAL; DNA, NEOPLASM; DNA, VIRAL; FEMALE; HUMANS; MALE; MIDDLE AGED; NUCLEIC ACID HYBRIDIZATION; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; POLYMERASE CHAIN REACTION; RISK FACTORS; SURVIVAL RATE; TONSILLAR NEOPLASMS; TUMOR VIRUS INFECTIONS;

EID: 0141523103     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.11371     Document Type: Article

References (37)

1. Bray F, Sankila R, Ferlay J, Parkin DM. Estimates of cancer incidence and mortality in Europe in 1995. Eur J Cancer 2002;38:99-166.
2. Ortega IS NC, Forcelledo MFF, Gomis JE. Lymph node response and its relationship to prognosis in carcinoma of the head and neck. Clin Otolaryngol 1987;12:241-7.
3. Redon R, Muller D, Caulee K, Wanherdrick K, Abecassis J, du Manoir S. A simple specific pattern of chromosomal aberrations at early stages of head and neck squamous cell carcinomas: PIK3CA but not p63 gene as a likely target of 3q26-qter gains. Cancer Res 2001;61:4122-9.
4. Gillison ML, Koch WM, Capone RB, Spafford M, Westra WH, Wu L, Zahurak ML, Daniel RW, Viglione M, Symer DE, Shah KV. Sidransky D. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 2000;92:709-20.
5. Frisch M, Biggar RJ. Aetiological parallel between tonsillar and anogenital squamous-cell carcinomas. Lancet 1999;354:1442-3.
6. Mork J, Lie AK, Glattre E, Hallmans G. Jellum E, Koskela P, Moller B, Pukkala E, Schiller JT, Youngman L, Lehtinen M, Dillner J. Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med 2001;344:1125-31.
7. McKaig RG, Baric, Ralph S, Olhsan AF. Human papillomavirus and head neck cancer: epidemiology and molecular biology. Head Neck 1998;20:250-65.
8. Mellin H, Friesland S, Lewensohn R, Dalianis T, Munck-Wikland E. Human papillomavirus (HPV) DNA in tonsillar cancer: clinical correlates, risk of relapse, and survival. Int J Cancer 2000;89:300-4.
9. Paz BI, Cook N, Odom-Maryon T, Xie Y, Wilczynski SP. Human papillomavirus (HPV) in head and neck cancer: an association of HPV 16 with squamous cell carcinoma of Waldeyer's tonsillar ring. Cancer 1997;79:595-604.
10. Mellin H, Dahlgren L, Munck-Wikland E, Lindholm J, Rabbani H, Kalantari M, Dalianis T. Human papillomavirus type 16 is episomal and a high viral load may be correlated to better prognosis in tonsillar; cancer. Int J Cancer 2002;102:152-8.
11. Snijders PJ, Meijer CJ, van den Brule AJ, Schrijnemakers HF. Snow GB, Walboomers JM. Human papillomavirus (HPV) type 16 and 33 E6/E7 region transcripts in tonsillar carcinomas can originate from integrated and episomal HPV DNA. J Gen Virol 1992;73:2059-66.
12. Halbert CL, Demers GW, Galloway DA. The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells. J Virol 1991;65:473-8.
13. zur Hausen H. Papillomavirus infections - a major cause of human cancers. Biochim Biophys Acta 1996;1288:F55-78.
14. Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 1990;63:1129-36.
15. Werness BA, Levine AJ, Howley PM. Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 1990;248:76-9.
16. Klingelhutz AJ, Foster SA, McDougall JK. Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature 1996:380:79-82.
17. Munger K, Werness BA, Dyson N, Phelps WC, Harlow E, Howley PM. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J 1989;8:4099-105.
18. Gebhart E, Liehr T. Patterns of genomic imbalances in human solid tumors. Int J Oncol 2000;16:383-99.
19. Califano J, van der Riet P, Westra W, Nawroz H, Clayman G, Piantadosi S, Corio R, Lee D, Greenberg B, Koch W, Sidransky D. Genetic progression model for head-and-neck cancer: implications for field cancerization. Cancer Res 1996;56:2488-92.
20. Scully C, Field JK, Tanzawa H. Genetic aberrations in oral or head and neck squamous cell carcinoma 2: chromosomal aberrations. Oral Oncol 2000;36:311-27.
21. McGlennen RC. Human papillomavirus oncogenesis. Clin Lab Med 2000;20:383-406.
22. Bergamo NA, Rogatto SR, Poli-Frederico RC, Reis PP, Kowalski LP, Zielenska M, Squire JA. Comparative genomic hybridization analysis detects frequent over-representation of DNA sequences at 3q, 7p, and 8q in head and neck carcinomas. Cancer Genet Cytogenet 2000;119:48-55.
23. Wilczynski SP, Lin BT, Xie Y, Paz IB. Detection of human papillomavirus DNA and oncoprotein overexpression are associated with distinct morphological patterns of tonsillar squamous cell carcinoma. Am J Pathol 1998;152:145-56.
24. Knuutila S, Aalto Y, Autio K, Bjorkqvist AM, El-Rifai W, Hemmer S, Huhta T, Kettunen E, Kiuru-Kuhlefelt S, Larramendy ML, Lushnikova T, Monni O, et al. DNA copy number losses in human neoplasms. Am J Pathol 1999;155:683-94.
25. Struski S, Doco-Fenzy M, Cornillet-Lefebvre P. Compilation of published comparative genomic hybridization studies. Cancer Genet Cytogenet 2002;135:63-90.
26. de Roda Husman AM, Walboomers JM, van den Brule AJ, Meijer CJ, Snijders PJ. The use of general primers GP5 and GP6 elongated at their 3′ ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR. J Gen Virol 1995;76:1057-62.
27. Tieben LM, ter Schegget J, Minnaar RP, Bouwes Bavinck JN, Berkhout RJ, Vermeer BJ. Jebbink MF, Smits HL. Detection of cutaneous and genital HPV types in clinical samples by PCR using consensus primers. J Virol Methods 1993;42:265-79.
28. Kallioniemi A, Kallioniemi OP, Sudar D, Rutovitz D, Gray JW, Waldman F, Pinkel D. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 1992;258:818-21.
29. Karlsen F, Kalantari M, Jenkins A, Pettersen E, Kristensen G, Holm R, Johansson B, Hagmar B. Use of multiple PCR primer sets for optimal detection of human papillomavirus. J Clin Microbiol 1996;34:2095-100.
30. Ried T, Just KE. Holtgreve-Grez H, du Manoir S, Speicher MR, Schrock E, Latham C, Blegen H, Zetterberg A, Cremer T, et al. Comparative genomic hybridization of formalin-fixed, paraffin-embedded breast tumors reveals different patterns of chromosomal gains and losses in fibroadenomas and diploid and aneuploid carcinomas. Cancer Res 1995;55:5415-23.
31. Ried T, Heselmeyer-Haddad K, Blegen H, Schrock E, Auer G. Genomic changes defining the genesis, progression, and malignancy potential in solid human tumors: a phenotype/genotype correlation. Genes Chromosomes Cancer 1999;25:195-204.
32. Bockmuhl U, Wolf G, Schmidt S, Schwendel A, Jahnke V, Dietel M, Petersen I. Genomic alterations associated with malignancy in head and neck cancer. Head Neck 1998;20:145-51.
33. Roh HJ, Shin DM, Lee JS, Ro JY, Tainsky MA, Hong WK, Hittelman WN. Visualization of the timing of gene amplification during multi-step head and neck tumorigenesis. Cancer Res 2000;60:6496-502.
34. Heselmeyer K, Schröck E, Du Manior S, Blegen H, Shah K, Steinbeck R, Auer G, Ried T. Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma or the uterine cervix. Proc Natl Acad Sci USA 1996;93:479-84.
35. Bosch FX, Lorincz A, Munoz N, Meijer CJ, Shah KV. The causal relation between human papillomavirus and cervical cancer. J Clin Pathol 2002:55:244-65.
36. Redon R, Hussenet T, Bour G, Caulee K, Jost B, Muller D, Abecassis J, du Manoir S. Amplicon mapping and transcriptional analysis pin-point cyclin L as a candidate oncogene in head-and-neck cancer. Cancer Res 2002;62:6211-7.
37. Veldman T, Horikawa I, Barrett JC. Schlegel R. Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoprotein. J Virol 2001;75:4467-72.