Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization

Cancer Genetics and Cytogenetics

Volumn 144, Issue 2, 2003, Pages 165-174

  Tremmel, Susanne C ^a   Götte, Karl ^c   Popp, Susanne ^a,b   Weber, Susanne ^a   Hörmann, Karl ^c   Bartram, Claus R ^a   Jauch, Anna ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CANCER STAGING; CHROMOSOME 11Q; CHROMOSOME 3Q; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; FEMALE; GENE LOCATION; GENETIC HETEROGENEITY; GENETIC SELECTION; HEAD AND NECK CARCINOMA; HUMAN; HYPOPHARYNX; LARYNX; MALE; MEDICAL EXAMINATION; METASTASIS; MOUTH CAVITY; OROPHARYNX; PRIORITY JOURNAL; PROGNOSIS; TUMOR;

EID: 0038354620     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-4608(03)00011-6     Document Type: Article

References (57)

1. Jin Y., Mertens F., Mandahl N., Heim S., Olegard C., Wennerberg J., Biörklund A., Mitelman F. Chromosome abnormalities in eighty-three head and neck squamous cell carcinomas: influence of culture conditions on karyotypic pattern. Cancer Res. 53:1993;2140-2146.
2. Jin Y., Mertens F., Jin C., Akervall J., Wennerberg J., Gorunova L., Mandahl N., Heim S., Mitelman F. Nonrandom chromosome abnormalities in short-term cultured primary squamous cell carcinomas of the head and neck. Cancer Res. 55:1995;3204-3210.
3. Van Dyke D.L., Worsham M.J., Benninger M.S., Krause C.J., Baker S.R., Wolf G.T., Drumheller T., Tilley B.C., Carey T.E. Recurrent cytogenetic abnormalities in squamous cell carcinomas of the head and neck region. Genes Chromosomes Cancer. 3:1994;192-206.
4. Nowell P.C. The clonal evolution of tumor cell populations. Science. 194:1976;23-28.
5. Nowell P.C. Chromosomal and molecular clues to tumor progression. Semin Oncol. 16:1989;116-127.
6. Slaughter D.P., Southwick H.W., Smejkal W. "Field cancerization" in oral stratified squamous epithelium. Cancer. 6:1953;963-968.
7. Carey T.E., Van Dyke D.L., Worsham M.J. Nonrandom chromosomes aberrations and clonal populations in head and neck cancer. Anticancer Res. 13:1993;2561-2568.
8. Soder A.I., Hopman A.H., Ramaekers F.C., Conradt C., Bosch F.X. Distinct nonrandom patterns of chromosomal aberrations in the progression of squamous cell carcinomas of the head and neck. Cancer Res. 55:1995;5030-5037.
9. Speicher M.R., Howe C., Crotty P., du Manoir S., Costa J., Ward D.C. Comparative genomic hybridization detects novel deletions and amplifications in head and neck squamous cell carcinomas. Cancer Res. 55:1995;1010-1013.
10. Brzoska P.M., Levin N.A., Fu K.K., Kaplan M.J., Singer M.I., Gray J.W., Christman M.F. Frequent novel DNA copy number increase in squamous cell head and neck tumors. Cancer Res. 55:1995;3055-3059.
11. Bockmühl U., Schwendel A., Dietel M., Petersen I. Distinct patterns of chromosomal alterations in high- and low-grade head and neck squamous cell carcinomas. Cancer Res. 56:1996;5325-5329.
12. Bockmühl U., Petersen S., Schmidt S., Wolf G., Jahnke V., Dietel M., Petersen I. Patterns of chromosomal alterations in metastasizing and nonmetastasizing primary head and neck carcinomas. Cancer Res. 57:1997;5213-5216.
13. Bockmühl U., Wolf G., Schmidt S., Schwendel A., Jahnke V., Dietel M., Petersen I. Genomic alterations associated with malignancy in head and neck cancer. Head Neck. 20:1998;145-151.
14. Weber R.G., Scheer M., Born I.A., Joos S., Cobbers J.M., Hofele C., Reifenberger G., Zoller J.E., Lichter P. Recurrent chromosomal imbalances detected in biopsy material from oral premalignant and malignant lesions by combined tissue microdissection, universal DNA amplification, and comparative genomic hybridization. Am J Pathol. 153:1998;295-303.
15. Bergamo N.A., Rogatto S.R., Poli-Frederico R.C., Reis P.P., Kowalski L.P., Zielenska M., Squire J.A. Comparative genomic hybridization analysis detects frequent overrepresentation of DNA sequences at 3q, 7p, and 8q in head and neck carcinomas. Cancer Genet Cytogenet. 119:2000;48-55.
16. Hermsen M.A., Joenje H., Arwert F., Braakhuis B.J., Baak J.P., Westerveld A., Slater R. Assessment of chromosomal gains and losses in oral squamous cell carcinoma by comparative genomic hybridisation. Oral Oncol. 33:1997;414-418.
17. Oga A., Kong G., Tae K., Lee Y., Sasaki K. Comparative genomic hybridization analysis reveals 3q gain resulting in genetic alteration in 3q in advanced oral squamous cell carcinoma. Cancer Genet Cytogenet. 127:2001;24-29.
18. Huang Q., Yu G.P., McCormick S.A., Mo J., Datta B., Mahimkar M., Lazarus P., Schäffer A.A., Desper R., Schantz S.P. Genetic differences detected by comparative genomic hybridization in head and neck squamous cell carcinomas from different tumor sites: construction of oncogenetic trees for tumor progression. Genes Chromosomes Cancer. 34:2002;224-233.
19. Welkoborsky H.J., Bernauer H.S., Riazimand H.S., Jacob R., Mann W.J., Hinni M.L. Patterns of chromosomal aberrations in metastasizing and nonmetastasizing squamous cell carcinomas of the oropharynx and hypopharynx. Ann Otol Rhinol Laryngol. 109:2000;401-410.
20. Bockmühl U., Schluns K., Schmidt S., Matthias S., Petersen I. Chromosomal alterations during metastasis formation of head and neck squamous cell carcinoma. Genes Chromosomes Cancer. 33:2002;29-35.
21. Fleming I.D., Cooper J.S., Henson D.E., Hutter R.V.P., Kennedy B.J., Murphy G.P., O'Sullivan B., Sobin L.H., Yarbro J.W. AJCC cancer staging manual. 5th edition :1997;Lippincott-Raven, Philadelphia.
22. Telenius H., Pelmear A.H., Tunnacliffe A., Carter N.P., Behmel A., Ferguson-Smith M.A., Nordenskjold M., Pfragner R., Ponder B.A. Cytogenetic analysis by chromosome painting using DOP-PCR amplified flow-sorted chromosomes. Genes Chromosomes Cancer. 4:1992;257-263.
23. Du Manoir S., Speicher M.R., Joos S., Schröck E., Popp S., Döhner H., Kovacs G., Robert-Nicoud M., Lichter P., Cremer T. Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization. Hum Genet. 90:1993;590-610.
24. Waldman F.M., DeVries S., Chew K.L., Moore D.H. II, Kerlikowske K., Ljung B.M. Chromosomal alterations in ductal carcinomas in situ and their in situ recurrences. J Natl Cancer Inst. 92:2000;313-320.
25. Forastiere A., Koch W., Trotti A., Sidransky D. Head and neck cancer. N Engl J Med. 345:2001;1890-1900.
26. Gollin S.M. Chromosomal alterations in squamous cell carcinomas of the head and neck: window to the biology of disease. Head Neck. 23:2001;238-253.
27. Crowe D.L., Hacia J.G., Hsieh C.L., Sinha U.K., Rice H. Molecular pathology of head and neck cancer. Histol Histopathol. 17:2002;909-914.
28. Sun P.C., el-Mofty S.K., Haughey B.H., Scholnick S.B. Allelic loss in squamous cell carcinomas of the larynx: discordance between primary and metastatic tumors. Genes Chromosomes Cancer. 14:1995;145-148.
29. Leong P.P., Rezai B., Koch W.M., Reed A., Eisele D., Lee D.J., Sidransky D., Jen J., Westra W.H. Distinguishing second primary tumors from lung metastases in patients with head and neck squamous cell carcinoma. J Natl Cancer Inst. 90:1998;972-977.
30. Takes R.P., Baatenburg de Jong R.J., Wijffels K., Schuuring E., Litvinov S.V., Hermans J., van Krieken J.H. Expression of genetic markers in lymph node metastases compared with their primary tumors in head and neck cancer. J Pathol. 194:2001;298-302.
31. Götte K., Riedel F., Schäfer C., Coy J.F., Hörmann K. Genetic discordance between primary tumors and metastases of head and neck cancer detected by microsatellite analysis. Oncol Rep. 9:2002;829-834.
32. Tabor M.P., van Houten V.M., Kummer J.A., Vosjan M.J., Vlasblom R., Snow G.B., Leemans C.R., Braakhuis B.J., Brakenhoff R.H. Discordance of genetic alterations between primary head and neck tumors and corresponding metastases associated with mutational status of the TP53 gene. Genes Chromosomes Cancer. 33:2002;168-177.
33. El-Naggar A.K., Lopez-Varela V., Luna M.A., Weber R., Batsakis J.G. Intratumoral DNA content heterogeneity in laryngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 118:1992;169-173.
34. El-Naggar A.K., Hurr K., Luna M.A., Goepfert H., Hong W.K., Batsakis J.G. Intratumoral genetic heterogeneity in primary head and neck squamous carcinoma using microsatellite markers. Diagn Mol Pathol. 6:1997;305-308.
35. Bockmühl U., Schmidt S., Petersen S., Petersen I. Deletionen des Chromosoms 10q- Marker für die Metastasierung bei Kopf-HalsKarzinomen? [Deletion of chromosome 10q- a marker for metastasis of head-neck carcinomas?]. Laryngorhinootologie. 79:2000;81-85. [in German].
36. Hermsen M., Guervos M.A., Meijer G., Baak J., van Diest P., Marcos C.A., Sampedro A. New chromosomal regions with high-level amplifications in squamous cell carcinomas of the larynx and pharynx, identified by comparative genomic hybridization. J Pathol. 194:2001;177-182.
37. Wolff E., Girod S., Liehr T., Vorderwülbecke U., Ries J., Steininger H., Gebhart E. Oral squamous cell carcinomas are characterized by a rather uniform pattern of genomic imbalances detected by comparative genomic hybridisation. Oral Oncol. 34:1998;186-190.
38. Singh B., Stoffel A., Gogineni S., Poluri A., Pfister D.G., Shaha A.R., Pathak A., Bosl G., Cordon-Cardo C., Shah J.P., Rao P.H. Amplification of the 3q26.3 locus is associated with progression to invasive cancer and is a negative prognostic factor in head and neck squamous cell carcinomas. Am J Pathol. 161:2002;365-371.
39. Shayesteh L., Lu Y., Kuo W.L., Baldocchi R., Godfrey T., Collins C., Pinkel D., Powell B., Mills G.B., Gray J.W. PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet. 21:1999;99-102.
40. Ma Y.Y., Wei S.J., Lin Y.C., Lung J.C., Chang T.C., Whang-Peng J., Liu J.M., Yang D.M., Yang W.K., Shen C.Y. PIK3CA as an oncogene in cervical cancer. Oncogene. 19:2000;2739-2744.
41. Hibi K., Trink B., Patturajan M., Westra W.H., Caballero O.L., Hill D.E., Ratovitski E.A., Jen J., Sidransky D. AIS is an oncogene amplified in squamous cell carcinoma. Proc Natl Acad Sci USA. 97:2000;5462-5467.
42. Yamaguchi K., Wu L., Caballero O.L., Hibi K., Trink B., Resto V., Cairns P., Okami K., Koch W.M., Sidransky D., Jen J. Frequent gain of the p40/p51/p63 gene locus in primary head and neck squamous cell carcinoma. Int J Cancer. 86:2000;684-689.
43. Akervall J.A., Michalides R.J., Mineta H., Balm A., Borg A., Dictor M.R., Jin Y., Loftus B., Mertens F., Wennerberg J.P. Amplification of cyclin D1 in squamous cell carcinoma of the head and neck and the prognostic value of chromosomal abnormalities and cyclin D1 overexpression. Cancer. 79:1997;380-389.
44. Namazie A., Alavi S., Olopade O.I., Pauletti G., Aghamohammadi N., Aghamohammadi M., Gornbein J.A., Calcaterra T.C., Slamon D.J., Wang M.B., Srivatsan E.S. Cyclin D1 amplification and p16 (MTS1/CDK4I) deletion correlate with poor prognosis in head and neck tumors. Laryngoscope. 112:2002;472-481.
45. Rodrigo J.P., Gonzalez M.V., Lazo P.S., Ramos S., Coto E., Alvarez I., Garcia L.A., Suarez C. Genetic alterations in squamous cell carcinomas of the hypopharynx with correlations to clinicopathological features. Oral Oncol. 38:2002;357-363.
46. Reed A.L., Califano J., Cairns P., Westra W.H., Jones R.M., Koch W., Ahrendt S., Eby Y., Sewell D., Nawroz H., Bartek J., Sidransky D. High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma. Cancer Res. 56:1996;3630-3633.
47. Nunn J., Scholes A.G., Liloglou T., Nagini S., Jones A.S., Vaughan E.D., Gosney J.R., Rogers S., Fear S., Field J.K. Fractional allele loss indicates distinct genetic populations in the development of squamous cell carcinoma of the head and neck (SCCHN). Carcinogenesis. 20:1999;2219-2228.
48. Bazan V., Zanna I., Migliavacca M., Sanz-Casla M.T., Maestro M.L., Corsale S., Macaluso M., Dardanoni G., Restivo S., Quintela P.L., Bernaldez R., Salerno S., Morello V., Tomasino R.M., Gebbia N., Russo A. Prognostic significance of p16INK4a alterations and 9p21 loss of heterozygosity in locally advanced laryngeal squamous cell carcinoma. J Cell Physiol. 192:2002;286-293.
49. Knuutila S., Aalto Y., Autio K., Björkqvist A.M., El-Rifai W., Hemmer S., Huhta T., Kettunen E., Kiuru-Kuhlefelt S., Larramendy M.L., Lushnikova T., Monni O., Pere H., Tapper J., Tarkkanen M., Varis A., Wasenius V.M., Wolf M., Zhu Y. DNA copy number losses in human neoplasms. Am J Pathol. 155:1999;683-694.
50. Piccinin S., Gasparotto D., Vukosavljevic T., Barzan L., Sulfaro S., Maestro R., Boiocchi M. Microsatellite instability in squamous cell carcinomas of the head and neck related to field cancerization phenomena. Br J Cancer. 78:1998;1147-1151.
51. Partridge M., Emilion G., Pateromichelakis S., Phillips E., Langdon J. Location of candidate tumour suppressor gene loci at chromosomes 3p, 8p and 9p for oral squamous cell carcinomas. Int J Cancer. 83:1999;318-325.
52. Pateromichelakis S., Lee G., Langdon J.D., Partridge M. The FHIT gene in oral squamous cell carcinoma: allelic imbalance is frequent but cDNA aberrations are uncommon. Oral Oncol. 36:2000;180-188.
53. Hogg R.P., Honorio S., Martinez A., Agathanggelou A., Dallol A., Fullwood P., Weichselbaum R., Kuo M.J., Maher E.R., Latif F. Frequent 3p allele loss and epigenetic inactivation of the RASSF1A tumour suppressor gene from region 3p21.3 in head and neck squamous cell carcinoma. Eur J Cancer. 38:2002;1585-1592.
54. Van den Brekel M.W., Balm A.J. Editorial comment on 'Frequent 3p allele loss and epigenetic inactivation of the RASSF1A tumour suppressor gene from region 3p21.3 in head and neck squamous cell carcinoma' by Hogg and colleagues. Eur J Cancer. 38:2002;1561-1563.
55. Petersen I., Hidalgo A., Petersen S., Schluns K., Schewe C., Pacyna-Gengelbach M., Goeze A., Krebber B., Knosel T., Kaufmann O., Szymas J., von Deimling A. Chromosomal imbalances in brain metastases of solid tumors. Brain Pathol. 10:2000;395-401.
56. Jin C., Jin Y., Wennerberg J., Akervall J., Dictor M., Mertens F. Karyotypic heterogeneity and clonal evolution in squamous cell carcinomas of the head and neck. Cancer Genet Cytogenet. 132:2002;85-96.
57. Klein C.A., Blankenstein T.J.F., Schmidt-Kittler O., Petronio M., Polzer B., Stoecklein N.H., Riethmüller G. Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer. Lancet. 360:2002;683-689.