Molecular introduction to head and neck cancer (HNSCC) carcinogenesis

British Journal of Plastic Surgery

Volumn 57, Issue 7, 2004, Pages 595-602

  Chin, David ^a   Boyle, Glen M ^a   Theile, David R ^a   Parsons, Peter G ^a   Coman, William B ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Angiogenesis; HNSCC; Molecular markers; Oncogenes; Tumorigenesis

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR; JANUS KINASE; MOLECULAR MARKER; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P16; PROTEIN P21; PROTEIN P53; STAT PROTEIN; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN; VASCULOTROPIN;

ANGIOGENESIS; APOPTOSIS; ARTICLE; BREATHING; CANCER MORTALITY; CANCER PAIN; CANCER RADIOTHERAPY; CANCER STAGING; CARCINOGENESIS; CELL CYCLE; CHROMOSOME 11Q; CONSERVATIVE TREATMENT; GENE AMPLIFICATION; HEAD AND NECK CANCER; HEREDITY; HUMAN; MEDICAL DECISION MAKING; MOLECULAR BIOLOGY; MOLECULAR GENETICS; NECK DISSECTION; ONCOGENE; PLASTIC SURGERY; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROGNOSIS; REGULATOR GENE; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SPEECH DISORDER; SURGICAL TECHNIQUE; SURVIVAL; SWALLOWING; TUMOR BIOPSY; TUMOR SUPPRESSOR GENE; CHROMOSOME 11; GENE; GENETICS; HEAD AND NECK TUMOR; NEOVASCULARIZATION (PATHOLOGY); PEDIGREE; REVIEW; UPREGULATION;

APOPTOSIS; CHROMOSOMES, HUMAN, PAIR 11; GENE AMPLIFICATION; GENES, CDC; GENES, P53; GENES, TUMOR SUPPRESSOR; HEAD AND NECK NEOPLASMS; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; ONCOGENES; PEDIGREE; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 6344254595     PISSN: 00071226     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bjps.2004.06.010     Document Type: Review

References (85)

1. Fearon E.R. Vogelstein B. A genetic model for colorectal tumorigenesis Cell 61 1990 759-767
2. Califano J. van der Riet P. Westra W. et al. Genetic progression model for head and neck cancer: Implications for field cancerization Cancer Res 56 1996 2488-2492
3. Taylor D. Koch W.M. Zahurak M. et al. Immunohistochemical detection of p53 protein accumulation in head and neck cancer: Correlation with p53 gene alterations Hum Pathol 30 1999 1221-1225
4. Sartor M. Steingrimsdottir H. Elamin F. et al. Role of p16/MTS1, cyclin D1 and RB in primary oral cancer and oral cancer cell lines Br J Cancer 80 1999 79-86
5. Grandis J.R. Tweardy D.J. Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer Cancer Res 53 1993 3579-3584
6. Copper M.P. Jovanovic A. Nauta J.J. et al. Role of genetic factors in the etiology of squamous cell carcinoma of the head and neck Arch Otolaryngol Head Neck Surg 121 1995 157-160
7. Foulkes W.D. Brunet J.S. Kowalski L.P. Narod S.A. Franco E.L. Family history of cancer is a risk factor for squamous cell carcinoma of the head and neck in Brazil: A case-control study Int J Cancer 63 1995 769-773
8. Klein G. Klein E. Evolution of tumours and the impact of molecular oncology Nature 315 1985 190-195
9. Haluska F.G. Tsujimoto Y. Croce C.M. Oncogene activation by chromosome translocation in human malignancy Annu Rev Genet 21 1987 321-345
10. Alitalo K. Schwab M. Oncogene amplification in tumor cells Adv Cancer Res 47 1986 235-281
11. Bishop Cellular oncogenes and retroviruses Ann Rev Biochem 52 1983 301-354
12. Saranath D. Panchal R.G. Nair R. et al. Amplification and overexpression of epidermal growth factor receptor gene in human oropharyngeal cancer Eur J Cancer B Oral Oncol 28B 1992 139-143
13. Grandis J.R. Melhem M.F. Gooding W.E. et al. Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival J Natl Cancer Inst 90 1998 824-832
14. He Y. Zeng Q. Drenning S.D. et al. Inhibition of human squamous cell carcinoma growth in vivo by epidermal growth factor receptor antisense RNA transcribed from the U6 promoter J Natl Cancer Inst 90 1998 1080-1087
15. Nguyen D.C. Parsa B. Close A. et al. Overexpression of cell cycle regulatory proteins correlates with advanced tumor stage in head and neck squamous cell carcinomas Int J Oncol 22 2003 1285-1290
16. Xia W. Lau Y.K. Zhang H.Z. et al. Strong correlation between c-erbB-2 overexpression and overall survival of patients with oral squamous cell carcinoma Clin Cancer Res 3 1997 3-9
17. Bockmuhl U. Schwendel A. Dietel M. Petersen I. Distinct patterns of chromosomal alterations in high- and low-grade head and neck squamous cell carcinomas Cancer Res 56 1996 5325-5329
18. Meredith S.D. Levine P.A. Burns J.A. et al. Chromosome 11q13 amplification in head and neck squamous cell carcinoma. Association with poor prognosis Arch Otolaryngol Head Neck Surg 121 1995 790-794
19. Akervall J.A. Jin Y. Wennerberg J.P. et al. Chromosomal abnormalities involving 11q13 are associated with poor prognosis in patients with squamous cell carcinoma of the head and neck Cancer 76 1995 853-859
20. Rubin J.S. Qiu L. Etkind P. Amplification of the Int-2 gene in head and neck squamous cell carcinoma J Laryngol Otol 109 1995 72-76
21. Callender T. el-Naggar A.K. Lee M.S. et al. PRAD-1 (CCND1)/cyclin D1 oncogene amplification in primary head and neck squamous cell carcinoma Cancer 74 1994 152-158
22. Williams M.E. Gaffey M.J. Weiss L.M. et al. Chromosome 11Q13 amplification in head and neck squamous cell carcinoma Arch Otolaryngol Head Neck Surg 119 1993 1238-1243
23. Bockmuhl U. Kuchler I. Petersen I. Improved prognostic assessment of head-neck carcinomas by new genetic markers Hno 48 2000 451-456
24. Namazie A. Alavi S. Olopade O.I. et al. Cyclin D1 amplification and p16(MTS1/CDK4I) deletion correlate with poor prognosis in head and neck tumors Laryngoscope 112 2002 472-481
25. Somers K.D. Cartwright S.L. Schechter G.L. Amplification of the int-2 gene in human head and neck squamous cell carcinomas Oncogene 5 1990 915-920
26. Merritt W.D. Weissler M.C. Turk B.F. Gilmer T.M. Oncogene amplification in squamous cell carcinoma of the head and neck Arch Otolaryngol Head Neck Surg 116 1990 1394-1398
27. Yunis J.J. The chromosomal basis of human neoplasia Science 221 1983 227-235
28. Izzo J.G. Papadimitrakopoulou V.A. Li X.Q. et al. Dysregulated cyclin D1 expression early in head and neck tumorigenesis: In vivo evidence for an association with subsequent gene amplification Oncogene 17 1998 2313-2322
29. Kyomoto R. Kumazawa H. Toda Y. et al. Cyclin-D1-gene amplification is a more potent prognostic factor than its protein over-expression in human head-and-neck squamous-cell carcinoma Int J Cancer 74 1997 576-581
30. Saranath D. Panchal R.G. Nair R. et al. Oncogene amplification in squamous cell carcinoma of the oral cavity Jpn J Cancer Res 80 1989 430-437
31. Frederick M.J. Holton P.R. Hudson M. Wang M. Clayman G.L. Expression of apoptosis-related genes in human head and neck squamous cell carcinomas undergoing p53-mediated programmed cell death Clin Cancer Res 5 1999 361-369
32. Xu J. Gimenez-Conti I.B. Cunningham J.E. et al. Alterations of p53, cyclin D1, Rb, and H-ras in human oral carcinomas related to tobacco use Cancer 83 1998 204-212
33. Saranath D. Chang S.E. Bhoite L.T. et al. High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in India Br J Cancer 63 1991 573-578
34. Grandis J.R. Zeng Q. Drenning S.D. Epidermal growth factor receptor-mediated stat3 signaling blocks apoptosis in head and neck cancer Laryngoscope 110 2000 868-874
35. Grandis J.R. Drenning S.D. Zeng Q. et al. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo Proc Natl Acad Sci USA 97 2000 4227-4232
36. Nagpal J.K. Mishra R. Das B.R. Activation of Stat-3 as one of the early events in tobacco chewing-mediated oral carcinogenesis Cancer 94 2002 2393-2400
37. Weinberg R. Tumour suppressor genes Science 254 1991 1138-1146
38. Levine A.J. The tumor suppressor genes Annu Rev Biochem 62 1993 623-651
39. Levine A.J. The cellular gatekeeper for growth and division Cell 88 1997 323-331
40. Nigro J.M. Baker S.J. Preisinger A.C. et al. Mutations in the p53 gene occur in diverse human tumour types Nature 342 1989 705-708
41. Hollstein M. Sidransky D. Vogelstein B. Harris C.C. p53 mutations in human cancers Science 253 1991 49-53
42. Levine A.J. Momand J. Finlay C.A. The p53 tumour suppressor gene Nature 351 1991 453-456
43. Bartek J. Bartkova J. Vojtesek B. et al. Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies Oncogene 6 1991 1699-1703
44. Levesque M.A. Tadross L. Diamandis E.P. D'Costa M. Comparison of immunofluorometry and immunohistochemistry for the detection of p53 protein in lung cancer specimens Am J Clin Pathol 107 1997 308-316
45. Allred D.C. Clark G.M. Elledge R. et al. Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer J Natl Cancer Inst 85 1993 200-206
46. Hartmann A. Blaszyk H. Kovach J.S. Sommer S.S. The molecular epidemiology of p53 gene mutations in human breast cancer Trends Genet 13 1997 27-33
47. Yamamoto M. Takahashi H. Immunohistochemical detection of the p53 oncoprotein in tumours of melanocytic origin Virchows Arch A Pathol Anat Histopathol 422 1993 127-132
48. Levesque M.A. Yu H. Clark G.M. Diamandis E.P. Enzyme-linked immunoabsorbent assay-detected p53 protein accumulation: A prognostic factor in a large breast cancer cohort J Clin Oncol 16 1998 2641-2650
49. Boyle J.O. Hakim J. Koch W. et al. The incidence of p53 mutations increases with progression of head and neck cancer Cancer Res 53 1993 4477-4480
50. Caamano J. Zhang S.Y. Rosvold E.A. Bauer B. Klein-Szanto A.J. p53 alterations in human squamous cell carcinomas and carcinoma cell lines Am J Pathol 142 1993 1131-1139
51. Nylander K. Dabelsteen E. Hall P.A. The p53 molecule and its prognostic role in squamous cell carcinomas of the head and neck J Oral Pathol Med 29 2000 413-425
52. Field J.K. Pavelic Z.P. Spandidos D.A. et al. The role of the p53 tumor suppressor gene in squamous cell carcinoma of the head and neck Arch Otolaryngol Head Neck Surg 119 1993 1118-1122
53. Hainaut P. Hernandez T. Robinson A. et al. IARC Database of p53 gene mutations in human tumors and cell lines: Updated compilation, revised formats and new visualisation tools Nucl Acids Res 26 1998 205-213
54. Kropveld A. Rozemuller E.H. Leppers F.G. et al. Sequencing analysis of RNA and DNA of exons 1 through 11 shows p53 gene alterations to be present in almost 100% of head and neck squamous cell cancers Lab Invest 79 1999 347-353
55. van Oijen M.G. van de Craats J.G. Slootweg P.J. p53 overexpression in oral mucosa in relation to smoking J Pathol 187 1999 469-474
56. Saranath D. Tandle A.T. Teni T.R. et al. p53 inactivation in chewing tobacco-induced oral cancers and leukoplakias from India Oral Oncol 35 1999 242-250
57. Brennan J.A. Boyle J.O. Koch W.M. et al. Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck N Engl J Med 332 1995 712-717
58. Shin D.M. Lee J.S. Lippman S.M. et al. p53 expressions: Predicting recurrence and second primary tumors in head and neck squamous cell carcinoma J Natl Cancer Inst 88 1996 519-529
59. Brennan J.A. Mao L. Hruban R.H. et al Molecular assessment of histopathological staging in squamous-cell carcinoma of the head and neck N Engl J Med 332 1995 429-435
60. Paz I.B. Cook N. Odom-Maryon T. Xie Y. Wilczynski S.P. Human papillomavirus (HPV) in head and neck cancer. An association of HPV 16 with squamous cell carcinoma of Waldeyer's tonsillar ring Cancer 79 1997 595-604
61. van Houten V.M. Snijders P.J. van den Brekel M.W. et al. Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas Int J Cancer 93 2001 232-235
62. Hafkamp H.C. Speel E.J. Haesevoets A. et al. A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4A and p53 in the absence of mutations in p53 exons 5-8 Int J Cancer 107 2003 394-400
63. Sisk E.A. Soltys S.G. Zhu S. et al. Human papillomavirus and p53 mutational status as prognostic factors in head and neck carcinoma Head Neck 24 2002 841-849
64. Bressac-dePaillerets B. Discovery of a new gene frequently inactivated in human cancers: Protein p16, a cell cycle regulator Bull Cancer 81 1994 853-856
65. Coleman K.G. Wautlet B.S. Morrissey D. et al. Identification of CDK4 sequences involved in cyclin D1 and p16 binding J Biol Chem 272 1997 18869-18874
66. Liggett W.H. Jr Sidransky D. Role of the p16 tumor suppressor gene in cancer J Clin Oncol 16 1998 1197-1206
67. Vogelstein B. Lane D. Levine A.J. Surfing the p53 network Nature 408 2000 307-310
68. Papadimitrakopoulou V. Izzo J. Lippman S.M. et al. Frequent inactivation of p16INK4a in oral premalignant lesions Oncogene 14 1997 1799-1803
69. Reed A.L. Califano J. Cairns P. et al. High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma Cancer Res 56 1996 3630-3633
70. Merlo A. Herman J.G. Mao L. et al. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers Nat Med 1 1995 686-692
71. Xie X. Clausen O.P. De Angelis P. Boysen M. The prognostic value of spontaneous apoptosis, Bax, Bcl-2, and p53 in oral squamous cell carcinoma of the tongue Cancer 86 1999 913-920
72. Roesler J.M. Livingston E.H. Srivatsan E. Chang P. Wang M.B. Deletion of P15 (MTS2) in head and neck squamous cell carcinomas J Surg Res 77 1998 50-54
73. Nawroz H. van der Riet P. Hruban R.H. et al. Allelotype of head and neck squamous cell carcinoma Cancer Res 54 1994 1152-1155
74. Harper J.W. Adami G.R. Wei N. Keyomarsi K. Elledge S.J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases Cell 75 1993 805-816
75. Xiong Y. Hannon G.J. Zhang H. et al. p21 is a universal inhibitor of cyclin kinases Nature 366 1993 701-704
76. Jordan R.C. Bradley G. Slingerland J. Reduced levels of the cell-cycle inhibitor p27Kip1 in epithelial dysplasia and carcinoma of the oral cavity Am J Pathol 152 1998 585-590
77. Hanahan D. Weinberg R.A. The hallmarks of cancer Cell 100 2000 57-70
78. Sauter E.R. Nesbit M. Watson J.C. et al. Vascular endothelial growth factor is a marker of tumor invasion and metastasis in squamous cell carcinomas of the head and neck Clin Cancer Res 5 1999 775-782
79. Smith B.D. Smith G.L. Carter D. Sasaki C.T. Haffty B.G. Prognostic significance of vascular endothelial growth factor protein levels in oral and oropharyngeal squamous cell carcinoma J Clin Oncol 18 2000 2046-2052
80. Bancroft C.C. Chen Z. Dong G. et al. Coexpression of proangiogenic factors IL-8 and VEGF by human head and neck squamous cell carcinoma involves coactivation by MEK-MAPK and IKK-NF-kappaB signal pathways Clin Cancer Res 7 2001 435-442
81. Riedel F. Gotte K. Bergler W. Rojas W. Hormann K. Expression of basic fibroblast growth factor protein and its down-regulation by interferons in head and neck cancer Head Neck 22 2000 183-189
82. Veikkola T. Alitalo K. VEGFs, receptors and angiogenesis Semin Cancer Biol 9 1999 211-220
83. O-charoenrat P. Rhys-Evans P. Eccles S.A. Expression of vascular endothelial growth factor family members in head and neck squamous cell carcinoma correlates with lymph node metastasis Cancer 92 2001 556-568
84. Riedel F. Gotte K. Li M. Hormann K. Grandis J.R. Abrogation of VEGF expression in human head and neck squamous cell carcinoma decreases angiogenic activity in vitro and in vivo Int J Oncol 23 2003 577-583
85. Riedel F. Hormann K. Anti-angiogenesis - a therapy concept in the treatment of head and neck carcinomas? A review Laryngorhinootologie 80 2001 535-541