High calcium activates the EGF receptor potentially through the calcium-sensing receptor in Leydig cancer cells

Growth Factors

Volumn 23, Issue 2, 2005, Pages 117-123

  Tfelt Hansen, Jacob ^a,b,c   Yano, Shozo ^a   MacLeod, R John ^a   Smajilovic, Sanela ^c   Chattopadhyay, Naibedya ^a   Brown, Edward M ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HVIDOVRE HOSPITAL   (Denmark)

^c Mental Health Center Glostrup   (Denmark)

Author keywords

Calcium sensing receptor; Epidermal growth factor receptor; Humoral hypercalcemia; Leydig cancer; Transactivation

Indexed keywords

CALCIUM; CALCIUM SENSING RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; G PROTEIN COUPLED RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PARATHYROID HORMONE RECEPTOR; TYROSINE KINASE RECEPTOR; PARATHYROID HORMONE RELATED PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM HOMEOSTASIS; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVATION; HORMONE RELEASE; HYPERCALCEMIA; IMMUNOPRECIPITATION; LEYDIG CELL TUMOR; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; DOSE RESPONSE; GENE EXPRESSION REGULATION; LEYDIG CELL; MALE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; TESTIS TUMOR; TRANSACTIVATION; TUMOR CELL LINE;

ANIMALIA;

ANIMALS; BLOTTING, WESTERN; CALCIUM; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, NEOPLASTIC; IMMUNOPRECIPITATION; LEYDIG CELLS; MALE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PARATHYROID HORMONE-RELATED PROTEIN; PHOSPHORYLATION; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, CALCIUM-SENSING; SIGNAL TRANSDUCTION; TESTICULAR NEOPLASMS; TRANS-ACTIVATION (GENETICS);

EID: 24944544464     PISSN: 08977194     EISSN: None     Source Type: Journal    
DOI: 10.1080/08977190500126272     Document Type: Article

References (36)

1. Asakura, M, Kitakaze, M, Takashima, S, Liao, Y, Ishikura, F, Yoshinaka, T, Ohmoto, H, Node, K, Yoshino, K, Ishiguro, H, Asanuma, H, Sanada, S, Matsumura, Y, Takeda, H, Beppu, S, Tada, M, Hori, M, Higashiyama, S. Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy Nat Med, 2002; 8: 35-40
2. Brown, EM, Gamba, G, Riccardi, D, Lombardi, M, Butters, R, Kifor, O, Sun, A, Hediger, MA, Lytton, J, Hebert, SC. Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid Nature, 1993; 366: 575-580
3. Chattopadhyay, N, MacLeod, RJ, Tfelt-Hansen, J, Brown, EM. 1alpha,25(OH)2-vitamin D3 inhibits HGF synthesis and secretion from MG-63 human osteosarcoma cells Am J Physiol Endocrinol Metab, 2003; 284: E219-E227
4. Chattopadhyay, N, Yano, S, Tfelt-Hansen, J, Rooney, P, Kanuparthi, D, Bandyopadhyay, S, Ren, X, Terwilliger, E, Brown, EM. Mitogenic action of calcium-sensing receptor on rat calvarial osteoblasts Endocrinology, 2004; 145: 3451-3462
5. 2+ and the protein kinase C-dependent activation of p42 mitogen-activated protein kinase Endocrinology, 1999; 140: 1639-1648
6. Guise, TA, Mundy, GR. Cancer and bone Endocr Rev, 1998; 19: 18-54
7. Ibbotson, KJ, D'Souza, SM, Smith, DD, Carpenter, G, Mundy, GR. EGF receptor antiserum inhibits bone resorbing activity produced by a rat Leydig cell tumor associated with the humoral hypercalcemia of malignancy Endocrinology, 1985; 116: 469-471
8. Kifor, O, MacLeod, RJ, Diaz, R, Bai, M, Yamaguchi, T, Yao, T, Kifor, I, Brown, EM. Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells Am J Physiol Renal Physiol, 2001; 280: F291-F302
9. Liu, B, Goltzman, D, Rabbani, SA. Regulation of parathyroid hormone-related peptide production in vitro by the rat hypercalcemic Leydig cell tumor H-500 Endocrinology, 1993; 132: 1658-1664
10. Luttrell, LM, Della Rocca, GJ, van Biesen, T, Luttrell, DK, Lefkowitz, RJ. Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation J Biol Chem., 1997; 272: 4637-4644
11. MacLeod, RJ, Chattopadhyay, N, Brown, EM. PTHrP stimulated by the calcium-sensing receptor requires MAP kinase activation Am J Physiol Endocrinol Metab, 2003; 284: E435-E442
12. MacLeod, RJ, Yano, S, Chattopadhyay, N, Brown, EM. Extracellular calcium-sensing receptor transactivates the epidermal growth factor receptor by a triple-membrane-spanning signaling mechanism Biochem Biophys Res Commun, 2004; 320: 455-460
13. Majercik, MH, Czerwiec, FS, Puett, D. Effects of hormones and intracellular mediators on differentiated functions of cultured Leydig tumor cells Steroids, 1989; 54: 627-645
14. McCole, DF, Keely, SJ, Coffey, RJ, Barrett, KE. Transactivation of the epidermal growth factor receptor in colonic epithelial cells by carbachol requires extracellular release of transforming growth factor-alpha J Biol Chem, 2002; 277: 42603-42612
15. Melien, O, Thoresen, GH, Sandnes, D, Ostby, E, Christoffersen, T. Activation of p42/p44 mitogen-activated protein kinase by angiotensin II, vasopressin, norepinephrine, and prostaglandin F2alpha in hepatocytes is sustained, and like the effect of epidermal growth factor, mediated through pertussis toxin-sensitive mechanisms J Cell Physiol, 1998; 175: 348-358
16. Murphy, LO, Smith, S, Chen, RH, Fingar, DC, Blenis, J. Molecular interpretation of ERK signal duration by immediate early gene products Nat Cell Biol, 2002; 4: 556-564
17. Musa, FR, Takenaka, I, Konishi, R, Tokuda, M. Effects of luteinizing hormone, follicle-stimulating hormone, and epidermal growth factor on expression and kinase activity of cyclin-dependent kinase 5 in Leydig TM3 and Sertoli TM4 cell lines J Androl, 2000; 21: 392-402
18. Nelson, S, Ascoli, M. Epidermal growth factor, a phorbol ester, and 3′,5′-cyclic adenosine monophosphate decrease the transcription of the luteinizing hormone/chorionic gonadotropin receptor gene in MA-10 Leydig tumor cells Endocrinology, 1992; 131: 615-620
19. Nemeth, EF, Steffey, ME, Hammerland, LG, Hung, BC, Van Wagenen, BC, DelMar, EG, Balandrin, MF. Calcimimetics with potent and selective activity on the parathyroid calcium receptor Proc Natl Acad Sci USA, 1998; 95: 4040-4045
20. Pai, R, Soreghan, B, Szabo, IL, Pavelka, M, Baatar, D, Tarnawski, AS. Prostaglandin E2 transactivates EGF receptor: A novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy Nat Med, 2002; 8: 289-293
21. Peavy, RD, Chang, MS, Sanders-Bush, E, Conn, PJ. Metabotropic glutamate receptor 5-induced phosphorylation of extracellular signal-regulated kinase in astrocytes depends on transactivation of the epidermal growth factor receptor J Neurosci, 2001; 21: 9619-9628
22. Prenzel, N, Zwick, E, Daub, H, Leserer, M, Abraham, R, Wallasch, C, Ullrich, A. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF Nature, 1999; 402: 884-888
23. Rabbani, SA, Gladu, J, Liu, B, Goltzman, D. Regulation in vivo of the growth of Leydig cell tumors by antisense ribonucleic acid for parathyroid hormone-related peptide Endocrinology, 1995; 136: 5416-5422
24. Sordoillet, C, Chauvin, MA, de Peretti, E, Morera, AM, Benahmed, M. Epidermal growth factor directly stimulates steroidogenesis in primary cultures of porcine Leydig cells: Actions and sites of action Endocrinology, 1991; 128: 2160-2168
25. Spiegel, AM, Saxe, AW, Deftos, LJ, Brennan, MF. Humoral hypercalcemia caused by a rat Leydig-cell tumor is associated with suppressed parathyroid hormone secretion and increased urinary cAMP excretion Horm Metab Res, 1983; 15: 299-304
26. Syed, V, Khan, SA, Nieschlag, E. Epidermal growth factor stimulates testosterone production of human Leydig cells in vitro J Endocrinol Investig, 1991; 14: 93-97
27. Tfelt-Hansen, J, Brown, EM. The calcium-sensing receptor in normal physiology and pathophysiology: A review Crit Rev Clin Lab Sci, 2005; 42: 35-70
28. Tfelt-Hansen, J, MacLeod, RJ, Chattopadhyay, N, Yano, S, Quinn, S, Ren, X, Terwilliger, EF, Schwarz, P, Brown, EM. Calcium-sensing receptor stimulates PTHrP release by pathways dependent on PKC, p38 MAPK, JNK, and ERK1/2 in H-500 cells Am J Physiol Endocrinol Metab, 2003a; 285: E329-E337
29. Tfelt-Hansen, J, Schwarz, P, Brown, EM, Chattopadhyay, N. The calcium-sensing receptor in human disease Front Biosci, 2003b; 8: s377-s390
30. Tfelt-Hansen, J, Schwarz, P, Terwilliger, EF, Brown, EM, Chattopadhyay, N. Calcium-sensing receptor induces messenger ribonucleic acid of human securin, pituitary tumor transforming gene, in rat testicular cancer Endocrinology, 2003c; 144: 5188-5193
31. Tfelt-Hansen, J, Chattopadhyay, N, Yano, S, Kanuparthi, D, Rooney, P, Schwarz, P, Brown, EM. Calcium-sensing receptor induces proliferation through p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase but not extracellularly regulated kinase in a model of humoral hypercalcemia of malignancy Endocrinology, 2004a; 145: 1211-1217
32. Tfelt-Hansen, J, Ferreira, A, Yano, S, Kanuparthi, D, Romero, JR, Brown, EM, Chattopadhyay, N. Calcium-sensing receptor activation induces nitric oxide production in H-500 Leydig cancer cells Am J Physiol Endocrinol Metab, 2005; 00492.2004
33. Ushio-Fukai, M, Griendling, KK, Becker, PL, Hilenski, L, Halleran, S, Alexander, RW. Epidermal growth factor receptor transactivation by angiotensin II requires reactive oxygen species in vascular smooth muscle cells Arterioscler Thromb Vasc Biol, 2001; 21: 489-495
34. Wetzker, R, Bohmer, FD. Transactivation joins multiple tracks to the ERK/ MAPK cascade Nat Rev Mol Cell Biol, 2003; 4: 651-657
35. Yan, Y, Shirakabe, K, Werb, Z. The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors J Cell Biol, 2002; 158: 221-226
36. Yano, S, Macleod, RJ, Chattopadhyay, N, Tfelt-Hansen, J, Kifor, O, Butters, RR, Brown, EM. Calcium-sensing receptor activation stimulates parathyroid hormone-related protein secretion in prostate cancer cells: Role of epidermal growth factor receptor transactivation Bone, 2004; 35: 664-672