Activation of p42/p44 mitogen-activated protein kinase by angiotensin II, vasopressin, norepinephrine, and prostaglandin F(2α) in hepatocytes is sustained, and like the effect of epidermal growth factor, mediated through pertussis toxin-sensitive mechanisms

Journal of Cellular Physiology

Volumn 175, Issue 3, 1998, Pages 348-358

  Melien, Øyvind ^a,b   Thoresen, G Hege ^a   Sandnes, Dagny ^a   Østby, Eva ^a   Christoffersen, Thoralf ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; EPIDERMAL GROWTH FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NORADRENALIN; PERTUSSIS TOXIN; PROSTAGLANDIN F2 ALPHA; VASOPRESSIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; ENZYME ACTIVATION; GROWTH REGULATION; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CELLS, CULTURED; DINOPROST; DNA; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; INOSITOL 1,4,5-TRISPHOSPHATE; LIVER; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; NEUROPEPTIDES; NOREPINEPHRINE; PERTUSSIS TOXIN; RATS; RATS, WISTAR; TIME FACTORS; VIRULENCE FACTORS, BORDETELLA;

ANIMALIA; TRIXIS;

EID: 0031971122     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199806)175:3<348::AID-JCP13>3.0.CO;2-1     Document Type: Article

References (92)

1. Adachi, T., Nakashima, S., Saji, S., Nakamura, T., and Nozawa, Y. (1996) Mitogen-activated protein kinase activation in hepatocyte growth factor-stimulated rat hepatocytes: Involvement of protein tyrosine kinase and protein kinase C. Hepatology, 23:1244-1253.
2. 2-adrenergic receptors expressed in fibroblasts. J. Biol. Chem., 268:22235-22238.
3. Anderson, N.G., Maller, J.L., Tonks, N.K., and Sturgill, T.W. (1990) Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase. Nature, 343:651-653.
4. 3H1 myocytes by fluoroaluminate. J. Biol. Chem., 266:10131-10135.
5. Bauer, P.H., Chiu, A.T., and Garrison, J.C. (1991) DuP 753 can antagonize the effects of angiotensin II in rat liver. Mol. Pharmacol., 39:579-585.
6. Berridge, M.J., and Irvine, R.F. (1984) Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature, 312:315-321.
7. 2+ inflow in hepatocytes. J. Biol. Chem., 270:25893-25897.
8. Bhat, N.R., Zhang, P., and Hogan, E.L. (1995) Thrombin activates mitogen-activated protein kinase in primary astrocyte cultures. J. Cell. Physiol., 165:417-424.
9. Blenis, J. (1993) Signal transduction via the MAP kinases: Proceed at your own RSK. Proc. Natl. Acad. Sci. USA, 90:5889-5892.
10. Bogoyevitch, M.A., Andersson, M.B., Gillespie-Brown, J., Clerk, A., Glennon, P.E., Fuller, S.J., and Sugden, P.H. (1996) Adrenergic receptor stimulation of the mitogen-activated protein kinase cascade and cardiac hypertrophy. Biochem. J., 314:115-121.
11. Boylan, J.M., and Gruppuso, P.A. (1994) In vitro and in vivo regulation of hepatic mitogen-activated protein kinases in fetal rats. Am. J. Physiol. Gastrointest. Liver Physiol., 267:G1078-G1086.
12. Bucher, N.L.R., and Strain, A.J. (1992) Regulatory mechanisms in hepatic regeneration. In: Wright's Liver and Biliary Disease. G.H. Millward-Sadler, R. Wright, and M.J.P. Arthur, eds. W.B. Saunders, London, Vol. 11, pp. 258-274.
13. Burt, A.R., Carr, I.C., Mullaney, I., Anderson, N.G., and Milligan, G. (1996) Agonist activation of p42 and p44 mitogen-activated protein kinases following expression of the mouse δ opioid receptor in Rat-1 fibroblasts: Effects of receptor expression levels and comparisons with G-protein activation. Biochem. J., 320:227-235.
14. 1-adrenergic receptor-coupled metabolic activation. J. Biol. Chem., 268:6081-6089.
15. Christoffersen, T., Refsnes, M., Brønstad, G.O., Østby, E., Huse, J., Haffner, F., Sand, T.-E., Hunt, N.H., and Sonne, O. (1984) Changes in hormone responsiveness and cyclic AMP metabolism in rat hepatocytes during primary culture and effects of supplementing the medium with insulin and dexamethasone. Eur. J. Biochem., 138:217-226.
16. Christoffersen, T., Thoresen, G.H., Dajani, O.F., Sandnes, D., and Refsnes, M. (1994) Growth stimulation mediated by G protein coupled receptors in hepatocytes: Synergism with epidermal growth factor and mechanisms of signal transduction. In: Liver Carcinogenesis: The Molecular Pathways. G.G. Skouteris, ed. NATO ASI Series, Vol H88, Springer Verlag, Berlin, pp. 73-91.
17. Church, J.G., and Buick, R.N. (1988) G-protein-mediated epidermal growth factor signal transduction in a human breast cancer cell line. J. Biol. Chem., 1988:4242-4246.
18. Cook, S.J., and McCormick, F. (1996) Kinetic and biochemical correlation between sustained p44ERK1 (44 kDa extracellular signal-regulated kinase 1) activation and lysophosphatidic acid-stimulated DNA synthesis in Rat-1 cells. Biochem. J., 320:237-245.
19. Crespo, P., Xu, N., Simonds, W.F., and Gutkind, J.S. (1994) Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits. Nature, 369:418-420.
20. s-cAMP-mediated inhibition. J. Biol. Chem., 270:25259-25265.
21. 2α. J. Cell. Physiol., 168:608-617.
22. Daub, H., Weiss, F.U., Wallasch, C., and Ullrich, A. (1996) Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature, 379:557-560.
23. Davis, R.J. (1993) The mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem., 268:14553-14556.
24. Dikic, I., Tokiwa, G., Lev, S., Courtneidge, S.A., and Schlessinger, J. (1996) A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature, 383:547-550.
25. Eguchi, S., Matsumoto, T., Motley, E.D., Utsunomiya, H., and Inagami, T. (1996) Identification of an essential signaling cascade for mitogen-activated protein kinase activation by angiotensin II in cultured rat vascular smooth muscle cells. J. Biol. Chem., 271:14169-14175.
26. Enslen, H., Tokumitsu, H., Stork, P.J.S., Davis, R.J., and Soderling, T.R. (1996) Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. Proc. Natl. Acad. Sci. USA, 93:10803-10808.
27. Exton, J.H. (1994) Phosphoinositide phospholipases and G proteins in hormone action. Annu. Rev. Physiol., 56:349-369.
28. Exton, J.H. (1996) Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu. Rev. Pharmacol. Toxicol., 36:481-509.
29. Faure, M., Voyno-Yasenetskaya, T.A., and Bourne, H.R. (1994) cAMP and βγ subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. J. Biol. Chem., 269:7851-7854.
30. 2+ inflow requires a pertussis toxin-sensitive trimeric G-protein. Biochem. J., 303:351-356.
31. Fujinaga, Y., Morozumi, N., Sato, K., Tokumitsu, Y., Fujinaga, K., Kondo, Y., Ui, M., and Okajima, F. (1989) A pertussis toxin-sensitive GTP-binding protein plays a role in the G0-G1 transition of rat hepatocytes following establishment in primary culture. FEBS Lett., 245:117-121.
32. 1-adrenergic action: Comparison with V1-vasopressin and A1-angiotensin. Circ. Res., 61(suppl.II):II-1-II-5.
33. Gines, P., Li, X., Zamarripa, J.L., Brown, S.E.S., Wieder, E.D., Nakamura, T., Guzelian, P.S., Schrier, R.W., Heasley, L.E., and Nemenoff, R.A. (1995) Tyrosine kinase growth factor receptors but not seven-membrane-spanning receptors or phorbol esters activate mitogen-activated protein kinase in rat hepatocytes. Hepatology, 22:1296-1303.
34. Gines, P., Li, X., Brown, S.E.S., Nakamura, T., Guzelian, P.S., Heasley, L.E., Schrier, R.W., and Nemenoff, R.A. (1996) Inhibitory actions of cyclic adenosine monophosphate and pertussis toxin define two distinct epidermal growth factor-regulated pathways leading to activation of mitogen-activated protein kinase in rat hepatocytes. Hepatology, 23:1167-1173.
35. Gotoh, Y., Nishida, E., Yamashita, T., Hoshi, M., Kawakami, M., and Sakai, H. (1990) Microtubule-associated-protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells. Eur. J. Biochem., 193:661-669.
36. Granot, Y., Erikson, E., Fridman, H., Van Putten, V., Williams, B., Schrier, R.W., and Mailer, J.L. (1993) Direct evidence for tyrosine and threonine phosphorylation and activation of mitogen-activated protein kinase by vasopressin in cultured rat vascular smooth muscle cells. J. Biol. Chem., 268:9564-9569.
37. Graves, L.M., and Lawrence, J.C. (1996) Insulin, growth factors, and cAMP. Antagonism in the signal transduction pathways. Trends Endocrinol. Metab., 7:43-50.
38. q-mediated mitogen-activated protein kinase activation. J. Biol. Chem., 270:17148-17153.
39. raf-1. J. Biol. Chem., 268:20717-20720.
40. 2+ stimulates the activation of mitogen-activated protein kinase and cell growth in human fibroblasts. Biochem. J., 310:881-885.
41. Huang, X.-C., Richards, E.M., and Sumners, C. (1996) Mitogen-activated protein kinases in rat brain neuronal cultures are activated by angiotensin II type 1 receptors and inhibited by angiotensin II type 2 receptors. J. Biol. Chem., 271:15635-15641.
42. MAP kinase in adult rat hepatocytes. FEBS Lett., 412:9-14.
43. Johnson, G.L., and Vaillancourt, R.R. (1994) Sequential protein kinase reactions controlling cell growth and differentiation. Curr. Opin. Cell Biol., 6:230-238.
44. i2, transduce mitogenic signals? J. Cell. Biochem., 54:415-422.
45. Johnson, R.M., Connelly, P.A., Sisk, R.B., Pobiner, B.F., Hewlett, E.L., and Garrison, J.C. (1986) Pertussis toxin or phorbol 12-myristate 13-acetate can distinguish between epidermal growth factor-and angiotensin-stimulated signals in hepatocytes. Proc. Natl. Acad. Sci. USA, 83:2032-2036.
46. Kahan, C., Seuwen, K., Meloche, S., and Pouysségur, J. (1992) Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. J. Biol. Chem., 267:13369-13375.
47. Kameshita, I., and Fujisawa, H. (1989) A sensitive method for detection of calmodulin-dependent protein kinase II activity in sodium dodecyl sulfate-polyacrylamide gel. Anal. Biochem., 183:139-143.
48. Keyse, S.M. (1995) An emerging family of dual specificity MAP kinase phosphatases. Biochim. Biophys. Acta Mol. Cell Res., 1265:152-160.
49. ras. Proc. Natl. Acad. Sci. USA, 91:12706-12710.
50. 2+-induced regulation of ion channel and MAP kinase functions. Nature, 376:737-745.
51. Liang, M., and Garrison, J.C. (1991) The epidermal growth factor receptor is coupled to a pertussis toxin-sensitive guanine nucleotide regulatory protein in rat hepatocytes. J. Biol. Chem., 266:13342-13349.
52. Luttrell, L.M., Hawes, B.E., van Biesen, T., Luttrell, D.K., Lansing, T.J., and Lefkowitz, R.J. (1996) Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gβγ subunit-mediated activation of mitogen-activated protein kinases. J. Biol. Chem., 271:19443-19450.
53. Malarkey, K., Belham, C.M., Paul, A., Graham, A., McLees, A., Scott, P.H., and Plevin, R. (1995) The regulation of tyrosine kinase signalling pathways by growth factor and G-protein-coupled receptors. Biochem. J., 309:361-375.
54. Marshall, C.J. (1995) Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation. Cell. 80:179-185.
55. Masuda, N., and Ui, M. (1991) Possible involvement of GTP-binding proteins in growth regulation of human epidermoid carcinoma cell line A431. FEBS Lett., 291:9-12.
56. 2α on hormone-induced cAMP accumulation in cultured hepatocytes. Eur. J. Biochem., 172:293-297.
57. mapk (ERK1) by growth factors: Correlation between late phase activation and mitogenicity. Mol. Endocrinol., 6:845-854.
58. Michalopoulos, G.K. (1990) Liver regeneration: Molecular mechanisms of growth control. FASEB J., 4:176-187.
59. Miyasaka, T., Chao, M.V., Sherline, P., and Saltiel, A.R. (1990) Nerve growth factor stimulates a protein kinase in PC-12 cells that phosphorylates microtubule-associated protein-2. J. Biol. Chem., 265:4730-4735.
60. Morel, A., O'Carroll, A.-M., Brownstein, M.J., and Lolait, S.J. (1992) Molecular cloning and expression of a rat V1a arginine vasopressin receptor. Nature, 356:523-526.
61. Murayama, T., and Ui, M. (1983) Loss of the inhibitory function of the guanine nucleotide regulatory component of adenylate cyclase due to its ADP ribosylation by islet-activating protein, pertussis toxin, in adipocyte membranes. J. Biol. Chem., 258:3319-3326.
62. 1 receptor: Gain-of-function study using gene transfer. Proc. Natl. Acad. Sci. USA, 92:10663-10667.
63. 3β subtype from rat hepatocytes. FEBS Lett., 351:119-122.
64. i2-mediated activation of the MAP kinase cascade. Mol. Biol. Cell, 6:1685-1695.
65. 3 in unstimulated and vasopressin-stimulated rat hepatocytes. Cell. Signal., 1:147-156.
66. Posada, J., and Cooper, J.A. (1992) Requirements for phosphorylation of MAP kinase during meiosis in Xenopus oocytes. Science, 255:212-215.
67. ras activity and consequent prolonged ERK activity. Neuron, 9:705-717.
68. Ramírez, I., Tebar, F., Grau, M., and Soley, M. (1995) Role of heterotrimeric G-proteins in epidermal growth factor signalling. Cell. Signal., 7:303-311.
69. Ray, L.B., and Sturgill, T.W. (1987) Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro. Proc. Natl. Acad. Sci. USA, 84:1502-1506.
70. Ray, L.B., and Sturgill, T.W. (1988) Insulin-stimulated microtubuleassociated protein kinase is phosphorylated on tyrosine and threonine in vivo. Proc. Natl. Acad. Sci. USA, 85:3753-3757.
71. Refsnes, M., Sandnes, D., Melien, ø., Sand, T.E., Jacobsen, S., and Christoffersen, T. (1983) Mechanisms for the emergence of catecholamine-sensitive adenylate cyclase and β-adrenergic receptors in cultured hepatocytes. FEBS Lett., 164:291-298.
72. 1-and beta-adrenergic mechanisms. J. Cell. Physiol., 151:164-171.
73. 2α: Additivity with the effect of norepinephrine, and synergism with epidermal growth factor. J. Cell. Physiol., 159:35-40.
74. Refsnes M., Dajani, O.F., Sandnes, D., Thoresen, G.H., Røttingen, J.-A., Iversen, J.-G., and Christoffersen, T. (1995) On the mechanisms of the growth-promoting effect of prostaglandins in hepatocytes: The relationship between stimulation of DNA synthesis and signaling mediated by adenylyl cyclase and phosphoinositide-specific phospholipase C. J. Cell. Physiol., 164:465-473.
75. Romanelli, A., and van de Werve, G. (1997) Activation of mitogen-activated protein kinase in freshly isolated rat hepatocytes by both a calcium- and a protein kinase C-dependent pathway. Metabolism. 46:548-555.
76. Ruiz-Opazo, N., Akimoto, K., and Herrera, V.L.M. (1995) Identification of a novel dual angiotensin II/vasopressin receptor on the basis of molecular recognition theory. Nature Med., 1:1074-1081.
77. Seger, R., and Krebs, E.G. (1995) The MAPK signaling cascade. FASEB J., 9:726-735.
78. Seglen, P.O. (1976) Preparation of isolated rat liver cells. Methods Cell Biol., 13:29-83.
79. Sim, P.J., Wolbers, W.B., and Mitchell, R. (1995) Activation of MAP kinase by the LHRH receptor through a dual mechanism involving protein kinase C and pertussis toxin-sensitive G protein. Mol. Cell. Endocrinol., 112:257-263.
80. Spector, M.S., Auer, K.L., Jarvis, W.D., Ishac, E.J.N., Gao, B., Kunos, G., and Dent, P. (1997) Differential regulation of the mitogen-activated protein and stress-activated protein kinase cascades by adrenergic agonists in quiescent and regenerating adult rat hepatocytes. Mol. Cell. Biol., 17:3556-3565.
81. Thoresen, G.H., Guren, T.K., Sandnes, D., Peak, M., Agius, L., and Christoffersen, T. (1998) Response to transforming growth factor α (TGFα) and epidermal growth factor (EGF) in hepatocytes: Lower EGF receptor affinity of TGFα is associated with more sustained activation of p42/p44 mitogen-activated protein kinase and greater efficacy in stimulation of DNA synthesis. J. Cell. Physiol. (in press).
82. Tobe, K., Kadowaki, T., Hara, K., Gotoh, Y., Kosako, H., Matsuda, S., Tamemoto, H., Ueki, K., Akanuma, Y., Nishida, E., and Yazaki, Y. (1992) Sequential activation of MAP kinase activator, MAP kinases, and S6 peptide kinase in intact rat liver following insulin injection. J. Biol. Chem., 267:21089-21097.
83. 1-adrenergic receptor with pertussis-toxin-sensitive guanine-nucleotide-binding regulatory proteins (G proteins) responsible for phospholipase C activation in rat liver plasma membranes. Eur. J. Biochem., 194:81-87.
84. Tsuda, T., Kawahara, Y., Ishida, Y., Koide, M., Shii, K., and Yokoyama, M. (1992) Angiotensin II stimulates two myelin basic protein/ microtubule-associated protein 2 kinases in cultured vascular smooth muscle cells. Circ. Res., 71:620-630.
85. van Biesen, T., Hawes, B.E., Luttrell, D.K., Krueger, K.M., Touhara, K., Porfiri, E., Sakaue, M., Luttrell, L.M., and Lefkowitz, R.J. (1995) Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signaling pathway. Nature, 376:781-784.
86. van Biesen, T., Luttrell, L.M., Hawes, B.E., and Lefkowitz, R.J. (1996) Mitogenic signaling via G protein-coupled receptors. Endocr. Rev., 17:698-714.
87. Wan, Y., Kurosaki, T., and Huang, X.-Y. (1996) Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors. Nature, 380:541-544.
88. q-protein-coupled pathway. J. Biol. Chem., 270:8984-8990.
89. Wen, Y., Nadler, J.L., Gonzales, N., Scott, S., Clauser, E., and Natarajan, R. (1996) Mechanisms of Ang II-induced mitogenic responses: Role of 12-lipoxygenase and biphasic MAP kinase. Am. J. Physiol., 271:C1212-C1220.
90. 2+ fluxes. Annu. Rev. Physiol., 51:107-124.
91. i protein involvement in epidermal growth factor-induced activation of phospholipase C-γ in rat hepatocytes. J. Biol. Chem., 266:22451-22458.
92. i-protein to activation of phospholipases in rat-cultured hepatocytes. J. Biol. Chem., 268:3739-3746.