Aspects of prevention and therapy of lipid metabolism disorders especially in considering the metabolic syndrome;Aspekte zur prävention und therapie von fettstoffwechselstörungen unter besonderer berücksichtigung des metabolischen syndroms

Deutsche Zeitschrift fur Sportmedizin

Volumn 56, Issue 3, 2005, Pages 74-82

  Berg, A ^a   Konig D ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Adiposity; Dyslipoproteinemia; Exercise; Lipoproteins; Metabolic syndrome

Indexed keywords

EID: 24944507607     PISSN: 03445925     EISSN: 03445925     Source Type: Journal    
DOI: None     Document Type: Review

References (91)

1. American College of Sports Medicine Position Stand: Exercise and physical activity for older adults American College of Sports Medicine Position Stand. The recommended quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness, and flexibility in healthy adults. Med Sci Sports Exerc 30 (1998) 992-1008.
2. American College of Sports Medicine Position Stand: The recommended quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness, and flexibility in healthy adults. Med Sci Sports Exerc 30 (1998) 975-991.
3. Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults: Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 285 (16-5-2001) 2486-2497.
4. Alexander CM, Landsman PB, Teutsch SM, Haffner SM: NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older. Diabetes 52 (2003) 1210-1214. .
5. The Scandinavian Simvastatin Survival Study: Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S). Lancet 344 (1994) 1383-1389
6. Ades PA: Cardiac rehabilitation and secondary prevention of coronary heart disease. N Engl J Med 345 (2001) 892-902.
7. Arnalich F, Hernanz A, Lopez-Maderuelo D, Pena JM, Camacho J, Madero R, Vazquez JJ, Montiel C: Enhanced acute-phase response and oxidative stress in older adults with type II diabetes. Horm Metab Res 32 (2000) 407-412.
8. Banz WJ, Maher MA, Thompson WG, Bassett DR, Moore W, Ashraf M, Keefer DJ, Zemel MB: Effects of resistance versus aerobic training on coronary artery disease risk factors. Exp Biol Med (Maywood) 228 (2003) 434-440.
9. Baumstark MW, Stöwesand U, Keul J, Berg A: Einfluß von Sport auf die Aktivität des Cholesterinester-Transfer-Proteins (CETP). Ciba-Geigy, Wehr, 1995, 126.
10. Beltowski J: Adiponectin and resistin - new hormones of white adipose tissue. Med Sci Monit 9 (2003) RA55-RA61.
11. Berg A, Frey I, Baumstark MW, Halle M, Keul J: Physical activity and lipoprotein lipid disorders. Sports Med 17 (1994) 6-21.
12. Berg A, Halle M: Körperliche Aktivität und kardiovaskuläre Mortalität: Von der Epidemiologie zur medizinischen Praxis. Med Welt 50 (1999) 359-362.
13. Berg A, Halle M, Franz I, Keul J: Physical activity and lipoprotein metabolism: Epidemiological evidence and clinical trials. Eur J of Med Res 2 (1997) 259-264.
14. Berg AH, Combs TP, Scherer PE: ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab 13 (2002) 84-89.
15. Blair SN, Cheng Y, Holder JS: Is physical activity or physical fitness more important in defining health benefits? Med Sci Sports Exerc 33 (2001) S379-S399.
16. Boquist S, Hamsten A, Karpe F, Ruotolo G: Insulin and non-esterified fatty acid relations to alimentary lipaemia and plasma concentrations of postprandial triglyceride-rich lipoproteins in healthy middle-aged men. Diabetologia 43 (2000) 185-193.
17. Bouchard C, An P, Rice T, Skinner JS, Wilmore JH, Gagnon J, Perusse L, Leon AS, Rao DC: Familial aggregation of VO(2max) response to exercise training: results from the HERITAGE Family Study. J Appl Physiol 87 (1999) 1003-1008.
18. Cohen JC, Vega GL, Grundy SM: Hepatic lipase: new insights from genetic and metabolic studies. Curr Op in Lipidol 10 (1999) 259-267.
19. Coppack SW: Pro-inflammatory cytokines and adipose tissue. Proceedings of the Nutrition Society 60 (2001) 349-356.
20. Despres JP, Couillard C, Gagnon J, Bergeron J, Leon AS, Rao DC, Skinner JS, Wilmore JH,Bouchard C: Race, visceral adipose tissue, plasma lipids, and lipoprotein lipase activity in men and women: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) family study. Arterioscler Thromb Vasc Biol 20 (2000) 1932-1938.
21. Despres JP, Gagnon J, Bergeron J, Couillard C, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C: Plasma post-heparin lipase activities in the HERITAGE Family Study: the reproducibility, gender differences, and associations with lipoprotein levels. Health, Risk factors, exercise Training and Genetics. Clin Biochem 32 (1999) 157-165.
22. Diamond FB, Jr., Eichler DC: Leptin and the adipocyte endocrine system. Crit Rev Clin Lab Sci 39 (2002) 499-525.
23. DiGuiseppi C, Roberts I, Li L: Influence of changing travel patterns on child death rates from injury: trend analysis. BMJ 314 (1997) 710-713.
24. Durstine JL, Grandjean PW, Cox CA, Thompson PD: Lipids, lipoproteins, and exercise. J Cardiopulm Rehabil 22 (2002) 385-398.
25. Durstine JL, Grandjean PW, Davis PG, Ferguson MA, Alderson NL, DuBose KD: Blood lipid and lipoprotein adaptations to exercise: a quantitative analysis. Sports Med 31 (2001) 1033-1062.
26. Evans RM, Barish GD, Wang YX: PPARs and the complex journey to obesity. Nature Med 10 (2004) 355-361.
27. Flegal KM, Carroll MD, Kuczmarski RJ, Johnson CL: Overweight and obesity in the United States: prevalence and trends, 1960-1994. Int J Obes Relat Metab Disord. 22 (1998) 39-47.
28. Franks PW, Ekelund U, Brage S, Wong MY, Wareham NJ: Does the association of habitual physical activity with the metabolic syndrome differ by level of cardiorespiratory fitness? Diab Care 27 (2004) 1187-1193.
29. Frayn KN: Adipose tissue as a buffer for daily lipid flux. Diabetologia 45 (2002) 1201-1210.
30. Fukuzako H, Hashiguchi T, Sakamoto Y, Okamura H, Doi W, Takenouchi K, Takigawa M: Metabolite changes with age measured by proton magnetic resonance spectroscopy in normal subjects. Psych Clin Neurosci 51 (1997) 261-263.
31. Gavrilova O, Marcus-Samuels B, Graham D, Kim JK, Shulman GI, Castle AL, Vinson C, Eckhaus M, Reitman ML: Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. J Clin Invest 105 (2000) 271-278.
32. Goldberg AP, Busby-Whitehead MJ, Katzel LI, Krauss RM, Lumpkin M, Hagberg JM: Cardiovascular fitness, body composition, and lipoprotein lipid metabolism in older men. J Gerontol A Biol Sci Med Sci 55 (2000) M342-M349.
33. Gray RE, Tanner CJ, Pories WJ, MacDonald KG, Houmard JA: Effect of weight loss on muscle lipid content in morbidly obese subjects. Am J Physiol Endocrinol Metab 284 (2003) E726-E732.
34. Greiwe JS, Cheng B, Rubin DC, Yarasheski KE, Semenkovich CF: Resistance exercise decreases skeletal muscle tumor necrosis factor alpha in frail elderly humans. FASEB Journal 15 (2001) 475-482.
35. Grundy SM: Hypertriglyceridemia, atherogenic dyslipidemia, and the metabolic syndrome. Am J Cardiol 81 (1998) 18B.
36. Grundy SM: Hypertriglyceridemia, insulin resistance, and the metabolic syndrome. Am J Cardiol 83 (13-5-1999) 25F.
37. Grundy SM, Hansen B, Smith SC, Jr., Cleeman JI,Kahn RA: Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management. Arterioscler Thromb Vasc Biol 24 (2004) e19-e24.
38. Halle M, Berg A, Baumstark MW, Frey I, Keul J: Association of physical fitness with LDL and HDL subfractions in young healthy men. Int J Sports Med 20 (1999) 464-469.
39. Halle M, Berg A, Frey I, König D, Keul J, Baumstark MW: Relationship between obesity and concentration and composition of low-density lipoprotein subfractions in normoinsulinemic men. Metabolism: Clinical & Experimental 44 (1995) 1384-1390.
40. Halle M, Berg A, Garwers U, Baumstark MW, Knisel W, Grathwohl D, König D, Keul J: Influence of 4 weeks' intervention by exercise and diet on low-density lipoprotein subfractions in obese men with type 2 diabetes. Metabolism: Clinical & Experimental 48 (1999) 641-644.
41. Halle M, Berg A, König D, Keul J, Baumstark MW: Differences in the concentration and composition of low-density lipoprotein subfraction particles between sedentary and trained hypercholesterolemic men. Metabolism: Clinical & Experimental 46 (1997) 186-191.
42. Hambrecht R, Niebauer J, Marburger C, Grunze M, Kälberer B, Hauer K, Schlierf G, Kübler W, Schuler G: Various intensities of leisure time physical activity in patients with coronary artery disease: effects of cardiorespirative fitness and progression of coronary atherosclerotic lesions. J Am Coll Cardiol 22 (1993) 468-477.
43. Haskell WL: J.B. Wolffe Memorial Lecture. Health consequences of physical activity: understanding and challenges regarding dose-response. Med Sci Sports Exerc 26 (1994) 649-660.
44. Haskell WL, Alderman EL, Fair JM, Maron DJ, Mackey SF, Superko HR, Williams PT, Johnstone IM, Champagne MA, Krauss RM, Farquhar JW: Effects of intensive multiple risk factor reduction on coronary atherosclerosis and clinical events in men and women with coronary artery disease. The Stanford Coronary Risk Intervention Project (SCRIP). Circulation 89 (1994) 975-990.
45. He J, Goodpaster BH, Kelley DE: Effects of weight loss and physical activity on muscle lipid content and droplet size. Obes Res 12 (2004) 761-769.
46. Jolliffe J, Rees K, Taylor RS, Thompson D, Oldridge NB, Ebrahim S: Exercise-based rehabilitation for coronary heart disease. Cochrane Database Syst Rev. 1 (2001) CD001800
47. Katzmarzyk PT, Leon AS, Wilmore JH, Skinner JS, Rao DC, Rankinen T, Bouchard C: Targeting the metabolic syndrome with exercise: evidence from the HERITAGE Family Study. Med Sci Sports Exerc 35 (2003) 1703-1709.
48. Kiens B, Essen-Gustavsson B, Christensen NJ, Saltin B: Skeletal muscle substrate utilization during submaximal exercise in man: effect of endurance training. J Physiol 469 (1993) 459-478.
49. Kimm SY, Glynn NW, Kriska AM, Barton BA, Kronsberg SS, Daniels SR, Crawford PB, Sabry ZI, Liu K: Decline in physical activity in black girls and white girls during adolescence. N Engl J Med 347 (2002) 709-715.
50. Klein S, Sheard NF, Pi-Sunyer X, Daly A, Wylie-Rosett J, Kulkarni K, Clark NG: Weight management through lifestyle modification for the prevention and management of type 2 diabetes: rationale and strategies: a statement of the American Diabetes Association, the North American Association for the Study of Obesity, and the American Society for Clinical Nutrition. Diab Care 27 (2004) 2067-2073.
51. Klein S, Sheard NF, Pi-Sunyer X, Daly A, Wylie-Rosett J, Kulkarni K, Clark NG: Weight management through lifestyle modification for the prevention and management of type 2 diabetes: rationale and strategies: a statement of the American Diabetes Association, the North American Association for the Study of Obesity, and the American Society for Clinical Nutrition. Diab Care 27 (2004) 2067-2073.
52. Kraus WE, Houmard JA, Duscha BD, Knetzger KJ, Wharton MB, McCartney JS, Bales CW, Henes S, Samsa GP, Otvos JD, Kulkarni KR, Slentz CA: Effects of the amount and intensity of exercise on plasma lipoproteins. N Engl J Med 347 (7-11-2002) 1483-1492.
53. Kriketos AD, Sharp TA, Seagle HM, Peters JC,Hill JO: Effects of aerobic fitness on fat oxidation and body fatness. Med Sci Sports Exerc 32 (2000) 805-811.
54. Kuo CH, Ding Z, Ivy JL: Interaction of exercise training and clenbuterol on GLUT-4 protein in muscle of obese Zucker rats. Am J Physiol 271 (1996) E847-E854.
55. Kwong LK, Sohal RS: Age-related changes in activities of mitochondrial electron transport complexes in various tissues of the mouse. Arch Biochem & Biophys 373 (1-1-2000) 16-22.
56. Larsen TM, Toubro S, Astrup A: PPARgamma agonists in the treatment of type II diabetes: is increased fatness commensurate with long-term efficacy? Int J Obes Relat Metab Disord 27 (2003) 147-161.
57. Leon AS, Rice T, Mandel S, Despres JP, Bergeron J, Gagnon J, Rao DC, Skinner JS, Wilmore JH, Bouchard C: Blood lipid response to 20 weeks of supervised exercise in a large biracial population: the HERITAGE Family Study. Metabolism: Clinical & Experimental 49 (2000) 513-520.
58. Luquet S, Lopez-Soriano J, Holst D, Fredenrich A, Melki J, Rassoulzadegan M, Grimaldi PA: Peroxisome proliferator-activated receptor delta controls muscle development and oxidative capability. FASEB Journal 17 (2003) 2299-2301.
59. Marques-Lopes I, Ansorena D, Astiasaran I, Forga L, Martinez JA: Postprandial de novo lipogenesis and metabolic changes induced by a highcarbohydrate, low-fat meal in lean and overweight men. Am J Clin Nutr 73 (2001) 253-261.
60. Mayer F, Gollhofer A, Berg A: Krafttraining mit Älteren und chronisch Kranken. Dtsch Z Sportmed 54 (2003) xx.
61. McConell G, McCoy M, Proietto J, Hargreaves M: Skeletal muscle GLUT-4 and glucose uptake during exercise in humans. J Appl Physiol 77 (1994) 1565-1568.
62. Mensink GB: Körperliche Aktivität. Gesundheitswesen 61 (1999) S126-S131.
63. Mokdad AH, Bowman BA, Ford ES, Vinicor F, Marks JS, Koplan JP: The continuing epidemics of obesity and diabetes in the United States. JAMA 286 (12-9-2001) 1195-1200.
64. Moller DE: Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes. Trends Endocrinol Metab 11 (2000) 212-217.
65. Morss GM, Jordan AN, Skinner JS, Dunn AL, Church TS, Earnest CP, Kampert JB, Jurca R, Blair SN: Dose Response to Exercise in Women aged 45-75 yr (DREW): design and rationale. Med Sci Sports Exerc 36 (2004) 336-344.
66. Must A, Spadano J, Coakley EH, Field AE, Colditz G, Dietz WH: The disease burden associated with overweight and obesity. JAMA 282 (27-10-1999) 1523-1529.
67. Papadia F, Marinari GM, Camerini G, Civalleri D, Scopinaro N, Adami GF: Leptin and insulin action in severely obese women. Obes Surg 13 (2003) 241-244.
68. Perseghin G, Scifo P, Danna M, Battezzati A, Benedini S, Meneghini E, Del Maschio A, Luzi L: Normal insulin sensitivity and IMCL content in overweight humans are associated with higher fasting lipid oxidation. Am J Physiol Endocrinol Metab 283 (2002) E556-E564.
69. Perusse L, Rice T, Province MA, Gagnon J, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C: Familial aggregation of amount and distribution of subcutaneous fat and their responses to exercise training in the HERITAGE family study. Obes Res 8 (2000) 140-150.
70. Prins JB: Adipose tissue as an endocrine organ. Best Pract Res Clin Endocrinol Metab 16 (2002) 639-651.
71. Ravussin E, Smith SR: Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and type 2 diabetes mellitus. Ann N Y Acad Sci 967 (2002) 363-378.
72. Reynisdottir S, Angelin B, Langin D, Lithell H, Eriksson M, Holm C, Arner P: Adipose tissue lipoprotein lipase and hormone-sensitive lipase. Contrasting findings in familial combined hyperlipidemia and insulin resistance syndrome. Arterioscler Thromb Vasc Biol 17 (1997) 2287-2292.
73. Rifai N, Joubran R, Yu H, Asmi M, Jouma M: Inflammatory markers in men with angiographically documented coronary heart disease. Clin Chem 45 (1999) 1967-1973.
74. Romijn JA, Coyle EF, Sidossis LS, Rosenblatt J, Wolfe RR: Substrate metabolism during different exercise intensities in endurance-trained women. J Appl Physiol 88 (2000) 1707-1714.
75. Sacks FM, Pfeffer MA, Moye LA, Rouleau JL, Rutherford JD, Cole TG, Brown L, Warnica JW, Arnold JM, Wun CC, Davis BR, Braunwald E: The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. N Engl J Med 335 (1996) 1001-1009.
76. Schrezenmeir J, Fenselau S, Keppler I, Abel J, Orth B, Laue C, Sturmer W, Fauth U, Halmagyi M, Marz W: Postprandial triglyceride high response and the metabolic syndrome. Ann N Y Acad Sci 827 (1997) 353-368.
77. Schulze PC, Gielen S, Schuler G, Hambrecht R: Chronic heart failure and skeletal muscle catabolism: effects of exercise training. Int J Cardiol 85 (2002) 141-149.
78. Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, Macfarlane PW, McKillop JH, Packard CJ: Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. N Engl J Med 333 (1995) 1301-1307.
79. Skinner JS, Jaskolski A, Jaskolska A, Krasnoff J, Gagnon J, Leon AS, Rao DC, Wilmore JH, Bouchard C: Age, sex, race, initial fitness, and response to training: the HERITAGE Family Study. J Appl Physiol 90 (2001) 1770-1776.
80. Sohal RS,Orr WC: Relationship between antioxidants, prooxidants, and the aging process. Ann N Y Acad Sci 663 (1992) 74-84.
81. Stefanick ML, Mackey S, Sheehan M, Ellsworth N, Haskell WL, Wood PD: Effects of diet and exercise in men and postmenopausal women with low levels of HDL cholesterol and high levels of LDL cholesterol. N Engl J Med 339 (1998) 12-20.
82. Thompson PD, Buchner D, Pina IL, Balady GJ, Williams MA, Marcus BH, Berra K, Blair SN, Costa F, Franklin B, Fletcher GF, Gordon NF, Pate RR, Rodriguez BL, Yancey AK, Wenger NK: Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity). Circulation 107 (2003) 3109-3116.
83. Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M: Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344 (2001) 1343-1350.
84. Wajchenberg BL: Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 21 (2000) 697-738.
85. Wareham NJ, Hennings SJ, Byrne CD, Hales CN, Prentice AM, Day NE: A quantitative analysis of the relationship between habitual energy expenditure, fitness and the metabolic cardiovascular syndrome. Brit J Nutr 80 (1998) 235-241.
86. Wareham NJ, Wong MY, Day NE: Glucose intolerance and physical inactivity: the relative importance of low habitual energy expenditure and cardiorespiratory fitness. Am J Epidemiol 152 (2000) 132-139.
87. Whaley MH, Kampert JB, Kohl HW, III, Blair SN: Physical fitness and clustering of risk factors associated with the metabolic syndrome. Med Sci Sports Exerc 31 (1999) 287-293.
88. Williams PT: High-density lipoprotein cholesterol and other risk factors for coronary heart disease in female runners. N Engl J Med 334 (1996) 1298-1303.
89. Winkler K, Abletshauser C, Hoffmann MM, Friedrich I, Baumstark MW, Wieland H, Marz W: Effect of fluvastatin slow-release on low density lipoprotein (LDL) subfractions in patients with type 2 diabetes mellitus: baseline LDL profile determines specific mode of action. J Clin Endocrinol Metab 87 (2002) 5485-5490.
90. Zamboni M, Zoico E, Fantin F, Panourgia MP, Di F, V, Tosoni P, Solerte B, Vettor R, Bosello O: Relation between leptin and the metabolic syndrome in elderly women. J Gerontol A Biol Sci Med Sci 59 (2004) 396-400.
91. The Cochrane Library (Hrsg.): Sport als Therapie bei chronischen Erkrankungen. Chichester, UK: John Wiley & Sons, LTD.