Postprandial triglyceride high response and the metabolic syndrome

Annals of the New York Academy of Sciences

Volumn 827, Issue , 1997, Pages 353-368

  Schrezenmeir, J ^a   Fenselau, S ^a   Keppler, I ^a   Abel, J ^a   Orth, B ^a   Laue, Ch ^a   Sturmer W ^b   Fauth, U ^c   Halmagyi, M ^c   Marz W ^d  

^a Kiel and Lungen Clinic Grosshansdorf   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

^d UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; LIPID; LIPOPROTEIN LIPASE; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE;

ADULT; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; ENERGY EXPENDITURE; ENZYME ACTIVITY; HUMAN; HUMAN EXPERIMENT; INSULIN RESISTANCE; LIPID BLOOD LEVEL; LIPID METABOLISM; MALE; METABOLIC DISORDER; NORMAL HUMAN; ORAL GLUCOSE TOLERANCE TEST; PHENOTYPE; POSTPRANDIAL STATE;

EID: 0030703674     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb51847.x     Document Type: Conference Paper

References (40)

1. GROOT, P. H. E., W. A. H. J. VAN STIPHOUT, X. H. KRAUSS, H. JANSEN, A. VAN TOL, E. VAN RAMSHORST, S. CHIN-ON, A. HOFMAN, S. R. CROSSWELL& L. HAVEKES. 1991. Postprandial lipoprotein metabolism in normolipidemic men with and without coronary artery disease. Atheroscler. Thromb. 11: 653-662.
2. BAGGIO, G., R. FELUN, M. R. BAIOCCHI, S. MARTINI, G. BALDO, E. MANZATO & G. CREPALDI. 1980. Relationship between triglyceride-rich lipoproteins (chylomicrons and VLDL) and HDL2 and HDL3 in the postprandial phase in humans. Atherosclerosis 87: 271-276.
3. PATSCH, J. R., S. PRASAD, A. M. Gorro & G. BENGTSSON-OUVECRONA. 1984. Postprandial lipemia: a key for the conversion of HDL2 into HDL3 by hepatic lipase. J. Clin. Invest. 74: 2017-2023.
4. PATSCH, J. R., S. PRASAD, A. M. GOTTO & W. PATSCH. 1987. HDL2: relationship of the plasma level of this lipoprotein species to its composition, to the magnitude of postprandial lipemia, and to the activities of lipoprotein lipase and hepatic lipase. J. Clin. Invest. 80: 341-347.
5. WEINTRAUB, S., S. EISENBERG & J. L. BRESLOW. 1987. Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals. J. Clin. Invest. 79: 1110-1119.
6. REAVEN, G. M., R. L. LEARNER, M. P. STERN & J. W. FARQUHAR. 1967. Role of insulin in endogenous hypertriglyceridemia. J. Clin. Invest. 46: 1756-1767.
7. SCHMAHL, R W., P. PRICKLER, W. PÖTTER, B. TSCHIRCKEWAHN & F. H. HECKERS. 1983. Are fasting triglycerides sufficient for determining the risk factor status of hypertriglyceridemia of the atherosclerotic vascular disease? VASA 12: 303-356.
8. BARR, S. I., B. A. KOTTE & T. S. MAO. 1985. Postprandial distribution of apolipoprotein C-II and C-III in normal subjects and patients with mild hypertriglyceridemia: comparison of meals containing corn oil and medium-chain triglyceride oil. Metabolism 34: 983-992.
9. WEBER, P., J. SCHREZENMEIR, S. FENSELAU, S. AUSIEKER, R. PROBST, H. D. ZUCHHOLD, W. PRELLWITZ & J. BEYER. 1993. Prolonged postprandial increment in triglycerides and decreased postprandial response of very low density lipoproteins in type 2 diabetics following an oral lipid load. Ann. N.Y. Acad. Sci. 683: 315-321.
10. SCHREZENMEIR, J., P. WEBER, R. PROBST, H. K. BIESALSKI, C. LULEY, W. PRELLWITZ, U. KRAUSE & J. BEYER. 1992. Postprandial pattern of triglyceride-rich lipoproteins in normal-weight humans after an oral lipid load: exaggerated triglycerides and altered insulin response in some subjects. Ann. Nutr. Metab. 36: 186-196.
11. SCHREZENMEIR, J., I. KEPPLER, S. FENSELAU, P. WEBER, H. K. BIESALSKI, R. PROBST, CH. LAUE, H. D. ZUCHHOLD, W. PRELLWITZ & J. BEYER. 1993. The phenomenon of a high triglyceride response to an oral lipid load in healthy subjects and its link to the metabolic syndrome. Ann. N.Y. Acad. Sci. 683: 302-314.
12. BERGERON, N. & R. J. HAVEL. 1995. Influence of diets rich in saturated and omega-6 polyunsaturated fatty acids on the postprandial responses of apolipoprotein B-48, B-100, E, and lipids in triglyceride-rich lipoproteins. Arterioscler. Thromb. Vase. Biol. 15: 2111-2121.
13. GRANT, K. I., M. P. MARAIS & M. A. DHANSAY. 1994. Sucrose in a lipid-rich meal amplifies the postprandial excursion of serum and lipoprotein triglyceride and cholesterol concentrations by decreasing triglyceride clearance. Am. J. Clin. Nutr. 59: 853-860.
14. SUPERKO, H. R. 1992. Effects of acute and chronic alcohol consumption on postprandial lipemia in healthy normotriglyceridemic men. Am. J. Cardiol. 69: 701-704.
15. BREWSTER, A. C., H. G. LANKFORD, M. G. SCHWARTZ & J. F. SULLIVAN. 1966. Ethanol and alimentary lipemia. Am. J. Clin. Nutr. 19: 255-259.
16. GINSBERG, H., J. OLEFSKY, J. W. FARQUHAR & G. REAVEN. 1974. Moderate ethanol ingestion and triglyceride levels. Ann. Intern. Med. 80: 143-149.
17. NESTEL, P. J. 1964. Relationship between plasma triglycerides and removal of chylomicrons. J. Clin. Invest. 43: 943-949.
18. BAGGIO, G., C. GABELU, R. FELLIN, M. R. BAIOCCHI, S. MARTINI, G. BALDO, E. MANZATO & G. CREPALDI. 1983. Metabolism of lipoproteins in the postprandial phase. Prog. Biochem. Pharmacol. 19: 129-140.
19. LEWIS, G. F., N. M. O'MEARA, P. A. SOLTYS, J. D. BLACKMAN, P. H. IVERIUS, A. F. DRUETZLER, G. S. GETZ & K. S. POLONSKY. 1990. Postprandial lipoprotein metabolism in normal and obese subjects: comparison after the vitamin A fat loading test. J. Clin. Endocrinol. Metab. 71: 1041-1050.
20. SCHREZENMEIR, J. 1996. Hypcrinsulinemia, hyperproinsulinemia, and insulin resistance in the metabolic syndrome. Experientia 5: 426-432.
21. SCHREZENMEIR, J., B. CLARK, S. FENSELAU, J. ABEL, J. BEYER & C. N. HALES. 1994. Incomplete proinsulin processing in subjects with postprandial high triglyceride response (premetabolic syndrome). Exp. Clin. Endocrinol. 102(suppl. 2): 175.
22. BUCOLO, G. & H. DAVID. 1973. Quantitative determination of serum triglycerides by the use of enzymes. Clin. Chem. 19: 476-482.
23. SOBEY, W. J., S. F. BEER, C. A. CARRINGTON, P. M. S. CLARK, B. H. FAANK, I. P. GRAY, S. D. Luzio, D. P. OWENS, A. E. SCHNEIDER, K. SIDDLE, R. C. TEMPLE & C. N. HALES. 1989. Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split, and 32-33 split proinsulin. Biochem. J. 260: 535-541.
24. ARMELUNI, F., M. ZAMBONI, L. RIGO, I. BERGAMO-ANDREIS, R. ROBBO, M. DE MARCHI & O. BOSELLO. 1991. Sonography detection of small intra-abdominal fat variations. Int. J. Obes. 15: 847-852.
25. MÄRZ, W., S. CEZANNE & W. GROSS. 1991. Phenotyping of lipoprotein E by immunoblotting in immobilized pH gradients. Electrophoresis 12: 59-63.
26. ZECHNER, R. 1990. Rapid and simple isolation procedure for lipoprotein lipase from human milk. Biochim. Biophys. Acta 1044: 20-25.
27. SCHOTZ, M. C., A. S. GARFINKEL, R. J. HEUBOTTER & J. E. STEWART. 1970. A rapid assay for lipoprotein lipase. J. Lipid Res. 11: 68-69.
28. SCHREZENMEIR, J., S. FENSELAU, B. STRAUSBERGER & L. SCHANDT. 1995. Association of increased adrenal reactivity with abdominal adipose tissue, high postprandial triglyceride response, and increased dietary-induced thermogenesis. Exp. Clin. Endocrinol. 103(suppl. 1): 82.
29. FENSELAU, S., A. DIBA, I. KEPPLER, P. WEBER, W. MÄRZ, J. BEYER & J. SCHREZENMEIR. 1994. Apolipoprotein phenotypes in NIDDM, high, and normal triglyceride responders. Diabetologia 37(suppl. 1): A86.
30. WARD, W. K., E. C. LA CAVA, T. L. PAQUETTE, J. C. BLARD, B. J. WALLUM & D. J. R. PORTE. 1987. Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance. Diabetologia 30: 698-702.
31. VAN GAAL, L. 1996. Personal communication.
32. WAHRENBERG, H., F. LÖNNQUIST & P. ARNER. 1989. Mechanisms underlying regional differences in lipolysis in human adipose tissue. J. Clin. Invest. 84: 458-467.
33. VAN GAAL, L. F., J. L. VANUYTSEL, G. A. VANSANT & I. M. DE LEEUW. 1994. Sex hormones, body fat distribution, resting metabolic rate, and glucose-induced thermogenesis in premenopausal obese women. Int. J. Obes. 18: 333-338.
34. ASSMANN, G., G. SCHMITZ, H. J. MENZEL & H. SCHULTE. 1984. Apolipoprotein E polymorphism and hyperlipidemia. Clin. Chem. 30: 641-643.
35. VOGELBERG, K. H. & E. MANCY. 1988. Apo E2 phenotypes in type 2 diabetics with and without insulin therapy. Klin. Wbchenschr. 66: 690-693.
36. FERRANNINI, E., E. J. BARRET, S. BEVILACQUA & R. A. DEFRONZO. 1983. Effect of fatty acids in glucose production and utilization in man. J. Clin. Invest. 72: 1737-1747.
37. BODEN, G., X. CHEN, J. Ruiz, J. V. WHITE & L. ROSSETTI. 1994. Mechanism of fatty acid-induced inhibition of glucose uptake. J. Clin. Invest. 93: 2438-2446.
38. ECKEL, R. H. 1989. Lipoprotein lipase: a multifunctional enzyme relevant to common metabolic diseases. N. Engl. J. Med. 320: 1060-1068.
39. GOLDBERG, I. J. 1996. Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherosclerosis. J. Lipid Res. 37: 693-707.
40. SCHREZENMEIR, J., I. KEPPLER, J. ABEL, S. FENSELAU, P. WEBER & J. BEYER. 1993. Dissociation of insulin sensitivity towards glucose and fat metabolism at an early stage of the metabolic syndrome. Int. J. Obes. 17(suppl. 2): 97.