Hepatic lipase: New insights from genetic and metabolic studies

Current Opinion in Lipidology

Volumn 10, Issue 3, 1999, Pages 259-267

  Cohen, Jonathan C ^a,b   Vega, Gloria L ^a   Grundy, Scott M ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANABOLIC AGENT; HEPARIN; HIGH DENSITY LIPOPROTEIN; INTERMEDIATE DENSITY LIPOPROTEIN; LIPOPROTEIN; LIVER TRIACYLGLYCEROL LIPASE; PHOSPHOLIPID; TRIACYLGLYCEROL;

CLINICAL TRIAL; CORONARY ARTERY ATHEROSCLEROSIS; ENZYME ACTIVITY; ENZYME DEFICIENCY; ETHNIC GROUP; GENETIC LINKAGE; GENETIC POLYMORPHISM; HUMAN; HYDROLYSIS; HYPERLIPOPROTEINEMIA; HYPERTRIGLYCERIDEMIA; LIPOPROTEIN BLOOD LEVEL; LIPOPROTEIN METABOLISM; NONHUMAN; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; REVIEW; TRIACYLGLYCEROL BLOOD LEVEL;

CHOLESTEROL, HDL; CORONARY DISEASE; ETHNIC GROUPS; HUMANS; LINKAGE (GENETICS); LIPASE; LIVER; POLYMORPHISM, GENETIC;

EID: 0032839019     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-199906000-00008     Document Type: Review

References (63)

1. 1 Stahnke G, Sprengel R, Augustin J, Will H. Human hepatic triglyceride lipase: cDNA cloning, amino acid sequence and expression in a cultured cell line. Differentiation 1987; 35:45-52.
2. 2 Datta S, Luo CC, Li WH, VanTuinen P, Ledbetter DH, Brown MA, et al. Human hepatic lipase. Cloned cDNA sequence, restriction fragment length polymorphisms, chromosomal localization, and evolutionary relationships with lipoprotein lipase and pancreatic lipase. J Biol Chem 1988; 263:1107-1110.
3. 3 Sanan DA, Fan J, Bensadoun A, Taylor JM. Hepatic lipase is abundant on both hepatocyte and endothelial cell surfaces in the liver. J Lipid Res 1997; 38:1002-1013.
4. 4 Coffill CR, Ramsamy TA, Hutt DM, Schult; JR, Sparks DL. Diacylglycerol is the preferred substrate in high density lipoproteins for human hepatic lipase. J Lipid Res 1997; 38:2224-2231.
5. 5 Deckelbaum RJ, R. Ramakrishnan S, Eisenberg T, Olivecrona T Bengtsson-Olivecrona G. Triacylglycerol and phospholipid hydrolysis in human plasma lipoproteins: role of lipoprotein and hepatic lipase. Biochemistry 1992; 31:8544-8551.
6. 6 Shirai K, Barnhart RL, Jackson RL. Hydrolysis of human plasma high density lipoprotein 2-phospholipids and triglycerides by hepatic lipase. Biochem Biophys Res Commun 1981; 100:591-599.
7. 7 Santamarina-Fojo S, Haudenschild C, Amar M. The role of hepatic lipase in lipoprotein metabolism and atherosclerosis. Curr Opin Lipidol 1998; 9:211-219.
8. 8 Beisiegel U. New aspects on the role of plasma lipases in lipoprotein catabolism and atherosclerosis. Atherosclerosis 1996; 124:1-8.
9. 9 Guerra R, Wang JP, Grundy SM, Cohen JC. A hepatic lipase (LIPC) allele associated with high plasma concentrations of high density lipoprotein cholesterol. Proc Natl Acad Sci USA 1997; 94:4532-4537.
10. 10 Blades B, Vega GL, Grundy SM. Activities of lipoprotein lipase and hepatic triglyceride lipase in postheparin plasma of patients with low concentrations of HDL cholesterol. Arterioscler Thrombosis 1993; 13:1227-1235.
11. 11 Applebaum-Bowden D, Haffner SM, Wahl PW, Hoover JJ, Warnick GR, Albers JJ, Hazzard WR. Postheparin plasma triglyceride lipases. Relationships with very low density lipoprotein triglyceride and high density lipoprotein2 cholesterol. Arteriosclerosis 1985; 5:273-282.
12. 12 Kuusi T, Ehnholm C, Viikari J, Harkonen R, Vartiainen E, Puska P, Taskinen M-R. Postheparin plasma lipoprotein and hepatic lipase are determinants of hypo-and hyperalphalipoproteinemia. J Lipid Res 1989; 30:1117-1126.
13. 13 Jackson RL, Yates MT, McNerney CA, Kashyap ML. Relationship between post-heparin plasma lipases, triglycerides and high density lipoproteins in normal subjects. Hormone Metab Res 1990; 22:289-294.
14. 14 Kuusi T, Saarinen P, Nikkila EA. Evidence for the role of hepatic endothelial lipase in the metabolism of plasma high density lipoprotein2 in man. Atherosclerosis 1980; 36:589-593.
15. 15 Haffner SM, Kushwaha RS, Foster DM, Applebaum-Bowden D, Hazzard WR. Studies on the metabolic mechanism of reduced high density lipoproteins during anabolic steroid therapy. Metabolism 1983; 32:413-420.
16. 16 Applebaum-Bowden D, Haffner SM, Hazzard WR. The dyslipoproteinemia of anabolic steroid therapy: increase in hepatic triglyceride lipase precedes the decrease in high density lipoprotein2 cholesterol. Metabolism 1987; 36:949-952.
17. 17 Kantor MA, Bianchini A, Bernier D, Sady SP, Thompson PD. Androgens reduce HDL2-cholesterol and increase hepatic triglyceride lipase activity. Med Sci Sports Exercise 1985; 17:462-465.
18. 18 Zambon A, Austin MA, Brown BG, Hokanson JE, Brunzell JD. Effect of hepatic lipase on LDL in normal men and those with coronary artery disease. Arterioscler Thromb 1993; 13:147-153.
19. 19 Watson TD. Determinants of LDL subfraction distribution and concentrations in young normolipidemic subjects. Arterioscler Thromb 1994; 14:902-910.
20. 20 Vega GL, Grundy SM. Effect of statins on metabolism of apo-B-containing lipoproteins in hypertriglyceridemic men. Am J Cardiol 1998; 81:36B-42B.
21. 21 Bausserman LL, Saritelli AL, Herbert PN. Effects of short-term stanozolol administration on serum lipoproteins in hepatic lipase deficiency. Metabolism 1997; 46:992-996.
22. 22 Hegele RA, Little JA, Vezina A, Maguire GF, Tu L, Wolever TS, et al. Hepatic lipase deficiency. Clinical, biochemical, and molecular genetic characteristics. Arterioscler Thromb 1993; 13:720-728.
23. 23 Demant T, Carlson LA, Holmquist L, Karpe F, Nilsson-Ehle P, Packard CJ, Shepherd J, Lipoprotein metabolism in hepatic lipase deficiency: studies on the turnover of apolipoprotein B and on the effect of hepatic lipase on high density lipoprotein. J Lipid Res 1988; 29:1603-1611.
24. 24 Carlson LA. Deficiency of hepatic lipase activity in post-heparin plasma in familial hyper-alpha-triglyceridemia. Acta Med Scand 1986; 219:435-447.
25. 25 Auwerx JH, Marzetta CA, Hokanson JE, Brunzell JD. Large buoyant LDL-like particles in hepatic lipase deficiency. Arteriosclerosis 1989; 9:319-325.
26. 26 Connelly PW, Maguire GF, Lee M, Little JA. Plasma lipoproteins in familial hepatic lipase deficiency. Arteriosclerosis 1990; 10:40-48.
27. 27 Kuusi T, Kesaniemi YA, Vuoristo M, Miettinen TA, Koskenvuo M. Inheritance of high density lipoprotein and lipoprotein lipase and hepatic lipase activity. Arteriosclerosis 1907; 7:421-425.
28. 28 Perusse L, Rice T, Despres J-P, Bergeron J, Province MA, Gagnon J, et al. Familial resemblance of plasma lipids, lipoproteins and postheparin lipoprotein and hepatic lipases in the HERITAGE family study. Arterioscler Thromb Vasc Biol 1997; 17:3263-3269.
29. 29 Cohen JC, Wang Z, Grundy SM, Stoesz MR, Guerra R. Variation at the hepatic lipase and apolipoprotein AI/CIII/AIV loci is a major cause of genetically determined variation in plasma HDL cholesterol levels. J Clin Invest 1994; 94:2377-2384.
30. 30 Lander ES, Schork NJ. Genetic dissection of complex traits. Science 1994; 265:2037-2048.
31. 31 Haseman JK, Elston RC. The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 1972; 2:3-19.
32. 32 Mahaney MC, Blangero J, Rainwater DL, Comuzzie AG, VandeBerg JL, Stern MP et al. A major locus influencing plasma high-density lipoprotein cholesterol levels in the San Antonio Family Heart Study. Segregation and linkage analyses. Arterioscler Thromb Vasc Biol 1995; 15:1730-1739.
33. 33 Jansen H, Verhoeven AM, Weeks L, Kastelein JP, Halley DJ, Vandenouweland A, et al. Common c-to-t substitution at position -480 of the hepatic lipase promoter associated with a lowered lipase activity in coronary artery disease patients. Arterioscler Thromb Vasc Biol 1997; 17:2837-2842.
34. 34 Murtomaki S, Tahvanainen E, Antikainen M, Tiret L, Nicaud V, Jansen H, Ehnholm C. Hepatic lipase gene polymorphisms influence plasma HDL levels. Results from Finnish EARS participants. European Atherosclerosis Research Study. Arterioscler Thromb Vasc Biol 1997; 17:1879-1884.
35. 35 Tahvanainen E, Syvanne M, Frick MH, Murtomaki-Repo S, Antikainen M, Kesaniemi YA, et al. Association of variation in hepatic lipase activity with promoter variation in the hepatic lipase gene. The LOCAT Study Investigators. J Clin Invest 1998; 101:956-960.
36. 36 Zambon A, Deeb SS, Hokanson JE, Brown BG, Brunzell JD. Common variants in the promoter of the hepatic lipase gene are associated with lower levels of hepatic lipase activity, buoyant LDL, and higher HDL2 cholesterol. Arterioscler Thromb Vasc Biol. 1998 (in press).
37. 37 Vega GL, Clark LT, Tang A, Marcovina S, Grundy SM, Cohen JC. Hepatic lipase activity is lower in African American than in white American men: effects of 5' flanking polymorphism in the hepatic lipase gene. J Lipid Res 1998; 39:228-232.
38. 38 Vega GL, Gao J, Bersot TP, Mahley RW, Verstraete R, Grundy SM, et al. The -514 polymorphism in the hepatic lipase gene (LIPC) does not influence androgen-mediated stimulation of hepatic lipase activity. J Lipid Res 1998; 39:1520-1524.
39. 39 Grundy SM, Vega GL, Otvos JD, Rainwater DL, Cohen JC. Hepatic lipase activity influences high density lipoprotein subclass distribution in normotriglyceridemic men. Genetic and pharmacological evidence. J Lipid Res 1999; 40:229-234.
40. 40 Jansen H. The T allele of the hepatic lipase promoter variant C-480T is associated with increased fasting lipids and HDL and increased preprandial and postprandial LpCIII:B: European Atherosclerosis Research Study (EARS) II. Arterioscler Thromb Vasc Biol. 1999; 19:303-308.
41. 41 Barth JD, Jansen H, Hugenholtz PG, Birkenhager JC. Post-heparin lipases, lipids and related hormones in men undergoing coronary arteriography to assess atherosclerosis. Atherosclerosis 1983; 48:235-241.
42. 42 Barth JD, Jansen H, Kromhout D, Reiber JH, Birkenhager JC, Arntzenius AC. Diet and the role of lipoproteins, lipases, and thyroid hormones in coronary lesion growth. J Cardiovasc Pharmacol. 1987; 10(Suppl 9):S42-S46.
43. 43 Barth JD, Jansen H, Kromhout D, Reiber JH, Birkenhager JC, Arntzenius AC. Progression and regression of human coronary atherosclerosis. The role of lipoproteins, lipases and thyroid hormones in coronary lesion growth. Atherosclerosis 1987; 68:51-58.
44. 44 Groot PH, van Stiphout SW, Krauss XH, Jansen H, van Tol TA, van Ramshorst E, et al. Postprandial lipoprotein metabolism in normolipidemic men with and without coronary artery disease. Arterioscler Thromb 1991; 11:653-662.
45. 45 Katzel Li, Coon PJ, Busby MJ, Gottlieb SO, Krauss RM, Goldberg AP. Reduced HDL2 cholesterol subspecies and elevated postheparin hepatic lipase activity in older men with abdominal obesity and asymptomatic myocardial ischemia. Arterioscler Thromb 1992; 12:814-823.
46. 46 Baynes C, Henderson AD, Anyaoku V, Richmond W, Hughes CL, Johnston DG, Elkeles RS. The role of insulin insensitivity and hepatic lipase in the dyslipidaemia of type 2 diabetes. Diabet Med 1991; 8:560-566.
47. 47 Tikkanen MJ, Nikkila EA. Regulation of hepatic lipase and serum lipoproteins by sex steroids. Am Heart J 1987; 113:562-567.
48. 48 Cominacini L, Garbin U, Davoli A, Campagnola M, De SA, Pasini, et al. High-density lipoprotein cholesterol concentrations and postheparin hepatic and lipoprotein lipases in obesity: relationships with plasma insulin levels. Ann Nutr Metab 1993; 37:175-184.
49. 49 Nie L, Wang J, Clark LT, Tang A, Vega GL, Grundy SM, Cohen JC. Body mass index and hepatic lipase gene (LIPC) polymorphism jointly influence postheparin plasma hepatic lipase activity. J Lipid Res 1998; 39:1127-1130.
50. 50 Shohet RV, Vega GL, Anwar A, Grundy SM, Cohen JC. Hepatic lipase promoter polymorphism in men with coronary artery disease: allele frequency and effects on hepatic lipase activity and plasma HDL-cholesterol concentrations. Arterioscler Thromb Vasc Biol 1999 (in press).
51. 51 Tyroler HA, Glueck CJ, Christensen B, Kwiterovich Jr PO. Plasma high-density lipoprotein cholesterol comparisons in black and white populations. The Lipid Research Clinics Program Prevalence Study. Circulation 1980; 62:IV99-107.
52. 52 Sprafka JM, Norsted SW, Folsom AR, Burke GL, Luepker RV. Life-style factors do not explain racial differences in high-density lipoprotein cholesterol: the Minnesota Heart Survey. Epidemiology 1992; 3:156-163.
53. 53 Webber LS, Srinivasan SR, Wattigney WA, Berenson GS. Tracking of serum lipids and lipoproteins from childhood to adulthood. The Bogalusa Heart Study. Am J Epidemiol 1991; 133:884-899.
54. 54 Brown SA, Hutchinson R, Morrisett J, Boerwinkle E, Davis CE, Gotto Jr AM, Patsch W. Plasma lipid, lipoprotein cholesterol, and apoprotein distributions in selected US communities. The Atherosclerosis Risk in Communities (ARIC) Study. Arterioscler Thromb 1993, 13:1139-1158.
55. 55 Nie LC, Niu SJ, Vega GL, Clark LT, Tang A, Grundy SM, Cohen JC. Three polymorphisms associated with low hepatic lipase activity are common in African Americans. J Lipid Res 1998; 39:1900-1903.
56. 56 Knudsen P, Antikainen M, Ehnholm S, Uusi-Oukari M, Tenkanen H, Lahdenpera S, et al. A compound heterozygote for hepatic lipase gene mutations Leu334→Phe and Thr383→Met: correlation between hepatic lipase activity and phenotypic expression. J Lipid Res 1996; 37:825-834.
57. 57 Hegele RA, Tu L, Connelly PW. Human hepatic lipase mutations and polymorphisms. Hum Mutat 1992; 1:320-324.
58. 58 Mahley RW, Palaoglu KE, Atak Z, Dawson-Pepin J, Langlois AM, Cheung H, et al. Turkish Heart Study: lipids, lipoproteins, and apolipoproteins. J Lipid Res 1995; 36:839-859.
59. 59 Bersot TP, Vega GL, Grundy SM, Palaoglu KE, Atagunduz P, Ozbayrakci S et al. Elevated hepatic lipase activity and low levels of high density lipoprotein in a normotriglyceridemic, nonobese, Turkish population. J Lipid Res 1999 (in press).
60. 60 Despres J-P, Ferland M, Moorjani S, Nadeau A, Tremblay A, Lupien PJ, et al. Role of hepatic-triglyceride lipase activity in the association between intra-abdominal fat and plasma HDL cholesterol in obese women. Arteriosclerosis 1989; 9:485-492.
61. 61 Sorbris R, Petersson BG, Nilsson-Ehle P. Effects of weight reduction on plasma lipoproteins and adipose tissue metabolism in obese subjects. Eur J Clin Invest 1981; 11:491-498.
62. 62 Pollare T, Vessby B, Lithell H. Lipoprotein lipase activity in skeletal muscle is related to insulin sensitivity. Arterioscler Thromb 1991; 11:1192-1203.
63. 63 Reitman JS, Kosmakos FC, Howard BV, Taskinen M-R, Kuusi T, Nikkila EA. Characterization of lipase activities in obese Pima Indians. Decreases with weight reduction. J Clin Invest 1982; 70:791-797.