Inactivation of the Leishmania tarentolae Pterin Transporter (BT1) and Reductase (PTR1) Genes Leads to Viable Parasites with Changes in Folate Metabolism and Hypersensitivity to the Antifolate Methotrexate

Journal of Biological Chemistry

Volumn 279, Issue 18, 2004, Pages 18575-18582

  El Fadili, Amal ^a   Kündig, Christoph ^a   Roy, Gaétan ^a   Ouellette, Marc ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; METABOLISM; SUBSTRATES;

FOLATE METABOLISMS; WILD-TYPE CELLS;

BIOCHEMISTRY;

BIOPTERIN; DIHYDROFOLATE REDUCTASE; FOLIC ACID; GAMMA GLUTAMYL HYDROLASE; METHOTREXATE; PROTOZOAL PROTEIN; PTERIN; PTERIN REDUCTASE; PTERIN TRANSPORTER; UNCLASSIFIED DRUG;

ARTICLE; BT1 GENE; CELL VIABILITY; CONTROLLED STUDY; DRUG HYPERSENSITIVITY; DRUG RESISTANCE; ENZYME ACTIVITY; FOLATE METABOLISM; GENE; GENE AMPLIFICATION; GENE DELETION; GENE INACTIVATION; LEISHMANIA; LEISHMANIA TARENTOLAE; NONHUMAN; PARASITE DEVELOPMENT; PHENOTYPE; PRIORITY JOURNAL; PROTEIN TRANSPORT; PTR1 GENE;

ANIMALS; BIOPTERIN; CARRIER PROTEINS; CELL SURVIVAL; DRUG RESISTANCE; FOLIC ACID; FOLIC ACID ANTAGONISTS; GENE SILENCING; LEISHMANIA; MEMBRANE TRANSPORT PROTEINS; METHOTREXATE; OXIDOREDUCTASES; PEPTIDE SYNTHASES; PROTOZOAN PROTEINS;

LEISHMANIA TARENTOLAE; PROTOZOA;

EID: 2442502624     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M400652200     Document Type: Article

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