Glutamyl hydrolasepharmacological role and enzymatic characterization

Pharmacology and Therapeutics

Volumn 85, Issue 3, 2000, Pages 207-215

  Galivan, John ^a   Ryan, Thomas J ^a   Chave, Karen ^a   Rhee, Myung ^a   Yao, Rong ^a   Yin, Dezhong ^a  

^a WADSWORTH CENTER   (United States)

Author keywords

Antifolate polyglutamates; Folate polyglutamates; Glutamate carboxypeptidase II; Glutamyl hydrolase; Methotrexate; Sulfhydryl protease

Indexed keywords

FLUOROURACIL; FOLIC ACID ANTAGONIST; GAMMA GLUTAMYL HYDROLASE; HYDROLASE; HYDROLASE INHIBITOR; METHOTREXATE; THIOL PROTEINASE; CARBOXYPEPTIDASE; COMPLEMENTARY DNA; CYSTEINE; GLUTAMATE CARBOXYPEPTIDASE II; GLUTAMATE CARBOXYPEPTIDASE II, HUMAN; MEMBRANE ANTIGEN; PTEROPTIN;

CONFERENCE PAPER; ENZYME ANALYSIS; ENZYME LOCALIZATION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; HYDROLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR; ANIMAL; DRUG RESISTANCE; ENZYMOLOGY; GENETICS; KIDNEY; LIVER; METABOLISM; RAT; REVIEW; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIGENS, SURFACE; CARBOXYPEPTIDASES; CYSTEINE; DNA, COMPLEMENTARY; DRUG RESISTANCE, NEOPLASM; FOLIC ACID ANTAGONISTS; GAMMA-GLUTAMYL HYDROLASE; GLUTAMATE CARBOXYPEPTIDASE II; HUMANS; HYDROLYSIS; KIDNEY; LIVER; PTEROYLPOLYGLUTAMIC ACIDS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033622009     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(99)00063-7     Document Type: Conference Paper

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