Thrombospondin 1 precedes and predicts the development of tubulointerstitial fibrosis in glomerular disease in the rat

Kidney International

Volumn 53, Issue 2, 1998, Pages 302-311

  Hugo, Christian ^a,b   Shankland, Stuart J ^a   Pichler, Raimund H ^a   Couser, William G ^a   Johnson, Richard J ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

Author keywords

Glomerulonephritis; TGF activation; Thrombospondin 1; Tubulointerstitial fibrosis

Indexed keywords

MESSENGER RNA; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; GLOMERULONEPHRITIS; HEYMANN NEPHRITIS; IN SITU HYBRIDIZATION; KIDNEY FIBROSIS; MALE; NEPHROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RNA ANALYSIS;

EID: 0031932966     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1998.00774.x     Document Type: Article

References (45)

1. SCHAINUCK L, STRICKER G, CUTLER R, BENDITT E: Structural-functional correlations in renal disease. Part II. The correlations. Hum Pathol 1:631-641, 1970
2. BOHLE A, GLOMB D, GRUND K, MACKENSEN S: Correlations between relative interstitial volume of the renal cortex and serum creatinine concentration in minimal changes with nephrotic syndrome and in focal sclerosing glomerulonephritis. Virchows Arch 376:221-232, 1977
3. BOHLE A, GRUND K, MACKENSEN S, TOLON M: Correlations between renal interstitium and level of serum creatinine. Morphometric investigations of biopsies in perimembranous glomerulonephritis. Virchows Arch 373:15-22, 1977
4. MACKENSEN S, GRUND K, SINDJIC M, BOHLE A: Influence of the renal cortical interstitium on the serum creatinine concentration and serum creatinine clearance in different chronic sclerosing interstitial nephritides. Nephron 24:30-34, 1979
5. NICOLIC-PATERSON D, LAN H, ATKINS R: Macrophages in renal injury. Kidney Int 45:79-82, 1994
6. KLAHR S: Interstitial macrophages. Semin Nephrol 13:488-495, 1993
7. ALPERS C, HUDKINS K, FLOEGE J, JOHNSON R: Human renal cortical interstitial cells with some features of smooth muscle cells participate in tubulointerstitial and crescentic glomerular injury. J Am Soc Nephrol 5:201-210, 1994
8. ALPERS C, PICHLER R, JOHNSON R: Phenotypic features of cortical interstitial cells potentially important in fibrosis. Kidney Int 49:28-31, 1996
9. DIAMOND J, VAN GOOR H, DING G, ENGELMYER E: Myofibroblasts in experimental hydronephrosis. Am J Pathol 146:121-129, 1995
10. KLIEM V, JOHNSON R, ALPERS C, YOSHIMURA A, COUSER W, KOCH K, FLOEGE J: Mechanisms involved in the pathogenesis of tubulointerstitial fibrosis in 5/6-nephrectomized rats. Kidney Int 49:666-678, 1996
11. TANG WW, ULLICH TR, LACEY DL, HILL DQ QI M, KAUFMAN SA, VAN GY, TARPELY JE, YEE JS: Platelet-derived growth factor-BB induced renal tubulointerstitial myofibroblast formation and tubulointerstitial nephritis. Am J Pathol 148:1169-1180, 1996
12. EDDY A: Experimental insights into the tubulointerstitial disease accompanying primary glomerular lesions. J Am Soc Nephrol 5:1273-1287, 1994
13. FRAZIER W: Thrombospondins. Curr Opin Cell Biol 3:792-799, 1991
14. HUGO C, PICHLER R, MEEK R, GORDON K, KYRIAKIDES T, FLOEGE J, BORNSTEIN P, COUSER W, JOHNSON RJ: Thrombospondin 1 is expressed by proliferating mesangial cells in vivo and is upregulated by PDGF and bFGF. Kidney Int 48:1846-1856, 1995
15. BORNSTEIN P: Diversity of function is inherent in matricellular proteins: An appraisal of thrombospondin 1. J Cell Biol 130:503-506, 1995
16. SCHULTZ-CHERRY S, MURPHY-ULLRICH JE: Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism. J Cell Biol 122:923-932, 1993
17. SCHULTZ-CHERRY S, RIBEIRO S, GENTRY L, MURPHY-ULLRICH JE: Thrombospondin binds and activates the small and large forms of latent transforming growth factor-beta in a chemically defined system. J Biol Chem 269:26775-26782, 1994
18. BORDER WA, OKUDA S, LANGUINO LR, SPORN MB, RUOSLAHTI E: Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1. Nature 346:371-374, 1990
19. JOHNSON RJ, PRITZL P, IIDA H, ALPERS CE: Platelet-complement interactions in mesangial proliferative nephritis in the rat. Am J Pathol 138:313-321, 1991
20. ALOUSI M, POST R, HEYMANN W: Experimental autoimmune nephrosis in rats. Am J Pathol 54:47-71, 1969
21. SALANT DJ, DARBY C, COUSER WG: Experimental membranous glomerulonephritis in rats. Quantitative studies of glomerular immune deposit formation in isolated glomeruli and whole animals. J Clin Invest 66:71-81, 1980
22. PICHLER R, GIACHELLI CM, LOMBARDI D, PIPPIN J, GORDON K, ALPERS CE, SCHWARTZ SM, JOHNSON RJ: Tubulointerstitial disease in glomerulonephritis. Potential role of osteopontin (uropontin). Am J Pathol 144:915-926, 1994
23. FLOEGE J, BURNS MW, ALPERS CE, YOSHIMURA A, PRITZL P, GORDON K, SEIFERT RA, BOWEN PDF, COUSER WG, JOHNSON RJ: Glomerular cell proliferation and PDGF expression precede glomerulosclerosis in the remnant kidney model. Kidney Int 41:297-309, 1992
24. JOHNSON RJ, GARCIA RL, PRITZL P, ALPERS CE: Platelets mediate glomerular cell proliferation in immune complex nephritis induced by anti-mesangial cell antibodies in the rat. Am J Pathol 136:369-374, 1990
25. DIXIT VM, GALVIN NJ, O'ROURKE KM, FRAZIER WA: Monoclonal antibodies that recognize calcium-dependent structures of human thrombospondin. Characterization and mapping of their epitopes. J Biol Chem 261:1962-1968, 1986
26. BARCELLOS-HOFF M, DERYNCK R, TSANG M-S, WEATHERBEE J: Transforming growth factor-beta activation in irradiated murine mammary gland. J Clin Invest 93:892-899, 1994
27. WILCOX JN, SMITH KM, SCHWARTZ SM, GORDON D: Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque. Proc Nat Acad Sci USA 86:2839-2843, 1989
28. SHANKLAND SJ, PIPPIN J, PICHLER RH, GORDON K, FRIEDMAN S, GOLD LI, JOHNSON RJ, COUSER WG: Differential expression of transforming growth factor-β isoforms and receptors in experimental membranous nephropathy. Kidney Int 50:116-124, 1996
29. NATH K: Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis 20:1-17, 1992
30. LAN H, PATERSON D, ATKINS R: Initiation and evolution of interstitial leukocytic infiltration in experimental glomerulonephritis. Kidney Int 40:425-433, 1991
31. DIAMOND J, PESEK-DIAMOND I: Sublethal X-irradiation during acute puromycin nephrosis prevents late renal injury: Role of macrophages. Am J Physiol 260:F779-F786, 1991
32. HARRIS K, LEFKOWITH J, KLAHR S, SCHREINER G: Essential fatty acid deficiency ameliorates acute renal dysfunction in the rat after the administration of the aminonucleoside of puromycin. J Clin Invest 86:1115-1123, 1990
33. MAJACK RA, GOODMAN LV, DIXIT VM: Cell surface thrombospondin is functionally essential for vascular smooth muscle cell proliferation. J Cell Biol 106:415-422, 1988
34. MARINIDES GN, SUCHARD SJ, MOOKERJEE BK: Role of thrombospondin in mesangial cell growth: Possible existence of an autocrine feedback growth circuit. Kidney Int 46:350-357, 1994
35. NICOSIA RF, TUSZYNSKI GP: Matrix-bound thrombospondin promotes angiogenesis in vitro. J Cell Biol 124:183-193, 1994
36. HUBER A, ELLIS S, JOHNSON K, DIXIT V, VARANI J: Monocyte diapedesis through an in vitro vessel wall construct: Inhibition with monoclonal antibodies to thrombospondin. J Leukoc Biol 52:524-528, 1992
37. BORDER WA, BREES D, NOBLE NA: Transforming growth factor-beta and extracellular matrix deposition in the kidney. Contrib Nephrol 107:140-145, 1994
38. ISAKA Y, FUJIWARA Y, UEDA N, KANEDA Y, KAMADA T, IMAI E: Glomerulosclerosis induced by in vivo transfection of transforming growth factor beta or platelet-derived growth factor gene into the rat kidney. J Clin Invest 92:2597-2601, 1993
39. JONES C, BUCH S, POST M, MCCULLOCH L, LIU E, EDDY A: Renal extracellular matrix accumulation in acute puromycin aminonucleoside nephrosis in rats. Am J Pathol 141:1381-1396, 1992
40. EDDY A: Expression of genes that promote renal interstitial fibrosis in rats with proteinuria. Kidney Int 49:49-54, 1996
41. DERYNCK R, JARRETTT J, CHEN E, EATON H, BELL J, ASSOIAN R, ROBERTS A, SPORN M, GOEDDEL D: Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. Nature 316:701-705, 1985
42. WAKEFIELD L, SMITH D, FLANDERS K, SPORN M: Latent transforming growth factor-beta from human platelets: A high molecular weight complex containing precursor sequences. J Biol Chem 263:7646-7654, 1988
43. MIYAZONO K, HELLMAN U, WERNSTEDT C, HELDIN C: Latent high molecular weight complex of transforming growth factor-beta1: Purification from human platelets and structural characterization. J Biol Chem 263:6407-6415, 1988
44. SCHULTZ-CHERRY S, LAWLER J, MURPHY-ULLRICH JE: The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta. J Biol Chem 269:26783-26788, 1994
45. SCHULTZ-CHERRY S, CHEN H, MOSHER D, MISENHEIMER T, KRUTZSCH H, ROBERTS D, MURPHY-ULLRICH J: Regulation of transforming growth factor-beta activation by discrete sequences of thrombospondin 1. J Biol Chem 270:7304-7310, 1995-