Activations of ERK1/2 and JNK by transforming growth factor β negatively regulate Smad3-induced alkaline phosphatase activity and mineralization in mouse osteoblastic cells

Journal of Biological Chemistry

Volumn 277, Issue 39, 2002, Pages 36024-36031

  Sowa, Hideaki ^a   Kaji, Hiroshi ^a   Yamaguchi, Toru ^a   Sugimoto, Toshitsugu ^a   Chihara, Kazuo ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BONE; CELLS; COLLAGEN; GROWTH KINETICS;

MINERALIZATION;

ENZYME KINETICS;

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALKALINE PHOSPHATASE; COLLAGEN TYPE 1; CURCUMIN; DICOUMAROL; MITOGEN ACTIVATED PROTEIN KINASE; SMAD3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; GENE ACTIVITY; GENETIC TRANSCRIPTION; MINERALIZATION; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING;

ALKALINE PHOSPHATASE; ANIMALS; BLOTTING, WESTERN; BUTADIENES; CULTURE MEDIA, SERUM-FREE; CURCUMIN; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; FLAVONOIDS; GENES, DOMINANT; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NITRILES; OSTEOBLASTS; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TIME FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA;

EID: 0037184053     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M206030200     Document Type: Article

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