Overweight in children is associated with arterial endothelial dysfunction and intima-media thickening

International Journal of Obesity

Volumn 28, Issue 7, 2004, Pages 852-857

  Woo, K S ^a   Chook, P ^a   Yu, C W ^a   Sung, R Y T ^a   Qiao, M ^a   Leung, S S F ^a   Lam, C W K ^a   Metreweli, C ^a   Celermajer, D S ^b  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

Author keywords

Atherosclerosis; Body mass index; Carotid intima media thickening; Endothelium; Overweight in children

Indexed keywords

CHOLESTEROL; GLUCOSE; INSULIN; LIPID; TRIACYLGLYCEROL;

ARTERY ENDOTHELIUM; ARTICLE; ATHEROSCLEROSIS; BLOOD PRESSURE; BODY FAT; BODY MASS; CAROTID ARTERY; CELL FUNCTION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; FEMALE; GLUCOSE BLOOD LEVEL; HIP; HUMAN; INSULIN BLOOD LEVEL; LIPID BLOOD LEVEL; MALE; MULTIVARIATE ANALYSIS; OBESITY; PRIORITY JOURNAL; ULTRASOUND;

ANTHROPOMETRY; BODY CONSTITUTION; BRACHIAL ARTERY; CAROTID ARTERIES; CASE-CONTROL STUDIES; CHILD; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MALE; OBESITY; TUNICA INTIMA; TUNICA MEDIA;

EID: 3442880238     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0802539     Document Type: Article

References (40)

1. Kopelman PG. Obesity as a medical problem. Nature 2000; 404: 635-643.
2. Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Health CW. Body-mass index and mortality in a prospective cohort of US adults. N Engl J Med 1999; 341: 1097-1105.
3. Reilly JJ, Dorosty AR, Emmett PM. Prevalence of overweight and obesity in British children: cohort study. Br Med J 1999; 319: 1039.
4. Freedman DS, Dietz WH, Srinivasan SR, Berenson GS. The relation of overweight to cardiovascular risk factors among children and adolescents: the Bogalusa heart study. Paediatrics 1999; 103: 1175-1182.
5. Berenson GS, Srinvasan SR, Bao W, Newman III WP, Tracy RE, Wattigney WA. For the Bogalusa Heart Study Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. N Engl J Med 1998; 338: 1650-1656.
6. Tounian P, Aggoun Y, Dubern B, Varille V, Guy-Grand B, Sidi D, Girardet JP, Bonnet D. Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study. Lancet 2001; 358: 1400-1404.
7. Celermajer DS. Endothelial dysfunction: does it matter? Is it reversible? J Am Coll Cardiol 1997; 30: 325-333.
8. O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. N Engl J Med 1999; 340: 14-22.
9. Järvisalo MJ, Putto-Laurila A, Jartti L, Lehtimäki T, Solakivi T, Rönnemaa T, Raitakari OT. Carotid artery intima-media thickness in children with Type 1 diabetes. Diabetes 2002; 51: 493-498.
10. Lavrenèiè A, Kosmina B, Keber I, Videènik V, Keber D. Carotid intima-media thickness in young patients with familial hypercholesterolaemia. Heart 1996; 76: 321-325.
11. Tonstad S, Joakimsen O, Stensland-Bugge E, Leren TP, Ose L, Russell D, Bonaa KH. Risk factors related to carotid intima-media thickness and plaque in children with familial hypercholesterolemia and control subjects. Arterioscler Thromb Vasc Biol 1996; 16: 984-991.
12. Ogden CL, Kuczmarski RJ, Flegal KM, Mei Z, Guo S, Wei R, Grummer-Strawn LM, Curtin LR, Roche AF, Johnson CL. Centers for Disease Control and Prevention 2000 growth charts for the United States: improvements to the 1977 National Center for Health Statistics version. Pediatrics 2002; 109: 45-60.
13. Adams MR, Robinson J, Sorensen KE, Deanfield JE, Celermajer DS. Normal ranges for brachial artery flow-mediated dilation: a non-invasive ultrasound test of arterial endothelial function. J Vasc Invest 1996; 2: 146-150.
14. Leung SSF, Chan YL, Lau CWK, Chook P, Woo KS, Metreweli C. Body fatness and serum lipids of 11 years-old Chinese children. Acta Paediatr 1998; 87: 363-367.
15. Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child 1969; 44: 291-303.
16. Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child 1970; 45: 13-23.
17. Woo KS, McCrohon JA, Chook P, Adams MR, Robinson JT, McCredie RJ, Lam CW, Feng JZ, Celermajer DS. Chinese adults are less susceptible than whites to age-related endothelial dysfunction. J Am Coll Cardiol 1997; 30: 113-118.
18. Celermajer DS, Sorensen KE, Georgakopoulos D, Bull C, Thomas O, Robinson J, Deanfield JE. Vascular endothelial responses, prostanoids, and flow: cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation 1993; 88: 2149-2155.
19. Sorensen KE, Celermajer DS, Spiegelhalter DJ, Georgakopoulos D, Robinson J, Thomas O, Deanfield JE. Non-invasive measurement of human endothelium dependent arterial responses: accuracy and reproducibility. Br Heart J 1995; 74: 247-253.
20. Joannides R, Haefeli WE, Linder L, Richard V, Bakkali EH, Thuillez C, Luscher TF. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation 1995; 91: 1314-1319.
21. Anderson TJ, Uehata A, Gerhard MD, Knab S, Delagrange D, Lieberman EH, Ganz P, Creager MA, Yeung AC, Selwyn AP, Meredith IT. Close relationship of endothelial cell function in the human coronary and peripheral circulations. J Am Coll Cardiol 1995; 26: 1235-1241.
22. Neunteufl T, Heher S, Katzenschlager R, Wolfl G, Kostner K, Maurer G, Weidinger F. Late prognostic value of flow-mediated dilation in the brachial artery of patients with chest pain. Am J Cardiol 2000; 86: 207-210.
23. Salonen JT, Salonen R. Ultrasonographically assessed carotid morphology and the risk of coronary heart disease. Arterioscler Thromb Vasc Biol 1991; 11: 1245-1249.
24. Bots ML, Hoes AW, Koudstaal PJ, Hofman A, Grobbee DE. Common carotid intima-media thickness and risk of stroke and myocardial infarction: The Rotterdam Study. Circulation 1997; 96: 1432-1437.
25. Woo KS, Chook P, Raitakari OT, McQuillian B, Feng JZ, Celermajer DS. Westernization of Chinese adults and increased subclinical atherosclerosis. Atheroscl Thromb Vaascul Biol 1999; 19: 2487-2493.
26. Hochberg Y. A sharper Bonferroni procedure for multiple tests of significance. Biometrika 1988; 75: 800-802.
27. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. Br Med J 2000; 320: 1240-1243.
28. Steinberg HO, Chaker H, Learning R, Johnson A, Brechtel G, Baron AD. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest 1996; 97: 2601-2610.
29. Hashimoto M, Akishita M, Eto M, Kozaki K, Ako J, Sugimoto N, Yoshizumi M, Toba K, Ouchi Y. The impairment of flow-mediated vasodilatation in obese men with visceral fat accumulation. Int J Obes Relat Metab Disord 1998; 22: 477-484.
30. Suwaidi JA, Higano ST, Holmes Jr DR, Lennon R, Lerman A. Obesity is independently associated with coronary endothelial dysfunction in patients with normal or mildly diseased coronary arteries. J Am Coll Cardiol 2001; 37: 1523-1528.
31. Michele MD, Pancio S, Iannuzzi A, Celentano E, Ciardullo AV, Glasso R, Sacchetti L, Zarrilli F, Bond MG, Rubba P. Association of obesity and central fat distribution with carotid artery wall thickening in middle-aged women. Stroke 2002; 33: 2923-2928.
32. Singhal A, Farooqi S, Cole TJ, O'Rahilly S, Fewtrell M, Kattenhorn M, Lucas A, Deanfield J. Influcence of leptin on arterial distensibility: a novel link between obesity and cardiovascular disease? Circulation 2002; 106: 1919-1924.
33. Yudkin JS, Stehouwer CDA, Emeis JJ, Coppack SW. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 1999; 19: 972-978.
34. Nishina PM, Naggert JK, Verstudyft J, Paigen B. Atherosclerosis in genetically obese mice: the mutants obese, diabetes, fat, tubby and lethal yellow. Metabolism 1994; 43: 554-558.
35. Beller GA. The epidemic of type 2 diabetes and obesity in the US: cause for alarm. J Am Coll Cardiol 2000; 36: 2348-2350.
36. Martorell R, Kettel Khan L, Hughes ML, Grummer-Strawn LM. Overweight and obesity in preschool children from developing countries. Int J Obes Relat Metab Disord 2000; 24: 959-967.
37. Reddy KS, Yusuf S. Emerging epidemic of cardiovascular disease in developing countries. Circulation 1998; 97: 596-601.
38. Seidell JC. The burden of obesity and its sequelae. Disease Manage Health Outcomes 1999; 5: 13-21.
39. Bray GA. Obesity: a time bomb to be defused. Lancet 1998; 352: 160-161.
40. Woo KS, Chook P, Yu CW, Sung RYT, Lam CWK, Celermajer DS. Effect of diet and exercise on obesity-related vascular dysfunction in children. Circulation 2001; 104, (Suppl II) 803.