L-arginine-nitric oxide kinetics in normal and type 2 diabetic subjects: A stable-labelled 15N arginine approach

Diabetes

Volumn 52, Issue 3, 2003, Pages 795-802

  Avogaro, Angelo ^a,b   Toffolo, Gianna ^a   Kiwanuka, Edward ^a   De Kreutzenberg, Saula Vigili ^a   Tessari, Paolo ^a   Cobelli, Claudio ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b Cattedra di Malattie del Metabolismo   (Italy)

Author keywords

FSR, fractional synthetic rate; IRMS,isotope ratio mass spectrometry

Indexed keywords

ARGININE; NITRATE; NITRIC OXIDE;

ADULT; ARTICLE; ATHEROSCLEROSIS; CALCULATION; CLINICAL ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; ENDOTHELIUM INJURY; HUMAN; KINETICS; MALE; NITRATE METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOGENESIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TIME SERIES ANALYSIS; TURNOVER TIME; URINALYSIS;

ARGININE; DIABETES MELLITUS, TYPE 2; HUMANS; KINETICS; MALE; NITRATES; NITRIC OXIDE; NITROGEN ISOTOPES;

EID: 0345700728     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.3.795     Document Type: Article

References (25)

1. Hsueh WA, Quinones MJ, Creager MA: Endothelium in insulin resistance and diabetes. Diabetes Rev 5:343-352, 1997
2. Verma S, Anderson TJ: Fundamentals of endothelial function for the clinical cardiologist. Circulation 105:546-549, 2002
3. 15N]citrulline labeling. Proc Natl Acad Sci U S A 93:11460-11465, 1996
4. Lau T, Owen W, Yu YM, Noviski N, Lyons J, Zurakowski D, Tsay R, Ajami A, Young VR, Castillo L: Arginine, citrulline, and nitric oxide metabolism in end-stage renal disease patients. J Clin Invest 105:1217-1225, 2000
5. Forte P, Smith LM, Milne E, Benjamin N: Measurement of nitric oxide synthesis in humans using L-[15N2] arginine. Methods Enzymol 301:92-98, 1999
6. Forte P, Copland M, Smith LM, Milne E, Sutherland J, Benjamin N: Basal nitric oxide synthesis in essential hypertension. Lancet 349:837-842, 1997
7. O'Byrne S, Forte P, Roberts LJ 2nd, Morrow JD, Johnston A, Anggard E, Leslie RD, Benjamin N: Nitric oxide synthesis and isoprostane production in subjects with type 1 diabetes and normal urinary albumin excretion. Diabetes 49:857-862, 2000
8. Katz SD, Khan T, Zeballos GA, Mathew L, Potharlanka P, Knecht M, Whelan J: Decreased activity of the L-arginine-nitric oxide metabolic pathway in patients with congestive heart failure. Circulation 99:2113-2117, 1999
9. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR: Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 126:131-138, 1982
10. Avogaro A, Piarulli F, Valerio A, Miola M, Calveri M, Pavan P, Vicini P, Cobelli C, Tiengo A, Calo L, Del Prato S: Forearm nitric oxide balance, vascular relaxation, and glucose metabolism in NIDDM patients. Diabetes 46:1040-1046, 1997
11. Castillo L, Ajami A, Branch S, Chapman TE, Yu YM, Burke JF, Young VR: Plasma arginine kinetics in adult man: response to an arginine-free diet. Metabolism 43:114-122, 1994
12. Cobelli C, Toffolo G, Foster DM: Tracer-to-tracee ratio for analysis of stable isotope tracer data: link with radioactive kinetic formalism. Am J Physiol 262:E968-E975, 1992
13. Cobelli C, Foster D, Toffolo G: Tracer Kinetic in Biomedical Research: From Data to Model. New York, Kluwer Academic/Plenum Publishers, 2000
14. Baylis C, Vallance P: Measurement of nitrite and nitrate levels in plasma and urine-what does this measure tell us about the activity of the endogenous nitric oxide system? Curr Opin Nephrol Hypertens 7:59-62, 1998
15. Barret PHR, Bell BM, Cobelli C, Golde H, Schumitzky A, Vicini P, Foster D: SAAM II: simulation, analysis and modeling software for tracer and pharmacokinetics studies. Metabolism 47:484-492, 1998
16. Wever R, Boer P, Hijmering M, Stroes E, Verhaar M, Kastelein J, Versluis K, Lagerwerf F, van Rijn H, Koomans H, Rabelink T: Nitric oxide production is reduced in patients with chronic renal failure. Arterioscler Thromb Vasc Biol 19:1168-1172, 1999
17. Wu G, Morris SM Jr: Arginine metabolism: nitric oxide and beyond. Biochem J 336:1-17, 1998
18. Castillo L, deRojas TC, Chapman TE, Vogt J, Burke JF, Tannenbaum SR, Young VR: Splanchnic metabolism of dietary arginine in relation to nitric oxide synthesis in normal adult man. Proc Natl Acad Sci U S A 90:193-197, 1993
19. Jungermann K, Katz N: Functional specialization of different hepatocyte populations. Physiol Rev 69:708-764, 1989
20. Fard A, Tuck CH, Donis JA, Sciacca R, Di Tullio MR, Wu HD, Bryant TA, Chen NT, Torres Tamayo M, Ramasamy R, Berglund L, Ginsberg HN, Homma S, Cannon PJ: Acute elevations of plasma asymmetric dimethylarginine and impaired endothelial function in response to a high-fat meal in patients with type 2 diabetes. Arterioscler Thromb Vasc Biol 20:2039-2044, 2000
21. Zeballos GA, Bernstein RD, Thompson CI, Forfia PR, Seyedi N, Shen W, Kaminiski PM, Wolin MS, Hintze TH: Pharmacodynamics of plasma nitrate/nitrite as an indication of nitric oxide formation in conscious dogs. Circulation 91:2982-2988, 1995
22. Jungersten L, Edlund A, Petersson AS, Wennmalm A: Plasma nitrate as an index of nitric oxide formation in man: analyses of kinetics and confounding factors. Clin Physiol 16:369-379, 1996
23. Harrison DG: Cellular and molecular mechanisms of endothelial cell dysfunction. J Clin Invest 100:2153-2157, 1997
24. Farouque HM, Meredith IT: The assessment of endothelial function in humans. Coron Artery Dis 12:445-454, 2001
25. Beaumier L, Castillo L, Yu YM, Ajami AM, Young VR: Arginine: new and exciting developments for an old amino acid. Biomed Environ Sci 9:296-315, 1996