Modeling acid and cationic catalysis on the reactivity of duocarmycins

Journal of Organic Chemistry

Volumn 70, Issue 18, 2005, Pages 7098-7106

  Freccero, Mauro ^a   Gandolfi, Remo ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; CATALYSIS; COMPLEXATION; DRUG PRODUCTS; ELECTROSTATICS; MATHEMATICAL MODELS; ORGANIC ACIDS; SOLVENT EXTRACTION;

C-PCM SOLVATION MODEL; DUOCARMYCINS; PHYSIOLOGICAL CONDITIONS; WATER SOLUTIONS;

CATALYSTS;

9 METHYLADENINE; ACID; AMMONIA; CATION; CYCLOPROPA[C]PYRROLO[3,2 E]INDOL 4(5H) ONE; DNA; DUOCARMYCIN DERIVATIVE; FORMIC ACID; INDOLE DERIVATIVE; PHOSPHORIC ACID; PYRONE DERIVATIVE; SODIUM; UNCLASSIFIED DRUG; WATER;

ACIDITY; ALKYLATION; ARTICLE; CATALYSIS; CATALYST; CHEMICAL MODEL; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); DENSITY FUNCTIONAL THEORY; DNA DRUG COMPLEX; DRUG DNA BINDING; DRUG DNA INTERACTION; ENTROPY; PKA; SOLVATION;

ADENINE; ALKYLATING AGENTS; ALKYLATION; CATALYSIS; INDOLES; MODELS, MOLECULAR; PYRROLIDINONES; QUATERNARY AMMONIUM COMPOUNDS; SODIUM;

EID: 24144492999     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo050751p     Document Type: Article

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