Nucleophilic Cyclopropane Ring Opening in Duocarmycin SA Derivatives by Methanol under Acid Conditions: A Quantum Mechanical Study in the Gas-Phase and in Solution

Journal of Organic Chemistry

Volumn 69, Issue 8, 2004, Pages 2816-2824

  Cimino, P ^a,b   Improta, R ^a,c   Bifulco, G ^b   Riccio, R ^b   Gomez Paloma, L ^b   Barone, V ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

^c CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADDITION REACTIONS; CATALYSIS; DERIVATIVES; DNA; HARDNESS; METHANOL; ORGANIC SOLVENTS; QUANTUM THEORY; SOLUTIONS; STEREOCHEMISTRY;

ELECTROPHILICITY; POLARIZABLE CONTINUUM MODEL (PCM); SPIROCYCLIC SYSTEMS;

PROPANE;

ACID; ALKADIENE; ALKYLATING AGENT; CYCLOPROPANE DERIVATIVE; DUOCARMYCIN SA; METHANOL; SOLVENT;

ARTICLE; CALCULATION; CATALYSIS; CATALYST; DENSITY FUNCTIONAL THEORY; GAS; QUANTUM MECHANICS; REACTION ANALYSIS; RING OPENING; SOLVOLYSIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

EID: 1842739257     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0303517     Document Type: Article

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