Regulation of ubiquitin ligase dynamics by the nucleolus

Journal of Cell Biology

Volumn 170, Issue 5, 2005, Pages 733-744

  Mekhail, Karim ^a   Khacho, Mireille ^a   Carrigan, Amanda ^b   Hache, Robert R J ^b   Gunaratnam, Lakshman ^a   Lee, Stephen ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; PROTEIN MDM2; PROTEIN P53; UBIQUITIN PROTEIN LIGASE; VON HIPPEL LINDAU PROTEIN;

ARTICLE; BETA SHEET; BLEACHING; CELL FUNCTION; CELL STRUCTURE; COMPLEX FORMATION; ENZYME REGULATION; MOLECULAR DYNAMICS; NUCLEOLUS; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN SECRETION; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE, TUMOR; CELL NUCLEOLUS; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; HUMANS; HYDROGEN-ION CONCENTRATION; MICE; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN SORTING SIGNALS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RATS; RECOMBINANT FUSION PROTEINS; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

MURINAE;

EID: 24144477311     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200506030     Document Type: Article

References (56)

1. Abney, J.R., B. Cutler, M.L. Fillbach, D. Axelrod, and B.A. Scalettar. 1997. Chromatin dynamics in interphase nuclei and its implications for nuclear structure. J. Cell Biol. 137:1459-1468.
2. Andersen, J.S., Y.W. Lam, A.K. Leung, S.E. Ong, C.E. Lyon, A.I. Lamond, and M. Mann. 2005. Nucleolar proteome dynamics. Nature. 433:77-83.
3. Appella, E., and C.W. Anderson. 2001. Post-translational modifications and activation of p53 by genotoxic stresses. Eur. J. Biochem. 268:2764-2772.
4. Azzam, R., S.L. Chen, W. Shou, A.S. Mah, G. Alexandru, K. Nasmyth, R.S. Annan, S.A. Carr, and R.J. Deshaies. 2004. Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus. Science. 305:516-519.
5. Bonicalzi, M.E., I. Groulx, N. de Paulsen, and S. Lee. 2001. Role of exon 2-encoded beta-domain of the von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 276:1407-1416.
6. Carmo-Fonseca, M. 2002. The contribution of nuclear compartmentalization to gene regulation. Cell. 108:513-521.
7. Carmo-Fonseca, M., L. Mendes-Soares, and I. Campos. 2000. To be or not to be in the nucleolus. Nat. Cell Biol. 2:E107-E112.
8. Chen, D., and S. Huang. 2001. Nucleolar components involved in ribosome biogenesis cycle between the nucleolus and nucleoplasm in interphase cells. J. Cell Biol. 153:169-176.
9. Cheutin, T., A.J. McNairn, T. Jenuwein, D.M. Gilbert, P.B. Singh, and T. Misteli. 2003. Maintenance of stable heterochromatin domains by dynamic HP1 binding. Science. 299:721-725.
10. Ciechanover, A. 2005. Proteolysis: from the lysosome to ubiquitin and the proteasome. Nat. Rev. Mol. Cell Biol. 6:79-87.
11. Cockman, M.E., N. Masson, D.R. Mole, P. Jaakkola, G.W. Chang, S.C. Clifford, E.R. Maher, C.W. Pugh, P.J. Ratcliffe, and P.H. Maxwell. 2000. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 275:25733-25741.
12. Corless, C.L., A.S. Kibel, O. Iliopoulos, and W.G. Kaelin Jr. 1997. Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues. Hum. Pathol. 28:459-464.
13. Daelemans, D., S.V. Costes, S. Lockett, and G.N. Pavlakis. 2005. Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo. Mol. Cell. Biol. 25:728-739.
14. Dundr, M., T. Misteli, and M.O. Olson. 2000. The dynamics of postmitotic reassembly of the nucleolus. J. Cell Biol. 150:433-446.
15. Dundr, M., U. Hoffmann-Rohrer, Q. Hu, I. Grummt, L.I. Rothblum, R.D. Phair, and T. Misteli. 2002. A kinetic framework for a mammalian RNA polymerase in vivo. Science. 298:1623-1626.
16. Festenstein, R., S.N. Pagakis, K. Hiragami, D. Lyon, A. Verreault, B. Sekkali, and D. Kioussis. 2003. Modulation of heterochromatin protein 1 dynamics in primary Mammalian cells. Science. 299:719-721.
17. Freedman, D.A., and A.J. Levine. 1998. Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6. Mol. Cell. Biol. 18:7288-7293.
18. Gillette, T.G., W. Huang, S.J. Russell, S.H. Reed, S.A. Johnston, and E.C. Friedberg. 2001. The 19S complex of the proteasome regulates nucleotide excision repair in yeast. Genes Dev. 15:1528-1539.
19. Groulx, I., and S. Lee. 2002. Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein. Mol. Cell. Biol. 22:5319-5336.
20. Groulx, I., M.E. Bonicalzi, and S. Lee. 2000. Ran-mediated nuclear export of the von Hippel-Lindau tumor suppressor protein occurs independently of its assembly with cullin-2. J. Biol. Chem. 275:8991-9000.
21. Kaelin, W.G., Jr. 2002. Molecular basis of the VHL hereditary cancer syndrome. Nat. Rev. Cancer. 2:673-682.
22. Kibel, A., O. Iliopoulos, J.A. DeCaprio, and W.G. Kaelin Jr. 1995. Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C. Science. 269:1444-1446.
23. Kimura, H., and P.R. Cook. 2001. Kinetics of core histones in living human cells: little exchange of H3 and H4 and some rapid exchange of H2B. J. Cell Biol. 153:1341-1353.
24. Lam, Y.W., L. Trinkle-Mulcahy, and A.I. Lamond. 2005. The nucleolus. J. Cell Sci. 118:1335-1337.
25. Lee, S., M. Neumann, R. Stearman, R. Stauber, A. Pause, G.N. Pavlakis, and R.D. Klausner. 1999. Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein. Mol. Cell. Biol. 19:1486-1497.
26. Lippincott-Schwartz, J., N. Altan-Bonnet, and G.H. Patterson. 2003. Photobleaching and photoactivation: following protein dynamics in living cells. Nat. Cell Biol. (Suppl):S7-S14.
27. Llanos, S., P.A. Clark, J. Rowe, and G. Peters. 2001. Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus. Nat. Cell Biol. 3:445-452.
28. Lohrum, M.A., R.L. Ludwig, M.H. Kubbutat, M. Hanlon, and K.H. Vousden. 2003. Regulation of HDM2 activity by the ribosomal protein L11. Cancer Cell. 3:577-587.
29. Maison, C., and G. Almouzni. 2004. HP1 and the dynamics of heterochromatin maintenance. Nat. Rev. Mol. Cell Biol. 5:296-304.
30. Mekhail, K., L. Gunaratnam, M.E. Bonicalzi, and S. Lee. 2004a. HIF activation by pH-dependent nucleolar sequestration of VHL. Nat. Cell Biol. 6:642-647.
31. Mekhail, K., M. Khacho, L. Gunaratnam, and S. Lee. 2004b. Oxygen sensing by H+: implications for HIF and hypoxic cell memory. Cell Cycle. 3:1027-1029.
32. Michael, D., and M. Oren. 2003. The p53-Mdm2 module and the ubiquitin system. Semin. Cancer Biol. 13:49-58.
33. Misteli, T. 2001. Protein dynamics: implications for nuclear architecture and gene expression. Science. 291:843-847.
34. Momand, J., G.P. Zambetti, D.C. Olson, D. George, and A.J. Levine. 1992. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell. 69:1237-1245.
35. Muratani, M., and W.P. Tansey. 2003. How the ubiquitin-proteasome system controls transcription. Nat. Rev. Mol. Cell Biol. 4:192-201.
36. Oliner, J.D., J.A. Pietenpol, S. Thiagalingam, J. Gyuris, K.W. Kinzler, and B. Vogelstein. 1993. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature. 362:857-860.
37. Pause, A., S. Lee, R.A. Worrell, D.Y. Chen, W.H. Burgess, W.M. Linehan, and R.D. Klausner. 1997. The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc. Natl. Acad. Sci. USA. 94:2156-2161.
38. Paushkin, S.V., M. Patel, B.S. Furia, S.W. Peltz, and C.R. Trotta. 2004. Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3′ end formation. Cell. 117:311-321.
39. Petroski, M.D., and R.J. Deshaies. 2005. Function and regulation of cullin-RING ubiquitin ligases. Nat. Rev. Mol. Cell Biol. 6:9-20.
40. Phair, R.D., and T. Misteli. 2000. High mobility of proteins in the mammalian cell nucleus. Nature. 404:604-609.
41. Rabut, G., V. Doye, and J. Ellenberg. 2004. Mapping the dynamic organization of the nuclear pore complex inside single living cells. Nat. Cell Biol. 6:1114-1121.
42. Roth, J., M. Dobbelstein, D.A. Freedman, T. Shenk, and A.J. Levine. 1998. Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. EMBO J. 17:554-564.
43. Russell, S.J., S.H. Reed, W. Huang, E.C. Friedberg, and S.A. Johnston. 1999. The 19S regulatory complex of the proteasome functions independently of proteolysis in nucleotide excision repair. Mol. Cell. 3:687-695.
44. Semenza, G.L. 2000. HIF-1 and human disease: one highly involved factor. Genes Dev. 14:1983-1991.
45. Shou, W., J.H. Seol, A. Shevchenko, C. Baskerville, D. Moazed, Z.W. Chen, J. Jang, H. Charbonneau, and R.J. Deshaies. 1999. Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell. 97:233-244.
46. Shou, W., K.M. Sakamoto, J. Keener, K.W. Morimoto, E.E. Traverso, R. Azzam, G.J. Hoppe, R.M. Feldman, J. DeModena, D. Moazed, et al. 2001. Net1 stimulates RNA polymerase I transcription and regulates nucleolar structure independently of controlling mitotic exit. Mol. Cell. 8:45-55.
47. Stauber, R., G.A. Gaitanaris, and G.N. Pavlakis. 1995. Analysis of trafficking of Rev and transdominant Rev proteins in living cells using green fluorescent protein fusions: transdominant Rev blocks the export of Rev from the nucleus to the cytoplasm. Virology. 213:439-449.
48. Tao, W., and A.J. Levine. 1999. P19(ARF) stabilizes p53 by blocking nucleocytoplasmic shuttling of Mdm2. Proc. Natl. Acad. Sci. USA. 96:6937-6941.
49. Terrell, J., S. Shih, R. Dunn, and L. Hicke. 1998. A function for monoubiquitination in the internalization of a G protein-coupled receptor. Mol. Cell. 1:193-202.
50. Tsai, R.Y., and R.D. McKay. 2005. A multistep, GTP-driven mechanism controlling the dynamic cycling of nucleostemin. J. Cell Biol. 168:179-184.
51. van den Boom, V., E. Citterio, D. Hoogstraten, A. Zotter, J.M. Egly, W.A. van Cappellen, J.H. Hoeijmakers, A.B. Houtsmuller, and W. Vermeulen. 2004. DNA damage stabilizes interaction of CSB with the transcription elongation machinery. J. Cell Biol. 166:27-36.
52. Visintin, R., E.S. Hwang, and A. Amon. 1999. Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus. Nature. 398:818-823.
53. Walther, R.F., C. Lamprecht, A. Ridsdale, I. Groulx, S. Lee, Y.A. Lefebvre, and R.J. Hache. 2003. Nuclear export of the glucocorticoid receptor is accelerated by cell fusion-dependent release of calreticulin. J. Biol. Chem. 278:37858-37864.
54. Weber, J.D., L.J. Taylor, M.F. Roussel, C.J. Sherr, and D. Bar-Sagi. 1999. Nucleolar Arf sequesters Mdm2 and activates p53. Nat. Cell Biol. 1:20-26.
55. Weber, J.D., M.L. Kuo, B. Bothner, E.L. DiGiammarino, R.W. Kriwacki, M.F. Roussel, and C.J. Sherr. 2000. Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex. Mol. Cell. Biol. 20:2517-2528.
56. Weissman, A.M. 2001. Themes and variations on ubiquitylation. Nat. Rev. Mol. Cell Biol. 2:169-178.