Vitamin K analog (compound 5) induces apoptosis in human hepatocellular carcinoma independent of the caspase pathway

Anti-Cancer Drugs

Volumn 16, Issue 8, 2005, Pages 837-844

  Enokimura, Naoyuki ^a   Shiraki, Katsuya ^a   Kawakita, Tomoyuki ^a   Saitou, Yukiko ^a   Inoue, Hidekazu ^a   Okano, Hiroshi ^a   Yamamoto, Norihiko ^a   Sugimoto, Kazushi ^a   Carr, Brian I ^b   Nakano, Takeshi ^a  

^a MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Apoptosis; Caspase independent pathway; Compound 5; Human hepatocellular carcinoma; Vitamin K

Indexed keywords

2 (2 MERCAPTOETHANOL) 3 METHYL 1,4 NAPHTHOQUINONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYLFLUOROMETHYLKETONE; CASPASE 3; CASPASE 8; CASPASE INHIBITOR; CYSTEINE PROTEINASE; LIPOCORTIN 5; PROCASPASE 8; PROTEIN BCL XL; PROTEIN P53; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; VITAMIN K GROUP; X LINKED INHIBITOR OF APOPTOSIS;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL LEVEL; CELL STRAIN HEPG2; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DEGRANULATION; DRUG EFFECT; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; UPREGULATION; WILD TYPE;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-X PROTEIN; CARCINOMA, HEPATOCELLULAR; CASPASES; ENZYME INHIBITORS; HUMANS; LIVER NEOPLASMS; MEMBRANE GLYCOPROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA; TUMOR SUPPRESSOR PROTEIN P53; VITAMIN K; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 24044491266     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.cad.0000175583.78574.d7     Document Type: Article

References (56)

1. Krammer PH. CD95(APO-1/Fas)-mediated apoptosis: live and let die. Adv Immunol 1999; 71:163-210.
2. Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995; 267:1456-1462.
3. Schulte-Hermann R, Bursch W, Low-Baselli A, Wagner A, Grasl-Kraupp B. Apoptosis in the liver and its role in hepatocarcinogenesis. Cell Biol Toxicol 1997; 13:339-348.
4. Thorgeirsson SS, Teramoto T, Factor VM. Dysregulation of apoptosis in hepatocellular carcinoma. Semin Liver Dis 1998; 18:115-122.
5. Okano H, Shiraki K, Inoue H, Kawakita T, Yamanaka T, Deguchi M, et al. Cellular FLICE/caspase-8-inhibitory protein as a principal regulator of cell death and survival in human hepatocellular carcinoma. Lab Invest 2003; 83:1033-1043.
6. Strand S, Hofmann WJ, Hug H, Muller M, Otto G, Strand D, et al. Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells - a mechanism of immune evasion? Nat Med 1996; 2: 1361-1366.
7. Fujikawa K, Shiraki K, Sugimoto K, Ito T, Yamanaka T, Takase K, et al. Reduced expression of ICE/caspase1 and CPP32/caspase3 in human hepatocellular carcinoma. Anticancer Res 2000; 20(3B):1927-1932.
8. Soini Y, Virkajarvi N, Lehto VP, Paakko P. Hepatocellular carcinomas with a high proliferation index and a low degree of apoptosis and necrosis are associated with a shortened survival. Br J Cancer 1996; 73:1025-1030.
9. L in human hepatocellular carcinomas. Hepatology 2001; 34:55-61.
10. Ito T, Shiraki K, Sugimoto K, Yamanaka T, Fujikawa K, Ito M, et al. Survivin promotes cell proliferation in human hepatocellular carcinoma. Hepatology 2000; 31:1080-1085.
11. Shiraki K, Takase K, Nakano T. The emerging role of caspase inhibitors in gastrointestinal cancers. J Gastroenterol 2002; 37:323-331.
12. Sugimoto K, Shiraki K, Ito T, Fujikawa K, Takase K, Tameda Y, et al. Expression of functional CD40 in human hepatocellular carcinoma. Hepatology 1999; 30:920-926.
13. Suzuki A, Hayashida M, Kawano H, Sugimoto K, Nakano T, Shiraki K. Hepatocyte growth factor promotes cell survival from fas-mediated cell death in hepatocellular carcinoma cells via Akt activation and Fas-death-inducing signaling complex suppression. Hepatology 2000; 32:796-802.
14. Lamson DW, Plaza SM. The anticancer effects of vitamin K. Altern Med Rev 2003; 8:303-318.
15. 3 (menadione) inhibits the growth of mammalian tumor cells in culture. Life Sci 1981; 29: 1387-1392.
16. Chlebowski RT, Akman SA, Block JB. Vitamin K in the treatment of cancer. Cancer Treat Rev 1985; 12:49-63.
17. 3 action. Cancer 1989; 63:901-906.
18. Ngo EO, Sun TP, Chang JY, Wang CC, Chi KH, Cheng AL, et al. Menadione-induced DNA damage in a human tumor cell line. Biochem Pharmacol 1991; 42:1961-1968.
19. 3-induced cell cycle arrest and apoptotic cell death are accompanied by altered expression of c-fos and c-myc in nasopharyngeal carcinoma cells. Oncogene 1993; 8:2237-2244.
20. 3) against rat transplantable hepatoma induced by 3′-methyl-4-dimethyl-aminoazobenzene. Gaoxiong Yi Xue Ke Xue Za Zhi 1991; 7: 454-459.
21. 3 and methotrexate in tumor-bearing animals. Cancer Treat Rep 1986; 70:1433-1435.
22. Wang Z, Wang M, Finn F, Carr BI. The growth inhibitory effects of vitamins K and their actions on gene expression. Hepatology 1995; 22:876-882.
23. Nishikawa Y, Carr BI, Wang M, Kar S, Finn F, Dowd P, et al. Growth inhibition of hepatoma cells induced by vitamin K and its analogs. J Biol Chem 1995; 270:28304-28310.
24. Wang Z, Wang M, Carr BI. Involvement of hepatocyte epidermal growth factor receptor mediated activation of mitogen-activated protein kinase signaling pathways in response to growth inhibition by a novel K vitamin. J Cell Physiol 2000; 183:338-346.
25. 3 oxide inhibit growth of Hep 3B and Hep G2. Bioorg Chem 1995; 23:101-108.
26. Stone RL, Dixon JE. Protein-tyrosine phosphatases. J Biol Chem 1994; 269:31323-31326.
27. 3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy. Eur J Med Chem 2003; 38:451-457.
28. 3 (menadione) in mouse liver microsomes. Int J Biochem 1988; 20: 1073-1079.
29. 3 inhibition of malignant murine cell growth and human tumor colony formation. Cancer Treat Rep 1985; 69:527-532.
30. cdc2 kinase and phosphatase. Biochem Biophys Res Commun 1993; 190:907-913.
31. Ni R, Nishikawa Y, Carr BI. Cell growth inhibition by a novel vitamin K is associated with induction of protein tyrosine phosphorylation. J Biol Chem 1998; 273:9906-9911.
32. Osada S, Carr BI. Mechanism of novel vitamin K analog induced growth inhibition in human hepatoma cell line. J Hepatol 2001; 34:676-682.
33. Kar S, Adachi T, Carr BI. EGFR-independent activation of ERK1/2 mediates growth inhibition by a PTPase antagonizing K-vitamin analog. J Cell Physiol 2002; 190:356-364.
34. Wang Z, Nishikawa Y, Wang M, Carr BI. Induction of apoptosis via mitogen-activated protein kinase pathway by a K vitamin analog in rat hepatocytes. J Hepatol 2002; 36:85-92.
35. Cohen GM. Caspases: the executioners of apoptosis. Biochem J 1997; 326:1-16.
36. Thornberry NA, Lazebnik Y. Caspases: enemies within. Science 1998; 281:1312-1316.
37. Boise LH, Gonzalez-Garcia M, Postema CE, Ding L, Lindsten T, Turka LA, et al. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 1993; 74:597-608.
38. Duckett CS, Nava VE, Gedrich RW, Clem RJ, Van Dongen JL, Gilfillan MC, et al. A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. EMBO J 1996; 15:2685-2694.
39. Deveraux QL, Takahashi R, Salvesen GS, Reed JC. X-linked IAP is a direct inhibitor of cell-death proteases. Nature 1997; 388:300-304.
40. Shiraki K, Sugimoto K, Yamanaka Y, Yamaguchi Y, Saitou Y, ito K, et al. Overexpression of X-linked inhibitor of apoptosis in human hepatocellular carcinoma. Int J Mol Med 2003; 12:705-708.
41. Yamanaka T, Shiraki K, Sugimoto K, Ito T, Fujikawa K, ito M, et al. Chemotherapeutic agents augment TRAIL-induced apoptosis in human hepatocellular carcinoma cell lines. Hepatology 2000; 32:482-490.
42. Koike Y, Shiratori Y, Shiina S, Teratani T, Obi S, Sato S, et al. Randomized prospective study of prevention from tumor invasion into portal vein in 120 patients with hepatocellular carcinoma by vitamin K-II administration. Gastroenterology 2002; 122:643a (abstr).
43. 2 analog, on recurrence of hepatocellular carcinoma improved patient survival. Gastroenterology 2002; 126:736a. (abstr)
44. 2 in the development of hepatocellular carcinoma in women with viral cirrhosis of the liver. J Am Med Ass 2004; 292:358-361.
45. Nishikawa Y, Wang Z, Kerns J, Wilcox CS, Carr BI. Inhibition of hepatoma cell growth in vitro by arylating and non-arylating K vitamin analogs. Significance of protein tyrosine phosphatase inhibition. J Biol Chem 1999; 274:34803-34810.
46. Ge L, Wang Z, Wang M, Kar S, Carr BI. Involvement of c-Myc in growth inhibition of Hep 3B human hepatoma cells by a vitamin K analog. J Hepatol 2004; 41:823-829.
47. Kar S, Wang M, Wilcox CS, Carr BI. Antitumor and anticarcinogenic actions of Cpd 5: a new class of protein phosphatase inhibitor. Carcinogenesis 2003; 24:411-416.
48. Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, et al. The receptor for the cytotoxic ligand TRAIL. Science 1997; 276:111-113.
49. Schneider P, Thome M, Burns K, Bodmer JL, Hofmann K, Kataoka T, et al. TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB. Immunity 1997; 7:831-836.
50. Zhang JH, Zhang Y, Herman B. Caspases, apoptosis and aging. Ageing Res Rev 2003; 2:357-366.
51. Budihardjo I, Oliver H, Lutter M, Luo X, Wang X. Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol 1999; 15:269-290.
52. Cande C, Cohen I, Daugas E, Ravagnan L, Larochette N, Zamzami N, et al. Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria. Biochimie 2002; 84:215-222.
53. Johnson DE. Noncaspase proteases in apoptosis. Leukemia 2000; 14:1695-1703.
54. Li LY, Luo X, Wang X. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 2001; 412:95-99.
55. Heibein JA, Barry M, Motyka B, Bleackley RC. Granzyme B-induced loss of mitochondrial inner membrane potential (Delta Psi m) and cytochrome c release are caspase independent. J Immunol 1999; 163:4683-4693.
56. He Q, Liang Y, Wang D, Li YY, Li D. Non-caspase-mediated apoptosis contributes to the potent cytotoxicity of the enediyne antibiotic lidamycin toward human tumor cells. Biochem Pharmacol 2003; 65:1767-1775.