EGFR-independent activation of ERK1/2 mediates growth inhibition by a PTPase antagonizing K-vitamin analog

Journal of Cellular Physiology

Volumn 190, Issue 3, 2002, Pages 356-364

  Karr, Siddhartha ^a   Adachi, Takahito ^a   Carr, Brian I ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 1,4 NAPHTHOQUINONE DERIVATIVE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYSTEINE; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE; VITAMIN K GROUP;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL GROWTH; CELL LYSATE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FIBROBLAST; GROWTH INHIBITION; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

CDC25 PHOSPHATASE; CELL DIVISION; CELLS, CULTURED; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; FIBROBLASTS; GROWTH INHIBITORS; MAP KINASE KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS C-RAF; RECEPTOR, EPIDERMAL GROWTH FACTOR; REFERENCE VALUES; TIME FACTORS; TRANSFECTION; TYROSINE; VITAMIN K;

EID: 0036152581     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.10063     Document Type: Article

References (35)

1. Growth control and gene expression in a new hepatocellular carcinoma cell line, Hep40: Inhibitory actions of vitamin K
2. Epidermal growth factor-induced growth inhibition requires Stat 1 activation
3. Cell movement elicited by epidermal growth factor receptor requires kinase and autophosphorylation but is separable from mitogenesis
4. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences
5. Redox cycling and sulphydryl arylation; their relative importance in the mechanism of quinone cytotoxicity to isolated hepatocytes
6. Protein kinases and phosphatases: The yin and yang of protein phosphorylation and signaling
7. Tyrosine phosphorylation: Past present and future
8. cdk2 kinase and phosphatase
9. Vitamin K analog compound 5 inhibits rat liver regeneration after partial hepatectomy
10. Growth inhibition and protein tyrosine phosphorylation in MCF 7 breast cancer cells by a novel K vitamin
11. Thioalkyl derivatives of vitamin K3 and vitamin K3 oxide inhibit growth of Hep 3B and Hep G2 cells
12. Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents
13. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
14. A novel mitogen-activated protein kinase phosphatase
15. Cell growth inhibition by a novel K-vitamin is associated with induction of tyrosine phosphorylation
16. Growth inhibition of hepatoma cells induced by vitamin K and its analogs
17. Inhibition of Hepatoma cell growth in vitro by arylating and non-arylating analogs
18. DNA strand scission and free radical production in menadione-treated cells. Correlation with cytotoxicity and role of NADPH quinone acceptor oxidoreductase
19. Critical role of extracellular signal-regulated kinase (ERK) phosphorylation in novel vitamin K analog-induced cell death
20. Vitamin K3 (menadione) inhibits the growth of mammalian tumor cells in culture
21. Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway
22. Interaction of menadione (2-methyl-1,4-naphthoquinone) with glutathione
23. The role of oxidative processes in the cytotoxicity of substituted 1,4-naphthoquinones in isolated hepatocytes
24. Crystal structure of the MAPK phosphatase Pyst I catalytic domain and implication for regulated activation
25. Synthesis of vitamin K-dependent proteins
26. Cdc25 inhibition and cell cycle arrest by a synthetic thioalkyl vitamin K analogue
27. The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications
28. The mitogen activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic
29. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor
30. Signal transduction by receptors with tyrosine kinase activity
31. Spatial analysis of key signaling proteins by high-content solid-phase cytometry in Hep3B cells treated with an inhibitor of Cdc25 dual-specificity phosphatases
32. Growth inhibitory effects of vitamins K and their actions on gene expression
33. Involvement of hepatocyte epidermal growth factor receptor mediated activation of mitogen-activated protein kinase signalling pathways in response to growth inhibition by a novel K vitamin
34. Reactivity of thiols towards derivatives of 2- and 6-methyl-1,4-naphthoquinone bioreductive alkylating agents
35. Vitamin K3-induced cell cycle arrest and apoptotic cell death are accompanied by altered expression of c-fos and c-myc in nasopharyngeal carcinoma cells