Hepatocyte growth factor promotes cell survival from Fas-mediated cell death in hepatocellular carcinoma cells via Akt activation and Fas-death-inducing signaling complex suppression

Hepatology

Volumn 32, Issue 4 I, 2000, Pages 796-802

  Suzuki, Atsushi ^a   Hayashida, Midori ^a   Kawano, Hirokazu ^a   Sugimoto, Kazushi ^b   Nakano, Takeshi ^b   Shiraki, Katsuya ^b  

^a DAIICHI SANKYO CO   (Japan)

^b MIE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; PROTEIN KINASE B; SCATTER FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEPATOBLASTOMA; HUMAN; HUMAN CELL; LIVER CARCINOMA; LIVER CELL; PRIORITY JOURNAL;

EID: 0033806932     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2000.17738     Document Type: Article

References (45)

1. Cell death: The significance of apoptosis
2. Apoptosis by death factor
3. The Fas death factor
4. Human ICE/CED-3 protease nomenclature
5. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
6. Interleukin-3-induced phosphorylation of BAD through protein kinase Akt
7. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal
8. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
9. Akt phosphorylation of Bad couples survival signals to the cell-intrinsic death machinery
10. Regulation of cell death protease caspase-9 by phosphorylation
11. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcriptional factor
12. Hepatocyte growth factor promotes renal epithelial cell survival by dual mechanisms
13. Cellular survival: A play in three Akts
14. The opposing roles of the Akt and c-myc signaling pathways in survival from CD95-mediated apoptosis
15. Mechanism of activation of protein kinase B by insulin and IGF-1
16. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
17. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-triphosphate and Akt/protein kinase B signaling pathway
18. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
19. Molecular cloning and expression of human hepatocyte growth factor
20. Hepatocyte growth factor for liver disease
21. Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death
22. The dominant role of CPP32 subfamily in Fas-mediated hepatitis
23. Abrogation of Fas-induced fulminant hepatic failure in mice by hepatocyte growth factor
24. Hepatocyte growth factor gene therapy of liver cirrhosis in rats
25. Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers
26. Inhibition of neoplastic development in the liver by hepatocyte growth factor in a transgenic mouse model
27. Mitochondrial regulation of cell death: Mitochondria are essential for procaspase 3/p21 complex formation to resist Fas-mediated cell death
28. A cell killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor
29. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
30. Hepatocyte growth factor in transgenic mouse
31. Cell death induction by CTL: Perforin/Granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma
32. Protein kinases and phosphatases: The yin and yang of protein phosphorylation and signaling
33. Oncogenic K-Ras and basic fibroblast growth factor prevent Fas-mediated apoptosis in fibroblasts through activation of mitogen-activated protein kinase
34. Hepatocyte growth factor modulates motility and invasiveness of ovarian carcinoma via Ras-mediated pathway
35. Hepatocyte growth factor protects cultured rat cerebellar granule neurons from apoptosis via the phosphatidylinositol-3 kinase/Akt pathway
36. HGF triggers activation of the COX-2 gene in rat gastric epithelial cells: Action mediated through the ERK2 signaling pathway
37. Proapoptotic activity of Caenorhabditis elegans CED-4 protein in Drosophila: Implicated mechanism for caspase activation
38. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent kinase and protein kinase C
39. Wortmannin, a microbial product inhibitor of myosin light chain kinase
40. The bisindolylmaleimide GF109203X is a potent and selective inhibitor of protein kinase C
41. Mitochondria and apoptosis
42. Two CD95 (APO-1/Fas) signaling pathways
43. Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces Bax and promotes cell death
44. Functional absence of FADD in PLC/PRF/5 cells: Possible involvement in the transformation to hepatoma in HBV-infected hepatocyte
45. Fas antigen and p55 TNF receptor signal apoptosis through distinct pathway