Non-caspase-mediated apoptosis contributes to the potent cytotoxicity of the enediyne antibiotic lidamycin toward human tumor cells

Biochemical Pharmacology

Volumn 65, Issue 11, 2003, Pages 1767-1775

  Wang, Zhen ^a   He, Qiyang ^a,d   Liang, Yunyan ^b   Wang, Daishu ^b   Li, Yi Yang ^c   Li, Diandong ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

^b PEKING UNIVERSITY CANCER HOSPITAL AND INSTITUTE   (China)

^c BAYER AG   (Germany)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Breast carcinoma MCF 7 cells; Caspases; DNA cleavage; Hepatoma BEL 7402 cells; Lidamycin

Indexed keywords

ANTIBIOTIC AGENT; CASPASE; CASPASE 3; CASPASE 3 INHIBITOR; CASPASE 6; CASPASE 7; CASPASE 9; CASPASE INHIBITOR; DNA; DYE; ETOPOSIDE; HISTONE H1; HOE 33342; LIDAMYCIN; MITOMYCIN C; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL STRAIN MCF 7; CHROMATIN CONDENSATION; CONTROLLED STUDY; CYTOTOXICITY; DNA CLEAVAGE; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MITOCHONDRION; NUCLEOSOME; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; TUMOR CELL LINE;

EID: 0038392581     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(03)00117-5     Document Type: Article

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