A profile of the residues in the first intracellular loop critical for Gs-mediated signaling of human prostacyclin receptor characterized by an integrative approach of NMR-experiment and mutagenesis

Biochemistry

Volumn 44, Issue 34, 2005, Pages 11389-11401

  Zhang, Lihai ^a   Huang, Gangxiong ^a   Wu, Jiaxin ^a   Ruan, Ke He ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; FLUORESCENCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SIGNALING;

EPITOPES; INTRACELLULAR LOOP; RESIDUES; SIDE CHAINS;

PROTEINS;

ALANINE; AMINO ACID; ARGININE; EPITOPE; PROSTACYCLIN RECEPTOR; PROSTANOID RECEPTOR; RECOMBINANT PROTEIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; HUMAN; MUTAGENESIS; PREDICTION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; CONSERVED SEQUENCE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, EPOPROSTENOL; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 23944506541     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi050483p     Document Type: Article

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