Homologous regulation of the heptahelical D1A receptor responsiveness: Specific cytoplasmic tail regions mediate dopamine-induced phosphorylation, desensitization and endocytosis

Journal of Neurochemistry

Volumn 82, Issue 3, 2002, Pages 683-697

  Jackson, Adele ^a   Iwasiow, Rafal M ^a   Chaar, Ziad Y ^a   Nantel, Marie France ^a   Tiberi, Mario ^a  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

D1A receptor; Dopamine; Endocytosis; Human embryonic kidney cells; Mutagenesis; Phosphorylation

Indexed keywords

DOPAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE 1A RECEPTOR; G PROTEIN COUPLED RECEPTOR; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; ENDOCYTOSIS; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; SEQUENCE ANALYSIS;

ADENYLATE CYCLASE; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; DOPAMINE; DRUG RESISTANCE; ENDOCYTOSIS; ENZYME ACTIVATION; HUMANS; KIDNEY; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN CONFORMATION; RATS; RECEPTORS, DOPAMINE D1; SEQUENCE DELETION; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

KOBUS;

EID: 0036323308     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.01001.x     Document Type: Article

References (72)

1. C-terminal truncation of the neurokinin-2 receptor causes enhanced and sustained agonist-induced signaling. Role of receptor phosphorylation in signal attenuation
2. Homologous desensitization of the D1 dopamine receptor
3. A betaarrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation
4. Desensitization of DA1 dopamine receptors coupled to adenylyl cyclase in opossum kidney cells
5. Addiction, dopamine, and the molecular mechanisms of memory
6. Cyclic AMP-mediated desensitization of D1 dopamine receptor-coupled adenylyl cyclase in NS20Y neuroblastoma cells
7. Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonistpromoted desensitization
8. A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor
9. Theodore Cooper Lecture: Renal dopamine system: Paracrine regulator of sodium homeostasis and blood pressure
10. The cytoplasmic tail of the D1A receptor subtype: Identification of specific domains controlling dopamine cellular responsiveness
11. Dopamine-induced homologous and heterologous desensitizations of adenylate cyclase-coupled receptors on striatal neurons
12. Simultaneous analysis of families of sigmoidal curves: Application to bioassay, radioligand assay, and physiological dose-response curves
13. Dopamine D5 receptor agonist high affinity and constitutive activity profile conferred by carboxyl-terminal tail sequence
14. Receptor class desensitization of leukocyte chemoattractant receptors
15. Characterization of the phosphorylation sites involved in G protein-coupled receptor kinase- and protein kinase C-mediated desensitization of the alpha1B-adrenergic receptor
16. Internalization of D1 dopamine receptor in striatal neurons in vivo as evidence of activation by dopamine agonists
17. Dopamine tone regulates D1 receptor trafficking and delivery in striatal neurons in dopamine transporter-deficient mice
18. Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitization and signaling
19. Role of β-arrestin in mediating agonist-promoted G protein-coupled receptor internalization
20. Cloning and characterization of a truncated dopamine D1 receptor from goldfish retina: Stimulation of cyclic AMP production and calcium mobilization
21. Role of the C terminus in histamine H2 receptor signaling, desensitization, and agonistinduced internalization
22. The role of phosphorylation/dephosphorylation in agonist-induced desensitization of D1 dopamine receptor function: Evidence for a novel pathway for receptor dephosphorylation
23. Structural basis of agonist-induced desensitization and sequestration of the P2Y2 nucleotide receptor. Consequences of truncation of the C terminus
24. Heptahelical receptor signaling: Beyond the G protein paradigm
25. G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction
26. Regulation of human chemokine receptors CXCR4. Role of phosphorylation in desensitization and internalization
27. The cytoplasmic tail of the G-protein-coupled receptor for parathyroid hormone and parathyroid hormone-related protein contains positive and negative signals for endocytosis
28. The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization
29. Delineation of the structural basis for the activation properties of the dopamine D1 receptor subtypes
30. Distinct function of the cytoplasmic tail in human D1-like receptor ligand binding and coupling
31. Functional importance of the carboxyl tail cysteine residues in the human D1 dopamine receptor
32. Regulation of D1 dopamine receptors with mutations of protein kinase phosphorylation sites: Attenuation of the rate of agonist-induced desensitization
33. Distinct domains of the CB1 cannabinoid receptor mediate desensitization and internalization
34. Determination of adenylyl cyclase catalytic activity using single and double column procedures
35. Functional consequences of altering myocardial adrenergic receptor signaling
36. The role of receptor kinases and arrestins in G protein-coupled receptor regulation
37. Distinct residues in the carboxyl tail mediate agonist-induced desensitization and internalization of the human dopamine D1 receptor
38. Truncation of the receptor carboxyl terminus impairs agonist-dependent phosphorylation and desensitization of the α1B-adrenergic receptor
39. Signal transduction
40. Homologous desensitization of the D1A dopamine receptor: Efficacy in causing desensitization dissociates from both receptor occupancy and functional potency
41. Regulation of dopamine D1 receptor trafficking by protein kinase A-dependent phosphorylation
42. Synergistic regulation of β2-adrenergic receptor sequestration: Intracellular complement of betaadrenergic receptor kinase and beta-arrestin determine kinetics of internalization
43. Dopamine receptors: From structure to function
44. The palmitoylation state of the β2-adrenergic receptor regulates the synergistic action of cyclic AMP-dependent protein kinase and β-adrenergic receptor kinase involved in its phosphorylation and desensitization
45. Learning about addiction from the genome
46. Desensitization, phosphorylation and palmitoylation of the human dopamine D1 receptor
47. Agonist-induced desensitization of dopamine D1 receptor-stimulated adenylyl cyclase activity is temporally and biochemically separated from D1 receptor internalization
48. Agonist-induced desensitization of dopamine D-1 receptors in bovine retina and rat striatum
49. Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET
50. Classical and new roles of betaarrestins in the regulation of G-protein-coupled receptors
51. G proteincoupled receptor kinases
52. Modeling activation and desensitization of G-protein coupled receptors provides insight into ligand efficacy
53. Acute in vivo amphetamine produces a homologous desensitization of dopamine receptorcoupled adenylate cyclase activities and decreases agonist binding to the D1 site
54. Dopamine-1 receptor coupling defect in renal proximal tubule cells in hypertension
55. New insights into dopaminergic receptor function using antisense and genetically altered animals
56. Agonist-induced phosphorylation of the angiotensin AT1a receptor is localized to a serine/threoninerich region of its cytoplasmic tail
57. The carboxyl terminus of the hamster β-adrenergic receptor expressed in mouse L cells is not required for receptor sequestration
58. Regulation of adenosine 3′:5′-monophosphate content of human astrocytoma cells: Mechanism of agonist-specific desensitization
59. Angiotensin II receptor endocytosis involves two distinct regions of the cytoplasmic tail. A role for residues on the hydrophobic face of a putative amphipathic helix
60. Stable expression of a truncated AT1A receptor in CHO-K1 cells. The carboxyl-terminal region directs agonist-induced internalization but not receptor signaling or desensitization
61. Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases
62. Radiotracer imaging of dopaminergic transmission in neuropsychiatric disorders
63. Distinct dynamin-dependent and -independent mechanisms target structurally homologous dopamine receptors to different endocytic membranes
64. Properties of secretin receptor internalization differ from those of the β2-adrenergic receptor
65. Restricting mobility of Gsalpha relative to the β2-adrenoceptor enhances adenylate cyclase activity by reducing Gsalpha GTPase activity
66. Physiological roles of G-protein-coupled receptor kinases revealed by gene-targeting technology
67. Polymorphisms in dopamine receptors: What do they tell us?
68. Interaction of arrestins with intracellular domains of muscarinic and alpha2-adrenergic receptors
69. Identification of a cyclic adenosine 3′,5′-monophosphate-dependent protein kinase phosphorylation site in the carboxy terminal tail of human D1 dopamine receptor
70. Prenatal exposure to cocaine disrupts D1A dopamine receptor function via selective inhibition of protein phosphatase 1 pathway in rabbit frontal cortex
71. Desensitization of D1 dopamine receptor: Evidence for involvement of both cyclic AMP-dependent kinase and receptor-specific protein kinases