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Volumn 10, Issue 4, 2005, Pages 831-840

Insulin-like growth factor-I induces the phosphorylation and nuclear exclusion of forkhead transcription factors in human neuroblastoma cells

Author keywords

FKHR; FKHRL1; Forkhead; IGF I; IGF IR; Neuroblastoma

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; EXPORTIN 1; GREEN FLUORESCENT PROTEIN; LEPTOMYCIN B; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; SERINE; SOMATOMEDIN C; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1;

EID: 23944475155     PISSN: 13608185     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10495-005-0429-y     Document Type: Article
Times cited : (36)

References (75)
  • 1
    • 0026590078 scopus 로고
    • Neuroblastoma: Epidemiology and pattern of regression. Problems in interpreting results of mass screening
    • Carlsen NLT. Neuroblastoma: Epidemiology and pattern of regression. Problems in interpreting results of mass screening. Amer J Ped Hematol/Oncol 1992; 14: 103-110.
    • (1992) Amer J Ped Hematol/Oncol , vol.14 , pp. 103-110
    • Carlsen, N.L.T.1
  • 2
    • 0026596475 scopus 로고
    • Overview of current treatment of neuroblastoma
    • Philip T. Overview of current treatment of neuroblastoma. Amer J Ped Hematol/Oncol 1992; 14: 97-102.
    • (1992) Amer J Ped Hematol/Oncol , vol.14 , pp. 97-102
    • Philip, T.1
  • 3
    • 0031827078 scopus 로고    scopus 로고
    • The NGF story and neuroblastoma
    • Nakagawara A. The NGF story and neuroblastoma. Med Ped Oncol 1998; 31: 113-115.
    • (1998) Med Ped Oncol , vol.31 , pp. 113-115
    • Nakagawara, A.1
  • 4
    • 1542531898 scopus 로고    scopus 로고
    • NGF activation of TrkA decreases N-myc expression via MAPK path leading to a decrease in neuroblastoma cell number
    • Woo CW, Lucarelli E, Thiele CJ. NGF activation of TrkA decreases N-myc expression via MAPK path leading to a decrease in neuroblastoma cell number. Oncogene 2004; 23: 1522-1530.
    • (2004) Oncogene , vol.23 , pp. 1522-1530
    • Woo, C.W.1    Lucarelli, E.2    Thiele, C.J.3
  • 5
    • 0037112433 scopus 로고    scopus 로고
    • Resistance to chemotherapy mediated by TrkB in neuroblastomas
    • Ho R, Eggert A, Hishiki T, et al. Resistance to chemotherapy mediated by TrkB in neuroblastomas. Cancer Res 2002; 62: 6462-6466.
    • (2002) Cancer Res , vol.62 , pp. 6462-6466
    • Ho, R.1    Eggert, A.2    Hishiki, T.3
  • 6
    • 0037112455 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3′-kinase pathway
    • Jaboin J, Kim CJ, Kaplan DR, Thiele CJ. Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3′-kinase pathway. Cancer Res 2002; 62: 6756-6703.
    • (2002) Cancer Res , vol.62 , pp. 6756-16703
    • Jaboin, J.1    Kim, C.J.2    Kaplan, D.R.3    Thiele, C.J.4
  • 7
    • 0037366067 scopus 로고    scopus 로고
    • Neuroblastoma: Biological insights into a clinical enigma
    • Brodeur GM. Neuroblastoma: Biological insights into a clinical enigma. Nature Rev Cancer 2003; 3: 203-216.
    • (2003) Nature Rev Cancer , vol.3 , pp. 203-216
    • Brodeur, G.M.1
  • 8
    • 0033987491 scopus 로고    scopus 로고
    • Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis
    • van Golen CM, Feldman EL. Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol 2000; 182: 24-32.
    • (2000) J Cell Physiol , vol.182 , pp. 24-32
    • Van Golen, C.M.1    Feldman, E.L.2
  • 9
    • 0033937809 scopus 로고    scopus 로고
    • IGF-I receptor activation and Bcl-2 overexpression prevent early apoptotic events in human neuroblastoma
    • van Golen CM, Castle VP, Feldman EL. IGF-I receptor activation and Bcl-2 overexpression prevent early apoptotic events in human neuroblastoma. Cell Death and Differentiation 2000; 7: 654-665.
    • (2000) Cell Death and Differentiation , vol.7 , pp. 654-665
    • Van Golen, C.M.1    Castle, V.P.2    Feldman, E.L.3
  • 10
    • 0035829692 scopus 로고    scopus 로고
    • Insulin-like growth factor I stimulates motility in human neuroblastoma cells
    • Meyer GE, Shelden E, Kim B, Feldman EL. Insulin-like growth factor I stimulates motility in human neuroblastoma cells. Oncogene 2001; 20: 7542-7550.
    • (2001) Oncogene , vol.20 , pp. 7542-7550
    • Meyer, G.E.1    Shelden, E.2    Kim, B.3    Feldman, E.L.4
  • 11
    • 0942290417 scopus 로고    scopus 로고
    • Insulin-like growth factor-I signaling in human neuroblastoma cells
    • Kim B, van Golen C, Feldman EL. Insulin-like growth factor-I signaling in human neuroblastoma cells. Oncogene 2004; 23: 130-141.
    • (2004) Oncogene , vol.23 , pp. 130-141
    • Kim, B.1    Van Golen, C.2    Feldman, E.L.3
  • 12
    • 0027512244 scopus 로고
    • The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro
    • Giorgetti S, Ballotti R, Kowalski-Chauvel A, Tartare S, Van Obberghen E. The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro. Journal of Biological Chemistry 1993; 268: 7358-7364.
    • (1993) Journal of Biological Chemistry , vol.268 , pp. 7358-7364
    • Giorgetti, S.1    Ballotti, R.2    Kowalski-Chauvel, A.3    Tartare, S.4    Van Obberghen, E.5
  • 13
    • 0028486018 scopus 로고
    • Phosphatidylinositol 3-kinase
    • Kapeller R, Cantley LC. Phosphatidylinositol 3-kinase. Bioessays 1994; 16: 565-576.
    • (1994) Bioessays , vol.16 , pp. 565-576
    • Kapeller, R.1    Cantley, L.C.2
  • 14
    • 0028859279 scopus 로고
    • Protein modules and signalling networks
    • Pawson T. Protein modules and signalling networks. Nature 1995; 373: 573-580.
    • (1995) Nature , vol.373 , pp. 573-580
    • Pawson, T.1
  • 15
    • 0027165150 scopus 로고
    • The mitognen-activated protein kinase signal transduction pathway
    • Davis RJ. The mitognen-activated protein kinase signal transduction pathway. Journal of Biological Chemistry 1993; 268: 14553-14556.
    • (1993) Journal of Biological Chemistry , vol.268 , pp. 14553-14556
    • Davis, R.J.1
  • 16
    • 0026696360 scopus 로고
    • Mitogen-activated protein kinases: Versatile transducers for cell signaling
    • Pelech SL, Sanghera JS. Mitogen-activated protein kinases: Versatile transducers for cell signaling. Trends in the Biochemical Sciences 1992; 17: 233-238.
    • (1992) Trends in the Biochemical Sciences , vol.17 , pp. 233-238
    • Pelech, S.L.1    Sanghera, J.S.2
  • 18
    • 0028904053 scopus 로고
    • Insulin action and insulin signaling network
    • Cheatham B, Kahn CR. Insulin action and insulin signaling network. Endocrine Reviews 1995; 16: 117-142.
    • (1995) Endocrine Reviews , vol.16 , pp. 117-142
    • Cheatham, B.1    Kahn, C.R.2
  • 19
    • 0029011218 scopus 로고
    • The MAPK signaling cascade
    • Seger R, Krebs EG. The MAPK signaling cascade. FASEB Journal 1995; 9: 726-735.
    • (1995) FASEB Journal , vol.9 , pp. 726-735
    • Seger, R.1    Krebs, E.G.2
  • 20
    • 0031014651 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways
    • Párrizas M, Saltiel AR, LeRoith D. Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways. Journal of Biological Chemistry 1997; 272: 154-161.
    • (1997) Journal of Biological Chemistry , vol.272 , pp. 154-161
    • Párrizas, M.1    Saltiel, A.R.2    LeRoith, D.3
  • 21
    • 0029079275 scopus 로고
    • The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
    • Franke TF, Yang S-I, Chan TO, et al. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 1995; 81: 727-736.
    • (1995) Cell , vol.81 , pp. 727-736
    • Franke, T.F.1    Yang, S.-I.2    Chan, T.O.3
  • 22
    • 0030904561 scopus 로고    scopus 로고
    • The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal
    • Kennedy SG, Wagner AJ, Conzen SD, et al. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes and Development 1997; 11: 701-713.
    • (1997) Genes and Development , vol.11 , pp. 701-713
    • Kennedy, S.G.1    Wagner, A.J.2    Conzen, S.D.3
  • 23
    • 0031053586 scopus 로고    scopus 로고
    • Regulation of neuronal survival by the serine-threonine protein kinase Akt
    • Dudek H, Datta SR, Franke TF, et al. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 1997; 275: 661-665.
    • (1997) Science , vol.275 , pp. 661-665
    • Dudek, H.1    Datta, S.R.2    Franke, T.F.3
  • 24
    • 0032189381 scopus 로고    scopus 로고
    • Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
    • Coffer PJ, Jin J, Woodgett JR. Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochemical Journal 1998; 335(Pt 1): 1-13.
    • (1998) Biochemical Journal , vol.335 , Issue.1 PART , pp. 1-13
    • Coffer, P.J.1    Jin, J.2    Woodgett, J.R.3
  • 25
    • 15644381754 scopus 로고    scopus 로고
    • Role of translocation in the activation and function of protein kinase B
    • Andjelkovic M, Alessi DR, Meier R, et al. Role of translocation in the activation and function of protein kinase B. Journal of Biological Chemistry 1997; 272: 31515-31524.
    • (1997) Journal of Biological Chemistry , vol.272 , pp. 31515-31524
    • Andjelkovic, M.1    Alessi, D.R.2    Meier, R.3
  • 26
    • 0029160069 scopus 로고
    • Protein kinsase B (c-Akt) in phosphatidylinositol 3-OH kinase signal transduction
    • Burgering BMT, Coffer PJ. Protein kinsase B (c-Akt) in phosphatidylinositol 3-OH kinase signal transduction. Nature 1995; 376: 599-602.
    • (1995) Nature , vol.376 , pp. 599-602
    • Burgering, B.M.T.1    Coffer, P.J.2
  • 27
    • 0031034574 scopus 로고    scopus 로고
    • Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
    • Kulik G, Klippel A, Weber MJ. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Molecular Cell Biology 1997; 17: 1595-1606.
    • (1997) Molecular Cell Biology , vol.17 , pp. 1595-1606
    • Kulik, G.1    Klippel, A.2    Weber, M.J.3
  • 30
    • 0030727172 scopus 로고    scopus 로고
    • Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta
    • Meier R, Alessi DR, Cron P, Andjelkovic M, Hemmings BA. Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta. J Biol Chem 1997; 272: 30491-30497.
    • (1997) J Biol Chem , vol.272 , pp. 30491-30497
    • Meier, R.1    Alessi, D.R.2    Cron, P.3    Andjelkovic, M.4    Hemmings, B.A.5
  • 31
    • 0032529189 scopus 로고    scopus 로고
    • Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor
    • Paradis S, Ruvkun G. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes and Development 1998; 12: 2488-2498.
    • (1998) Genes and Development , vol.12 , pp. 2488-2498
    • Paradis, S.1    Ruvkun, G.2
  • 32
    • 0027521658 scopus 로고
    • Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma
    • published erratum appears in Nat Genet 1994; 6(2): 214
    • Galili N, Davis RJ, Fredericks WJ, et al. Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma [published erratum appears in Nat Genet 1994; 6(2): 214]. Nature Genetics 1993; 5: 230-235.
    • (1993) Nature Genetics , vol.5 , pp. 230-235
    • Galili, N.1    Davis, R.J.2    Fredericks, W.J.3
  • 34
    • 0030869789 scopus 로고    scopus 로고
    • AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily
    • Hillion J, Le Coniat M, Jonveaux P, Berger R, Bernard OA. AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily. Blood 1997; 90: 3714-3719.
    • (1997) Blood , vol.90 , pp. 3714-3719
    • Hillion, J.1    Le Coniat, M.2    Jonveaux, P.3    Berger, R.4    Bernard, O.A.5
  • 35
    • 0032518255 scopus 로고    scopus 로고
    • Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily
    • Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC. Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. Genomics 1998; 47: 187-199.
    • (1998) Genomics , vol.47 , pp. 187-199
    • Anderson, M.J.1    Viars, C.S.2    Czekay, S.3    Cavenee, W.K.4    Arden, K.C.5
  • 36
    • 0031031378 scopus 로고    scopus 로고
    • Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)
    • Borkhardt A, Repp R, Haas OA, et al. Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23). Oncogene 1997; 14: 195-202.
    • (1997) Oncogene , vol.14 , pp. 195-202
    • Borkhardt, A.1    Repp, R.2    Haas, O.A.3
  • 37
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    • Brunet A, Bonni A, Zigmond MJ, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999; 96: 857-868.
    • (1999) Cell , vol.96 , pp. 857-868
    • Brunet, A.1    Bonni, A.2    Zigmond, M.J.3
  • 38
    • 0033546439 scopus 로고    scopus 로고
    • Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
    • Rena G, Guo S, Cichy SC, Unterman TG, Cohen P. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J. Biol. Chem. 1999; 274: 17179-17183.
    • (1999) J Biol Chem , vol.274 , pp. 17179-17183
    • Rena, G.1    Guo, S.2    Cichy, S.C.3    Unterman, T.G.4    Cohen, P.5
  • 40
    • 0039425278 scopus 로고    scopus 로고
    • Negative regulation of the forkhead transcription factor FKHR by Akt
    • Tang ED, Nunez G, Barr FG, Guan KL. Negative regulation of the forkhead transcription factor FKHR by Akt. J. Biol. Chem. 1999; 274: 16741-16746.
    • (1999) J Biol Chem , vol.274 , pp. 16741-16746
    • Tang, E.D.1    Nunez, G.2    Barr, F.G.3    Guan, K.L.4
  • 41
    • 0033522897 scopus 로고    scopus 로고
    • Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway
    • Nakae J, Park BC, Accili D. Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. Journal of Biological Chemistry 1999; 274: 15982-15985.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 15982-15985
    • Nakae, J.1    Park, B.C.2    Accili, D.3
  • 42
    • 0034161544 scopus 로고    scopus 로고
    • Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR
    • Nakae J, Barr V, Accili D. Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR. EMBO Journal 2000; 19: 989-996.
    • (2000) EMBO Journal , vol.19 , pp. 989-996
    • Nakae, J.1    Barr, V.2    Accili, D.3
  • 44
    • 0034254446 scopus 로고    scopus 로고
    • A member of Forkhead family transcription factor, FKHRL1, is one of the downstream molecules of phosphatidylinositol 3-kinase-Akt activation pathway in erythropoietin signal transduction
    • Kashii Y, Uchida M, Kirito K, et al. A member of Forkhead family transcription factor, FKHRL1, is one of the downstream molecules of phosphatidylinositol 3-kinase-Akt activation pathway in erythropoietin signal transduction. Blood 2000; 96: 941-949.
    • (2000) Blood , vol.96 , pp. 941-949
    • Kashii, Y.1    Uchida, M.2    Kirito, K.3
  • 46
    • 0034462121 scopus 로고    scopus 로고
    • Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN
    • Nakamura N, Ramaswamy S, Vazquez F, Signoretti S, Loda M, Sellers WR. Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Molecular Cell Biology 2000; 20: 8969-8982.
    • (2000) Molecular Cell Biology , vol.20 , pp. 8969-8982
    • Nakamura, N.1    Ramaswamy, S.2    Vazquez, F.3    Signoretti, S.4    Loda, M.5    Sellers, W.R.6
  • 47
    • 0033518120 scopus 로고    scopus 로고
    • Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt
    • del Peso L, Gonzalez VM, Hernandez R, Barr FG, Nunez G. Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt. Oncogene 1999; 18: 7328-7333.
    • (1999) Oncogene , vol.18 , pp. 7328-7333
    • Del Peso, L.1    Gonzalez, V.M.2    Hernandez, R.3    Barr, F.G.4    Nunez, G.5
  • 48
    • 0030052757 scopus 로고    scopus 로고
    • Insulin-like growth factor I rescues SH-SY5Y human neuroblastoma cells from hyperosmotic induced programmed cell death
    • Matthews CC, Feldman EL. Insulin-like growth factor I rescues SH-SY5Y human neuroblastoma cells from hyperosmotic induced programmed cell death. Journal of Cellular Physiology 1996; 166: 323-331.
    • (1996) Journal of Cellular Physiology , vol.166 , pp. 323-331
    • Matthews, C.C.1    Feldman, E.L.2
  • 49
    • 0033546192 scopus 로고    scopus 로고
    • Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence
    • Guo S, Rena G, Cichy S, He X, Cohen P, Unterman T. Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence. J Biol Chem 1999; 274: 17184-17192.
    • (1999) J Biol Chem , vol.274 , pp. 17184-17192
    • Guo, S.1    Rena, G.2    Cichy, S.3    He, X.4    Cohen, P.5    Unterman, T.6
  • 50
    • 0028170210 scopus 로고
    • A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one(LY294002)
    • Vlahos CJ, Matter WF, Hui KY, Brown RF. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4- one(LY294002). J. Biol. Chem. 1994; 269: 5241-5248.
    • (1994) J Biol Chem , vol.269 , pp. 5241-5248
    • Vlahos, C.J.1    Matter, W.F.2    Hui, K.Y.3    Brown, R.F.4
  • 52
    • 0030886673 scopus 로고    scopus 로고
    • Nuclear export receptors: From importin to exportin
    • Ullman KS, Powers MA, Forbes DJ. Nuclear export receptors: From importin to exportin. Cell 1997; 90: 967-970.
    • (1997) Cell , vol.90 , pp. 967-970
    • Ullman, K.S.1    Powers, M.A.2    Forbes, D.J.3
  • 53
    • 0028318159 scopus 로고
    • Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression
    • Nishi K, Yoshida M, Fujiwara D, Nishikawa M, Horinouchi S, Beppu T. Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression. Journal of Biological Chemistry 1994; 269: 6320-6324.
    • (1994) Journal of Biological Chemistry , vol.269 , pp. 6320-6324
    • Nishi, K.1    Yoshida, M.2    Fujiwara, D.3    Nishikawa, M.4    Horinouchi, S.5    Beppu, T.6
  • 54
    • 0033529866 scopus 로고    scopus 로고
    • Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region
    • Kudo N, Matsumori N, Taoka H, et al. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proceedings of the National Academy of Sciences of the USA 1999; 96: 9112-9117.
    • (1999) Proceedings of the National Academy of Sciences of the USA , vol.96 , pp. 9112-9117
    • Kudo, N.1    Matsumori, N.2    Taoka, H.3
  • 55
    • 0035034038 scopus 로고    scopus 로고
    • Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX
    • Brownawell AM, Kops GJ, Macara IG, Burgering BM. Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX. Molecular Cell Biology 2001; 21: 3534-3546.
    • (2001) Molecular Cell Biology , vol.21 , pp. 3534-3546
    • Brownawell, A.M.1    Kops, G.J.2    Macara, I.G.3    Burgering, B.M.4
  • 56
    • 0029738916 scopus 로고    scopus 로고
    • Insulin-like growth factor I receptor prevents apotosis and enhances neuroblastoma tumorigenesis
    • Singleton JR, Randolph AE, Feldman EL. Insulin-like growth factor I receptor prevents apotosis and enhances neuroblastoma tumorigenesis. Cancer Research 1996; 56: 4522-4529.
    • (1996) Cancer Research , vol.56 , pp. 4522-4529
    • Singleton, J.R.1    Randolph, A.E.2    Feldman, E.L.3
  • 57
    • 0031007044 scopus 로고    scopus 로고
    • Insulin-like growth factor-I is an osmoprotectant in human neuroblastoma cells
    • Matthews CC, Odeh H, Feldman EL. Insulin-like growth factor-I is an osmoprotectant in human neuroblastoma cells. Neuroscience 1997; 79: 525-534.
    • (1997) Neuroscience , vol.79 , pp. 525-534
    • Matthews, C.C.1    Odeh, H.2    Feldman, E.L.3
  • 59
    • 0032734953 scopus 로고    scopus 로고
    • Insulin-like growth factor-I prevents caspase mediated apoptosis in Schwann cells
    • Delaney CL, Cheng H-L, Feldman EL. Insulin-like growth factor-I prevents caspase mediated apoptosis in Schwann cells. Journal of Neurobiology 1999; 41: 540-548.
    • (1999) Journal of Neurobiology , vol.41 , pp. 540-548
    • Delaney, C.L.1    Cheng, H.-L.2    Feldman, E.L.3
  • 60
    • 0032958415 scopus 로고    scopus 로고
    • Insulin-like growth factor-I prevents apoptosis in sympathetic neurons exposed to high glucose
    • Russell JW, Feldman EL. Insulin-like growth factor-I prevents apoptosis in sympathetic neurons exposed to high glucose. Hormone and Metabolic Research 1999; 31: 90-96.
    • (1999) Hormone and Metabolic Research , vol.31 , pp. 90-96
    • Russell, J.W.1    Feldman, E.L.2
  • 61
    • 0031691771 scopus 로고    scopus 로고
    • Insulin-like growth factor-I prevents apoptosis in neurons after nerve growth factor withdrawal
    • Russell JW, Windebank AJ, Schenone A, Feldman EL. Insulin-like growth factor-I prevents apoptosis in neurons after nerve growth factor withdrawal. Journal of Neurobiology 1998; 36: 455-467.
    • (1998) Journal of Neurobiology , vol.36 , pp. 455-467
    • Russell, J.W.1    Windebank, A.J.2    Schenone, A.3    Feldman, E.L.4
  • 62
    • 0033937058 scopus 로고    scopus 로고
    • Putative role of the phosphatidylinositol 3-kinase-Akt signaling pathway in the survival of granulosa cells
    • Westfall SD, Hendry IR, Obholz KL, Rueda BR, Davis JS. Putative role of the phosphatidylinositol 3-kinase-Akt signaling pathway in the survival of granulosa cells. Endocrine 2000; 12: 315-321.
    • (2000) Endocrine , vol.12 , pp. 315-321
    • Westfall, S.D.1    Hendry, I.R.2    Obholz, K.L.3    Rueda, B.R.4    Davis, J.S.5
  • 63
    • 0031770827 scopus 로고    scopus 로고
    • Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I
    • Kulik G, Weber MJ. Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I. Molecular and Cellular Biology 1998; 18: 6711-6718.
    • (1998) Molecular and Cellular Biology , vol.18 , pp. 6711-6718
    • Kulik, G.1    Weber, M.J.2
  • 64
    • 0030845224 scopus 로고    scopus 로고
    • Insulin-like growth factor-I-mediated neurite outgrowth in vitro requires MAP kinase activation
    • Kim B, Leventhal PS, Saltiel AR, Feldman EL. Insulin-like growth factor-I-mediated neurite outgrowth in vitro requires MAP kinase activation. J. Biol. Chem. 1997; 272: 21268-21273.
    • (1997) J Biol Chem , vol.272 , pp. 21268-21273
    • Kim, B.1    Leventhal, P.S.2    Saltiel, A.R.3    Feldman, E.L.4
  • 65
    • 0031846706 scopus 로고    scopus 로고
    • Differential regulation of focal adhesion kinase and mitogen-activated protein kinase tyrosine phosphorylation during insulin-like growth factor-I-mediated cytoskeletal reorganization
    • Kim B, Feldman EL. Differential regulation of focal adhesion kinase and mitogen-activated protein kinase tyrosine phosphorylation during insulin-like growth factor-I-mediated cytoskeletal reorganization. Journal of Neurochemistry 1998; 71: 1333-1336.
    • (1998) Journal of Neurochemistry , vol.71 , pp. 1333-1336
    • Kim, B.1    Feldman, E.L.2
  • 66
    • 0031727143 scopus 로고    scopus 로고
    • Differential regulation of insulin receptor substrate-2 and mitogen-activated protein kinase tyrosine phosphorylation by phosphatidylinositol 3-kinase inhibitors in SH-SY5Y human neuroblastoma cells
    • Kim B, Leventhal PS, White MF, Feldman EL. Differential regulation of insulin receptor substrate-2 and mitogen-activated protein kinase tyrosine phosphorylation by phosphatidylinositol 3-kinase inhibitors in SH-SY5Y human neuroblastoma cells. Endocrinology 1998; 139: 4881-4889.
    • (1998) Endocrinology , vol.139 , pp. 4881-4889
    • Kim, B.1    Leventhal, P.S.2    White, M.F.3    Feldman, E.L.4
  • 67
    • 0034671848 scopus 로고    scopus 로고
    • Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by akt kinase in PC12 cells
    • Zheng WH, Kar S, Quirion R. Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by akt kinase in PC12 cells. J. Biol. Chem. 2000; 275: 39152-39158.
    • (2000) J Biol Chem , vol.275 , pp. 39152-39158
    • Zheng, W.H.1    Kar, S.2    Quirion, R.3
  • 69
    • 0037158513 scopus 로고    scopus 로고
    • Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: Therapeutic implications
    • Mitsiades CS, Mitsiades N, Poulaki V, et al. Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: Therapeutic implications. Oncogene 2002; 21: 5673-5683.
    • (2002) Oncogene , vol.21 , pp. 5673-5683
    • Mitsiades, C.S.1    Mitsiades, N.2    Poulaki, V.3
  • 70
    • 0036078618 scopus 로고    scopus 로고
    • Insulin-like growth factor-1-induced phosphorylation of transcription factor FKHRL1 is mediated by phosphatidylinositol 3-kinase/Akt kinase and role of this pathway in insulin-like growth factor-1-induced survival of cultured hippocampal neurons
    • Zheng WH, Kar S, Quirion R. Insulin-like growth factor-1-induced phosphorylation of transcription factor FKHRL1 is mediated by phosphatidylinositol 3-kinase/Akt kinase and role of this pathway in insulin-like growth factor-1-induced survival of cultured hippocampal neurons. Molecular Pharmacology 2002; 62: 225-233.
    • (2002) Molecular Pharmacology , vol.62 , pp. 225-233
    • Zheng, W.H.1    Kar, S.2    Quirion, R.3
  • 71
    • 0033305739 scopus 로고    scopus 로고
    • FKHR binds the insulin response element in the insulin-like growth factor binding protein-1 promoter
    • Durham SK, Suwanichkul A, Scheimann AO, et al. FKHR binds the insulin response element in the insulin-like growth factor binding protein-1 promoter. Endocrinology 1999; 140: 3140-3146.
    • (1999) Endocrinology , vol.140 , pp. 3140-3146
    • Durham, S.K.1    Suwanichkul, A.2    Scheimann, A.O.3
  • 73
    • 0034699325 scopus 로고    scopus 로고
    • Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells
    • Jackson JG, Kreisberg JI, Koterba AP, Yee D, Brattain MG. Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells. Oncogene 2000; 19: 4574-4581.
    • (2000) Oncogene , vol.19 , pp. 4574-4581
    • Jackson, J.G.1    Kreisberg, J.I.2    Koterba, A.P.3    Yee, D.4    Brattain, M.G.5
  • 74
    • 9444237919 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and Akt effectors mediate insulin-like growth factor-I neuroprotection in dorsal root ganglia neurons
    • Leinninger GM, Backus C, Uhler MD, Lentz SI, Feldman EL. Phosphatidylinositol 3-kinase and Akt effectors mediate insulin-like growth factor-I neuroprotection in dorsal root ganglia neurons. FASEB Journal 2004; 18: 1544-1546.
    • (2004) FASEB Journal , vol.18 , pp. 1544-1546
    • Leinninger, G.M.1    Backus, C.2    Uhler, M.D.3    Lentz, S.I.4    Feldman, E.L.5
  • 75
    • 0036191716 scopus 로고    scopus 로고
    • Expression of FKHR, FKHRL1, and AFX Genes in the Rodent Ovary: Evidence for Regulation by IGF-I, Estrogen, and the Gonadotropins
    • Richards JS, Sharma SC, Falender AE, Lo YH. Expression of FKHR, FKHRL1, and AFX Genes in the Rodent Ovary: Evidence for Regulation by IGF-I, Estrogen, and the Gonadotropins. Molecular Endocrinology 2002; 16: 580-599.
    • (2002) Molecular Endocrinology , vol.16 , pp. 580-599
    • Richards, J.S.1    Sharma, S.C.2    Falender, A.E.3    Lo, Y.H.4


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