Differential regulation of insulin receptor substrate-2 and mitogen- activated protein kinase tyrosine phosphorylation by phosphatidylinositol 3- kinase inhibitors in SH-SY5Y human neuroblastoma cells

Endocrinology

Volumn 139, Issue 12, 1998, Pages 4881-4889

  Kim, Bhumsoo ^a   Leventhal, Phillip S ^a   White, Morris F ^b   Feldman, Eva L ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE; NEUROTROPHIC FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; WORTMANNIN;

ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0031727143     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.12.6348     Document Type: Article

References (55)

1. Humbel RE 1990 Insulin-like growth factors I and II. Eur J Biochem 190:445-462
2. White M, Kahn CR 1994 The insulin signaling system. J Biol Chem 269:1-4
3. Van Obberghen E 1994 Signaling through the insulin receptor and the insulin-like growth factor-I receptor. Diabetologia [Suppl 2] 37:S125-S134
4. Chou CK, Dull TJ, Russell DS, Gherzi R, Lebwohl D, Ullrich A, Rosen OM 1987 Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin. J Biol Chem 262:1842-1847
5. Kato H, Faria TN, Stannard B, Roberts Jr CT, LeRoith D 1993 Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (αIR-3). J Biol Chem 268:2655-2661
6. Myers Jr MG, White MF 1996 Insulin signal transduction and the IRS protein. Annu Rev Pharmacol Toxicol 36:615-658
7. Waters SB, Pessin JE 1996 Insulin receptor substrate 1 and 2 (IRS1 and IRS2): what a tangled web we weave. Trends Cell Biol 6:1-4
8. Skolnik EY, Lee C-H, Batzer A, Vincentini LM, Zhou M, Daly R, Myers MG, Jr., Backer JM, Ullrich A, White MF, Schlessinger J 1993 The SH2/SH3 domain-containing protein Grb2 interacts with tyrosine-phosphorylated IRS 1 and She: implications for insulin control of ras signaling. EMBOJ 12:1929-1936
9. Giorgetti S, Pelicci PG, Pelicci G, Van Obberghen E 1994 Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-facror-I-receptor. Eur J Biochem 223:195-202
10. Davis RJ 1993 The mitognen-activated protein kinase signal transduction pathway. J Biol Chem 268:14553-14556
11. Pelech SL, Sanghera JS 1992 Mitogen-activated protein kinases: versatile transducers for cell signaling. Trends Biochem Sci 17:233-238
12. Carpenter CL, Cantley LC 1996 Phosphoinositide 3-kinase and the regulation of cell growth. Biochim Biophys Acta 1288:M11-M16
13. Varticovski L, Harrison-Findik D, Keeler ML, Susa M 1994 Role of PI 3-kinase in mitogenesis. Biochim Biophys Acta 1226:1-11
14. Cheatham B, Kahn CR 1995 Insulin action and insulin signaling network. Endocr Rev 16:117-142
15. Tamemoto H, Kadowaki T, Tobe K, Yagi T, Sakura H, Hayakawa T, Terauchi Y, Ueki K, Kaburagi Y, Satoh S, Sekihara H, Yoshioka S, Horikoshi H, Furuta Y, Ikawa Y, Kasuga M, Yazaki Y, Aizawa S 1994 Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 372:182-186
16. Araki E, Lipes MA, Patti M-E, Bruning JC, Haag III B, Johnson RS, Kahn CR 1994 Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene. Nature 372:186-190
17. Rondinone CM, Wang LM, Lonnroth P, Wesslau C, Pierce JH 1997 Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 94:4171-4175
18. Bruning JC, Winnay J, Cheatham B, Kahn CR 1997 Differential signaling by insulin receptor substrate-1 (IRS-1) and IRS-2 in IRS-1-deficient cells. Mol Cell Biol 17:1513-1521
19. Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren J-M, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MF 1998 Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391:900-904
20. Feldman EL, Sullivan KA, Kim B, Russell JW 1997 Insulin-like growth factors regulate neuronal differentiation and survival. Neurobiol Dis 4:201-214
21. Kim B, Leventhal PS, Saltiel AR, Feldman EL 1997 Insulin-like growth factor-I-mediated neunte outgrowth in vitro requires MAP kinase activation. J Biol Chem 272:21268-21273
22. Singleton JR, Dixit VM, Feldman EL 1996 Type I insulin-like growth factor receptor activation regulates apoptotic proteins. J Biol Chem 271:31791-31794
23. Leventhal PS, Shelden EA, Kim B, Feldman EL 1997 Tyrosine phosphorylation of paxillin and focal adhesion kinase during insulin-like growth factor-I-stimulated lamellipodial advance. J Biol Chem 272:5214-5218
24. Leventhal PS, Feldman EL 1997 Insulin-like growth factors as regulators of cell motility: signaling mechanisms. Trends Endocrinol Metab 8:1-6
25. Argetsinger LS, Norstedt G, Billestrup N, White MF, Carter-Su C 1996 Growth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling. J Biol Chem 271:29415-29421
26. Jones J, Clemmons D 1995 Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 16:3-34
27. Feldman EL, Randolph A, Yee D 1993 Insulin-like growth factor binding protein expression in SH-SY5Y neuroblastoma cells. In: Raizada MK, LeRoith D (eds) The Role of Insulin-Like Growth Factors in the Nervous System. New York Academy of Science, New York, pp 262-264
28. c-src complexes, and PI3-kinase. Cell 65:91-104
29. Paz K, Hemi R, LeRoith D, Karasik A, Elhanany E, Kanety H, Zick Y 1997 A molecular basis for insulin resistance. J Biol Chem 272:29911-29918
30. Tanti JF, Gremeaux T, VanObberghen E, LeMarchand-Brustel Y 1994 Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling. J Biol Chem 269:6051-6057
31. Lam K, Carpenter CL, Ruderman NB, Friel JC, Kelly KL 1994 The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. J Biol Chem 269:20648-20652
32. Tanti JF, Gremeaux T, VanObberghen E, LeMarchand-Brustel Y 1994 Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase. Biochem J 304:17-21
33. Sun JS, Rothenburg P, Kahn CR, Backer JM, Aracki E, Wilden PA, Cahill DA, Oldstein BJ, White MF 1991 Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352:73-77
34. Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, Ullrich A, Skolnik EY, Bar-Sagi D, Schlessinger J 1992 The SH2 and SH3 domaincontaining protein GRB2 links receptor tyrosine kinases to ras signaling. Cell 70:431-442
35. Skolnik EY, Batzer A, Li N, Lee C-H, Lowenstein E, Mohammadi M, Margolis B, Schlessinger J 1993 The function of GRB2 in linking the insulin receptor to Ras signaling pathways. Science 260:1953-1955
36. Kimura K, Hattori S, Kabuyama Y, Shizawa Y, Takayanagi J, Nakamura S, Toki S, Matsuda Y, Onedera K, Fukui Y 1994 Neurite outgrowth of PC12 cells is supressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase. J Biol Chem 269:18961-18967
37. Ui M, Okada T, Hazeki K, Hazeki O 1995 Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. Trends Biochem Sci 20:303-307
38. Vlahos CJ, Matter WF, Hui KY, Brown RF 1994 A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269:5241-5248
39. Welham MJ, Bone H, Levings M, Learmonth L, Wang L-M, Leslie KB, Pierce JH, Schrader JW 1997 Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells. J Biol Chem 272:1377-1381
40. Ogihara T, Shin BC, Anai M, Katagiri H, Inukai K, Funaki M, Fukushima Y, Ishihara H, Takata K, Kikuchi M, Yazaki Y, Oka Y, Asano T 1997 Insulin receptor substrate (IRS)-2 is dephosphorylated more rapidly than IRS-1 via its association with phosphatidylinositol 3-kinase in skeletal muscle cells. J Biol Chem 272:12868-12873
41. Li PM, Goldstein BJ 1996 Differential regulation of insulin-stimulated tyrosine phosphorylation of IRS-1 and SHC by wortmannin in intact cells. Biochem Biophys Res Commun 223:80-84
42. Mothe I, Van Obberghen E 1996 Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action. J Biol Chem 271:11222-11227
43. Heller-Harrison RA, Morin M, Czech MP 1995 Insulin regulation of membrane-associated insulin receptor substrate 1. J Biol Chem 270:24442-24450
44. Smith LK, Bradshaw M, Croall DE, Garner CW 1993 The insulin receptor substrate (IRS-1) is a PEST protein that is susceptible to calpain degradation in vitro. Biochem Biophys Res Commun 196:767-772
45. Kanety H, Feinstein R, Papa MZ, Hemi R, Karasik A 1995 Tumor necrosis factor α-induced phosphorylation of insulin receptor substrate-1 (IRS-1). J Biol Chem 270:23780-23784
46. Hofmann C, Lorenz K, Braithwaite SS, Colca JR, Palazuk BJ, Hotamisligil GS, Spiegelman BM 1994 Altered gene expression for tumor necrosis factor-α and its receptors during drug and dietary modulation of insulin resistance. Endocrinology 134:264-270
47. Hotamisligil GS, Shargill NS, Spiegelman BM 1993 Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 259:87-91
48. Myers MG, Jr., Wang L-M, Sun XJ, Zhang Y, Yenush L, Schlessinger J, Pierce JH, White MF 1994 Role of IRS-1-Grb-2 complex in insulin signaling. Mol Cell Biol 14:3577-3587
49. Hu Q, Klippel A, Muslin AJ, Fantl WJ, Williams LT 1995 Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science 268:100-102
50. Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfield MD, Downward J 1994 Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370:527-532
51. Welsh GI, Foulstone EJ, Young SW, Tavare JM, Proud CG 1994 Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase. Biochem J 303:15-20
52. Shepherd PR, Nave BT, Rincon J, Haigh RJ, Foulstone E, Proud C, Zierath JR, Siddle K, Wallberg-Henriksson H 1997 Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle: implications for glucose metabolism. Diabetologia 40:1172-1177
53. Suga J, Yoshimasa Y, Yamada K, Yamamoto Y, Inoue G, Okamoto M, Hayashi T, Shigemoto M, Kosaki A, Kuzuya H, Nakao K 1997 Differential activation of mitogen-activated protein kinase by insulin and epidermal growth factor in 3T3-L1 adipocytes. Diabetes 46:735-741
54. Duckworth BC, Cantley LC 1997 Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. J Biol Chem 272:27665-27670
55. Jackson TR, Blader IJ, Hammonds-Odie LP, Burga CR, Cooke F, Hawkins PT, Wolf AG, Heldman KA, Theibert AB 1996 Initiation and maintenance of NGF-stimulated neunte outgrowth requires activation of a phosphoinositide 3-kinase. J Cell Sci 109:289-300